左志成｜上海工程技术大学｜学者主页

期刊论文

2026

Differential Allosteric Modulation of Cas9 Specificity

Yuanhao Li, Xin Li, Yingjie Chen, Yanqing Wang, Zhicheng Zuo

Journal of Chemical Theory and Computation

DOI

2025

Catching CRISPR-Cas9 in Action

Yingjie Chen, Yuanhao Li, Penghai Li, Xin Li, Shuxin Zhao, Zhicheng Zuo

Journal of Chemical Theory and Computation

DOI

2024

Secondary Conformational Checkpoint in CRISPR-Cas9

Shuxin Zhao, Jin Liu, Zhicheng Zuo

Journal of Chemical Theory and Computation

DOI

2023

Identification of a Cryptic Binding Site in CRISPR-Cas9 for Targeted Inhibition

Niu Zhang, Zhicheng Zuo

Journal of Chemical Information and Modeling

DOI

2022

Molecular Mechanism of D1135E-Induced Discriminated CRISPR-Cas9 PAM Recognition

Minjie Kang, Zhicheng Zuo, Zhixiang Yin, Jianrong Gu

Journal of Chemical Information and Modeling

DOI

2022

Discovery and evaluation of cytisine N-isoflavones as novel EGFR/HER2 dual inhibitors

Yanqing Wang, Xiaoying Yin, Ling‐Yan Chen, Zhixiang Yin, Zhicheng Zuo

Bioorganic Chemistry

DOI

2022

Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects

Zhicheng Zuo, Kesavan Babu, Chhandosee Ganguly, Ashwini Zolekar, Sydney N. Newsom, Rakhi Rajan, Yu-Chieh Wang, Jin Liu

The CRISPR Journal

DOI

2020

A positive, growth-based PAM screen identifies noncanonical motifs recognized by the S. pyogenes Cas9

Daphne Collias, Ryan T. Leenay, Rebecca Slotkowski, Zhicheng Zuo, Scott P. Collins, B. A. McGirr, Jin Liu, Chase L. Beisel

Science Advances

DOI

2020

Allosteric regulation of CRISPR-Cas9 for DNA-targeting and cleavage

Zhicheng Zuo, Jin Liu

Current Opinion in Structural Biology

DOI

2019

Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

Zhicheng Zuo, Ashwini Zolekar, Kesavan Babu, Victor J. T. Lin, Hamed S. Hayatshahi, Rakhi Rajan, Yu-Chieh Wang, Jin Liu

eLife

DOI

2019

Author response: Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

Zhicheng Zuo, Ashwini Zolekar, Kesavan Babu, Victor J. T. Lin, Hamed S. Hayatshahi, Rakhi Rajan, Yu-Chieh Wang, Jin Liu

DOI

2012

用分子模拟方法研究HIV-1 TAR RNA与环肽抑制剂及相关蛋白质的识别和相互作用

左志成

《北京工业大学》

会议论文

2016

多药外排泵体系AcrAB-TolC的转运机理:能量和构象变化

左志成，王贝贝，翁经纬，王文宁

《中国化学会第30届学术年会摘要集-第十九分会：化学中的量子与经典动力学》

左志成

精选作品

期刊论文

Differential Allosteric Modulation of Cas9 Specificity

Catching CRISPR-Cas9 in Action

Secondary Conformational Checkpoint in CRISPR-Cas9

Identification of a Cryptic Binding Site in CRISPR-Cas9 for Targeted Inhibition

Molecular Mechanism of D1135E-Induced Discriminated CRISPR-Cas9 PAM Recognition

Discovery and evaluation of cytisine N-isoflavones as novel EGFR/HER2 dual inhibitors

Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects

A positive, growth-based PAM screen identifies noncanonical motifs recognized by the S. pyogenes Cas9

Allosteric regulation of CRISPR-Cas9 for DNA-targeting and cleavage

Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

Author response: Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

用分子模拟方法研究HIV-1 TAR RNA与环肽抑制剂及相关蛋白质的识别和相互作用

会议论文

多药外排泵体系AcrAB-TolC的转运机理:能量和构象变化

研究方向