张隆华｜中国科学技术大学｜学者主页

期刊论文

2025

19 F NMR chemical shift encoded peptide screening targeting the potassium channel Kv1.3

Yong Zhang, Yongjie Zhu, Yi Zhang, Chaowei Shi, Longhua Zhang, Jun Liang, Changlin Tian, Pan Shi

Chemical Communications

2021

Structures of wild-type and H451N mutant human lymphocyte potassium channel KV1.3

Sanling Liu, Yue Zhao, Hao Dong, Liang Xiao, Yong Zhang, Yuqin Yang, Seow Theng Ong, K. George Chandy, Longhua Zhang, Changlin Tian

Cell Discovery

DOI

2020

Different conformational responses of the β2-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline

Fan Yang, Shenglong Ling, Yingxin Zhou, Yanan Zhang, Pei Lv, Sanling Liu, Wei Fang, Wenjing Sun, Liaoyuan A. Hu, Longhua Zhang, Pan Shi, Changlin Tian

National Science Review

DOI

2020

Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis

Siyu Li, Fan Yang, Demeng Sun, Yong Zhang, Mengge Zhang, Sanling Liu, Peng Zhou, Chaowei Shi, Longhua Zhang, Changlin Tian

Cell Research

DOI

2020

Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1

Demeng Sun, Sanling Liu, Siyu Li, Mengge Zhang, Fan Yang, Ming Wen, Pan Shi, Tao Wang, Man Pan, Shenghai Chang, Xing Zhang, Longhua Zhang, Changlin Tian, Lei Liu

eLife

DOI

2020

Author response: Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1

Demeng Sun, Sanling Liu, Siyu Li, Mengge Zhang, Fan Yang, Ming Wen, Pan Shi, Tao Wang, Man Pan, Shenghai Chang, Xing Zhang, Longhua Zhang, Changlin Tian, Lei Liu

DOI

2020

Ion channel modulation by scorpion hemolymph and its defensin ingredients highlights origin of neurotoxins in telson formed in Paleozoic scorpions

Lanxia Meng, Yonghui Zhao, Da‐Liang Qu, Zili Xie, Xingchen Guo, Zhanyong Zhu, Zongyun Chen, Longhua Zhang, Wenxin Li, Zhijian Cao, Changlin Tian, Yingliang Wu

International Journal of Biological Macromolecules

DOI

2018

Centipedes subdue giant prey by blocking KCNQ channels

Lei Luo, Bowen Li, Sheng Wang, Fangming Wu, Xiaochen Wang, Ping Liang, Rose Ombati, Junji Chen, Xiancui Lu, Jianmin Cui, Qiumin Lu, Longhua Zhang, Ming Zhou, Changlin Tian, Shilong Yang, Ren Lai

Proceedings of the National Academy of Sciences

DOI

2018

Cryo-EM structure of the ASIC1a–mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect

Demeng Sun, You Yu, Xiaobin Xue, Man Pan, Ming Wen, Siyu Li, Qian Qu, Xiaorun Li, Longhua Zhang, Xueming Li, Lei Liu, Maojun Yang, Changlin Tian

Cell Discovery

DOI

2018

Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors

Qing-Yan Guo, Longhua Zhang, Chao Zuo, Dong‐Liang Huang, Zhipeng A. Wang, Ji‐Shen Zheng, Changlin Tian

Protein & Cell

DOI

2017

离子通道受其辅助亚基及外源性毒素调控的作用机制

郭晓奇，文明，田长麟，张隆华

《中国科学:生命科学》

2016

Peptide toxins and small-molecule blockers of BK channels

Mu Yu, Sanling Liu, Peibei Sun, Hao Pan, Changlin Tian, Longhua Zhang

Acta Pharmacologica Sinica

DOI

2015

A distinct three-helix centipede toxin SSD609 inhibits Iks channels by interacting with the KCNE1 auxiliary subunit

Peibei Sun, Fangming Wu, Ming Wen, Xingwang Yang, Chenyang Wang, Yi‐Ming Li, Shufang He, Longhua Zhang, Yun Zhang, Changlin Tian

Scientific Reports

DOI

2015

Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells

Ming Wen, Xiaoqi Guo, Peibei Sun, Liang Xiao, Juan Li, Ying Xiong, Jin Bao, Tian Xue, Longhua Zhang, Changlin Tian

Chemical Communications

DOI

2015

K + preference at the NaK channel entrance revealed by fluorescence lifetime and anisotropy analysis of site-specifically incorporated (7-hydroxycoumarin-4-yl)ethylglycine

Sanling Liu, Pei Lv, Dong Li, Xiaoqi Guo, Bo Zhang, Mu Yu, Dandan Li, Ying Xiong, Longhua Zhang, Changlin Tian

Chemical Communications

DOI

2014

Differential Modulations of KCNQ1 by Auxiliary Proteins KCNE1 and KCNE2

Pan Li, Haowen Liu, Chaohua Lai, Peibei Sun, Wenping Zeng, Fangming Wu, Longhua Zhang, Sheng Wang, Changlin Tian, Jiuping Ding

Scientific Reports

DOI

2013

Intracellular segment between transmembrane helices S0 and S1 of BK channel α subunit contains two amphipathic helices connected by a flexible loop

Pan Shi, Dong Li, Chaohua Lai, Longhua Zhang, Changlin Tian

Biochemical and Biophysical Research Communications

DOI

2012

Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation

Meina Wang, Matthew N. Hill, Longhua Zhang, Boris B. Gorzalka, Cecilia J. Hillard, Bradley E. Alger

Journal Of Psychopharmacology，Vol. 260, No. 1

DOI

2006

海马甘氨酸受体功能研究

张隆华

《中国科学技术大学》

会议论文

2020

Preliminary Analysis of Fundamental Properties of Ion Channels using Molecular Biophysical Methods

Changlin Tian, Chaowei Shi, Yao He, Sanling Liu, Demeng Sun, Longhua Zhang, Hao Dong

《第十八次中国暨国际生物物理大会摘要集》

DOI

2018

NaK离子通道选择性配位构象及离子结合偏好性分析

何垚，史朝为，蔡萧颖，张隆华，田长麟

《中国化学会第五届全国生物物理化学会议（NCBPC5）摘要集》

DOI

2018

连续波与脉冲电子顺磁共振用于膜蛋白结构研究

凌盛龙，王维，于璐，张隆华，田长麟

《2018第二十届全国波谱学学术年会会议论文摘要集》

2015

A distinct three-helix centipede toxin SSD609 demonstrate different inhibition modes between cardiomyocyte I kr and I ks currents

Changlin Tian, Peibei Sun, Ming Wen, Xingwang Yang, Longhua Zhang, Yun Zhang

《第12届生物毒素研究及医药应用学术大会论文集》

2014

Binding Sites of the Toxin Peptide Mambalgin-1 on the Acid-Sensing Ion Channel 1a

Ming Wen, Man Pan, Qing Liu, Changlin Tian, Longhua Zhang

10th IST Asia Pacific Congress on Animal,Plant and Microbial Toxins

2014

Toxin Chemical Synthesis,Structure Determination using Solution NMR and Function Analysis

Yao He, Jisheng Zheng, Hongkui Cui, Fangming Wu, Longhua Zhang, Lei Liu, Changlin Tian

10th IST Asia Pacific Congress on Animal,Plant and Microbial Toxins

预印本

2019

Structure of Lymphocyte Potassium Channel K v1.3 and Modulation by Cell-Penetrating Immunomodulatory Plant Defensin

Seow Theng Ong, Sanling Liu, Saumya Bajaj, Yue Zhao, Mark R. Tanner, Shih Chieh Chang, Yong Zhang, Bankala Krishnarjuna, Xuan Rui Ng, Rodrigo A. V. Morales, Wei Chen Ming, Dahai Luo, Dharmeshkumar J. Patel, Sabina Yasmin, Jeremy Jun Heng Ng, Hai Minh Nguyen, Abbas El Sahili, Julien Lescar, Rahul Patil, Susan A. Charman, Edward George Robins, Julian Goggi, Wen Peng, Pragalath Sadasivam, Boominathan Ramasamy, Hartimath SV, Vikas Dhawan, Janna Bednenko, Paul A. Colussi, Heike Wulff, Longhua Zhang, Michael W. Pennington, Serdar Kuyucak B, Raymond S. Norton, Christine Beeton, Changlin Tian, George Chandy

SSRN Electronic Journal

DOI

张隆华

精选作品

期刊论文

19 F NMR chemical shift encoded peptide screening targeting the potassium channel Kv1.3

Structures of wild-type and H451N mutant human lymphocyte potassium channel KV1.3

Different conformational responses of the β2-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline

Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis

Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1

Author response: Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1

Ion channel modulation by scorpion hemolymph and its defensin ingredients highlights origin of neurotoxins in telson formed in Paleozoic scorpions

Centipedes subdue giant prey by blocking KCNQ channels

Cryo-EM structure of the ASIC1a–mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect

Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors

离子通道受其辅助亚基及外源性毒素调控的作用机制

Peptide toxins and small-molecule blockers of BK channels

A distinct three-helix centipede toxin SSD609 inhibits Iks channels by interacting with the KCNE1 auxiliary subunit

Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells

K + preference at the NaK channel entrance revealed by fluorescence lifetime and anisotropy analysis of site-specifically incorporated (7-hydroxycoumarin-4-yl)ethylglycine

Differential Modulations of KCNQ1 by Auxiliary Proteins KCNE1 and KCNE2

Intracellular segment between transmembrane helices S0 and S1 of BK channel α subunit contains two amphipathic helices connected by a flexible loop

Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation

海马甘氨酸受体功能研究

会议论文

Preliminary Analysis of Fundamental Properties of Ion Channels using Molecular Biophysical Methods

NaK离子通道选择性配位构象及离子结合偏好性分析

连续波与脉冲电子顺磁共振用于膜蛋白结构研究

A distinct three-helix centipede toxin SSD609 demonstrate different inhibition modes between cardiomyocyte I kr and I ks currents

Binding Sites of the Toxin Peptide Mambalgin-1 on the Acid-Sensing Ion Channel 1a

Toxin Chemical Synthesis,Structure Determination using Solution NMR and Function Analysis

预印本

Structure of Lymphocyte Potassium Channel K v1.3 and Modulation by Cell-Penetrating Immunomodulatory Plant Defensin

研究方向