百晓学者学者目录

滕乐生

副教授、博士生导师、教授、讲师,吉林大学

精选作品

期刊论文

2026

Cell-Penetrating Peptide Conjugated Polyzwitterion-Drug Enhances Tumor Retention

Jie Feng, Weixin Zhang, Ning Yang, Yuyang Chen, Shixin Xie, Huijia Lei, Yunfei Dai, Ye Bi, Lesheng Teng

Nano Letters

2026

Folic Acid-Functionalized Liposomes Co-Loaded with Doxorubicin and Indocyanine Green for Combined Chemophotothermal Therapy of Cervical Cancer

Huijia Lei, Yiying Cui, Jicong Chen, Yuanhao Yu, Jinsheng Yang, Jie Yang, Lesheng Teng

ACS Applied Materials & Interfaces

2025

A lymph node-targeted cell-nanoadjuvant conjugate enhances dendritic cell-T cell crosstalk for cancer immunotherapy

Shuangshuang Hu, Wen-zhe Yi, Zhiwen Zhao, Xin-di Qian, Linyang Jiang, Ying Cao, Dan Yan, Lesheng Teng, Yaping Li

Acta Pharmaceutica Sinica B

2025

Precise nanoscale fabrication technologies, the “last mile” of medicinal development

Ye Bi, Sen-Sen Xie, Ziwei Li, Shiyan Dong, Lesheng Teng

Acta Pharmaceutica Sinica B

2025

Correction: Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis

Xiang-Yu Li, Yufei Hou, Xiangxue Meng, Ge Li, Fei Xu, Lesheng Teng, Feng-Ying Sun, You-Xin Li

RSC Advances

2025

A Generative Artificial Intelligence Copilot for Biomedical Nanoengineering.

Yi-Fan Wang, Haitao Song, Yue Teng, Guang Huang, J. Qian, Hongyu Wang, Shiyan Dong, JongHoon Ha, Yi-Fan Ma, Mengyu Chang, Seongdong Jeong, W. Deng, Benjamin R. Schrank, Adam J. Grippin, Annette Wu, Jared L. Edwards, Yixiang Zhang, Yuanyuan Lin, Wilson Poon, Stefan Wilhelm, Ye Bi, Lesheng Teng, Zi-Kai Wang, Betty Y. S. Kim, Wen Jiang

ACS Nano

2024

The size-switchable microspheres co-loaded with RANK siRNA and salmon calcitonin for osteoporosis therapy

Xueyan Zhang, Jicong Chen, Songren Han, Shiyan Dong, Huan Zhang, Yuhong Man, Jie Yang, Ye Bi, Lesheng Teng

Chinese Chemical Letters

2024

Albumin Nanoparticle-Based Drug Delivery Systems

Na Qu, Ke Song, Yating Ji, Ming-Xia Liu, Li-Jiang Chen, Robert J. Lee, Lesheng Teng

International Journal of Nanomedicine

2024

Engineering Therapeutical Extracellular Vesicles for Clinical Translation

Yi-Fan Ma, Shiyan Dong, Adam J. Grippin, Lesheng Teng, Andrew S Lee, Betty Y. S. Kim, Wen Jiang

Trends in Biotechnology

2024

Carrier-Free Nanoparticles via Coassembly of Paclitaxel and Gambogic Acid with Folate-Functionalized Albumin for Targeted Tumor Treatment

Fan-Chao Meng, Shi-Wei Ren, Guiyuan Wang, Yun-Fei Dai, Beilin Xue, Shiyan Dong, Xiang Pang, Yating Sun, Min-Zhe Zhang, Jie Yang, Lesheng Teng

ACS Applied Nano Materials

2024

Transdermal Delivery of Recombinant Human Growth Hormone by Liposomal Gel for Skin Photoaging Therapy.

Jiayi Chen, Siyuan Hu, Jingjing Zhang, Jiaxin Li, Jian-Ming Xing, Zhaogang Yang, Lesheng Teng

ACS Applied Bio Materials

2023

Multifunctional nanoadjuvant-driven microenvironment modulation for enhanced photothermal immunotherapy in breast cancer.

Ge Li, Jingbo Zhang, Shixin Zhang, Lesheng Teng, Feng-Ying Sun

Journal of Controlled Release

2023

Multi-Enzyme Cascade-Triggered Nitric Oxide Release Nanoplatform Combined with Chemo Starvation-like Therapy for Multidrug-Resistant Cancers.

Ge Li, Xin-Yue Lu, Shixin Zhang, Jingbo Zhang, Xiaoge Fu, Miao Zhang, Lesheng Teng, Feng-Ying Sun

ACS Applied Materials and Interfaces

2023

Oral liposomes encapsulating ginsenoside compound K for rheumatoid arthritis therapy.

Ziwei Li, Songren Han, Guilin Cui, Beilin Xue, Jiaxin Li, Yu-Hong Man, Huan Zhang, Lesheng Teng

International journal of pharmaceutics

2023

Acid-switchable nanoparticles induce self-adaptive aggregation for enhancing antitumor immunity of natural killer cells

Xiangshi Sun, Xiaoxuan Xu, Jue Wang, Xinyue Zhang, Zitong Zhao, Xiaochen Liu, Guan-ru Wang, Lesheng Teng, Xia Chen, Dangge Wang, Yaping Li

Acta Pharmaceutica Sinica B

2023

Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy

Yi You, Yu Tian, Zhaogang Yang, Junfeng Shi, K. Kwak, Yuhao Tong, Andreanne Poppy Estania, Jianhong Cao, Wei-Hsiang Hsu, Yutong Liu, Chi-Ling Chiang, B. Schrank, Kristin M. Huntoon, DaeYong Lee, Ziwei Li, Yarong Zhao, Huan Zhang, Thomas D Gallup, Jonghoon Ha, Shiyan Dong, Xue-Feng Li, Yifan Wang, Wen-jing Lu, Eman Bahrani, L. Lee, Lesheng Teng, Wen Jiang, Feng Lan, Betty Y. S. Kim, Andrew S. Lee

Nature Biomedical Engineering

2023

Exosomes as smart drug delivery vehicles for cancer immunotherapy

Huan Zhang, Simiao Wang, Man Sun, Yaxin Cui, Jian-Min Xing, Lesheng Teng, Zhifang Xi, Zhaogang Yang

Frontiers in Immunology

2023

Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy

Jie Yang, D. Dai, Xi Zhang, Lesheng Teng, Lian-Jun Ma, Ying‐Wei Yang

Theranostics

2023

Microfluidics for nano-drug delivery systems: From fundamentals to industrialization

Huan Zhang, Jie Yang, Rongze Sun, Songren Han, Zhaogang Yang, Lesheng Teng

Acta Pharmaceutica Sinica B

2022

Oral delivery of superoxide dismutase by lipid polymer hybrid nanoparticles for the treatment of ulcerative colitis

Yaxin Cui, Tianyu Zhu, Xueyan Zhang, Ji-Cong Chen, Feng-Ying Sun, You-Xin Li, Lesheng Teng

Chinese Chemical Letters

2022

Small extracellular vesicles encapsulating lefty1 mRNA inhibit hepatic fibrosis

Yarong Zhao, Yang Yu, Si-Miao Wang, Jiaxin Li, Lesheng Teng

Asian Journal of Pharmaceutical Sciences

2022

Exosomes in cancer immunoediting and immunotherapy

Yarong Zhao, Luotong Liu, Rongze Sun, Guilin Cui, Shu-Yu Guo, Songren Han, Ziwei Li, Tian Bai, Lesheng Teng

Asian Journal of Pharmaceutical Sciences

2022

Smart drug delivery systems for precise cancer therapy

Xiaoyou Wang, Chong Li, Yiguang Wang, Huabing Chen, Xinxin Zhang, Cong Luo, Wenhao Zhou, Lili Li, Lesheng Teng, Haijun Yu, Jiancheng Wang

Acta Pharmaceutica Sinica B

2022

Pulmonary delivery of liposomes co-loaded with SN38 prodrug and curcumin for the treatment of lung cancer.

Chengzhi Gao, Lanfang Zhang, Min-Hao Xu, Yi Luo, Ben Wang, Meiyan Kuang, Xing-You Liu, Mengqing Sun, Yue Guo, Lesheng Teng, Chen-Hui Wang, Yan Zhang, Jing Xie

European journal of pharmaceutics and biopharmaceutics

2022

A Multifunctional Nano-Delivery System Against Rheumatoid Arthritis by Combined Phototherapy, Hypoxia-Activated Chemotherapy, and RNA Interference

Xiang-Yu Li, Shixin Zhang, Miaomiao Zhang, Ge Li, Bo Yang, Xinyue Lu, Lesheng Teng, You-Xin Li, Feng-Ying Sun

International Journal of Nanomedicine

2022

Correction: Wang et al. Cell-Penetrating Peptide and Transferrin Co-Modified Liposomes for Targeted Therapy of Glioma. Molecules 2019, 24, 3540

Xi Wang, Yarong Zhao, Shiyan Dong, Robert J. Lee, Dongsheng Yang, Huan Zhang, Lesheng Teng

Molecules

2022

A nanotherapy responsive to the inflammatory microenvironment for the dual-targeted treatment of atherosclerosis.

Ge Li, Fei Xu, Bo Yang, Xin-Yue Lu, Xiang-Yu Li, Yan-Fei Qi, Lesheng Teng, You-Xin Li, Feng-Ying Sun, Wenhua Liu

Nanomedicine: Nanotechnology, Biology and Medicine

2022

Editorial: From Chronic Inflammation to Cancer: How Far Can Immunotherapy Go?

Xue-Feng Li, Lesheng Teng, Zhaogang Yang

Frontiers in Pharmacology

2021

外泌体介导的药物递送系统在肿瘤免疫治疗中的应用

孙榕泽,李佳欣,余杨,王思邈,滕乐生

《药学进展》

2021

Nanoparticles as Drug Delivery Systems of RNAi in Cancer Therapy

Diedie Li, Chengzhi Gao, Meiyan Kuang, Min-Hao Xu, Ben Wang, Yi-Heng Luo, Lesheng Teng, Jing Xie

Molecules

2021

PLGA/PCADK Composite Microspheres Containing Hyaluronic Acid-Chitosan siRNA Nanoparticles: A Rational Design for Rheumatoid Arthritis Therapy.

M. Zhao, Tianyu Zhu, Ji-Cong Chen, Yaxin Cui, Xueyan Zhang, Robert J. Lee, Feng-Ying Sun, You-Xin Li, Lesheng Teng

International journal of pharmaceutics

2021

Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis

Xiang-Yu Li, Yufei Hou, Xiangxue Meng, Ge Li, Fei Xu, Lesheng Teng, Feng-Ying Sun, You-Xin Li

RSC Advances

2021

Advances in Multiple Stimuli-Responsive Drug-Delivery Systems for Cancer Therapy

Ruixin Jia, Lesheng Teng, Lingyu Gao, Ting Su, Lu Fu, Zhidong Qiu, Ye Bi

International Journal of Nanomedicine

2021

Folate receptor-targeting semiconducting polymer dots hybrid mesoporous silica nanoparticles against rheumatoid arthritis through synergistic photothermal therapy, photodynamic therapy, and chemotherapy.

Xiang-Yu Li, Shixin Zhang, Xueyan Zhang, Yufei Hou, Xiangxue Meng, Ge Li, Fei Xu, Lesheng Teng, Yan-Fei Qi, Feng-Ying Sun, You-Xin Li

International journal of pharmaceutics

2021

Self-Assembled pH-Sensitive Polymeric Nanoparticles for the Inflammation-Targeted Delivery of Cu/Zn-Superoxide Dismutase.

Xiangshi Sun, Kongtong Yu, Yulin Zhou, Shiyan Dong, Wen-Ji Hu, Yating Sun, Yu-Huan Li, Jing Xie, Robert J. Lee, Feng-Ying Sun, Yifan Ma, Shengnian Wang, Betty Y. S. Kim, Yifan Wang, Zhaogang Yang, Wen Jiang, You-Xin Li, Lesheng Teng

ACS Applied Materials and Interfaces

2021

Polyketal Nanoparticles Co-loaded with miR-124 and Ketoprofen for Treatment of Rheumatoid Arthritis.

M. Zhao, Jiaqi Yao, Xiangxue Meng, Yaxin Cui, Tianyu Zhu, Feng-Ying Sun, You-Xin Li, Lesheng Teng

Journal of Pharmacy and Science

2021

Transferrin-conjugated Liposomes Loaded with Carnosic Acid Inhibit Liver Cancer Growth by Inducing Mitochondria-mediated Apoptosis.

Xin Liu, Shiyan Dong, Ming-Yuan Dong, Yuan Li, Zhen Sun, Xinrui Zhang, Yingwu Wang, Lesheng Teng, Di Wang

International journal of pharmaceutics

2021

Author Correction: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

Zhaogang Yang, Junfeng Shi, Jing Xie, Yifan Wang, Jing-Yao Sun, Tongzheng Liu, Yarong Zhao, Xiuting Zhao, Xin-Mei Wang, Yifan Ma, V. Malkoc, Chi-Ling Chiang, W. Deng, Yuanxin Chen, Yuan Fu, K. Kwak, Yamin Fan, Chen Kang, Chang-Cheng Yin, J. Rhee, P. Bertani, J. Otero, Wu Lu, Kyuson Yun, Andrew S. Lee, Wen Jiang, Lesheng Teng, Betty Y. S. Kim, L. Lee

Nature Biomedical Engineering

2021

High-density lipoprotein modulates tumor-associated macrophage for chemoimmunotherapy of hepatocellular carcinoma

Jun-Yang Wang, Chao Zheng, Yihui Zhai, Ying Cai, Robert J. Lee, Jian-Min Xing, Hao Wang, H. Zhu, Lesheng Teng, Ya-Ping Li, Pengcheng Zhang

2020

Dual Hypoxia-Targeting RNAi Nanomedicine for Precision Cancer Therapy

Yu-Jing Li, Jianxun Ding, Xiao-Ding Xu, Run Shi, P. Saw, Jun-Qing Wang, Shirley Chung, Wenliang Li, B. Aljaeid, Robert J. Lee, Wei Tao, Lesheng Teng, O. Farokhzad, Jin-Jun Shi

Nano letters (Print)

2020

Nanotechnology and Microtechnology in Drug Delivery Systems

Jing-Yao Sun, Zhaogang Yang, Lesheng Teng

Dose-Response

2020

Study of Double-Targeting Nanoparticles Loaded With MCL-1 siRNA and Dexamethasone for Adjuvant-induced Arthritis Therapy.

Xiang-Yu Li, Chang-Hui Yu, Xiangxue Meng, Yufei Hou, Yaxin Cui, Tianyu Zhu, Yi-Hao Li, Lesheng Teng, Feng-Ying Sun, You-Xin Li

European journal of pharmaceutics and biopharmaceutics

2020

Microfluidic self-assembly of high cabazitaxel loading albumin nanoparticles.

Yating Sun, Robert J. Lee, Fanchao Meng, Guiyuan Wang, Xiaolong Zheng, Shiyan Dong, Lesheng Teng

Nanoscale

2020

Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application

Jing Xie, Ye Bi, Huan Zhang, Shiyan Dong, Lesheng Teng, Robert J. Lee, Zhaogang Yang

Frontiers in Pharmacology

2020

Calcitriol‐Loaded Dual‐pH‐Sensitive Micelle Counteracts Pro‐Metastasis Effect of Paclitaxel in Triple‐Negative Breast Cancer Therapy

Zhong Zheng, Tianqun Lang, Xin Huang, Guan-ru Wang, Robert J. Lee, Lesheng Teng, Qi Yin, Ya-Ping Li

Advanced Healthcare Materials

2020

Cyclic RGD Peptide Targeting Coated Nano Drug Co-Delivery System for Therapeutic Use in Age-Related Macular Degeneration Disease

Jia-Xin Liu, Lifu Luo, Fei Xu, Ge Li, Ji-Cong Chen, Lesheng Teng, You-Xin Li, Feng-Ying Sun

Molecules

2020

A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine

Ye Bi, Bingcong Lv, Lianlian Li, Robert J. Lee, Jing Xie, Zhidong Qiu, Lesheng Teng

Molecules

2019

寡核苷酸微球制剂研究进展

张雪妍,崔雅欣,祝天宇,孙凤英,滕乐生

《中国医药工业杂志》

2019

Docetaxel-loaded human serum albumin (HSA) nanoparticles: synthesis, characterization, and evaluation

Na Qu, Yating Sun, Yu-Jing Li, Fei Hao, Peng-Yu Qiu, Lesheng Teng, Jing Xie, Yin Gao

BioMedical Engineering OnLine

2019

Delivery of siRNA using folate receptor-targeted pH-sensitive polymeric nanoparticles for rheumatoid arthritis therapy.

Xiangshi Sun, Shiyan Dong, Xiang-Yu Li, Kongtong Yu, Feng-Ying Sun, Robert J. Lee, You-Xin Li, Lesheng Teng

Nanomedicine: Nanotechnology, Biology and Medicine

2019

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

Zhaogang Yang, Junfeng Shi, Jing Xie, Yifan Wang, Jing-Yao Sun, Tongzheng Liu, Yarong Zhao, Xiuting Zhao, Xin-Mei Wang, Yifan Ma, V. Malkoc, Chi-Ling Chiang, W. Deng, Yuanxin Chen, Yuan Fu, K. Kwak, Yamin Fan, Chen Kang, C. Yin, J. Rhee, P. Bertani, J. Otero, Wu Lu, Kyuson Yun, Andrew S. Lee, Wen Jiang, Lesheng Teng, Betty Y. S. Kim, L. Lee

Nature Biomedical Engineering

2019

Cell-Penetrating Peptide and Transferrin Co-Modified Liposomes for Targeted Therapy of Glioma

Xi Wang, Yarong Zhao, Shiyan Dong, Robert J. Lee, Dongsheng Yang, Huan Zhang, Lesheng Teng

Molecules

2019

Anti-Angiogenic Activity Of Bevacizumab-Bearing Dexamethasone-Loaded PLGA Nanoparticles For Potential Intravitreal Applications

Jia-Xin Liu, Xueyan Zhang, Ge Li, Fei Xu, Shuang Li, Lesheng Teng, You-Xin Li, Feng-Ying Sun

International Journal of Nanomedicine

2019

Near-infrared light-responsive, pramipexole-loaded biodegradable PLGA microspheres for therapeutic use in Parkinson's disease.

Shuang Li, Jia-Xin Liu, Ge Li, Xueyan Zhang, Fei Xu, Zhijian Fu, Lesheng Teng, You-Xin Li, Feng-Ying Sun

European journal of pharmaceutics and biopharmaceutics

2019

Polyethylenimine-based formulations for delivery of oligonucleotides.

Fei Hao, Yu-Huan Li, Jing Zhu, Jing-Yao Sun, B. Marshall, Robert J. Lee, Lesheng Teng, Zhaogang Yang, Jing Xie

Current Medicinal Chemistry

2019

Trastuzumab-Coated Nanoparticles Loaded With Docetaxel for Breast Cancer Therapy

Xueyan Zhang, Jia-Xin Liu, Xiang-Yu Li, Fang Li, Robert J. Lee, Feng-Ying Sun, You-Xin Li, Zong-Yu Liu, Lesheng Teng

Dose-Response

2019

Liposomal Vitamin D3 as an Anti-aging Agent for the Skin

Ye Bi, Hong-Xi Xia, Lianlian Li, Robert J. Lee, Jing Xie, Zong-Yu Liu, Zhidong Qiu, Lesheng Teng

Pharmaceutics

2019

Targeted and Efficient Delivery of siRNA Using Tunable Polymeric Hybrid Micelles for Tumor Therapy

Fei Hao, Shiyan Dong, Chunmiao Yang, Ziwei Li, Zi-Yuan Cheng, Lihuang Zhong, Li-Rong Teng, Q. Meng, Jia-Hui Lu, Fan Wu, Jing Xie, Lesheng Teng, Robert J. Lee

Anticancer Research

2019

Hepatocellular Carcinoma Growth Retardation and PD-1 Blockade Therapy Potentiation with Synthetic High-density Lipoprotein.

Jun-Yang Wang, Jia Meng, Wei Ran, Robert J. Lee, Lesheng Teng, Pengcheng Zhang, Ya-Ping Li

Nano letters (Print)

2019

Highly bioactive, bevacizumab‐loaded, sustained‐release PLGA/PCADK microspheres for intravitreal therapy in ocular diseases

Jia-Xin Liu, Shuang Li, Ge Li, Xiang Li, Chang-Hui Yu, Zhi-Jian Fu, Xiang-Yu Li, Lesheng Teng, You-Xin Li, Feng-Ying Sun

International journal of pharmaceutics

2019

Thiophene Derivatives as New Anticancer Agents and Their Therapeutic Delivery Using Folate Receptor-Targeting Nanocarriers

M. Zhao, Yaxin Cui, Lang Zhao, Tianyu Zhu, Robert J. Lee, Weiwei Liao, Feng-Ying Sun, You-Xin Li, Lesheng Teng

ACS Omega

2019

Folate Receptor-Targeted Albumin Nanoparticles Based on Microfluidic Technology to Deliver Cabazitaxel

Fanchao Meng, Yating Sun, Robert J. Lee, Guiyuan Wang, Xiaolong Zheng, Huan Zhang, Yige Fu, Guo-Jun Yan, Yifan Wang, W. Deng, Emily Parks, Betty Y. S. Kim, Zhaogang Yang, Wen Jiang, Lesheng Teng

Cancers

2019

Multifunctional drug carrier based on PEI derivatives loaded with small interfering RNA for therapy of liver cancer.

Yarong Zhao, Robert J. Lee, Lu Liu, Shiyan Dong, Jing Zhang, Yu Zhang, Yicheng Yao, Jia-Hui Lu, Q. Meng, Jing Xie, Lesheng Teng

International journal of pharmaceutics

2018

Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy

Ye Bi, Robert J. Lee, Xinyu Wang, Yating Sun, Mengqiao Wang, Lianlian Li, Chenliang Li, Jing Xie, Lesheng Teng

International Journal of Nanomedicine

2018

Dual‐functional lipid polymeric hybrid pH‐responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis

Jin-Long Zhao, Xueyan Zhang, Xiangshi Sun, M. Zhao, Chang-Hui Yu, Robert J. Lee, Feng-Ying Sun, Yulin Zhou, You-Xin Li, Lesheng Teng

European journal of pharmaceutics and biopharmaceutics

2018

Delivery of paclitaxel using nanoparticles composed of poly(ethylene oxide)-b-poly(butylene oxide) (PEO-PBO).

Lijiang Wang, Ju Yao, Xiao-Min Zhang, Yingxin Zhang, Changyong Xu, Robert J. Lee, Gary Yu, Bo Yu, Lesheng Teng

Colloids and Surfaces B: Biointerfaces

2018

Self-assembled albumin nanoparticles as nanocarriers for delivery docetaxel

Yating Sun, Robert J. Lee, Na Qu, Jia-Hui Lu, Jing Xie, Lesheng Teng

Nanomedicine: Nanotechnology, Biology and Medicine

2018

Cell-penetrating Peptide-coated Liposomes for Drug Delivery Across the Blood–Brain Barrier

Bo Yuan, Yarong Zhao, Shiyan Dong, Yating Sun, Fei Hao, Jing Xie, Lesheng Teng, Robert J. Lee, Yao-Wen Fu, Ye Bi

Anticancer Research

2018

Butyl stearate prolongs the drug release period of isoperidone-loaded poly (lactic-co-glycolic acid) microspheres: In vitro and in vivo investigation

Feng-Ying Sun, Chang-Hui Yu, Xi-Ming Liu, Dan Wang, Na Liu, Jia-Xin Liu, Lesheng Teng, You-Xin Li

Molecular Medicine Reports

2018

siRNA delivery using lipid nanoparticle modified with cell penetrating peptide

Bi Ye, Robert J. Lee, Q. Meng, Di Wang, Lesheng Teng

Nanomedicine: Nanotechnology, Biology and Medicine

2018

Folic acid receptor-targeted human serum albumin nanoparticle formulation of cabazitaxel for tumor therapy

Yating Sun, Yarong Zhao, Shanshan Teng, Fei Hao, Huan Zhang, Fanchao Meng, Xiuting Zhao, Xiaolong Zheng, Ye Bi, Yicheng Yao, Robert J. Lee, Lesheng Teng

International Journal of Nanomedicine

2018

Ketoprofen and MicroRNA‐124 Co‐loaded poly (lactic‐co‐glycolic acid) microspheres inhibit progression of Adjuvant‐induced arthritis in rats

Chang-Hui Yu, Xueyan Zhang, Xiangshi Sun, Chaoxing Long, Feng-Ying Sun, Jia-Xin Liu, Xiang-Yu Li, Robert J. Lee, Na Liu, You-Xin Li, Lesheng Teng

International journal of pharmaceutics

2017

Effect of Binary Organic Solvents Together with Emulsifier on Particle Size and In vitro Behavior of Paclitaxel-Encapsulated Polymeric Lipid Nanoparticles.

Shuzhi Qin, Xiangshi Sun, Feng Li, Kongtong Yu, Yulin Zhou, Na Liu, Cheng-Guo Zhao, Lesheng Teng, You-Xin Li

Current Drug Delivery

2017

Enhancing the Therapeutic Delivery of Oligonucleotides by Chemical Modification and Nanoparticle Encapsulation

Yating Sun, Yarong Zhao, Xiuting Zhao, Robert J. Lee, Lesheng Teng, Chenguang Zhou

Molecules

2017

Microfluidic hydrodynamic focusing synthesis of polymer-lipid nanoparticles for siRNA delivery

Xueqin Huang, Robert J. Lee, Yuhang Qi, Yu-Jing Li, Jia-Hui Lu, Q. Meng, Lesheng Teng, Jing Xie

OncoTarget

2017

Single-step microfluidic synthesis of transferrin-conjugated lipid nanoparticles for siRNA delivery.

Yu-Jing Li, Robert J. Lee, Xueqin Huang, Yu-Huan Li, Bingcong Lv, T. Wang, Yuhang Qi, Fei Hao, Jia-Hui Lu, Q. Meng, Li-Rong Teng, Yulin Zhou, Jing Xie, Lesheng Teng

Nanomedicine: Nanotechnology, Biology and Medicine

2017

Targeted Delivery of Cordycepin to Liver Cancer Cells Using Transferrin-conjugated Liposomes.

Ye Bi, Yulin Zhou, Mengqiao Wang, Lianlian Li, Robert J. Lee, Jing Xie, Lesheng Teng

Anticancer Research

2017

A novel strategy for controlled synthesis of transferrin-conjugated lipid nanoparticles by a microfluidic device

Yu-Jing Li, Robert J. Lee, Yu-Huan Li, Yating Sun, Xueqin Huang, Jing Xie, Lesheng Teng

2017

Effects of microspheres loaded with ketoprofen and microRNA-124 on adjuvant- induced arthritis in rats

Chang-Hui Yu, Jin-Long Zhao, Jia-Xin Liu, Kongtong Yu, Zunkai Zhang, Lesheng Teng, Feng-Ying Sun, You-Xin Li

2017

Transferrin-conjugated liposomes loaded with novel dihydroquinoline derivatives as potential anticancer agents

Mengqiao Wang, Robert J. Lee, Ye Bi, Lianlian Li, Guo-Dong Yan, Jia-Hui Lu, Q. Meng, Lesheng Teng, Jing Xie

PLoS ONE

2017

Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis

Jin-Long Zhao, M. Zhao, Chang-Hui Yu, Xueyan Zhang, Jia-Xin Liu, Xin-Wei Cheng, Robert J. Lee, Feng-Ying Sun, Lesheng Teng, You-Xin Li

International Journal of Nanomedicine

2017

Anticancer effects of cabazitaxel-loaded human serum albumin (HSA) nanoparticles

Na Qu, Robert J. Lee, Jing Xie, Di Wang, Lesheng Teng

2017

Preparation and Evaluation of in vitro Self-assembling HSA Nanoparticles for Cabazitaxel.

Na Qu, Yating Sun, Jing Xie, Lesheng Teng

Anti-Cancer Agents in Medicinal Chemistry

2016

Comparison of three different conjugation strategies in the construction of herceptin-bearing paclitaxel-loaded nanoparticles.

Kongtong Yu, Yulin Zhou, Yu-Huan Li, Xiangshi Sun, Feng-Ying Sun, Xin-Mei Wang, Hong-Yan Mu, Jie Li, Xiao-Yue Liu, Lesheng Teng, You-Xin Li

Biomaterials Science

2016

Lipid Nanoparticles Composed of Quaternary Amine-Tertiary Amine Cationic Lipid Combination (QTsome) for Therapeutic Delivery of AntimiR-21 for Lung Cancer.

Bryant C. Yung, Ji-Long Li, Meng-Zi Zhang, Xin-Wei Cheng, Hong Li, Elaine Yung, Chen Kang, Lauren E Cosby, Yang Liu, Lesheng Teng, Robert J. Lee

Molecular Pharmaceutics

2016

Enhanced survivin siRNA delivery using cationic liposomes containing linoleic acid-modified polyethylenimine

Shuang Yang, Xue-Wei Yang, Jing Xie, Robert J. Lee, Lesheng Teng

2016

Actively Targeted Nanoparticles for Drug Delivery to Tumor.

Ye Bi, Fei Hao, Guo-Dong Yan, Lesheng Teng, Robert J. Lee, Jing Xie

Current drug metabolism

2016

Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation.

Zhaogang Yang, Jing Xie, Jing Zhu, Chen Kang, Chi-Ling Chiang, Xin-Mei Wang, Xiao-Bing Wang, Tai-Rong Kuang, Feng Chen, Zhou Chen, Ai-Li Zhang, Bo Yu, Robert J. Lee, Lesheng Teng, L. Lee

Journal of Controlled Release

2016

Delivery of siRNA Using Lipid Nanoparticles Modified with Cell Penetrating Peptide.

Yu-Huan Li, Robert J. Lee, Kongtong Yu, Ye Bi, Yuhang Qi, Yating Sun, Yu-Jing Li, Jing Xie, Lesheng Teng

ACS Applied Materials and Interfaces

2016

Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer

Na Qu, Robert J. Lee, Yating Sun, G. Cai, Jun-Yang Wang, Mengqiao Wang, Jia-Hui Lu, Q. Meng, Li-Rong Teng, Di Wang, Lesheng Teng

International Journal of Nanomedicine

2016

Oleic acid derivative of polyethylenimine-functionalized proliposomes for enhancing oral bioavailability of extract of Ginkgo biloba

Bin Zheng, Shuang Yang, Chunyu Fan, Ye Bi, Lin Du, Lingzhi Zhao, Robert J. Lee, Lesheng Teng, Li-Rong Teng, Jing Xie

Drug Delivery

2016

47 Gambogic acid delivery using lipid nanoparticles modified with cell-penetrating peptide

Ming-Zhi Zhao, Jingying Li, Luo Xiao, Jieming Zeng, Dan-Chun Zhang, Robert J. Lee, Lesheng Teng

Poster Session

2016

癌治療における植物化学物質のデリバリーのためのナノテクノロジー【Powered by NICT】

Jing Xie, Zhaogang Yang, Chenguang Zhou, Jing Zhu, J. Robert, Lesheng Teng

2016

Triple-Layered pH-Responsive Micelleplexes Loaded with siRNA and Cisplatin Prodrug for NF-Kappa B Targeted Treatment of Metastatic Breast Cancer

Haijun Yu, Chengyue Guo, Bing Feng, Jianping Liu, Xianzhi Chen, Dangge Wang, Lesheng Teng, You-Xin Li, Qi Yin, Zhiwen Zhang, Yaping Li

Theranostics

2016

Human Serum Albumin Nanoparticles as a Novel Delivery System for Cabazitaxel.

Guoming Zhou, Xiangyu Jin, Ping Zhu, Ju Yao, Yingxin Zhang, Lesheng Teng, Robert J. Lee, Xiao-Min Zhang, W. Hong

Anticancer Research

2016

Folate receptor targeted drug delivery- from the bench to the bedside

Jing Xie, Zhou Chen, Ai-Li Zhang, Bin Zheng, Shuang Yang, Lesheng Teng

2016

Synthesis of Polymer-Lipid Nanoparticles by Microfluidic Focusing for siRNA Delivery

Yu-Jing Li, Xueqin Huang, Robert J. Lee, Yuhang Qi, Kai-Kai Wang, Fei Hao, Yu Zhang, Jia-Hui Lu, Q. Meng, Shuai Li, Jing Xie, Lesheng Teng

Molecules

2016

Role of Four Different Kinds of Polyethylenimines (PEIs) in Preparation of Polymeric Lipid Nanoparticles and Their Anticancer Activity Study

Kongtong Yu, Jin-Long Zhao, Chang-Hui Yu, Feng-Ying Sun, Yan Liu, Yang Zhang, Robert J. Lee, Lesheng Teng, You-Xin Li

Journal of Cancer

2016

Nanotechnology for the delivery of phytochemicals in cancer therapy.

Jing Xie, Zhaogang Yang, Chenguang Zhou, Jing Zhu, Robert J. Lee, Lesheng Teng

Biotechnology Advances

2016

Synthesis, characterization, and evaluation of mPEG–SN38 and mPEG–PLA–SN38 micelles for cancer therapy

Jing Xie, Xiao-Min Zhang, Mei-Yu Teng, Bo Yu, Shuang Yang, Robert J. Lee, Lesheng Teng

International Journal of Nanomedicine

2016

48 Transferrin-modified self-assembled HSA (human serum albumin) nanoparticles enhance drug delivery to tumors

Yao Zhang, Ming-Shi Liu, Yi-Hong Hu, J. Wang, Qidan Chen, Robert J. Lee, Lesheng Teng

Poster Session

2016

Enhanced delivery of Paclitaxel using electrostatically-conjugated Herceptin-bearing PEI/PLGA nanoparticles against HER-positive breast cancer cells.

Kongtong Yu, Jin-Long Zhao, Zunkai Zhang, Yin Gao, Yulin Zhou, Lesheng Teng, You-Xin Li

International journal of pharmaceutics

2016

癌へのsiRNAのデリバリーに対する機能的エクソソーム類似物:in vitroとin vivoでの評価

Zhaogang Yang, Jing Xie, Jing Zhu, Chen Kang, Chi-Ling Chiang, Xin-Mei Wang, Xiao-Bing Wang, Tai-Rong Kuang, Feng Chen, Zhou Chen, Ai-Li Zhang, Bo Yu, J. Robert, Lesheng Teng, L. L. James

2015

用统计学方法优化硝苯地平脂质体处方

杨雪薇,杨爽,董冰雪,郭鲁强,刘晖,滕乐生

《吉林大学学报(理学版)》

2015

Non-covalent complexes of folic acid and oleic acid conjugated polyethylenimine: An efficient vehicle for antisense oligonucleotide delivery

Shuang Yang, Xue-Wei Yang, Yan Liu, Bin Zheng, Lingjun Meng, Robert J. Lee, Jing Xie, Lesheng Teng

Colloids and Surfaces B: Biointerfaces

2015

A Novel Isoquinoline Derivative Anticancer Agent and Its Targeted Delivery to Tumor Cells Using Transferrin-Conjugated Liposomes

Xue-Wei Yang, Shuang Yang, Hong-Yu Chai, Zhaogang Yang, Robert J. Lee, Weiwei Liao, Lesheng Teng

PLoS ONE

2015

Proliposomes containing a bile salt for oral delivery of Ginkgo biloba extract: Formulation optimization, characterization, oral bioavailability and tissue distribution in rats.

Bin Zheng, Li-Rong Teng, Gaoyang Xing, Ye Bi, Shuang Yang, Fei Hao, Guo-Dong Yan, Xin-Mei Wang, Robert J. Lee, Lesheng Teng, Jing Xie

European Journal of Pharmaceutical Sciences

2015

A novel reduction-sensitive modified polyethylenimine oligonucleotide vector.

Shuang Yang, Robert J. Lee, Xue-Wei Yang, Bin Zheng, Jing Xie, Lingjun Meng, Yan Liu, Lesheng Teng

International journal of pharmaceutics

2015

Non-covalent Nanocomplexes of Folic Acid and Reducible Polyethylenimine for Survivin siRNA Delivery.

Bin Zheng, Shuang Yang, Mengqiao Wang, Xue-Wei Yang, Li-Rong Teng, Jing Xie, Lesheng Teng, Robert J. Lee

Anticancer Research

2015

Preparation and in vivo evaluation of PCADK/PLGA microspheres for improving stability and efficacy of rhGH.

Chen-Hui Wang, Chang-Hui Yu, Jia-Xin Liu, Lesheng Teng, Feng-Ying Sun, You-Xin Li

International journal of pharmaceutics

2015

Preparation of a mixed-matrix hydrogel of vorinostat for topical administration on the rats as experimental model.

Wen-Wen Dai, Chen-Hui Wang, Chang-Hui Yu, Ju Yao, Feng-Ying Sun, Lesheng Teng, You-Xin Li

European Journal of Pharmaceutical Sciences

2015

Stabilization of Human Immunoglobulin G Encapsulated within Biodegradable Poly (Cyclohexane-1, 4-diyl Acetone Dimethylene Ketal) (PCADK)/ Poly (Lactic-co-Glycolic Acid) (PLGA) Blend Microspheres.

Chen-Hui Wang, Chang-Hui Yu, Jia-Xin Liu, Feng-Ying Sun, Lesheng Teng, You-Xin Li

Protein Peptide Letters

2015

Improving Protein Stability and Controlling Protein Release by Adding Poly (Cyclohexane-1, 4-Diyl Acetone Dimethylene Ketal) to PLGA Microspheres.

Chen-Hui Wang, Chang-Hui Yu, Kongtong Yu, Lesheng Teng, Jia-Xin Liu, Xuesong Wang, Feng-Ying Sun, You-Xin Li

Current Drug Delivery

2015

Enhanced survivin siRNA delivery using cationic liposome incorporating fatty acid-modified polyethylenimine

Shuang Yang, Zhihua Guo, Xue-Wei Yang, Jing Xie, Robert J. Lee, D. Jiang, Lesheng Teng

Chemical Research in Chinese Universities

2015

Efficient antisense oligonucleotide delivery via non-covalent complexes of folic acid and modified polyethylenimine.

Shuang Yang, Xue-Wei Yang, Jing Xie, Robert J. Lee, Lesheng Teng

Journal of Controlled Release

2015

Fatty acid modified octa-arginine for delivery of siRNA.

Yu-Huan Li, Yu-Jing Li, Xin-Mei Wang, Robert J. Lee, Lesheng Teng

International journal of pharmaceutics

2014

Oligonucleotide delivery system.

Lesheng Teng

Current Pharmaceutical Biotechnology

2014

Parenteral thermo-sensitive organogel for schizophrenia therapy, in vitro and in vivo evaluation.

Dan Wang, Jin-Long Zhao, Xi-Ming Liu, Feng-Ying Sun, Yulin Zhou, Lesheng Teng, You-Xin Li

European Journal of Pharmaceutical Sciences

2014

Insight into Mechanisms of Cellular Uptake of Lipid Nanoparticles and Intracellular Release of Small RNAs

Bo Yu, Xin-Mei Wang, Chenguang Zhou, Lesheng Teng, Wei Ren, Zhaogang Yang, Chih-Hsin Shih, Tianyou Wang, Robert J. Lee, Suoqin Tang, L. Lee

Pharmaceutical Research

2014

Nanomedicine based on nucleic acids: pharmacokinetic and pharmacodynamic perspectives.

Chenguang Zhou, Zhaogang Yang, Lesheng Teng

Current Pharmaceutical Biotechnology

2014

Enhanced antitumor efficacy of vitamin E TPGS-emulsified PLGA nanoparticles for delivery of paclitaxel.

Yanbin Sun, Bo Yu, Guoying Wang, Yongsheng Wu, Xiao-Min Zhang, Yanmin Chen, Suoqin Tang, Yuan Yuan, Robert J. Lee, Lesheng Teng, Shun Xu

Colloids and Surfaces B: Biointerfaces

2014

A microfluidic method for synthesis of transferrin-lipid nanoparticles loaded with siRNA LOR-1284 for therapy of acute myeloid leukemia

Zhaogang Yang, Bo Yu, Jing Zhu, Xiaomeng Huang, Jing Xie, Songlin Xu, Xiaojuan Yang, Xin-Mei Wang, Bryant C. Yung, L. Lee, Robert J. Lee, Lesheng Teng

Nanoscale

2013

Novel PLGA microspheres for sustained delivery of antisense oligonucleotide

Jing Xie, Xin Li, Chao Jiang, Robert J Lee, Yulin Zhou, Lesheng Teng

Chemical Research in Chinese Universities

2013

Nonionic surfactant vesicles for delivery of RNAi therapeutics

Orapan Paecharoenchai, Lesheng Teng, Bryant C. Yung, Li-Rong Teng, P. Opanasopit, Robert J. Lee

Nanomedicine

2013

A Polyethylenimine-Linoleic Acid Conjugate for Antisense Oligonucleotide Delivery

Jing Xie, Lesheng Teng, Zhaogang Yang, Chenguang Zhou, Yang Liu, Bryant C. Yung, Robert J. Lee

BioMed Research International

2012

Human serum albumin-coated lipid nanoparticles for delivery of siRNA to breast cancer

L. Piao, Hong Li, Lesheng Teng, Bryant C. Yung, Y. Sugimoto, R. Brueggemeier, Robert J. Lee

Nanomedicine : nanotechnology, biology, and medicine

2012

Clinical translation of folate receptor-targeted therapeutics

Lesheng Teng, Jing Xie, Li-Rong Teng, Robert J. Lee

Expert Opinion on Drug Delivery

2012

Enhanced siRNA delivery using oleic acid derivative of polyethylenimine.

Lesheng Teng, Jing Xie, Li-Rong Teng, Robert J. Lee

Anticancer Research

2012

Lipid Nanoparticles for Hepatic Delivery of Small Interfering RNA

Bo Yu, Shu-Hao Hsu, Chenguang Zhou, Xin-Mei Wang, M. Terp, Yun Wu, Lesheng Teng, Yi-Cheng Mao, Feng Wang, Wei-Ming Xue, S. Jacob, K. Ghoshal, Robert J. Lee, L. Lee

Biomaterials

2012

Long-acting formulation of a new muscarinic receptor antagonist for the treatment of overactive bladder

Lesheng Teng, Chaojun Jiang, Fengying Sun, Chunmei Li, Lirong Teng, Qingfan Meng, Robert J. Lee, Youxin Li

Journal of Microencapsulation

2011

Synthesis and evaluation of a novel lipophilic folate receptor targeting ligand.

Ying Liu, Songlin Xu, Lesheng Teng, Bryant C. Yung, Jing Zhu, Hong Ding, Robert J. Lee

Anticancer Research

2010

Studies on the preparation, characterization and pharmacological evaluation of tolterodine PLGA microspheres.

Feng-Ying Sun, Cheng Sui, Lesheng Teng, Xi-Ming Liu, Li-Rong Teng, Q. Meng, You-Xin Li

International journal of pharmaceutics

2008

Biodegradable PLGA microsphere for the controlled release of tolterodine derivative

Chao-Jun Jiang, Lesheng Teng, Lirong Teng, Chun-Mei Li, Youxin Li

会议论文

2018

长效PEG化的重组人生长激素的二次开发

刘佳欣,李爽,刘志红,李鸽,孙凤英,滕乐生,李春梅

《第八届泛环渤海生物化学与分子生物学会2018年学术交流会》

2018

Functional exosome-mimic for delivery of siRNA to cancer:in vitro and in vivo evaluation

Lesheng Teng

The 3rd International Conference on Nanomedicine of China(ChinaNanomedicine 2018)

2016

Effects of the degradation products of PCADK and PLGA on tertiary structure of Herceptin

Na Liu, Ningning Liang, Changhui Yu, Lesheng Teng, Fengying Sun, Youxin Li

《2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会2016年工作年会、国际控释协会中国分会2016年学术年会会议论文集》

2016

Stability of protein in the PCADK/PLGA Microspheres

Jiaxin Liu, Changhui Yu, Jinlong Zhao, Lesheng Teng, Youxin Li, Fengying Sun

《2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会2016年工作年会、国际控释协会中国分会2016年学术年会会议论文集》

2016

Preparation and in vitro release studies of herceptin-loaded microspheres

Chaoxing Long, Xiangyu Li, Changhui Yu, Lesheng Teng, Fengying Sun, Youxin Li

《2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会2016年工作年会、国际控释协会中国分会2016年学术年会会议论文集》

2016

A polyelectrolyte complexes tablet of Isoperidone for the treatment of mental illness

Zunkai Zhang, Kongtong Yu, Xiangshi Sun, Ying Liu, Ao Li, Zelei Zhou, Lesheng Teng, Fengying Sun, Youxin Li

《2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会工作年会、国际控释协会中国分会2016年学术年会》

2015

微流控技术制备脂质体纳米制剂的研究

黄学勤,李玉婧,逯家辉,滕乐生

《第五届泛环渤海生物化学与分子生物学会学术交流会论文集》

2014

Butyl stearate impacts structures of PLGA-based tolterodine microspheres

Ximing Liu, Wenwen Dai, Kongtong Yu, Lesheng Teng, Fengying Sun, Youxin Li

《2014中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会》

2013

RP-HPLC法测定脂质体中盐酸多柔比星的含量

李玉婧,彭小君,孟威,孟令军,滕乐生

《第四届泛环渤海生物化学与分子生物学会学术交流会》

2008

乳化溶剂挥发法制备缓释微球的研究

李春梅,蒋朝军,滕乐生,姜丹,陈亚光

《吉林省第六届生命科学大型学术报告会》

2008

用于治疗膀胱过度活动症的DD01长效缓释微球制剂研究

滕乐生,蒋朝军,李春梅,孟令军,李又欣

《吉林省第六届生命科学大型学术报告会论文集》

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