张明亮｜河南中医药大学｜学者主页

2026

基于β-catenin/c-Myc轴探究补骨脂抗多发性骨髓瘤作用机制

李明格，张明亮，马旭斌，张辉，王晓艳，李伟霞，李宇辉，张利园，朱珠，吴娅丽，杨柳青，陈小菲，唐进法

《中国中药杂志》

2026

基于代谢组学的补骨脂盐炙“润燥减毒”机制研究——以肾阴虚为例

李宇辉，陈小菲，曹梦珍，李明格，张辉，吴娅丽，杨柳青，张明亮，肖小河，唐进法

《中国中药杂志》

2026

基于真实世界数据的肾康注射液的上市后安全性评价及不良反应影响因素分析

霍梦琪，赵娅，张明亮，凌霄，杨亚蕾，张书琦，康冰亚，冯科冉，唐进法，陈小菲

《中国医院药学杂志》

2026

基于网络药理学及分子对接探究复方苦参注射液治疗多发性硬化症的作用机制

曹站霞，李小玉，陈诚，马旭斌，张辉，张利园，朱珠，王晓艳，陈小菲，张明亮，唐进法

《医药论坛杂志》

2026

基于“异类相制”理论探讨淫羊藿和女贞子对补骨脂诱导肾阴虚大鼠肝损伤的影响及作用机制

李宇辉，张明亮，陈小菲，孟高全，李明格，张辉，吴娅丽，杨柳青，肖小河，唐进法

《中草药》

2026

黄芩素-美罗培南联用在健康及肺炎大鼠模型中的药动学相互作用研究

王晴，张庆，吴娅丽，秦玺，赵娅，李明格，张辉，陈小菲，张明亮，王晓艳，李伟霞，唐进法

《中国医院药学杂志》

2026

中药注射液联合抗生素对肺炎克雷伯菌的抑菌作用评价

郑博文，吴娅丽，王晴，秦玺，赵娅，李旭阳，张明亮，王晓艳，李伟霞，陈小菲，唐进法

《中成药》

2026

基于指纹图谱、多成分含量测定及化学计量学的桃仁配方颗粒质量评价

孙文静，孟伟亭，李锦燕，王晓艳，张明亮，张辉，陈小菲，刘现磊，李明格，魏诗婷，李伟霞，唐进法

《世界中医药》

2026

基于UPLC指纹图谱和多成分含量测定结合化学计量学的甘草干姜汤配方颗粒质量评价

刘现磊，孟伟亭，李锦燕，王晓艳，张辉，张明亮，陈小菲，孙文静，李伟霞，唐进法

《药物分析杂志》

2026

基于RBMECs-PC12细胞共培养体系的缺糖缺氧/复氧损伤模型探讨当归-川芎药对活性成分脑保护作用机制

孙文静，纪秋如，李伟霞，王晓艳，张明亮，吴娅丽，杨柳青，孟伟亭，李旭阳，李锦燕，刘现磊，唐进法

《中国药理学通报》

2026

Repurposing Camellia sinensis Roots and Ginkgo biloba Leaves for Multiple Myeloma via Wnt/β‐Catenin–Dependent Cell Cycle Arrest and Apoptosis

Mingge Li, Mingliang Zhang, Xubin Ma, Gao Meng, Hui Zhang, Yingjie Ren, Linhong Fan, Yu-Hui Li, Yuehua Wu, Xiaoyan Wang, Weixia Li, Xiaofei Chen, Jinfa Tang

Chemistry and Biodiversity

DOI

2026

Panax ginseng-derived extracellular vesicles: A promising novel trend in functional nutrition and biomedical translational research

Linhong Fan, Mingliang Zhang, Si-Yu Chen, Yan Wang, Liuqing Yang, Hui Zhang, Yuehua Wu, Chunling Zhang, Yongshen Ren, Xiaofei Chen, Jinfa Tang

Trends in Food Science & Technology

DOI

2026

Shuxuening injection improves ventricular remodeling after myocardial infarction by indirectly promoting macrophage-mediated angiogenesis and lymphangiogenesis

Liuqing Yang, Xiaoshuai Zhang, Yajuan Zheng, He Wang, Mingliang Zhang, Ya-Li Wu, Hui Zhang, Xiaoyan Wang, Yi Cao, Pan Wang, Bin Wang, Shiting Wei, Yuhui Li, Weixia Li, Xiaofei Chen, Jinfa Tang

Chinese Medicine

DOI

2026

SARS-CoV-2 Mpro inhibitors from Siphonostegia chinensis: an integrated biophysical and computational study

Yingjie Ren, Wei Wang, Dai Zhang, Mingliang Zhang, Hui Zhang, Yuehua Wu, Fei Liu, Liuqing Yang, Pan Wang, Lei Chen, Xiaofei Chen, Jinfa Tang, Xian-Qing Ren

Frontiers in Chemistry

DOI

2026

Carbon monoxide activatable near-infrared fluorescent probe to explore drug-induced liver injury and protective effect of TCMs components.

Yilei Dong, Mingliang Zhang, Feiyan Liu, Man-Man Li, Hui Zhang, Xubin Ma, Yingjie Ren, Yuehua Wu, Liuqing Yang, Xiaodong Zhang, Xiaofei Chen, Jinfa Tang

Bioorganic chemistry (Print)

DOI

2026

An innovative "Parameter-Component" correlation strategy for mechanistic elucidation of green extraction technologies for natural products: mechanochemical extraction of saponins as case study.

Linhong Fan, Mingliang Zhang, Wen-Xiang Fan, Liuqing Yang, Yan Wang, Xiaofei Chen, Jinfa Tang, Zheng-Tao Wang, Li Yang

Food Chemistry

DOI

2026

Tanreqing injection regulates Sema7a/Plxnc1 signaling pathway mediated neutrophil extracellular trap formation to alleviate lipopolysaccharide-induced acute lung injury.

Meng-Qi Huo, Mingliang Zhang, Li-Ping Fan, Hui Zhang, Yan Wang, Weiting Meng, Yuehua Wu, Xubin Ma, Xiaofei Chen, Jinfa Tang

Journal of Ethnopharmacology

DOI

2026

Potential of traditional Chinese medicine-antibiotic combinations in combating multidrug-resistant organisms: Advances, mechanisms, and clinical implications.

Xi Qin, Yuehua Wu, Xin Pang, Ya Zhao, Xiaoyan Wang, Weixia Li, Mingliang Zhang, Linhong Fan, Hui Zhang, Qing Wang, Liuqing Yang, Xiaofei Chen, Jinfa Tang

Journal of Ethnopharmacology

DOI

2025

中药干预多发性硬化不同分期的组方规律分析和作用机制研究

司利玲，李月梅，张辉，李伟霞，王晓艳，李明格，李小玉，唐进法，张明亮，陈小菲

《医药论坛杂志》

2025

中医药干预HuR转录后调控的抗肿瘤作用研究进展

杨柳青，李伟霞，王晓艳，张明亮，张辉，吴娅丽，唐进法

《中国药理学通报》

2025

Shuxuening injection improves myocardial injury after myocardial infarction by regulating macrophage polarization via the TLR4/NF-κB and PI3K/Akt signaling pathways.

Xiaoshuai Zhang, Liuqing Yang, Kairui Feng, Hui Zhang, Yulong Chen, Weixia Li, Xiaoyan Wang, Mingliang Zhang, Yuehua Wu, Shiting Wei, Yajuan Zheng, Gao Meng, Weiting Meng, Xiaofei Chen, Jinfa Tang

Phytomedicine

DOI

2025

Unveiling TCM-antibiotic synergy through multi-omics: Shuganning injection potentiates the effect of linezolid against methicillin-resistant Staphylococcus aureus.

Qing Wang, Yuehua Wu, Yan Wang, Xin Pang, Mingliang Zhang, Ya Zhao, Xi Qin, B. Zheng, Ming-Yue Li, Xuyang Li, Weixia Li, Xiaoyan Wang, Liuqing Yang, Xiaofei Chen, Jinfa Tang

Phytomedicine

DOI

2025

Red-emitting fluorescent probe sequentially activated by peroxynitrite and monoamine oxidase for diagnosis and therapeutic evaluation of drug-induced liver injury.

Feiyan Liu, Mingliang Zhang, Man-Man Li, Weixia Li, Yingjie Ren, Linhong Fan, Yuehua Wu, Hui Zhang, Pan Wang, Liuqing Yang, Xiaoyan Wang, Jinfa Tang, Xiaofei Chen

European journal of medicinal chemistry

DOI

2024

基于生化指标与代谢组学特征关联探索热毒宁注射液与青霉素注射液序贯用药的风险“时间窗”

张明亮，陈毓龙，王晓艳，陈小菲，张辉，吴娅丽，杨柳青，张书琦，牛璐，冯科冉，李伟霞，唐进法

《药学学报》

DOI

2024

基于代谢组学结合生物信息学探讨热毒宁注射液与青霉素注射液联用致类过敏反应的潜在致敏原及作用机制

陈毓龙，翟优，王晓艳，李伟霞，张辉，吴娅丽，杨柳青，陈小菲，张书琦，牛璐，冯科冉，李琨，唐进法，张明亮

《药学学报》

2024

基于七情配伍理论的补骨脂药对配伍规律研究进展

王晓艳，陈小菲，张辉，张明亮，吴娅丽，杨柳青，唐进法，李伟霞

《中国药物警戒》

2024

Exploring the Anti-inflammatory and Immunomodulatory Potential of Licochalcone B against Psoralidin-Induced Liver Injury.

Yuehua Wu, Ke-Ran Feng, Yulong Chen, Hui Zhang, Mingliang Zhang, Bing Han, Xiaofei Chen, Liuqing Yang, Xiaoyan Wang, Weixia Li, Jinfa Tang

Journal of Ethnopharmacology

DOI

2024

Peroxynitrite-activated fluorescent probe with two reaction triggers for pathological diagnosis and therapeutic evaluation of inflammation.

Feiyan Liu, Man-Man Li, Weixia Li, Yingjie Ren, Mingliang Zhang, Hui Zhang, Pan Wang, Yuehua Wu, Ke-Han Wang, Xiaoyan Wang, Xiaofei Chen, Jinfa Tang

Bioorganic chemistry (Print)

DOI

2023

补骨脂“大燥伤肝”的客观性及生物学机制研究

张明亮，赵旭，李伟霞，王晓艳，陈毓龙，孔德鑫，吴承钊，陈小菲，柏兆方，牛明，王伽伯，赵艳玲，肖小河，唐进法

《药学学报》

2023

基于生物信息学的氧化苦参碱重定位及作用机制研究——以多发性硬化症为例

孔德鑫，张明亮，陈毓龙，李伟霞，王晓艳，吴娅丽，杨柳青，张辉，陈小菲，李寒冰，吴宿慧，唐进法

《中国药理学通报》

2023

基于病证毒理学的补骨脂毒—效转化与精准用药策略研究

张明亮

《成都中医药大学》

2023

补骨脂醇提物对免疫应激模型大鼠的特异质肝损伤及机制研究

陈小菲，王晓艳，李伟霞，张辉，张明亮，吴娅丽，张书琦，泥文娟，陈毓龙，李琨，冯科冉，唐进法

《中药药理与临床》

2023

Revealing active constituents within traditional Chinese Medicine used for treating bacterial pneumonia, with emphasis on the mechanism of baicalein against multi-drug resistant Klebsiella pneumoniae.

Xi Qin, Yuehua Wu, Ya Zhao, Shang-Shang Qin, Q. Ji, J. Jia, Meng-Qi Huo, Xiaoyu Zhao, Q. Ma, Xiaoyan Wang, Xiaofei Chen, Hui Zhang, Mingliang Zhang, Liuqing Yang, Weixia Li, Jinfa Tang

Journal of Ethnopharmacology

DOI

2022

补骨脂醇提物中8种成分在正常和脂多糖模型大鼠体内的组织分布比较研究

唐进法，牛璐，王晓艳，张辉，张明亮，吴娅丽，陈小菲，冯科冉，贾金浩，李伟霞

《中国中药杂志》

2021

基于代谢组学的补骨脂致特异质肝损伤机制研究

王晓艳，李伟霞，张辉，张明亮，吴娅丽，曹站霞，泥文娟，陈毓龙，李琨，冯科冉，唐进法

《中国药物警戒》

DOI

2021

恩替卡韦联合苦参素与单用恩替卡韦治疗CHB临床疗效及安全性的Meta分析

张明亮，马润然，刘方洲，李伟霞，王晓艳，张辉，陈盼盼，贾文汇，牛璐，王炎，唐进法

《重庆医学》

2020

异补骨脂素对L02细胞增殖、周期和凋亡的影响

王晓艳，李伟霞，张辉，张明亮，王炎，牛璐，贾文汇，泥文娟，唐进法

《毒理学杂志》

DOI

2018

苦参素对实验性自身免疫性脑脊髓炎大鼠CCL5、CCR5及CCR5mRNA表达的影响

刘楠，朱琳，张明亮，张慧君，张晓坚

《中国医院药学杂志》

2018

苦参素对实验性自身免疫性脑脊髓炎小鼠脊髓中P53、MDM2及IL-17表达的影响

刘淑情，吕莹，刘方洲，张慧君，张明亮，马雯迪，朱琳

《郑州大学学报(医学版)》

2017

苦参素对实验性自身免疫性脑脊髓炎大小鼠巨噬细胞免疫调节作用机制研究

张明亮

《郑州大学》

精选作品

期刊论文

基于β-catenin/c-Myc轴探究补骨脂抗多发性骨髓瘤作用机制

基于代谢组学的补骨脂盐炙“润燥减毒”机制研究——以肾阴虚为例

基于真实世界数据的肾康注射液的上市后安全性评价及不良反应影响因素分析

基于网络药理学及分子对接探究复方苦参注射液治疗多发性硬化症的作用机制

基于“异类相制”理论探讨淫羊藿和女贞子对补骨脂诱导肾阴虚大鼠肝损伤的影响及作用机制

黄芩素-美罗培南联用在健康及肺炎大鼠模型中的药动学相互作用研究

中药注射液联合抗生素对肺炎克雷伯菌的抑菌作用评价

基于指纹图谱、多成分含量测定及化学计量学的桃仁配方颗粒质量评价

基于UPLC指纹图谱和多成分含量测定结合化学计量学的甘草干姜汤配方颗粒质量评价

基于RBMECs-PC12细胞共培养体系的缺糖缺氧/复氧损伤模型探讨当归-川芎药对活性成分脑保护作用机制

Repurposing Camellia sinensis Roots and Ginkgo biloba Leaves for Multiple Myeloma via Wnt/β‐Catenin–Dependent Cell Cycle Arrest and Apoptosis

Panax ginseng-derived extracellular vesicles: A promising novel trend in functional nutrition and biomedical translational research

Shuxuening injection improves ventricular remodeling after myocardial infarction by indirectly promoting macrophage-mediated angiogenesis and lymphangiogenesis

SARS-CoV-2 Mpro inhibitors from Siphonostegia chinensis: an integrated biophysical and computational study

Carbon monoxide activatable near-infrared fluorescent probe to explore drug-induced liver injury and protective effect of TCMs components.

An innovative "Parameter-Component" correlation strategy for mechanistic elucidation of green extraction technologies for natural products: mechanochemical extraction of saponins as case study.

Tanreqing injection regulates Sema7a/Plxnc1 signaling pathway mediated neutrophil extracellular trap formation to alleviate lipopolysaccharide-induced acute lung injury.

Potential of traditional Chinese medicine-antibiotic combinations in combating multidrug-resistant organisms: Advances, mechanisms, and clinical implications.

中药干预多发性硬化不同分期的组方规律分析和作用机制研究

中医药干预HuR转录后调控的抗肿瘤作用研究进展

Shuxuening injection improves myocardial injury after myocardial infarction by regulating macrophage polarization via the TLR4/NF-κB and PI3K/Akt signaling pathways.

Unveiling TCM-antibiotic synergy through multi-omics: Shuganning injection potentiates the effect of linezolid against methicillin-resistant Staphylococcus aureus.

Red-emitting fluorescent probe sequentially activated by peroxynitrite and monoamine oxidase for diagnosis and therapeutic evaluation of drug-induced liver injury.

基于生化指标与代谢组学特征关联探索热毒宁注射液与青霉素注射液序贯用药的风险“时间窗”

基于代谢组学结合生物信息学探讨热毒宁注射液与青霉素注射液联用致类过敏反应的潜在致敏原及作用机制

基于七情配伍理论的补骨脂药对配伍规律研究进展

Exploring the Anti-inflammatory and Immunomodulatory Potential of Licochalcone B against Psoralidin-Induced Liver Injury.

Peroxynitrite-activated fluorescent probe with two reaction triggers for pathological diagnosis and therapeutic evaluation of inflammation.

补骨脂“大燥伤肝”的客观性及生物学机制研究

基于生物信息学的氧化苦参碱重定位及作用机制研究——以多发性硬化症为例

基于病证毒理学的补骨脂毒—效转化与精准用药策略研究

补骨脂醇提物对免疫应激模型大鼠的特异质肝损伤及机制研究

Revealing active constituents within traditional Chinese Medicine used for treating bacterial pneumonia, with emphasis on the mechanism of baicalein against multi-drug resistant Klebsiella pneumoniae.

补骨脂醇提物中8种成分在正常和脂多糖模型大鼠体内的组织分布比较研究

基于代谢组学的补骨脂致特异质肝损伤机制研究

恩替卡韦联合苦参素与单用恩替卡韦治疗CHB临床疗效及安全性的Meta分析

异补骨脂素对L02细胞增殖、周期和凋亡的影响

苦参素对实验性自身免疫性脑脊髓炎大鼠CCL5、CCR5及CCR5mRNA表达的影响

苦参素对实验性自身免疫性脑脊髓炎小鼠脊髓中P53、MDM2及IL-17表达的影响

苦参素对实验性自身免疫性脑脊髓炎大小鼠巨噬细胞免疫调节作用机制研究

研究方向