李光｜厦门大学｜学者主页

精选作品

期刊论文

2026

Human iPSC-derived heart valve-like assembloids model valve development and disease pathology

Yuan-Hang He, Abbas Jalili, C. Jones, Hao He, Lameck Beni, Daniel Lamont, Jun Hu, Macy Yost, Lance A. Davidson, Si-Yang Zheng, Guang Li

Cell Stem Cell

DOI

2026

Spatial transcriptomic profiling of developing mouse hearts reveals a spatially patterned signaling environment

Jun Hu, Hao He, Juan Xu, William A. MacDonald, Yuan-Hang He, Tian-Hao Liu, Wei Chen, Guang Li

Communications Biology

DOI

2026

Unbiased and Epicardial-Specific Lineage Tracing Reveal Epicardial Contribution to Vascular Endothelial Cells in Heart Development

Payal Ghosh, Zi-Bei Gao, Hao He, Juan Xu, Guang Li

bioRxiv

DOI

2026

Next-generation vascular organoids: multi-lineage and immune integration for disease modeling and regenerative medicine

Qiao-Wen Chen, Jia-Le Jin, Fahsai Kantawong, Guang Li, Jing-Yan Li

Vessel Plus

DOI

2026

Abstract Tue005: Vascularization of heart organoid enhanced cardiomyocyte maturation

Guang Li

Circulation Research

DOI

2026

Whole-genome duplication shaped cell-type evolution in the vertebrate brain

Yuanzhen Zhu, S Q Zhang, Jiankai Wei, Diego Dolgetta-Garcia, Katia Jindrich, Huimin Liu, Chenggang Shi, Rongrong Pan, Yuehua Chen, Y Xu, Qiye Li, Günter P. Wagner, Peter W. H. Holland, Guang Li, Sebastian M. Shimeld

Nature

DOI

2026

Evolutionary dynamics of sex determination in Branchiostoma belcheri driven by repeated transposition of a single novel gene

Huan Li, Fujiang Liu, Jingjing Li, Chenggang Shi, Zhenyi Lin, Yucheng Qin, Rongrong Pan, Xiaotong Wu, Yongying Peng, Chaofan Xing, Yiquan Wang, Qingming Qu, Guang Li

Nature Communications

DOI

2026

Fgf evolution in vertebrates: insights from cyclostomes

Liyan He, Zheng Dong, Baichuan Tong, Suhan Liu, Fujiang Liu, Zixiang Wu, Guang Li, Qingming Qu

BMC Genomics

DOI

2026

Germline de novo mutation rate of the highly heterozygous amphioxus genome

Jing Xue, Tao Lei, Junwei Cao, Liang Wu, Guang Li, Cai Li

Molecular Biology and Evolution

DOI

2025

Cited4a limits cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration

Rachel E. Forman-Rubinsky, A. Paul, Wei Feng, B. Schlegel, Daniel A. Zuppo, Katarzyna M Kedziora, Donna Stoltz, Simon C. Watkins, D. Rajasundaram, Guang Li, Michael Tsang

Development

DOI

2025

Cardiac fibroblasts regulate myocardium and coronary vasculature development in the murine heart via the collagen signaling pathway

Yiting Deng, Yuan-Hang He, Juan Xu, Hao He, Man-Ling Zhang, Guang Li

eLife

DOI

2025

Heart spheroids from primary cells for studying cardiac development

Cindy Chang, Juan Xu, Shirley Chang, Guang Li

bioRxiv

DOI

2024

Single-cell analysis of the amphioxus hepatic caecum and vertebrate liver reveals genetic mechanisms of vertebrate liver evolution

Baosheng Wu, Wenjie Xu, Kunjin Wu, Ye Li, Mingliang Hu, Chenguang Feng, Chenglong Zhu, Jiangmin Zheng, Xinxin Cui, Jing Li, Deqian Fan, Fenghua Zhang, Yuxuan Liu, Jinping Chen, Chang Liu, Guang Li, Qiang Qiu, Kai Qu, Wen Wang, Kun Wang

Nature Ecology & Evolution

DOI

2024

Evolutionary origin of the chordate nervous system revealed by amphioxus developmental trajectories

Yichen Dai, Yanhong Zhong, Rongrong Pan, Liang Yuan, Yongheng Fu, Yuwei Chen, Juan Du, Meng Li, Xiao Wang, Huimin Liu, Chenggang Shi, Gaoming Liu, Pingfen Zhu, Sebastian Shimeld, Xuming Zhou, Guang Li

Nature Ecology & Evolution

DOI

2024

Deep learning based characterization of human organoids using optical coherence tomography

Bingjie Wang, Razieh Ganjee, Irona Khandaker, Keevon Flohr, Yuan-Hang He, Guang Li, Joshua Wesalo, J. Sahel, S. da Silva, Shaohua Pi

Biomedical Optics Express

DOI

2024

Keratin 19 (Krt19) is a novel marker gene for epicardial cells

Juan Xu, Yiting Deng, Guang Li

Frontiers in Genetics

DOI

2024

Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates

Yichen Dai, Rongrong Pan, Qi Pan, Xiaotong Wu, Zexin Cai, Yongheng Fu, Chenggang Shi, Yizhe Sheng, Jingjing Li, Zhe Lin, Gaoming Liu, Pingfen Zhu, Meng Li, Guang Li, Xuming Zhou

Science Advances

DOI

2023

Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury

Daniel A. Zuppo, M. Missinato, Lucas Santana-Santos, Guang Li, P. Benos, Michael Tsang

Development

DOI

2023

Heterogeneity and Functional Analysis of Cardiac Fibroblasts in Heart Development

Yiting Deng, Yuanhang He, Juan Xu, Hao He, Guang Li

bioRxiv

DOI

2023

Amphioxus Gli knockout disrupts the development of left–right asymmetry but has limited impact on neural patterning

Xin Huang, Qiongqiong Ren, Yiquan Wang, Sebastian M. Shimeld, Guang Li

Marine Life Science & Technology

DOI

2023

Three amphioxus reference genomes reveal gene and chromosome evolution of chordates

Zhen J. Huang, Luohao Xu, Cheng Cai, Yitao Zhou, Jing Liu, Zaoxu Xu, Zexian Zhu, Wen Kang, Wan Cen, Surui Pei, Duo Chen, Chenggang Shi, Xiaotong Wu, Yongji Huang, Chaohua Xu, Yanan Yan, Ying Yang, Ting Xue, Wenjin He, Xuefeng Hu, Yanding Zhang, Youqiang Chen, Changwei Bi, Chunpeng He, Lingzhan Xue, Shijun Xiao, Zhicao Yue, Yu Jiang, Jr‐Kai Yu, Erich David Jarvis, Guang Li, Gang Lin, Qiujin Zhang, Qi Zhou

Proceedings of the National Academy of Sciences

DOI

2023

Evolution of the gene regulatory network of body axis by enhancer hijacking in amphioxus

Chenggang Shi, Shuang Chen, Huimin Liu, Shiqi Li, Yanhui Wang, Yanhui Wang, Rongrong Pan, Xiaotong Wu, Xuewen Li, Jingjing Li, 邢超凡, Xian Liu, Yiquan Wang, Yiquan Wang, Qingming Qu, Guang Li

eLife

DOI

2023

Author response: Evolution of the gene regulatory network of body axis by enhancer hijacking in amphioxus

Chenggang Shi, Shuang Chen, Huimin Liu, Rongrong Pan, Shiqi Li, Yanhui Wang, Xiaotong Wu, Jingjing Li, Xuewen Li, Chaofan Xing, Xian Liu, Yiquan Wang, Qingming Qu, Guang Li

DOI

2023

TransIntegrator: capture nearly full protein-coding transcript variants via integrating Illumina and PacBio transcriptomes

Zhe Lin, Yangmei Qin, Hao Chen, Dan Shi, Mindong Zhong, Te An, Linshan Chen, Yiquan Wang, Fan Lin, Guang Li, Zhi‐Liang Ji

Briefings in Bioinformatics

DOI

2022

Molecular hallmarks of heterochronic parabiosis at single cell resolution

Róbert Pálovics, A. Keller, N. Schaum, Weilun Tan, T. Fehlmann, M. Borja, Fabian Kern, L. Bonanno, K. Calcuttawala, James T. Webber, A. McGeever, Nicole Almanzar, Jane Antony, Ankit S. Baghel, Isaac Bakerman, Ishita Bansal, B. Barres, P. Beachy, Daniela Berdnik, Biter Bilen, D. Brownfield, Corey Cain, Charles K. F. Chan, Michelle B. Chen, M. F. Clarke, Stephanie D. Conley, Aaron Demers, K. Demir, A. de Morrée, Tessa Divita, Haley du Bois, H. Ebadi, F. H. Espinoza, Matt Fish, Qiang Gan, B. George, A. Gillich, R. Gómez-Sjöberg, Foad Green, Geraldine Genetiano, Xue-Ying Gu, G. Gulati, Oliver Hahn, Michael S. Haney, Y. Hang, Lincoln Harris, Mu He, Shayan Hosseinzadeh, Albin Huang, K. Huang, T. Iram, Taichi Isobe, Feather Ives, Robert C. Jones, Kevin S. Kao, Guruswamy Karnam, Aaron M. Kershner, Nathalie Khoury, Seung K. Kim, B. Kiss, William Kong, M. Krasnow, Maya E. Kumar, Christin S. Kuo, Jonathan Y. Lam, Davis P. Lee, S. Lee, B. Lehallier, Olivia Leventhal, Guang Li, Qing-Yun Li, Ling Liu, Annie Lo, Wan-Jin Lu, Maria F. Lugo-Fagundo, A. Manjunath, A. P. May, Ashley Maynard, Marina Mckay, M. W. McNerney, B. Merrill, Ross J. Metzger, Marco Mignardi, Dullei Min, A. Nabhan, K. Ng, P. Nguyen, Joseph J. Noh, R. Nusse, R. Patkar, Weng Peng, L. Penland, Katherine S. Pollard, R. Puccinelli, Zhen Qi, T. A. Rando, Eric J. Rulifson, J. Segal, Shaheen S. Sikandar, Rahul Sinha, R. Sit, J. Sonnenburg, Daniel Staehli, K. Szade, Michelle Tan, C. Tato, Krissie Tellez, Laughing Bear Torrez Dulgeroff, K. Travaglini, C. Tropini, Margaret Tsui, Lucas M. Waldburger, Bruce Wang, L. V. van Weele, K. Weinberg, Irving L. Weissman, Michael N. Wosczyna, Sean M. Wu, Jin-Yi Xiang, Soso Xue, K. Yamauchi, Andrew C. Yang, Lakshmi P. Yerra, Justin Youngyunpipatkul, Brian Yu, Fabio Zanini, Macy E. Zardeneta, Alexander Zee, Chun-Yu Zhao, Fan Zhang, Hui Zhang, Martin Jinye Zhang, Lu Zhou, James Zou, Jian Luo, A. Pisco, Jim Karkanias, N. Neff, S. Darmanis, S. Quake, T. Wyss-Coray

Nature

DOI

2022

Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages

Wei Feng, A. Bais, Hao He, Cassandra Rios, Shan Jiang, Juan Xu, Cindy M. Chang, Dennis Kostka, Guang Li

Nature Communications

DOI

2022

Modeling Human Heart Development and Congenital Defects Using Organoids: How Close Are We?

Shan Jiang, Wei Feng, Cindy M. Chang, Guang Li

Journal of Cardiovascular Development and Disease

DOI

2022

Computational profiling of hiPSC-derived heart organoids reveals chamber defects associated with NKX2-5 deficiency

Wei Feng, Hannah C. Schriever, Shan Jiang, A. Bais, Hao-Di Wu, Dennis Kostka, Guang Li

Communications Biology

DOI

2021

Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy

K. Kimura, Astrid Ooms, Kathrin Graf-Riesen, Maithreyan Kuppusamy, A. Unger, Julia Schuld, J. Daerr, A. Lother, C. Geisen, L. Hein, Satoru Takahashi, Guang Li, W. Röll, W. Bloch, P. F. M. van der Ven, W. Linke, Sean M. Wu, P. Huesgen, J. Höhfeld, D. Fürst, B. Fleischmann, M. Hesse

Nature Communications

DOI

2021

CRISPR/Cas9-based targeting of fluorescent reporters to human iPSCs to isolate atrial and ventricular-specific cardiomyocytes

O. Chirikian, W. Goodyer, E. Dzilic, V. Serpooshan, J. Buikema, Wesley L. McKeithan, Hao-Di Wu, Guang Li, Soah Lee, Markus W. Merk, Francisco X. Galdos, A. Beck, A. Ribeiro, Sharon L. Paige, M. Mercola, Joseph C. Wu, B. Pruitt, Sean M. Wu

Scientific Reports

DOI

2021

Pitx controls amphioxus asymmetric morphogenesis by promoting left-side development and repressing right-side formation

Chaofan Xing, Rongrong Pan, Guangwei Hu, Xian Liu, Yiquan Wang, Guang Li

BMC Biology

DOI

2021

A Potential Method for Rapid Screening of Amphioxus Founder Harboring Germline Mutation and Transgene

Jiaqi Zou, Xiaotong Wu, Chenggang Shi, Yanhong Zhong, Lei Zhang, Qiuning Yan, Liuru Su, Guang Li

Frontiers in Cell and Developmental Biology

DOI

2021

Hedgehog signaling controls mouth opening in the amphioxus

Guangwei Hu, Guang Li, Yiquan Wang

Zoological Letters

DOI

2020

Step-wise evolution of neural patterning by Hedgehog signalling in chordates

Qiongqiong Ren, Yanhong Zhong, Xin Huang, Brigid Leung, Chaofan Xing, Hui Wang, Guangwei Hu, Yiquan Wang, Sebastian M. Shimeld, Guang Li

Nature Ecology & Evolution

DOI

2020

A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse

N. Almanzar, Jane Antony, Ankit S. Baghel, Isaac Bakerman, Ishita Bansal, B. Barres, P. Beachy, D. Berdnik, Biter Bilen, D. Brownfield, Corey Cain, Charles K. F. Chan, Michelle B. Chen, M. F. Clarke, Stephanie D. Conley, S. Darmanis, Aaron Demers, K. Demir, A. de Morrée, Tessa Divita, Haley du Bois, H. Ebadi, F. H. Espinoza, Matt Fish, Qiang Gan, B. George, A. Gillich, R. Gómez-Sjöberg, Foad Green, Geraldine Genetiano, Xue-Ying Gu, G. Gulati, Oliver Hahn, Michael S. Haney, Y. Hang, Lincoln Harris, Mu He, Shayan Hosseinzadeh, Albin Huang, K. C. Huang, T. Iram, Taichi Isobe, Feather Ives, Robert C. Jones, Kevin S. Kao, Jim Karkanias, G. Karnam, A. Keller, Aaron M. Kershner, N. Khoury, Seung K. Kim, B. Kiss, W. Kong, M. Krasnow, Maya E. Kumar, Christin S. Kuo, Jonathan Y. Lam, Davis P. Lee, S. Lee, B. Lehallier, Olivia Leventhal, Guang Li, Qingyun Li, Ling Liu, Annie Lo, Wan-Jin Lu, Maria F. Lugo-Fagundo, A. Manjunath, A. May, A. Maynard, A. McGeever, Marina Mckay, M. W. McNerney, B. Merrill, Ross J. Metzger, Marco Mignardi, Dullei Min, A. Nabhan, N. Neff, K. Ng, P. Nguyen, Joseph J. Noh, R. Nusse, Róbert Pálovics, R. Patkar, Weng Peng, L. Penland, A. Pisco, Katherine S. Pollard, R. Puccinelli, Zhen Qi, S. Quake, T. Rando, Eric J. Rulifson, N. Schaum, J. Segal, Shaheen S. Sikandar, Rahul Sinha, R. Sit, J. Sonnenburg, Daniel Staehli, K. Szade, M. Tan, Weilun Tan, C. Tato, Krissie Tellez, Laughing Bear Torrez Dulgeroff, K. Travaglini, C. Tropini, Margaret Tsui, Lucas M. Waldburger, Bruce Wang, L. V. van Weele, Kenneth Weinberg, I. Weissman, Michael N. Wosczyna, Sean M. Wu, T. Wyss-Coray, Jin-Yi Xiang, Soso Xue, K. Yamauchi, Andrew C. Yang, Lakshmi P. Yerra, Justin Youngyunpipatkul, Brian Yu, Fabio Zanini, Macy E. Zardeneta, Alexander Zee, Chun-Yu Zhao, Fan Zhang, Hui Zhang, Martin Jinye Zhang, Lu Zhou, James Zou

Nature

DOI

2020

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-derived Cardiomyocytes

J. Buikema, Soah Lee, W. Goodyer, R. Maas, O. Chirikian, Guang Li, Y. Miao, Sharon L. Paige, Daniel Lee, Hao-Di Wu, David T. Paik, Siyeon Rhee, Lei Tian, Francisco X. Galdos, N. Puluca, Benjamin Beyersdorf, James B. Hu, A. Beck, Sneha Venkamatran, S. Swami, P. Wijnker, M. Schuldt, L. Dorsch, A. van Mil, Kristy Red-Horse, Joy Y. Wu, C. Geisen, M. Hesse, V. Serpooshan, Stefan Jovinge, B. Fleischmann, P. Doevendans, J. van der Velden, K. Garcia, Joseph C. Wu, J. Sluijter, Sean M. Wu

Cell Stem Cell

DOI

2020

Diversity of Organism-Wide and Organ-Specific Endothelial Cells

Andrew Przysinda, Wei Feng, Guang Li

Current Cardiology Reports

DOI

2020

Multiplexed Single Cell mRNA Sequencing Analysis of Mouse Embryonic Cells

Wei Feng, Andrew Przysinda, Guang Li

Journal of Visualized Experiments

DOI

2020

Mutation of amphioxus Pdx and Cdx demonstrates conserved roles for ParaHox genes in gut, anus and tail patterning

Yanhong Zhong, Carlos Herrera-Úbeda, Jordi García‐Fernàndez, Guang Li, Peter W. H. Holland

BMC Biology

DOI

2020

A ZZ/ZW Sex Chromosome System in Cephalochordate Amphioxus

Chenggang Shi, Xiaotong Wu, Liuru Su, Chaoqi Shang, Xuewen Li, Yiquan Wang, Guang Li

Genetics

DOI

2020

Application of CRISPR/Cas9 Nuclease in Amphioxus Genome Editing

Liuru Su, Chenggang Shi, Xin Huang, Yiquan Wang, Guang Li

Genes

DOI

2020

Differential expression pattern of two Brachyury genes in amphioxus embryos

Liang Yuan, Yiquan Wang, Guang Li

Gene Expression Patterns

DOI

2019

Single cell expression analysis reveals anatomical and cell cycle-dependent transcriptional shifts during heart development

Guang Li, Lei Tian, W. Goodyer, E. Kort, J. Buikema, Adele F. Xu, Joseph C. Wu, S. Jovinge, Sean M. Wu

Development

DOI

2019

Single Cell Analysis of Endothelial Cells Identified Organ-Specific Molecular Signatures and Heart-Specific Cell Populations and Molecular Features

Wei Feng, Lyuqin Chen, P. Nguyen, Sean M. Wu, Guang Li

Frontiers in Cardiovascular Medicine

DOI

2019

Transcriptomic Profiling of the Developing Cardiac Conduction System at Single-Cell Resolution

W. Goodyer, Benjamin Beyersdorf, David T. Paik, Lei Tian, Guang Li, J. Buikema, O. Chirikian, Shannon S. Choi, Sneha L. Venkatraman, Eliza L. Adams, M. Tessier-Lavigne, Joseph C. Wu, Sean M. Wu

Circulation Research

DOI

2019

Abstract 466: Myopathy Causing Bag3 P209L Protein Leads to Restrictive Cardiomyopathy Caused by Aggregate Formation and Sarcomere Disruption in Cardiomyocytes

Kathrin Graf-Riesen, K. Kimura, A. Unger, A. Lother, L. Hein, J. Daerr, Julia Braune, Astrid Ooms, Guang Li, Sean M. Wu, J. Höhfeld, W. Linke, D. Fürst, B. Fleischmann, M. Hesse

Circulation Research

DOI

2019

Cilia-driven asymmetric Hedgehog signalling determines the amphioxus left-right axis by controlling Dand5 expression

Xin Zhu, Chenggang Shi, Yanhong Zhong, Xian Liu, Qiuning Yan, Xiaotong Wu, Yiquan Wang, Guang Li

Development

DOI

2019

Interplay between Lefty and Nodal signaling is essential for the organizer and axial formation in amphioxus embryos

Huayang Zhang, Shuang Chen, Chaoqi Shang, Xiaotong Wu, Yiquan Wang, Guang Li

Developmental Biology

DOI

2019

The family of amphioxus chitin synthases offers insight into the evolution of chitin formation in chordates

Yi Shi, Zhaoyu Fan, Guang Li, Lei Zhang, Zirui Yue, Xinyu Yan, Anlong Xu, Shengfeng Huang

Molecular Phylogenetics and Evolution

DOI

2019

An Effective Microinjection Method and TALEN-Mediated Genome Editing in Pacific Abalone

Jianfang Huang, Weiwei You, Zhiwei Xu, Qiuning Yan, Chenggang Shi, Bin Tang, Xuan Luo, Guang Li, Caihuan Ke

Marine Biotechnology

DOI

2018

Generation of two transgenic amphioxus lines using the Tol2 transposon system

Chenggang Shi, Jing Huang, Shixi Chen, Guang Li, Yiquan Wang

Journal of genetics and genomics/Journal of Genetics and Genomics

DOI

2018

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

N. Schaum, Jim Karkanias, N. Neff, A. May, S. Quake, T. Wyss-Coray, S. Darmanis, Joshua Batson, O. Botvinnik, Michelle B. Chen, Steven Q. Chen, Foad Green, Robert C. Jones, A. Maynard, L. Penland, A. Pisco, R. Sit, Geoffrey M. Stanley, James T. Webber, Fabio Zanini, Ankit S. Baghel, Isaac Bakerman, Ishita Bansal, D. Berdnik, Biter Bilen, D. Brownfield, Corey Cain, M. Cho, Giana Cirolia, Stephanie D. Conley, Aaron Demers, K. Demir, A. Morrée, Tessa Divita, Haley du Bois, Laughing Bear Torrez Dulgeroff, H. Ebadi, F. H. Espinoza, Matt Fish, Qiang Gan, B. George, A. Gillich, Geraldine Genetiano, Xue-Ying Gu, G. Gulati, Y. Hang, Shayan Hosseinzadeh, Albin Huang, T. Iram, Taichi Isobe, Feather Ives, Kevin S. Kao, G. Karnam, Aaron M. Kershner, B. Kiss, W. Kong, Maya E. Kumar, Jonathan Y. Lam, Davis P. Lee, S. Lee, Guang Li, Qingyun Li, Ling Liu, Annie Lo, Wan-Jin Lu, A. Manjunath, Kaia L. May, O. L. May, Marina Mckay, Ross J. Metzger, Marco Mignardi, Dullei Min, A. Nabhan, K. Ng, Joseph J. Noh, R. Patkar, Weng Peng, R. Puccinelli, Eric J. Rulifson, Shaheen S. Sikandar, Rahul Sinha, K. Szade, Weilun Tan, C. Tato, Krissie Tellez, K. Travaglini, C. Tropini, Lucas M. Waldburger, L. V. van Weele, Michael N. Wosczyna, Jin-Yi Xiang, Soso Xue, Justin Youngyunpipatkul, Macy E. Zardeneta, Fan Zhang, Lu Zhou, Paola Castro, Derek Croote, J. Derisi, Christin S. Kuo, B. Lehallier, P. Nguyen, Serena Y. Tan, Bruce Wang, H. Yousef, P. Beachy, Charles K. F. Chan, K. C. Huang, K. Weinberg, Sean M. Wu, B. Barres, M. F. Clarke, Seung K. Kim, M. Krasnow, R. Nusse, T. Rando, J. Sonnenburg, I. Weissman

Nature

DOI

2018

Single cell analysis of early progenitor cells that build coronary arteries

Tianying Su, Geoffrey M. Stanley, Rahul Sinha, Gaetano D'Amato, Soumya Das, Siyeon Rhee, Andrew H Chang, Aruna Poduri, Brian C. Raftrey, T. T. Dinh, Walter A. Roper, Guang Li, K. E. Quinn, K. Caron, Sean M. Wu, L. Miquerol, E. Butcher, I. Weissman, S. Quake, Kristy Red-Horse

Nature

DOI

2018

P6220MYL2 reporter line allows purification of ventricular human iPSC induced cardiomyocytes

E. Dzilic, O. Chirikian, Alice Shieh, A. Ribeiro, R. G. Goodyer, V. Serpooshan, Guang Li, A. Kumar, M. Dreßen, H. Lahm, S. Doppler, Ruediger Lange, M. Krane, Shulin Wu

European Heart Journal

DOI

2017

YY1 expression is sufficient for the maintenance of cardiac progenitor cell state

S. Grégoire, Guang Li, Anthony C. Sturzu, R. Schwartz, Sean M. Wu

Stem Cells

DOI

2017

Mammalian Heart Regeneration: The Race to the Finish Line

S. Doppler, M. Deutsch, V. Serpooshan, Guang Li, E. Dzilic, R. Lange, M. Krane, Sean M. Wu

Circulation Research

DOI

2017

Strategies for the acquisition of transcriptional and epigenetic information in single cells.

Guang Li, E. Dzilic, Nick Flores, Alice Shieh, Sean M. Wu

Journal of Thoracic Disease

DOI

2017

Abstract 239: Transcriptomic Profiling Maps Anatomically Patterned Subpopulations Among Single Embryonic Cardiac Cells

Guang Li

Circulation Research

DOI

2017

Partial Reprogramming of Pluripotent Stem Cell-Derived Cardiomyocytes into Neurons

Wenpo Chuang, Arun Sharma, Praveen K. Shukla, Guang Li, M. Mall, Kuppusamy Rajarajan, Oscar J. Abilez, Ryoko Hamaguchi, Joseph C. Wu, Marius Wernig, Sean M. Wu

Scientific Reports

DOI

2017

Hedgehog participates in the establishment of left-right asymmetry during amphioxus development by controlling Cerberus expression

Guangwei Hu, Guang Li, Hui Wang, Yiquan Wang

Development

DOI

2017

Cerberus–Nodal–Lefty–Pitx signaling cascade controls left – right asymmetry in amphioxus

Guang Li, Xian Liu, Chaofan Xing, Huayang Zhang, Sebastian M. Shimeld, Yiquan Wang

Proceedings of the National Academy of Sciences

DOI

2016

Transcriptomic profiling maps anatomically patterned subpopulations among single embryonic cardiac cells

Guang Li, Adele F. Xu, Sopheak K. Sim, James R. Priest, Xueying Tian, Tooba Khan, T. Quertermous, Bin Zhou, Philip S. Tsao, S. Quake, Sean M. Wu

Developmental Cell

DOI

2016

Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls.

Hui Zhang, Wen-Juan Pu, Guang Li, Xiuzhen Huang, Lingjuan He, Xueying Tian, Qiaozhen Liu, Libo Zhang, Sean M. Wu, H. Sucov, Bin Zhou

Circulation Research

DOI

2015

文昌鱼Hedgehog基因敲除和突变体表型分析

王慧，李光，王义权

《遗传》

2015

Identification of cardiovascular lineage descendants at single-cell resolution

Guang Li, Karolina Plonowska, Rajarajan Kuppusamy, Anthony C. Sturzu, Sean M. Wu

Development

DOI

2015

Derivation of highly purified cardiomyocytes from human induced pluripotent stem cells using small molecule-modulated differentiation and subsequent glucose starvation

Arun Sharma, Guang Li, Kuppusamy Rajarajan, Ryoko Hamaguchi, P. Burridge, Sean M. Wu

Journal of Visualized Experiments

DOI

2015

The Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss

Anthony C. Sturzu, Kuppusamy Rajarajan, Derek Passer, Karolina Plonowska, Alyssa K. Riley, T. Tan, Arun Sharma, Adele F. Xu, M. Engels, Rebecca Feistritzer, Guang Li, M. Selig, R. Geissler, Keston D. Robertson, M. Scherrer-Crosbie, I. Domian, Sean M. Wu

Circulation

DOI

2015

Generating amphioxus Hedgehog knockout mutants and phenotype analysis.

Hui Wang, Guang Li, Yiquan Wang

PubMed

DOI

2014

Mutagenesis at Specific Genomic Loci of Amphioxus Branchiostoma belcheri Using TALEN Method

Guang Li, Jun Feng, Yong Lei, Jing Wang, Hui Wang, Li-Ke Shang, Dong-Teng Liu, Hui Zhao, Yong Zhu, Yi-Quan Wang

Journal of Genetics and Genomics

2014

Abstract 19300: Drug Screening in Human Neutral Lipid Storage Disease iPSCells Identifies Modulators of Intracellular Lipid Metabolism That Reduce Disease Phenotype in vitro

Rajarajan Kuppusamy, Becca Feistritzer, M. Engels, Anthony C. Sturzu, Karolina Plonowska, Guang Li, Arun Sharma, Kenta Nakamura, H. John, Xiaojing Huang, Wenpo Chuang, K. Hirano, Sean M. Wu

2014

Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes

Shengfeng Huang, Zelin Chen, Xinyu Yan, Ting Yu, Guangrui Huang, Qingyu Yan, Pierre Pontarotti, Hongchen Zhao, Jie Li, Ping Shih Yang, Ruihua Wang, Rui Li, Xin Tao, Ting Deng, Yiquan Wang, Guang Li, Qiujin Zhang, Sisi Zhou, Leiming You, Shaochun Yuan, Yonggui Fu, Fenfang Wu, Meiling Dong, Shangwu Chen, Anlong Xu

Nature Communications

DOI

2014

The role of the Pax1/9 gene in the early development of amphioxus pharyngeal gill slits

Xin Liu, Guang Li, Xian Liu, Yiquan Wang

Journal of Experimental Zoology Part B Molecular and Developmental Evolution

DOI

2014

Functional analysis of the promoter region of amphioxus β-actin gene: a useful tool for driving gene expression in vivo

Jun Feng, Guang Li, Xin Liu, Jing Wang, Yiquan Wang

Molecular Biology Reports

DOI

2013

后生动物非编码保守元件

冯俊，李光，王义权

《遗传》

2013

Research progress of conserved non-coding elements in metazoan

Jun Feng, Guang Li, Yiquan Wang

Hereditas (Beijing)

DOI

2013

Characterization and embryonic expression of four amphioxus Frizzled genes with important functions during early embryogenesis

Guanghui Qian, Guang Li, Xiaoying Chen, Yiquan Wang

Gene Expression Patterns

DOI

2013

The function of DrPax1b gene in the embryonic development of zebrafish

Xin Liu, Hua Wang, Guang Li, Huizhe Huang, Yiquan Wang

Genes & Genetic Systems

DOI

2012

HTS-PEG: A Method for High Throughput Sequencing of the Paired-Ends of Genomic Libraries

Sisi Zhou, Yonggui Fu, Jie Li, Lingyu He, Xingsheng Cai, Qingyu Yan, Xingqiang Rao, Shengfeng Huang, Guang Li, Yiquan Wang, Anlong Xu

PLoS ONE

DOI

2012

Consecutive Spawnings of Chinese Amphioxus, Branchiostoma belcheri, in Captivity

Guang Li, Xi Yang, ZongHuang Shu, XiaoYing Chen, Yiquan Wang

PLoS ONE

DOI

2012

Proteomic characterization and evolutionary analyses of zona pellucida domain-containing proteins in the egg coat of the cephalochordate, Branchiostoma belcheri

Qianghua Xu, Guang Li, Lixue Cao, Zhongjun Wang, Hua Ye, Xiaoyin Chen, Xi Yang, Yiquan Wang, Liangbiao Chen

BMC Evolutionary Biology

DOI

2011

Identification of up-regulated genes in amphioxus neurula and the expression of AmphiFABP

Xiaohui Liu, Yi Sun, Juyong Zhang, Guang Li, Yiquan Wang

Genes & Genetic Systems

DOI

2010

The origin and evolution of ARGFX homeobox loci in mammalian radiation

Guang Li, Peter WH Holland

BMC Evolutionary Biology

DOI

2009

Evolutionary and functional diversity of green fluorescent proteins in cephalochordates

Guang Li, Qiujin Zhang, Jing Zhong, Yiquan Wang

Gene

DOI

2009

The Evolutionarily Dynamic IFN-Inducible GTPase Proteins Play Conserved Immune Functions in Vertebrates and Cephalochordates

Guang Li, Jinlong Zhang, Y. Sun, Hui Wang, Y. Wang

Molecular Biology and Evolution

DOI

2007

Origin and evolution of vertebrate ABCA genes: A story from Amphioxus

Guang Li, Qiujin Zhang, Zhi‐Liang Ji, Yiquan Wang

Gene

DOI

2006

脊椎动物ABCA基因亚家族研究进展

李光，王义权

《遗传》

2006

Evolutionary dynamics of the ABCA chromosome 17q24 cluster genes in vertebrates

Guang Li, Peng Shi, Yiquan Wang

Genomics

DOI

2006

[Progress in the research on the ABCA gene family of vertebrates].

Guang Li, Yi-Quan Wang

PubMed

2005

脊椎动物线粒体DNA的基因重排

钟婧，李光，刘忠权，李庆伟，王义权

Journal of Genetics and Genomics

会议论文

2015

Cer-Nodal-Lefty-Pitx cascade plays conserved roles in amphioxus Left-Right axis determination

李光，刘娴，义权

《遗传多样性：前沿与挑战——中国的遗传学研究（2013-2015）——2015中国遗传学会大会论文摘要汇编》

2014

文昌鱼早期胚胎发育中Dvl基因的表达分析

王净，李光，王义权

《第三届“模式生物与人类健康”发育遗传学全国学术研讨会论文集》

预印本

2026

ASMIL: Attention-Stabilized Multiple Instance Learning for Whole Slide Imaging

Linfeng Ye, Shayan Mohajer Hamidi, Zhixiang Chi, Guang Li, Mert Pilanci, Takahiro Ogawa, Miki Haseyama, Konstantinos N. Plataniotis

arXiv preprint

2026

SIMPLER: H&E-Informed Representation Learning for Structured Illumination Microscopy

Abu Zahid Bin Aziz, Syed Fahim Ahmed, Gnanesh Rasineni, Mei Wang, Olcaytu Hatipoglu, Marisa Ricci, Malaiyah Shaw, Guang Li, J. Quincy Brown, Valerio Pascucci, Shireen Elhabian

arXiv preprint

2026

SALIENT: Frequency-Aware Paired Diffusion for Controllable Long-Tail CT Detection

Yifan Li, Mehrdad Salimitari, Taiyu Zhang, Guang Li, David Dreizin

arXiv preprint

2026

Noise2Match: Self-Supervised Low-Dose CT Denoising via Adaptive Inter-Slice Matching

Langrui Zhou, Guang Li, Xinyu Huang, Ziteng Zhou, Zuyang Huang, Hongming Shan, Shouhua Luo, Ning Gu

arXiv preprint

2025

Continual Self-supervised Learning Considering Medical Domain Knowledge in Chest CT Images

Ren Tasai, Guang Li, Ren Togo, Minghui Tang, Takaaki Yoshimura, Hiroyuki Sugimori, Kenji Hirata, Takahiro Ogawa, Kohsuke Kudo, Miki Haseyama

arXiv preprint

2025

Dual-Model Weight Selection and Self-Knowledge Distillation for Medical Image Classification

Ayaka Tsutsumi, Guang Li, Ren Togo, Takahiro Ogawa, Satoshi Kondo, Miki Haseyama

arXiv preprint

2025

Privacy-Aware Continual Self-Supervised Learning on Multi-Window Chest Computed Tomography for Domain-Shift Robustness

Ren Tasai, Guang Li, Ren Togo, Takahiro Ogawa, Kenji Hirata, Minghui Tang, Takaaki Yoshimura, Hiroyuki Sugimori, Noriko Nishioka, Yukie Shimizu, Kohsuke Kudo, Miki Haseyama

arXiv preprint

2024

Chained Flexible Capsule Endoscope: Unraveling the Conundrum of Size Limitations and Functional Integration for Gastrointestinal Transitivity

Sishen Yuan, Guang Li, Baijia Liang, Lailu Li, Qingzhuo Zheng, Shuang Song, Zhen Li, Hongliang Ren

arXiv preprint

2024

Reliable Multi-modal Medical Image-to-image Translation Independent of Pixel-wise Aligned Data

Langrui Zhou, Guang Li

arXiv preprint

DOI

2024

Neighboring Slice Noise2Noise: Self-Supervised Medical Image Denoising from Single Noisy Image Volume

Langrui Zhou, Ziteng Zhou, Xinyu Huang, Huiru Wang, Xiangyu Zhang, Guang Li

arXiv preprint

2023

PainSeeker: An Automated Method for Assessing Pain in Rats Through Facial Expressions

Liu Liu, Guang Li, Dingfan Deng, Jinhua Yu, Yuan Zong

arXiv preprint

2023

The STOIC2021 COVID-19 AI challenge: applying reusable training methodologies to private data

Luuk H. Boulogne, Julian Lorenz, Daniel Kienzle, Robin Schon, Katja Ludwig, Rainer Lienhart, Simon Jegou, Guang Li, Cong Chen, Qi Wang, Derik Shi, Mayug Maniparambil, Dominik Muller, Silvan Mertes, Niklas Schroter, Fabio Hellmann, Miriam Elia, Ine Dirks, Matias Nicolas Bossa, Abel Diaz Berenguer, Tanmoy Mukherjee, Jef Vandemeulebroucke, Hichem Sahli, Nikos Deligiannis, Panagiotis Gonidakis, Ngoc Dung Huynh, Imran Razzak, Reda Bouadjenek, Mario Verdicchio, Pasquale Borrelli, Marco Aiello, James A. Meakin, Alexander Lemm, Christoph Russ, Razvan Ionasec, Nikos Paragios, Bram van Ginneken, Marie-Pierre Revel Dubois

arXiv preprint

2022

Self-Knowledge Distillation based Self-Supervised Learning for Covid-19 Detection from Chest X-Ray Images

Guang Li, Ren Togo, Takahiro Ogawa, Miki Haseyama

arXiv preprint

DOI

2022

Dataset Distillation for Medical Dataset Sharing

Guang Li, Ren Togo, Takahiro Ogawa, Miki Haseyama

arXiv preprint

2022

Compressed Gastric Image Generation Based on Soft-Label Dataset Distillation for Medical Data Sharing

Guang Li, Ren Togo, Takahiro Ogawa, Miki Haseyama

arXiv preprint

DOI

2022

Boosting Automatic COVID-19 Detection Performance with Self-Supervised Learning and Batch Knowledge Ensembling

Guang Li, Ren Togo, Takahiro Ogawa, Miki Haseyama

arXiv preprint

2022

RGMIM: Region-Guided Masked Image Modeling for Learning Meaningful Representations from X-Ray Images

Guang Li, Ren Togo, Takahiro Ogawa, Miki Haseyama

arXiv preprint

2021

Joint profiling of gene expression and chromatin accessibility of amphioxus development at single cell resolution

Pengcheng Ma, Xingyan Liu, Huimin Liu, Zaoxu Xu, Xiangning Ding, Zhen J. Huang, Chenggang Shi, Langchao Liang, Luohao Xu, Xiaolu Li, Guimei Li, Yuqi He, Zhaoli Ding, Chaochao Chai, Haoyu Wang, Jiaying Qiu, Jiacheng Zhu, Xiaoling Wang, Peiwen Ding, Si Zhou, Yuting Yuan, Wendi Wu, Yanan Yan, Yitao Zhou, Qi-Jun Zhou, Guodong Wang, Qiujin Zhang, Xun Xu, Guang Li, Shihua Zhang, Bingyu Mao, Dongsheng Chen

Research Square

DOI

2021

Soft-Label Anonymous Gastric X-ray Image Distillation

Guang Li, Ren Togo, Takahiro Ogawa, Miki Haseyama

arXiv preprint

DOI

2021

Self-Supervised Learning for Gastritis Detection with Gastric X-ray Images

Guang Li, Ren Togo, Takahiro Ogawa, Miki Haseyama

arXiv preprint

2021

Boost AI Power: Data Augmentation Strategies with unlabelled Data and Conformal Prediction, a Case in Alternative Herbal Medicine Discrimination with Electronic Nose

Li Liu, Xianghao Zhan, Rumeng Wu, Xiaoqing Guan, Zhan Wang, Wei Zhang, Mert Pilanci, You Wang, Zhiyuan Luo, Guang Li

arXiv preprint

2021

CPSC: Conformal prediction with shrunken centroids for efficient prediction reliability quantification and data augmentation, a case in alternative herbal medicine classification with electronic nose

Li Liu, Xianghao Zhan, Xikai Yang, Xiaoqing Guan, Rumeng Wu, Zhan Wang, Zhiyuan Luo, You Wang, Guang Li

arXiv preprint

2021

Classifying herbal medicine origins by temporal and spectral data mining of electronic nose

Li Liu, Xianghao Zhan, Ziheng Duan, Yi Wu, Rumeng Wu, Xiaoqing Guan, Zhan Wang, You Wang, Guang Li

arXiv preprint

2021

Unsupervised cross-user adaptation in taste sensation recognition based on surface electromyography with conformal prediction and domain regularized component analysis

Hengyang Wang, Xianghao Zhan, Li Liu, Asif Ullah, Huiyan Li, Han Gao, You Wang, Guang Li

arXiv preprint

2020

Integrate Heterogeneous NGS and TGS Data to Boost Genome-free Transcriptome Research

Yangmei Qin, Zhe Lin, Dan Shi, Mindong Zhong, Te An, Lin-Shan Chen, Yiquan Wang, Fan Lin, Guang Li, Zhi‐Liang Ji

bioRxiv (Cold Spring Harbor Laboratory)

DOI

2020

Single cell chromatin accessibility of the developmental cephalochordate

Dongsheng Chen, Dongsheng Chen, Zhen J. Huang, Xiangning Ding, Zaoxu Xu, Jixing Zhong, Langchao Liang, Luohao Xu, Chaochao Cai, Haoyu Wang, Jiaying Qiu, Jiacheng Zhu, Xiaoling Wang, Rong Xiang, Weiying Wu, Peiwen Ding, Feiyue Wang, Qikai Feng, Si Zhou, Yuting Yuan, Wendi Wu, Yanan Yan, Yitao Zhou, Duo Chen, Duo Chen, Guang Li, Shida Zhu, Fang Chen, Qiujin Zhang, Jihong Wu, Xun Xu

bioRxiv (Cold Spring Harbor Laboratory)

DOI

2018

Structure-sensitive Multi-scale Deep Neural Network for Low-Dose CT Denoising

Chenyu You, Qingsong Yang, Hongming Shan, Lars Gjesteby, Guang Li, Shenghong Ju, Zhuiyang Zhang, Zhen Zhao, Yi Zhang, Wenxiang Cong, Ge Wang

arXiv preprint

DOI

2018

CT Super-resolution GAN Constrained by the Identical, Residual, and Cycle Learning Ensemble(GAN-CIRCLE)

Chenyu You, Guang Li, Yi Zhang, Xiaoliu Zhang, Hongming Shan, Shenghong Ju, Zhen Zhao, Zhuiyang Zhang, Wenxiang Cong, Michael W. Vannier, Punam K. Saha, Ge Wang

arXiv preprint

DOI

书籍章节

2020

Laboratory Culture and Mutagenesis of Amphioxus (Branchiostoma floridae)

Linda Z. Holland, Guang Li

Methods in molecular biology

DOI

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