郑祖国｜中国药科大学｜学者主页

2026

Targeting vascular smooth muscle cells with natural compounds to combat atherosclerosis

Xiangyue Qin, Zihan Zhou, Zuguo Zheng, Xiaodong Wen, Hua Yang

Chinese Journal of Natural Medicines

2026

Astragaloside IV improves MASLD via GCN5-LXRα/SREBP1c signaling pathway-mediated hepatic de novo lipogenesis

Liang Hui-mei, Yin-Yue Xu, Kun Miao, Hai-Tao Xiao, Yongdan Wang, Jing Jin, He Wu, Bao-Yi Chen, Lijun Xu, Jiang-Ping Zhu, Li-Na Lai, Zu‐Guo Zheng

Chinese Medicine

DOI

2026

Structural basis and pathological function of TRIM71: An analysis based on the TRIM-NHL subfamily

Qi-Feng Gan, Zi-xv Han, Zu‐Guo Zheng

Biochemical Pharmacology

DOI

2026

GCN5 drives MASLD progression through LXRα/SREBP1c signaling pathway–mediated de novo lipogenesis

Haitao Xiao, Peng Kun Song, Jing Jin, Yongdan Wang, Yin-Yue Xu, He Wu, Xue-Xue Shao, Qi-Feng Gan, Jian He, Yan-Rong Wen, Jing Ke Zhu, Bao-Yi Chen, Ping Zhou, Lina Lai, Hua Yang, Ping Li, Zu‐Guo Zheng

Nature Communications

DOI

2026

Qigui jiangzhi formula ameliorates atherosclerosis by inhibiting macrophage foam cell formation via the PI3K/AKT/ABCA1 pathway

Zihan Zhou, Fanxing Zhou, Xudong Xing, Zuguo Zheng, Guangji Wang, Hua Yang

Fitoterapia

DOI

2026

Rational Design of Imidazo[1,2- a ]pyridine as an Effective TLR7 Antagonist for the Treatment of Psoriasis: Research Combined with In Silico Study

Peng Yao, Xing Li, Li Wang, Mingge Song, Tianming Yu, Zuguo Zheng, Yue Zhao, Jiaxing Li, Dawei Wang, Yasheng Zhu, Yi Hou, Jiayu Ding, Hao Shen, Guoyu Zhang, Meijie Ji, Hua Yang, Ping Li, Zhihong Liu, Peng Yang

Journal of Medicinal Chemistry

DOI

2025

Traditional Chinese Medicine in the Treatment of Diabetic Cardiomyopathy: A Comprehensive Review

Jia-Xin He, Haitao Xiao, Meng-Meng Du, Min Shan Hu, Zu‐Guo Zheng

Journal of Cardiovascular Pharmacology

DOI

2025

Synergistic potential of Berberine and Wogonin improved adipose inflammation and insulin resistance associated with obesity through HIF-α axis

Zihan Zhou, Mingsu Wang, Xiaoyu Zhang, Yinyue Xu, Ping Li, Zu‐Guo Zheng, Hua Qiang Yang

Chinese Medicine

DOI

2025

Bilirubin ameliorates metabolic dysregulation by targeting the HSP90β/SREBPs signaling axis to improve insulin resistance and mitigate ectopic lipid deposition

Jing Zhu, Haitao Xiao, Qiong Wu, Xue-Xue Shao, Yufan Meng, Jie Ding, Jia-Xin He, Li-Na Lai, Ning Xue, Zu‐Guo Zheng

Metabolism and Target Organ Damage

DOI

2025

Correction to: Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue

Lai Wang, Zu‐Guo Zheng, Lingchang Meng, Lijun Zhu, Ping Li, Jun Chen, Hua Qiang Yang

Cell Biology and Toxicology

DOI

2025

Aurora kinase B inhibitor AZD1152: repurposing for treatment of lupus nephritis driven by the results of clinical trials

Yue Zhao, Zu‐Guo Zheng, Xuexiao Jin, Shaoshan Liang, Changming Zhang, Mingchao Zhang, Yue Lang, Ping Li, Zhihong Liu

EBioMedicine

DOI

2025

Ergosterol alleviates hepatic steatosis and insulin resistance via promoting fatty acid β-oxidation by activating mitochondrial ACSL1

Zu‐Guo Zheng, Yiping Zhang, Xiao-Yu Zhang, Mengyao Qin, Yin-Yue Xu, He Wu, Run-Qing Liu, Qiong Wu, Mingsu Wang, Chong Zhang, Yueqin Zheng, Jianye Dai, Ping Li, Hua Yang

Cell Reports

DOI

2025

Therapeutic strategies targeting SREBP transcription factors: an update to 2024

Yongdan Wang, Haitao Xiao, Lina Lai, Zu‐Guo Zheng

Acta Materia Medica

DOI

2024

The combination of berberine and isoliquiritigenin synergistically improved adipose inflammation and obesity‐induced insulin resistance

Xiaoyu Zhang, Lingling Yu, Keke Wang, Mingsu Wang, Ping Li, Zu‐Guo Zheng, Hua Qiang Yang

Phytotherapy Research

DOI

2023

Ginkgo biloba extract promotes Treg differentiation to ameliorate ischemic stroke via inhibition of HIF ‐1α/ HK2 pathway

Wenyu Hui, Wei Jiang Huang, Zu‐Guo Zheng, Yi Li, Ping Li, Hua Qiang Yang

Phytotherapy Research

DOI

2023

Emerging role of GCN5 in human diseases and its therapeutic potential

Haitao Xiao, Jing Jin, Zu‐Guo Zheng

Biomedicine & Pharmacotherapy

DOI

2022

Toll样受体7抑制剂的高通量筛选模型建立及应用

赵越，郑祖国，周萍，李萍，刘志红

《肾脏病与透析肾移植杂志》

2022

Advancing targeted protein degradation for metabolic diseases therapy

Qianqian Zhou, Haitao Xiao, Fan Yang, Yongdan Wang, Ping Li, Zu‐Guo Zheng

Pharmacological Research

DOI

2022

Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis

Zu‐Guo Zheng, Yin-Yue Xu, Wenping Liu, Yang Zhang, Chong Zhang, Han-Ling Liu, Xiaoyu Zhang, Run‐Zhou Liu, Yiping Zhang, Meng-Ying Shi, Hua Qiang Yang, Ping Li

Cell Metabolism

DOI

2022

HSP90β promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-κB signaling

Huimin Cheng, Mingming Xing, Yaping Zhou, Weitao Zhang, Zeyu Liu, Lan Li, Zu‐Guo Zheng, Yuanchen Ma, Pingping Li, Xiaoxuan Liu, Ping Li, Xiaojun Xu

Cell Death and Differentiation

DOI

2022

Geranylgeranyl pyrophosphate depletion by statins compromises skeletal muscle insulin sensitivity

Lai Wang, Zu‐Guo Zheng, Lijun Zhu, Lingchang Meng, Hanling Liu, Keke Wang, Jun Chen, Ping Li, Hua Qiang Yang

Journal of Cachexia Sarcopenia and Muscle

DOI

2022

7-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis

Weitao Zhang, Hanyue Xue, Chen Zhou, Zu‐Guo Zheng, Mingming Xing, Hang Chu, Ping Li, Naixia Zhang, Yongjun Dang, Xiaojun Xu

Biochemical and Biophysical Research Communications

DOI

2022

Baohuoside I inhibits FXR signaling pathway to interfere with bile acid homeostasis via targeting ER α degradation

Zhen Zhou Zhao, Lulu Yang, Qiao-Lei Wang, Jinfa Du, Zu‐Guo Zheng, Yan Jiang, Ping Li, Hui‐Jun Li

Cell Biology and Toxicology

DOI

2022

Mevalonate pathway orchestrates insulin signaling via RAB14 geranylgeranylation-mediated phosphorylation of AKT to regulate hepatic glucose metabolism

Lai Wang, Lijun Zhu, Zu‐Guo Zheng, Lingchang Meng, Hanling Liu, Keke Wang, Jun Chen, Ping Li, Hua Qiang Yang

Metabolism

DOI

2021

miR122-controlled all-in-one nanoplatform for in situ theranostic of drug-induced liver injury by visualization imaging guided on-demand drug release

Lingchang Meng, Qiaolei Wang, Lai Wang, Zhen Zhou Zhao, Gui-Zhong Xin, Zu‐Guo Zheng, Ping Zhou, Ping Li, Yan Jiang, Hui‐Jun Li

Materials Today Bio

DOI

2020

长链非编码RNAs在心肌纤维化中的研究进展

李小诗，吴循循，郑祖国，杨华，李萍

《中国药科大学学报》

2020

ATG7-dependent and independent autophagy determine the type of treatment in lung cancer

Pinghu Zhang, Ling Li, Zu‐Guo Zheng, Yuqian Zhang, Ronghua Wang, Min Wu, Ni Zhang, Maozhi Hu, Xiaohui Yang

Pharmacological Research

DOI

2020

Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue

Lai Wang, Zu‐Guo Zheng, Lingchang Meng, Lijun Zhu, Ping Li, Jun Chen, Hua Qiang Yang

Cell Biology and Toxicology

DOI

2020

Discovery of Novel 2-aminonicotinonitrile Derivatives With New Potential Autophagy Activity

Pinghu Zhang, Zu‐Guo Zheng, Xiaohui Yang, Yuqian Zhang, Gendi Hu, Ronghua Wang, Yu Juan Dong, Dongping Wei

Future Medicinal Chemistry

DOI

2020

Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway

Zu‐Guo Zheng, Si-Tong Zhu, Huimin Cheng, Xin Zhang, Gang Cheng, Pyone Myat Thu, Supeng Perry Wang, Hui‐Jun Li, Ming Ding, Lei Qiang, Xiaowei Chen, Qing Zhong, Ping Li, Xiaojun Xu

Autophagy

DOI

2020

Dual targeting of SREBP2 and ERRα by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss

Zu‐Guo Zheng, Huimin Cheng, Yaping Zhou, Si-Tong Zhu, Pyone Myat Thu, Hui‐Jun Li, Ping Li, Xiaojun Xu

Cell Death and Differentiation

DOI

2020

Antidiabetic Effects and Mechanisms of Rosemary (Rosmarinus officinalisL.) and its Phenolic Components

Tian-Qi Bao, Yi Li, Cheng Qu, Zu‐Guo Zheng, Hua Qiang Yang, Ping Li

The American Journal of Chinese Medicine

DOI

2020

A sensitive upconverting nanoprobe based on signal amplification technology for real-time in situ monitoring of drug-induced liver injury

Lingchang Meng, Xian Zheng, Zu‐Guo Zheng, Zhen Zhou Zhao, Lai Wang, Ping Zhou, Gui-Zhong Xin, Ping Li, Hui‐Jun Li

Nanoscale

DOI

2019

植物甾醇降血脂机制研究进展

卢婧霞，郑祖国，徐志猛，杨华，李萍

《中国中药杂志》

DOI

2019

Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis

Pyone Myat Thu, Zu‐Guo Zheng, Yaping Zhou, Yanyan Wang, Xin Zhang, Dan Jing, Hui-Min Cheng, Ji Li, Ping Li, Xiaojun Xu

European Journal of Pharmacology

DOI

2019

Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System

Zu‐Guo Zheng, Xin Zhang, Xiao-Xiao Liu, Xiuxiu Jin, Lunzhi Dai, Huimin Cheng, Dan Jing, Pyone Myat Thu, Mu Zhang, Hongyang Li, Jing Zhu, Chang Liu, Bin Xue, Yu Li, Ligong Chen, Cheng Peng, Weiliang Zhu, Lin Wang, Junli Liu, Hui‐Jun Li, Ping Li, Xiaojun Xu

Theranostics

DOI

2019

Correction: Praeruptorin B improves diet-induced hyperlipidemia and alleviates insulin resistance via regulating SREBP signaling pathway

Zu‐Guo Zheng, Chong Lu, Pyone Myat Thu, Xin Zhang, Hui‐Jun Li, Ping Li, Xiaojun Xu

RSC Advances

DOI

2018

Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway

Mu Zhang, Qian Cheng, Zu‐Guo Zheng, Fei Qian, Yanyan Wang, Pyone Myat Thu, Xin Zhang, Yaping Zhou, Lifan Tu, Qingling Liu, Hui‐Jun Li, Hua Qiang Yang, Ping Li, Xiaojun Xu

Theranostics

DOI

2018

Praeruptorin B improves diet-induced hyperlipidemia and alleviates insulin resistance via regulating SREBP signaling pathway

Zu‐Guo Zheng, Chong Lu, Pyone Myat Thu, Xin Zhang, Hui‐Jun Li, Ping Li, Xiaojun Xu

RSC Advances

DOI

2017

w09, a novel autophagy enhancer, induces autophagy-dependent cell apoptosis via activation of the EGFR-mediated RAS-RAF1-MAP2K-MAPK1/3 pathway

Pinghu Zhang, Zu‐Guo Zheng, Ling Li, Xiaohui Yang, Ni Zhang, Xue Bing Wang, Maozhi Hu, Yu Xia, Yiwen Ma, Haoran Yang, Yunyi Wang, Hongqi Liu

Autophagy

DOI

2017

Anhydroicaritin, a SREBPs inhibitor, inhibits RANKL-induced osteoclastic differentiation and improves diabetic osteoporosis in STZ-induced mice

Zu‐Guo Zheng, Xin Zhang, Ya-Ping Zhou, Chong Lu, Pyone Myat Thu, Qian Cheng, Mu Zhang, Ping Li, Hui‐Jun Li, Xiaojun Xu

European Journal of Pharmacology

DOI

2017

Rapid discovery of cyclopamine analogs from Fritillaria and Veratrum plants using LC-Q-TOF-MS and LC-QqQ-MS

Yuan Du, Zu‐Guo Zheng, Yue Yu, Zi-Tian Wu, Dan Liang, Ping Li, Yan Jiang, Hui‐Jun Li

Journal of Pharmaceutical and Biomedical Analysis

DOI

2017

Evaluation of structure–activity relationships of ginsenosides against amyloid β induced pathological behaviours in transgenic Caenorhabditis elegans

Mu Zhang, Fei Qian, Qingling Liu, Qian Cheng, Pyone Myat Thu, Yanyan Wang, Zu‐Guo Zheng, Hua Qiang Yang, Ping Li, Xiaojun Xu

RSC Advances

DOI

2016

细胞自噬形成机制及其功能研究进展

郑祖国，张评浒

《中国细胞生物学学报》

2016

Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation

Zu‐Guo Zheng, Yaping Zhou, Xin Zhang, Pyone Myat Thu, Zhishen Xie, Chong Lu, Tao Pang, Bin Xue, Daqian Xu, Yan Chen, Xiaowei Chen, Hui‐Jun Li, Xiaojun Xu

Biochemical Pharmacology

DOI

精选作品

期刊论文

Targeting vascular smooth muscle cells with natural compounds to combat atherosclerosis

Astragaloside IV improves MASLD via GCN5-LXRα/SREBP1c signaling pathway-mediated hepatic de novo lipogenesis

Structural basis and pathological function of TRIM71: An analysis based on the TRIM-NHL subfamily

GCN5 drives MASLD progression through LXRα/SREBP1c signaling pathway–mediated de novo lipogenesis

Qigui jiangzhi formula ameliorates atherosclerosis by inhibiting macrophage foam cell formation via the PI3K/AKT/ABCA1 pathway

Rational Design of Imidazo[1,2- a ]pyridine as an Effective TLR7 Antagonist for the Treatment of Psoriasis: Research Combined with In Silico Study

Traditional Chinese Medicine in the Treatment of Diabetic Cardiomyopathy: A Comprehensive Review

Synergistic potential of Berberine and Wogonin improved adipose inflammation and insulin resistance associated with obesity through HIF-α axis

Bilirubin ameliorates metabolic dysregulation by targeting the HSP90β/SREBPs signaling axis to improve insulin resistance and mitigate ectopic lipid deposition

Correction to: Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue

Aurora kinase B inhibitor AZD1152: repurposing for treatment of lupus nephritis driven by the results of clinical trials

Ergosterol alleviates hepatic steatosis and insulin resistance via promoting fatty acid β-oxidation by activating mitochondrial ACSL1

Therapeutic strategies targeting SREBP transcription factors: an update to 2024

The combination of berberine and isoliquiritigenin synergistically improved adipose inflammation and obesity‐induced insulin resistance

Ginkgo biloba extract promotes Treg differentiation to ameliorate ischemic stroke via inhibition of HIF ‐1α/ HK2 pathway

Emerging role of GCN5 in human diseases and its therapeutic potential

Toll样受体7抑制剂的高通量筛选模型建立及应用

Advancing targeted protein degradation for metabolic diseases therapy

Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis

HSP90β promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-κB signaling

Geranylgeranyl pyrophosphate depletion by statins compromises skeletal muscle insulin sensitivity

7-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis

Baohuoside I inhibits FXR signaling pathway to interfere with bile acid homeostasis via targeting ER α degradation

Mevalonate pathway orchestrates insulin signaling via RAB14 geranylgeranylation-mediated phosphorylation of AKT to regulate hepatic glucose metabolism

miR122-controlled all-in-one nanoplatform for in situ theranostic of drug-induced liver injury by visualization imaging guided on-demand drug release

长链非编码RNAs在心肌纤维化中的研究进展

ATG7-dependent and independent autophagy determine the type of treatment in lung cancer

Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue

Discovery of Novel 2-aminonicotinonitrile Derivatives With New Potential Autophagy Activity

Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway

Dual targeting of SREBP2 and ERRα by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss

Antidiabetic Effects and Mechanisms of Rosemary (Rosmarinus officinalisL.) and its Phenolic Components

A sensitive upconverting nanoprobe based on signal amplification technology for real-time in situ monitoring of drug-induced liver injury

植物甾醇降血脂机制研究进展

Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis

Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System

Correction: Praeruptorin B improves diet-induced hyperlipidemia and alleviates insulin resistance via regulating SREBP signaling pathway

Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway

Praeruptorin B improves diet-induced hyperlipidemia and alleviates insulin resistance via regulating SREBP signaling pathway

w09, a novel autophagy enhancer, induces autophagy-dependent cell apoptosis via activation of the EGFR-mediated RAS-RAF1-MAP2K-MAPK1/3 pathway

Anhydroicaritin, a SREBPs inhibitor, inhibits RANKL-induced osteoclastic differentiation and improves diabetic osteoporosis in STZ-induced mice

Rapid discovery of cyclopamine analogs from Fritillaria and Veratrum plants using LC-Q-TOF-MS and LC-QqQ-MS

Evaluation of structure–activity relationships of ginsenosides against amyloid β induced pathological behaviours in transgenic Caenorhabditis elegans

细胞自噬形成机制及其功能研究进展

Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation