徐云根

2026

新型PARP7抑制剂的设计、合成与生物活性研究

《中国药物化学杂志》

DOI

2026

Discovery of Oxime Ether Derivatives as Second-Generation PRMT5 Inhibitors for the Treatment of Triple Negative Breast Cancer.

Journal of Medicinal Chemistry

DOI

2026

Discovery of Highly Potent Phthalazinone Derivatives as PARP14 Inhibitors: From Structure-Based Virtual Screening to In Vivo Pharmacodynamic Activity.

Journal of Medicinal Chemistry

DOI

2026

Discovery of Novel Orally Bioavailable Polθ Inhibitors with Arylalkyne Scaffolds for Targeting HR-Deficient Cancers.

Journal of Medicinal Chemistry

DOI

2026

Correction to "Discovery of Hydroxamic Acid Ester Derivatives as Second-Generation PRMT5 Inhibitors for the Treatment of Triple Negative Breast Cancer".

Journal of Medicinal Chemistry

DOI

2026

Identification of an Orally Bioavailable Quinoline-Based Small-Molecule Tumor Necrosis Factor α (TNF-α) Inhibitor Featuring a Spirocyclic Scaffold.

Journal of Medicinal Chemistry

DOI

2026

Discovery of Novel and Potent Dual PARP1/ERK Inhibitors as a Promising Strategy for Cancer Therapy.

Journal of Medicinal Chemistry

DOI

2026

In vitro and ex vivo Pharmacological Profile of HY-022619, a Novel Intravenous P2Y12 Receptor Antagonist with Rapid-onset and Sustained Antiplatelet Activity

Pharmaceutical Research

DOI

2026

ChalcoVina: Enhancing Molecular Docking Accuracy by Incorporating Chalcogen Bond-Aware Scoring

Journal of Chemical Information and Modeling

DOI

2026

Development of a Scalable Synthetic Route and a Crystal Morphology Characterization Method for the PDE4B Inhibitor HY-072808

Organic Process Research & Development

DOI

2026

Blood-Brain Barrier-Permeable siRNA Nanodrugs With Dual-Gene Knockdown for Alzheimer's Disease Therapy.

Clinical and Experimental Pharmacology and Physiology

DOI

2025

第二代蛋白精氨酸甲基转移酶5抑制剂的研究进展

《中国药科大学学报》

2025

靶向下丘脑-垂体-肾上腺轴的抗抑郁药物研究进展

《药学进展》

DOI

2025

异吲哚啉酮类ERK抑制剂的设计、合成及初步生物活性研究

《高等学校化学学报》

2025

基于QbD理念的药物合成工艺课程教学方法探讨

《药学教育》

DOI

2025

Discovery and Optimization of Potent and Highly Selective PARP14 Inhibitors for the Treatment of Atopic Dermatitis.

Journal of Medicinal Chemistry

DOI

2025

Discovery and Optimization of Novel Apo-IDO1 Inhibitors by a Pharmacophore-Based Structural Simplification Strategy.

Journal of Medicinal Chemistry

DOI

2025

Discovery of Novel and Highly Potent Wee1 and HDAC Dual-Target Inhibitors for the Treatment of Acute Myeloid Leukemia.

Journal of Medicinal Chemistry

DOI

2025

PARP7: an Emerging Therapeutic Target-Insights into Biological Functions and Advances in Small-Molecule Inhibitor Development.

Journal of Medicinal Chemistry

DOI

2025

Discovery of novel JAK3 inhibitors for the treatment of atopic dermatitis.

Bioorganic & Medicinal Chemistry Letters

DOI

2025

MDM2 Degrader as a Promising Therapeutic Strategy for Cancer Treatment.

Journal of Medicinal Chemistry

DOI

2025

Discovery of Orally Potent Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.

Journal of Medicinal Chemistry

DOI

2025

Discovery of PKMYT1 Inhibitors with a Novel Scaffold for the Treatment of Triple-Negative Breast Cancer.

Journal of Medicinal Chemistry

DOI

2025

Characterization of Protein-Ligand Chalcogen Bonds: Insights from Database Survey and Quantum Mechanics Calculations

Journal of Chemical Information and Modeling

DOI

2025

Discovery of a spirocyclic influenza RNA-dependent RNA polymerase inhibitor.

Bioorganic chemistry (Print)

DOI

2025

Parps in immune response: Potential targets for cancer immunotherapy.

Biochemical Pharmacology

DOI

2025

Discovery of a novel benzofuran-7-carboxamide-based PARP1/c-Met dual inhibitor for addressing c-Met amplification-mediated PARP1i acquired-resistance.

European journal of medicinal chemistry

DOI

2024

基于免疫调控的药物研发进展

《中国药科大学学报》

2024

人工智能技术在先导化合物发现与优化中的应用进展

《药学学报》

2024

BTK/JAK3双靶点抑制剂的设计合成和生物活性评价

《中国药科大学学报》

2024

肿瘤免疫治疗靶点CD73及其抑制剂研究进展

《中国现代应用药学》

2024

Rational Design of PARP1/c-Met Dual Inhibitors for Overcoming PARP1 Inhibitor Resistance Induced by c-Met Overexpression.

Journal of Medicinal Chemistry

DOI

2024

Discovery of Highly Potent Small-Molecule PD-1/PD-L1 Inhibitors with a Novel Scaffold for Cancer Immunotherapy.

Journal of Medicinal Chemistry

DOI

2024

Discovery of the novel and potent histamine H1 receptor antagonists for treatment of allergic diseases.

European journal of medicinal chemistry

DOI

2024

Discovery of novel EGFR-PROTACs capable of degradation of multiple EGFR-mutated proteins.

European journal of medicinal chemistry

DOI

2024

Discovery of the first ataxia telangiectasia and Rad3-related (ATR) degraders for cancer treatment.

European journal of medicinal chemistry

DOI

2024

Design, synthesis, and antitumor activity evaluation of 1,2,3-triazole derivatives as potent PD-1/PD-L1 inhibitors.

Bioorganic chemistry (Print)

DOI

2024

Discovery of highly potent PARP7 inhibitors for cancer immunotherapy.

Bioorganic chemistry (Print)

DOI

2024

New TIPARP inhibitor rescues mitochondrial function and brain injury in ischemic stroke.

Pharmacological Research

DOI

2023

药物化学

2023

在药物化学实验教学中培养学生的科研思维

《药学教育》

2023

PARP-1/PI3K双靶点抑制剂的设计、合成与生物活性

《中国药科大学学报》

2023

新型1,2,3-三氮唑类衍生物的合成及抗炎活性研究

《有机化学》

2023

Discovery of Highly Selective PARP7 Inhibitors with a Novel Scaffold for Cancer Immunotherapy.

Journal of Medicinal Chemistry

DOI

2023

Discovery of novel dual Bruton's tyrosine kinase (BTK) and Janus kinase 3 (JAK3) inhibitors as a promising strategy for rheumatoid arthritis.

Bioorganic & Medicinal Chemistry

DOI

2023

DCLK1 and its oncogenic functions: A promising therapeutic target for cancers.

Life Science

DOI

2023

An overview of limonoid synthetic derivatives as promising bioactive molecules.

European journal of medicinal chemistry

DOI

2023

Synthesis and Anti-inflammatory Evaluation of Novel 1,2,3-Triazole Derivatives

Youji huaxue

DOI

2022

SHP2小分子抑制剂研究进展及构效关系分析

《药学进展》

2022

蛋白质精氨酸甲基转移酶5小分子抑制剂的研究进展

《中国药学杂志》

2022

工具性导向的化学生物学课程教学探索

《药学教育》

2022

棕榈酸曲安奈德中未知杂质的鉴定（英文）

Journal of Chinese Pharmaceutical Sciences

2022

Discovery of the Potent and Highly Selective PARP7 Inhibitor as a Novel Immunotherapeutic Agent for Tumors.

Journal of Medicinal Chemistry

DOI

2022

Rational Design for Nitroreductase (NTR)-Responsive Proteolysis Targeting Chimeras (PROTACs) Selectively Targeting Tumor Tissues.

Journal of Medicinal Chemistry

DOI

2022

Design, synthesis and biological evaluation of novel 4-aminopiperidine derivatives as SMO/ERK dual inhibitors.

Bioorganic & Medicinal Chemistry

DOI

2022

Design, synthesis and antitumor activity study of PARP-1/HDAC dual targeting inhibitors.

Bioorganic & Medicinal Chemistry Letters

DOI

2022

Discovery of the First Selective IDO2 Inhibitor As Novel Immunotherapeutic Avenues for Rheumatoid Arthritis.

Journal of Medicinal Chemistry

DOI

2022

Rh(III)-Catalyzed C-H Activation and [4+1+1] Sequential Cyclization Cascade to Give Highly Fused Indano[1,2-b]azirines.

Organic Letters

DOI

2022

Preclinical Drug Pharmacokinetic, Tissue Distribution and Excretion Profiles of the Novel Limonin Derivate HY-071085 as an Anti-Inflammatory and Analgesic Candidate in Rats and Beagle Dogs

Pharmaceuticals

DOI

2022

Design, Synthesis and Biological Evaluation of Novel and Potent Protein Arginine Methyltransferases 5 Inhibitors for Cancer Therapy

Molecules

DOI

2022

Discovery of novel potent covalent inhibitor-based EGFR degrader with excellent in vivo efficacy.

Bioorganic chemistry (Print)

DOI

2022

Anti-inflammatory Effect of a Limonin Derivative In Vivo and Its Mechanisms in RAW264.7 Cells

Inflammation

DOI

2022

Dual‐target synergistic antithrombotic mechanism of a dabigatran etexilate analogue (HY023016)

Clinical and Experimental Pharmacology and Physiology

DOI

2022

Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration.

European journal of medicinal chemistry

DOI

2021

单-ADP核糖转移酶家族及其抑制剂在肿瘤治疗中的研究进展

《中国药科大学学报》

2021

Discovery of Potent and Novel Dual PARP/BRD4 Inhibitors for Efficient Treatment of Pancreatic Cancer.

Journal of Medicinal Chemistry

DOI

2021

Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy.

Journal of Medicinal Chemistry

DOI

2021

Design, synthesis and biological evaluation of novel molecules as potent PARP-1 inhibitors.

Bioorganic & Medicinal Chemistry Letters

DOI

2021

Discovery of novel IDO1 inhibitors targeting the protein's apo form through scaffold hopping from holo-IDO1 inhibitor.

Bioorganic & Medicinal Chemistry Letters

DOI

2021

Structure-activity relationships and antiproliferative effects of 1,2,3,4-4H-quinoxaline derivatives as tubulin polymerization inhibitors.

Bioorganic chemistry (Print)

DOI

2021

Design, synthesis and biological evaluation of novel benzoxaborole derivatives as potent PDE4 inhibitors for topical treatment of atopic dermatitis.

European journal of medicinal chemistry

DOI

2021

Discovery of novel and potent PARP/PI3K dual inhibitors for the treatment of cancer.

European journal of medicinal chemistry

DOI

2021

Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy

Molecules

DOI

2021

Curcumin Complex Analogues as Near-Infrared Fluorescent Probes for Monitoring all Aβ Species in the Early Alzheimer's Disease Model.

ACS Chemical Neuroscience

DOI

2020

1-（取代）苯磺酰基-3-烷胺基甲基吲哚衍生物的设计合成及其抑酸活性研究

《中国药物化学杂志》

DOI

2020

小分子ERK抑制剂的研究进展

《中国药科大学学报》

2020

BET溴结构域抑制剂的研究进展

《中国药物化学杂志》

DOI

2020

以培养自主学习能力为目标的药学工作坊建设

《药学教育》

DOI

2020

依伐卡托中间体的合成工艺改进

《化学试剂》

2020

抗丙肝新药盐酸氘代达卡他韦的合成

《中国医药工业杂志》

DOI

2020

含有黄嘌呤衍生物的N-杂环卡宾金属配合物的生物活性研究进展

《药学进展》

2020

Smoothened抑制剂的耐药机制及克服耐药性的策略研究

《药学进展》

2020

N-(三氘代甲氧羰基)-L-缬氨酸的合成

《药学与临床研究》

DOI

2020

Design, synthesis and biological evaluation of N-hydroxy-aminobenzyloxyarylamide analogues as novel selective κ opioid receptor antagonists.

Bioorganic & Medicinal Chemistry Letters

DOI

2020

Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors.

Bioorganic & Medicinal Chemistry

DOI

2020

Versatile near-infrared fluorescent probe for in vivo detection of Aβ oligomers.

Bioorganic & Medicinal Chemistry

DOI

2020

Platinum-based combination therapy: molecular rationale, current clinical uses, and future perspectives.

Journal of Medicinal Chemistry

DOI

2020

Discovery of Novel Dual Extracellular Regulated Protein Kinases (ERK) and Phosphoinositide 3-Kinase (PI3K) Inhibitors as a Promising Strategy for Cancer Therapy

Molecules

DOI

2020

Synthesis of Limonin Derivatives with Improved Anti-inflammatory and Analgesic Properties

DOI

2020

PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery

Autophagy

DOI

2020

Discovery of novel PARP/PI3K dual inhibitors with high efficiency against BRCA-proficient triple negative breast cancer.

European journal of medicinal chemistry

DOI

2020

Strategies targeting soluble β-Amyloid oligomers and their application to early diagnosis of Alzheimer's Disease.

Current Alzheimer Research

DOI

2020

A practical synthesis of amino limonin/deoxylimonin derivatives as effective mitigators against inflammation and nociception.

RSC Medicinal Chemistry

DOI

2020

Discovery of deoxylimonin δ-lactam derivative with favorable anti-inflammation and antinociception efficacy from chemical modified limonin/deoxylimonin analogs.

Bioorganic chemistry (Print)

DOI

2019

PARP-1抑制剂与其他药物联用克服耐药性的研究进展

《中国药科大学学报》

2019

盐酸绿卡色林的工艺研究?

《中国现代应用药学》

DOI

2019

PI3K&mTOR双重抑制剂Apitolisib的合成工艺改进

《广州化工》

2019

Janus激酶及其抑制剂的研究进展

《药学进展》

2019

Discovery of novel nonpeptide small-molecule NRP1 antagonists: Virtual screening, molecular simulation and structural modification.

Bioorganic & Medicinal Chemistry

DOI

2019

Design, synthesis and biological evaluation of novel desloratadine derivatives with anti-inflammatory and H1 antagonize activities.

Bioorganic & Medicinal Chemistry Letters

DOI

2019

Discovery of Novel Dual Poly(ADP-ribose)polymerase (PARP) and Phosphoinositide 3-kinase (PI3K) Inhibitors as A Promising Strategy for Cancer Therapy.

Journal of Medicinal Chemistry

DOI

2019

Transition Metal-Free C5 Tosyloxylation of 8-Aminoquinolines with Phenyliodine Bistrifluoroacetate and Substituted 1,2-Disulfonyl Hydrazides

Annalen der Pharmacie

DOI

2019

Discovery of potent, orally bioavailable ERK1/2 inhibitors with isoindolin-1-one structure by structure-based drug design.

European journal of medicinal chemistry

DOI

2019

Targeting VEGF-neuropilin interactions: a promising antitumor strategy.

Drug Discovery Today

DOI

2019

Half-curcumin analogues as PET imaging probes for amyloid beta species.

Chemical Communications

DOI

2019

Near-infrared Fluorescence Ocular Imaging (NIRFOI) of Alzheimer’s Disease

Molecular Imaging and Biology

DOI

2019

Identification of New Inhibitors of Mutant Isocitrate Dehydrogenase 2 through Molecular Similarity-based Virtual Screening

Letters in Drug Design & Discovery

DOI

2019

Highly specific detection of Aβ oligomers in early Alzheimer's disease by a near-infrared fluorescent probe with a "V-shaped" spatial conformation.

Chemical Communications

DOI

2019

The development of Near-infrared Fluorescent Probes in Alzheimer's disease.

Bioconjugate chemistry

DOI

2019

A new lysosome-targetable fluorescent probe with a large Stokes shift for detection of endogenous hydrogen polysulfides in living cells.

Analytica Chimica Acta

DOI

2018

阿片受体激动剂研究进展

《药学进展》

2018

Novel aromatic sulfonyl naphthalene-based boronates as 20S proteasome inhibitors.

Bioorganic & Medicinal Chemistry

DOI

2018

Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): An Update and Perspective.

Journal of Medicinal Chemistry

DOI

2018

Optimization of 5-arylidene barbiturates as potent, selective, reversible LSD1 inhibitors for the treatment of acute promyelocytic leukemia.

Bioorganic & Medicinal Chemistry

DOI

2018

A highly sensitive fluorescent probe for selective detection of cysteine/homocysteine from glutathione and its application in living cells and tissues

DOI

2018

A new fluorescent probe for quick and highly selective detection of hydrogen sulfide and its application in living cells

DOI

2018

Novel Opioid Receptor Agonists with Reduced Morphine-like Side Effects.

Mini-Reviews in Medical Chemistry

DOI

2018

Recent advances in inhibitors of sirtuin1/2: an update and perspective.

Future Medicinal Chemistry

DOI

2018

A novel limonin derivate modulates inflammatory response by suppressing the TLR4/NF-κB signalling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI

2018

Design, synthesis and biological activity of 4-(4-benzyloxy)phenoxypiperidines as selective and reversible LSD1 inhibitors.

Bioorganic chemistry (Print)

DOI

2017

PI3K抑制剂与其他药物联用克服耐药性的研究进展

《中国药科大学学报》

2017

绿卡色林衍生物的合成、体外代谢及体内活性研究

《高等学校化学学报》

2017

具有四氢苯并[4,5]咪唑并[1,2-a]吡嗪骨架凝血酶抑制剂的设计合成及生物活性研究

《高等学校化学学报》

2017

Design, synthesis and biological evaluation of novel 3H-imidazole [4,5-b] pyridine derivatives as selective mTOR inhibitors.

Bioorganic & Medicinal Chemistry Letters

DOI

2017

Identification of novel allosteric inhibitors of mutant isocitrate dehydrogenase 1 by cross docking-based virtual screening.

Bioorganic & Medicinal Chemistry Letters

DOI

2017

Design, synthesis and antithrombotic evaluation of novel non-peptide thrombin inhibitors.

Bioorganic & Medicinal Chemistry

DOI

2017

Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1.

Bioorganic & Medicinal Chemistry

DOI

2017

Copper(I) and N-fluorobenzenesulfonimide-mediated direct regioselective halogenation of 8-amidoquinolines on the C5 position

DOI

2017

Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer's Disease

Journal of Neural Transplantation and Plasticity

DOI

2017

Design, synthesis and biological evaluation of novel non-peptide boronic acid derivatives as proteasome inhibitors.

European journal of medicinal chemistry

DOI

2017

VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016)

Expert Opinion on Therapeutic Patents

DOI

2017

Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes.

Future Medicinal Chemistry

DOI

2017

Design and discovery of 4-anilinoquinazoline-urea derivatives as dual TK inhibitors of EGFR and VEGFR-2.

European journal of medicinal chemistry

DOI

2017

Design, synthesis and biological evaluation of aminobenzyloxyarylamide derivatives as selective κ opioid receptor antagonists.

European journal of medicinal chemistry

DOI

2017

Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease

Proceedings of the National Academy of Sciences of the United States of America

DOI

2016

减肥药的研究进展

《中国新药杂志》

2016

盐酸氯卡色林的合成研究进展

《中国新药杂志》

2016

BCR-ABL激酶抑制剂的研究进展

《中国现代应用药学》

2016

可逆型质子泵抑制剂最新研究进展

《药学进展》

2016

奥拉帕尼合成路线图解

《中国医药工业杂志》

2016

Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.

Journal of Medicinal Chemistry

DOI

2016

Design, synthesis and biological evaluation of novel 5-fluoro-1H-benzimidazole-4-carboxamide derivatives as potent PARP-1 inhibitors.

Bioorganic & Medicinal Chemistry Letters

DOI

2016

Design, synthesis and biological evaluation of novel tetrahydroisoquinoline quaternary derivatives as peripheral κ-opioid receptor agonists.

Bioorganic & Medicinal Chemistry

DOI

2016

Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation.

Bioorganic & Medicinal Chemistry

DOI

2016

塩酸LvKa色林の合成研究の進展【JST・京大機械翻訳】

2016

Progress in synthesis of lorcaserin hydrochloride

2016

Metal-Free Remote C-H Bond Amidation of 8-Amidoquinolines on the C5 Position under Mild Conditions.

Organic Letters

DOI

2016

Correction to "Metal-Free Remote C-H Bond Amidation of 8-amidoquinolines on the C5 Position under Mild Conditions".

Organic Letters

DOI

2016

Effect of CPU-XT-008, a combretastatin A-4 analogue, on the proliferation, apoptosis and expression of vascular endothelial growth factor and basic fibroblast growth factor in human umbilical vein endothelial cells.

Oncology Letters

DOI

2016

奥拉Pa尼合成ルート図解【JST・京大機械翻訳】

2016

Palladium-Catalyzed Synthesis of Novel O-Heterocycles by Domino Suzuki Coupling-Michael Addition Reaction

DOI

2016

Imaging hydrogen peroxide in Alzheimer’s disease via cascade signal amplification

Scientific Reports

DOI

2016

O1‐12‐04: Near Infrared Fluorescence Imaging of Reactive Oxygen Species in Alzheimer’s Disease Via Transformation From “Visible” to “Invisible”

DOI

2016

Identification of a novel selective inhibitor of mutant isocitrate dehydrogenase 1 at allosteric site by docking-based virtual screening

DOI

2015

Combretastatin A-4氨基糖类衍生物CPU-XT-008抑制血管内皮细胞增殖的分子机制

《中国药科大学学报》

2015

尼达尼布的合成

《合成化学》

2015

柠檬苦素类似物的生物活性和构效关系研究进展

《药学进展》

2015

Corrigendum to "Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2" [Bioorg. Med. Chem. 22 (2014) 4735-4744].

Bioorganic & Medicinal Chemistry

DOI

2015

Design, synthesis and antithrombotic evaluation of novel dabigatran etexilate analogs, a new series of non-peptides thrombin inhibitors.

Bioorganic & Medicinal Chemistry

DOI

2015

Discovery and SAR study of 2-(1-propylpiperidin-4-yl)-3H-imidazo[4,5-c]pyridine-7-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) for the treatment of cancer.

Bioorganic & Medicinal Chemistry

DOI

2015

Fluorescent Coumarin-Artemisinin Conjugates as Mitochondria-Targeting Theranostic Probes for Enhanced Anticancer Activities.

Chemistry

DOI

2015

Synthesis and biological evaluation of novel laropiprant derivatives as potential anti-allergic agents

Medicinal Chemistry Research

DOI

2015

Identification of new non-steroidal TGR5 agonists using virtual screening with combined pharmacophore models

Medicinal Chemistry Research

DOI

2015

Efficient Palladium-Catalyzed C—H Fluorination of C(sp3)—H Bonds: Synthesis of β-Fluorinated Carboxylic Acids.

DOI

2015

A class of derivatives of ca-4, their preparation, and pharmaceutical use

2015

Synthesis of 6-Substituted Phenanthridine Derivatives by Palladium-Catalyzed Domino Suzuki—Miyaura/Aza-Michael Reactions.

DOI

2015

Novel Synthesis of Antiobesity Drug Lorcaserin Hydrochloride

DOI

2015

Design, Synthesis, and Biological Evaluation of Dabigatran Etexilate Mimics, a Novel Class of Thrombin Inhibitors

Archiv der Pharmazie

DOI

2015

Identification of Novel Selective Lysine‐Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore‐Based Virtual Screening Combined with Docking

Chemical Biology and Drug Design

DOI

2014

Synthesis and pharmacological evaluation of novel limonin derivatives as anti-inflammatory and analgesic agents with high water solubility.

Bioorganic & Medicinal Chemistry Letters

DOI

2014

Development and validation of a liquid chromatography/tandem mass spectrometry assay for the simultaneous determination of dabigatran etexilate, intermediate metabolite and dabigatran in 50μL rat plasma and its application to pharmacokinetic study.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI

2014

Synthesis of 6-Substituted Phenanthridine Derivatives by Palladium-Catalysed Domino Suzuki–Miyaura/Aza-Michael Reactions

DOI

2014

Synthesis Process of Cinacalcet Hydrochloride

2014

p-Toluenesulfonohydrazide as highly efficient initiator for direct C-H arylation of unactivated arenes.

Organic Letters

DOI

2014

Design, Synthesis and Anti-Allergic Activity Evaluation of Aryl-Acetic Acid Derivatives

2013

考布他汀A-4衍生物CPU-XT-006对人脐静脉内皮细胞增殖、凋亡及VEGF、bFGF表达的影响

《中国药科大学学报》

2013

蒽环类抗肿瘤化合物的研究进展

《中国新药杂志》

2013

Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors.

Bioorganic & Medicinal Chemistry Letters

DOI

2013

Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor.

Bioorganic & Medicinal Chemistry

DOI

2013

Synthesis and anti-angiogenetic activity evaluation of N-(3-aryl acryloyl)aminosaccharide derivatives.

Carbohydrate Research

DOI

2013

2-[(4-cyano-benzyl)amino]ethyl acetate hydrochloride preparation method

2013

An efficient procedure for synthesis of 2, 3-dihydro-1H-indene-1-methanamines

Research on chemical intermediates (Print)

DOI

2013

Recent progress in research on anthracyclines

2013

Design, Synthesis and Biological Evaluation of Novel Aminosaccharide Derivatives of Combretastatin A-4

DOI

2012

来那度胺及其氨基糖偶联物的合成及抗肿瘤血管生成活性

《中国药科大学学报》

2012

对叠氮-L-苯丙氨酸盐酸盐的合成及其在重组人内皮抑素中的定点引入

《中国药科大学学报》

2012

4（6）-{2-[4-（2,3,4-三甲氧基苄基）哌嗪-1-基]-2-氧代乙氧基}芳甲酰胍类化合物的合成及其Na+/H+交换器1抑制活性

《有机化学》

2012

来源于天然产物的乙酰胆碱酯酶抑制剂研究进展

《药学进展》

2012

Palladium-Catalyzed Tandem Reactions of β-(2-Bromophenyl)-α,β-Unsaturated Carbonyl Compounds with 2-Hydroxyphenylboronic Acid: A New Route to Benzo[c]chromenes.

DOI

2012

Convenient Chlorination of Some Special Aromatic Compounds Using N‐Chlorosuccinimide.

DOI

2012

Scale-Up Synthesis of Antidepressant Drug Vilazodone

DOI

2011

茚喹诺啉对映体的手性拆分及转化研究

《药物分析杂志》

2011

取代苯甲酰胍与曲美他嗪偶联物的合成及对Na+/H+交换器-1的抑制活性

《中国药科大学学报》

2011

细胞毒药物与肿瘤血管生成

《中国现代应用药学》

2011

阿魏酰胍丁胺类似物的设计、合成及Na+/H+交换器-1抑制活性

《药学学报》

2011

Silver-Catalyzed Intramolecular Hydroamination of Alkynes in Aqueous Media: Efficient and Regioselective Synthesis for Fused Benzimidazoles.

DOI

2011

An Improved Synthesis of Substituted Indan‐1‐carboxylic Acid.

DOI

2011

Study on chiral separation and transformation of indiquinoline enantiomers

2011

An Effective Synthetic Entry to Fused Benzimidazoles via Iodocyclization

DOI

2011

Synthesis of N-Heteroaryl Aminosaccharide Derivatives as Fibroblast Growth Factor 2 Signaling Modulators.

DOI

2010

Synthesis of N-heteroaroyl aminosaccharide derivatives as fibroblast growth factor 2 signaling modulators.

Chemical and pharmaceutical bulletin

DOI

2009

Synthesis and Na+/H+ Exchanger‐1 Inhibitory Activity of Substituted (Quinolinecarbonyl)guanidine Derivatives

Chemistry and Biodiversity

DOI

2008

A Review of Immunosuppressant FTY720 and its Analogs

2007

2-[5-取代苯并咪(噻)唑-2-硫基]-1-(4-取代苯基)乙酮缩氨基胍的合成及NHE1抑制活性

《中国药物化学杂志》

2007

N-[4-(苯并咪唑-2-硫基)苯基]-N′-烷基胍类衍生物的合成和生物活性

《药学学报》

2007

达泊西汀的合成进展

《中国新药杂志》

2006

1-烷基-3-[4-(苯并噻唑-2-巯基)苯基]胍类化合物的合成及其生物活性

《中国药科大学学报》

2006

2-芳亚胺基-4-噻唑烷酮类化合物的合成及生物活性

《药学学报》

2006

卡立泊来德的合成工艺改进

《中国药物化学杂志》

2005

Na+/H+交换器抑制剂研究进展

《中国药学杂志》

2004

4-(苯并咪(噻)唑2-)苯甲脒类化合物的合成及其一氧化氮合酶抑制活性

《中国药科大学学报》

2004

烟拉文的合成工艺改进

《中国药物化学杂志》

2004

抗肿瘤药泰克地那林的合成工艺改进

《中国药物化学杂志》

2004

1-烃基(或氢)-3-[4-(5-取代苯并咪(噻)唑-2-巯基)苯基]硫脲的合成及其iNOS抑制活性

《中国药科大学学报》

2003

四氢异喹啉衍生的硫脲和异硫脲化合物的合成及NOS抑制活性研究Ⅰ.

《中国药科大学学报》

2002

盐酸洛美利嗪的NMR研究

《中国药科大学学报》

2002

HPLC法测定西尼地平及其片剂的含量

《中国药科大学学报》

2001

高效液相色谱法测定利塞膦酸钠片的含量

《中国药科大学学报》

2001

氨氯地平衍生物的合成和降血压活性研究

《中国药科大学学报》

2000

5,6-二甲氧基-1-吲酮的合成

《中国现代应用药学》

2000

盐酸西布曲明的合成

《中国现代应用药学》

1999

醋氯酚酸原料含量测定方法的研究

《中国药科大学学报》

1997

头孢哌酮合成工艺的改进

《中国药科大学学报》

1997

催眠药替马西泮的合成

《中国药科大学学报》

1996

吡拉西坦的一步合成新方法

《中国药科大学学报》

1991

3-取代二碘苯甲酰吲哚衍生物的合成

《中国药科大学学报》

2018

Design,synthesis and biological evaluation of limonin derivatives

《第11届世界华人药物化学研讨会（ISCMC 2018）论文摘要集》

2018

Design,synthesis and biological evaluation of novel μ-opioid receptor agonists

《第11届世界华人药物化学研讨会（ISCMC 2018）论文摘要集》

2018

Discovery of IDO1/IDO2 dual inhibitors with high antitumor efficiency:design,synthesis,and preliminary mechanism exploration

《第11届世界华人药物化学研讨会（ISCMC 2018）》

2012

来那度胺及其氨基糖偶联物的合成与生物活性研究

《2012长三角药物化学研讨会论文集》

2012

PARP-1抑制剂的设计,合成及生物活性研究

《2012长三角药物化学研讨会论文集》

2012

An Efficient Synthesis of Antidepressant Drug Vilazodone

《2012长三角药物化学研讨会》

2011

DP1受体拮抗剂拉罗匹仑的合成工艺研究

《2011年全国药物化学学术会议——药物的源头创新论文摘要集》

2011

Design and Synthesis of Novel Derivatives of Dabigatran Based-on Scaffold Hopping

《2011年全国药物化学学术会议——药物的源头创新》