袁凯｜亳州学院｜学者主页

2026

Integrative analysis reveals intra-tumoral microbial enterotypes shape host transcriptomes in colorectal cancer.

Kai Yuan, Yi-Fan Lian, Ping-Mei Huang, Fang Cao, Xiaoning Yang, Yapi Lu, Xiao Ding, Lu-Yao Wang, Huan Yang, Z. Ye, Qing-Gui Chen, Jinbo Fu, Sibo Yuan, Yanyun Fan, Shun-Tian Cai, Dan Du, Jian-Lin Ren, Xiang Zhang, Hong-Zhi Xu

Cell Reports

DOI

2025

IDDF2025-ABS-0378 Tumor-resident probioticclostridium butyricumfacilitates immunotherapy in colorectal cancer via SECD-GRP78 axis

Ming-Xu Xie, Kai Yuan, Yong-Xin Zhang, Ya-Ting Zhang, Ru-Yi Zhang, Jiuhe Gao, Wen-Chao Wei, Lanping Jiang, Tianhui Li, Yan-Qiang Ding, Lu-Yao Wang, Yufeng Lin, C. Wong, Jun Yu

Young Investigator Award

DOI

2025

Intraneoplastic fungal dysbiosis is associated with colorectal cancer progression and host gene mutation

Kai Yuan, Hong-Zhi Xu, Sheng-Mian Li, O. Coker, Wei-Xin Liu, Lu-Yao Wang, Xiang Zhang, Jun Yu

EBioMedicine

DOI

2025

652: PEPTOSTREPTOCOCCUS ANAEROBIUS INDUCES COLORECTAL CANCER STEMNESS AND CHEMORESISTANCE VIA ITS SURFACE PROTEIN NIPC/P60 INTERACTING WITH ANNEXIN A2 TO ACTIVATE YAP/HIPPO SIGNALING PATHWAY

Ya-Li Liu, Chi-Chun Wong, Ya-Ting Zhang, Kai Yuan, Chuan-Fa Liu, Wei-Xin Liu, Ming-Xu Xie, Jun Yu

Gastroenterology

DOI

2025

Abstract LB154: Peptostreptococcus anaerobius induces colorectal cancer stemness and chemoresistance via its surface protein NIpC/P60 interacting with Annexin A2 to activate YAP/Hippo signaling pathway

Ya-Li Liu, C. Wong, Ya-Ting Zhang, Kai Yuan, Chuan-Fa Liu, Wei-Xin Liu, Ming-Xu Xie, Jun Yu

Cancer Research

DOI

2025

Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity.

Xiao Ding, N. Ting, C. Wong, Ping-Mei Huang, Lanping Jiang, Chuan-Fa Liu, Yufeng Lin, Shi-Yu Li, Yujie Liu, Ming-Xu Xie, Wei-Xin Liu, Kai Yuan, Lu-Yao Wang, Xin-Yue Zhang, Yan-Qiang Ding, Qing Li, Yang Sun, Ying-Lei Miao, Lan-Qing Ma, Xiang Gao, Wei-Xun Li, W. K. Wu, J. J. Sung, Sunny H. Wong, Jun Yu

Cell Host and Microbe

DOI

2025

Targeting cancer stem cells enhances multikinase inhibitor therapy in metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma

Ya-Si Pan, Xiang Zhang, C. Wong, Hua-Rong Chen, Stephianie Ma, T. K. Lee, Kai Yuan, Cong Liang, Xing-Yu Zhou, H. C. Lau, Ping-Mei Huang, Dan-Yu Chen, Li-Na Wang, Yan-Qiang Ding, Qin-Yao Wei, A. H. Cheung, Ka-Fai To, Jun Yu

Gut

DOI

2025

IDDF2025-ABS-0362 CD133+ cancer stem cell drives MASLD-related hepatocellular carcinoma and is a therapeutic target

Ya-Si Pan, Xiang Zhang, Chi-Chun Wong, Hua-Rong Chen, Kai Yuan, Xing-Yu Zhou, Jun Yu

Basic Hepatology

DOI

2025

YTHDF1 targets the chemotherapy response by suppressing NOTCH1-induced stemness in colorectal cancer

Henley Cheung, Hua-Rong Chen, Dan-Yu Chen, Heming Zhou, Cong Liang, Wei-Xin Liu, A. Cheung, Yan-Qiang Ding, Kai Yuan, Xiao-Xing Li, Yong-Xin Zhang, Shiyan Wang, Wei Kang, Ka-Fai To, Hou-Sheng H. He, C. Wong, Jun Yu

Signal Transduction and Targeted Therapy

DOI

2025

Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression.

Ming-Xu Xie, Kai Yuan, Yong-Xin Zhang, Ya-Ting Zhang, Ru-Yi Zhang, Jiuhe Gao, Wen-Chao Wei, Lanping Jiang, Tianhui Li, Yan-Qiang Ding, Lu-Yao Wang, Yufeng Lin, C. Wong, Jun Yu

Cancer Cell

DOI

2025

Mo1540: GUT MICROBIAL STRUCTURAL VARIATIONS ARE ASSOCIATED WITH COLORECTAL CANCER PROGRESSION

Lu-Yao Wang, O. Coker, Yufeng Lin, Kai Yuan, Jun Yu

Gastroenterology

DOI

2025

Sa1509: CD133+ CANCER STEM CELLS PROMOTE MASLD-HCC AND IS A THERAPEUTIC TARGET

Ya-Si Pan, Xiang Zhang, Chi-Chun Wong, Hua-Rong Chen, Kai Yuan, Jun Yu

Gastroenterology

DOI

2025

Abstract LB177: Visualization and targeting of CD133+ cancer stem cells in MASLD-related hepatocellular carcinoma

Ya-Si Pan, Xiang Zhang, C. Wong, Hua-Rong Chen, Kai Yuan, Jun Yu

Cancer Research

DOI

2025

Targeting of the m6A eraser ALKBH5 suppresses stemness and chemoresistance of colorectal cancer

Heming Zhou, Hua-Rong Chen, Wei-Xin Liu, Cong Liang, Shiyan Wang, Kai Yuan, A. Cheung, Yuet Wu, Wei Kang, Henley Cheung, Yan-Qiang Ding, Qin-Yao Wei, Hao Su, Tianhui Li, W.J. Luo, Su-Jun Chen, C. Wong, Jun Yu

Nature Communications

DOI

2024

711 TUMOR-RESIDENT PROBIOTIC CLOSTRIDIUM BUTYRICUM FACILITATES IMMUNE THERAPY IN COLORECTAL CANCER BY TARGETING SECDGRP78 AXIS

Ming-Xu Xie, Ya-Ting Zhang, Kai Yuan, Yong-Xin Zhang, Wen-Chao Wei, Lanping Jiang, Tianhui Li, Ru-Yi Zhang, Jun Yu

Gastroenterology

DOI

2024

310 FUNGI COMMUNITY WITHIN COLORECTAL NEOPLASIA AND ITS CONTRIBUTION TO COLORECTAL CARCINOGENESIS

Kai Yuan, Wei-Xin Liu, Xiang Zhang, Jun Yu

Gastroenterology

DOI

2024

IDDF2024-ABS-0331 Fungi community within colorectal neoplasia and its contribution to colorectal carcinogenesis

Kai Yuan, Wei-Xin Liu, Xiang Zhang, Jun Yu

Basic Gastroenterology

DOI

2021

产教融合视域下应用型本科高校实践教学改革

袁凯，秦亚冰

《南昌师范学院学报》

2021

应用型本科院校产教融合“双元”育人模式研究

袁凯，秦亚冰

《辽宁科技学院学报》

袁凯

精选作品

期刊论文

Integrative analysis reveals intra-tumoral microbial enterotypes shape host transcriptomes in colorectal cancer.

IDDF2025-ABS-0378 Tumor-resident probioticclostridium butyricumfacilitates immunotherapy in colorectal cancer via SECD-GRP78 axis

Intraneoplastic fungal dysbiosis is associated with colorectal cancer progression and host gene mutation

652: PEPTOSTREPTOCOCCUS ANAEROBIUS INDUCES COLORECTAL CANCER STEMNESS AND CHEMORESISTANCE VIA ITS SURFACE PROTEIN NIPC/P60 INTERACTING WITH ANNEXIN A2 TO ACTIVATE YAP/HIPPO SIGNALING PATHWAY

Abstract LB154: Peptostreptococcus anaerobius induces colorectal cancer stemness and chemoresistance via its surface protein NIpC/P60 interacting with Annexin A2 to activate YAP/Hippo signaling pathway

Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity.

Targeting cancer stem cells enhances multikinase inhibitor therapy in metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma

IDDF2025-ABS-0362 CD133+ cancer stem cell drives MASLD-related hepatocellular carcinoma and is a therapeutic target

YTHDF1 targets the chemotherapy response by suppressing NOTCH1-induced stemness in colorectal cancer

Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression.

Mo1540: GUT MICROBIAL STRUCTURAL VARIATIONS ARE ASSOCIATED WITH COLORECTAL CANCER PROGRESSION

Sa1509: CD133+ CANCER STEM CELLS PROMOTE MASLD-HCC AND IS A THERAPEUTIC TARGET

Abstract LB177: Visualization and targeting of CD133+ cancer stem cells in MASLD-related hepatocellular carcinoma

Targeting of the m6A eraser ALKBH5 suppresses stemness and chemoresistance of colorectal cancer

711 TUMOR-RESIDENT PROBIOTIC CLOSTRIDIUM BUTYRICUM FACILITATES IMMUNE THERAPY IN COLORECTAL CANCER BY TARGETING SECDGRP78 AXIS

310 FUNGI COMMUNITY WITHIN COLORECTAL NEOPLASIA AND ITS CONTRIBUTION TO COLORECTAL CARCINOGENESIS

IDDF2024-ABS-0331 Fungi community within colorectal neoplasia and its contribution to colorectal carcinogenesis

产教融合视域下应用型本科高校实践教学改革

应用型本科院校产教融合“双元”育人模式研究