朱宏莉｜西北大学｜学者主页

2026

Integrating Machine-learning and Ultra-high-throughput Screening for Enzyme spaces exploration

Yitao Ke, Yanzhe Zhang, Minchao Fang, Jingyang Zhao, Hongli Zhu, Zehui Xu, Long-Xing Cao

bioRxiv

DOI

2026

De novo design of metalloproteases for targeted amyloid-β cleavage

Yannan Qu, Chentong Wang, Hongli Zhu, Yan-Jun Wang, Long-Xing Cao

bioRxiv

DOI

2024

Proteus: Exploring Protein Structure Generation for Enhanced Designability and Efficiency

Chentong Wang, Yannan Qu, Fred Zhangzhi Peng, Yukai Wang, Hongli Zhu, Dachuan Chen, Longxing Cao

bioRxiv

DOI

2021

Ferrous hemoglobin and hemoglobin‐based oxygen carriers acting as a peroxidase can inhibit oxidative damage to endothelial cells caused by hydrogen peroxide

Shuangshuang Huo, Xiaofeng Lei, Dan He, Hua Zhang, Zhipeng Yang, Wenhua Mu, Ke Fang, Dan Xue, He Li, Xiaoyan Li, Nan Jia, Hongli Zhu, Chao Chen, Kunping Yan

Artificial Organs

DOI

2018

HPLC method for Residual 2-Bromoethylamine Hydrobromide in Hemoglobin-based Oxygen Carriers Derived with 4-Methoxybenzenesulfonyl Chloride

Qiuhui Li, Huiya Ma, Yuanyuan Zhang, Kun Feng, Pengfei Yang, Jianjun Li, Hongli Zhu, Chao Chen, Kunping Yan

Journal of Liquid Chromatography & Related Technologies

DOI

2018

Study of the pharmacokinetics of polymerized porcine hemoglobin (pPolyHb)

Yuesheng Shen, Wenjin Zhu, Mengye Zhao, Guige Zhao, Geng Niu, Yuwei Bai, Bo Yang, Chao Chen, Hongli Zhu

Artificial Cells Nanomedicine and Biotechnology

DOI

2017

Glutaraldehyde-polymerized hemoglobin and tempol (PolyHb-tempol) has superoxide dismutase activity that can attenuate oxidative stress on endothelial cells induced by superoxide anion

Mengdi Wu, Kun Feng, Qiuhui Li, Huiya Ma, Hongli Zhu, Yudou Xie, Gaofei Yan, Chao Chen, Kunping Yan

Artificial Cells Nanomedicine and Biotechnology

DOI

2017

The effect of pPolyHb on hemodynamic stability and mesenteric microcirculation in a rat model of hemorrhagic shock

Jing Zhao, Chengbin Yan, Lijuan Xu, Kunping Yan, Bao Feng, Mengye Zhao, Geng Niu, Mengdi Wu, Chao Chen, Hongli Zhu

Artificial Cells Nanomedicine and Biotechnology

DOI

2016

Study of the effects of polymerized porcine hemoglobin (pPolyHb) in an acute anemia rat model

Huifang Liu, Chengbin Yan, Kunping Yan, Wenjin Zhu, Yuesheng Shen, Bo Yang, Chao Chen, Hongli Zhu

Artificial Cells Nanomedicine and Biotechnology

DOI

2016

Effects of resuscitation with polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and oxygen delivery in a rat model of hemorrhagic shock

Li Wang, Fang Liu, Kunping Yan, Wencan Pan, Lijuan Xu, Huifang Liu, Chengbin Yan, Chao Chen, Hongli Zhu

Artificial Cells Nanomedicine and Biotechnology

DOI

2016

Study of the inflammatory response of immunocytes to polymerized porcine hemoglobin (pPolyHb).

Wenjin Zhu, Fang Liu, Jianguo Xin, Zhilan Xie, Boya Su, Chengbin Yan, Jia Zhang, Chao Chen, Hongli Zhu

PubMed

DOI

2015

The protective effect of polymerized porcine hemoglobin (pPolyHb) on transient focal cerebral ischemia/reperfusion injury

Zhilan Xie, Lijun Liu, Wenjin Zhu, Huifang Liu, Li Wang, Jia Zhang, Chao Chen, Hongli Zhu

Artificial Cells Nanomedicine and Biotechnology

DOI

2015

Pretreatment with pPolyHb attenuates H 2 O 2 -induced endothelial cell injury through inhibition of JNK/p38 MAPK pathway by upregulation of heme oxygenase-1

Haiyan Xue, Kunping Yan, Xiu-Fang Zhao, Wenjin Zhu, Lijun Liu, Zhilan Xie, Hongli Zhu, Chao Chen

Artificial Cells Nanomedicine and Biotechnology

DOI

2013

人工氧载体在器官保存中的应用研究

马军，朱雯谨，黄鹤，潘文灿，詹花，张璐，李晋，朱宏莉

《中国输血杂志》

2011

邻二氮菲-铁(Ⅲ)测定血红蛋白氧载体中巯基抗氧化剂含量

严坤平，惠文利，朱宏莉，杨鹏飞，朱雅清，陈超

《药物分析杂志》

2011

三氯乙酸沉淀法结合姜黄素法测定血红蛋白氧载体中残余硼

严坤平，朱宏莉，惠文利，范杰，陈超

《分析试验室》

2011

Immune Safety Evaluation of Polymerized Porcine Hemoglobin (pPolyHb): A Potential Red Blood Cell Substitute

Hongli Zhu, Kunping Yan, Xiaodong Dang, He Huang, Erfang Chen, Bang Chen, Chao Luo, Thomas Ming Swi Chang, Penggao Dai, Chao Chen

Artificial Cells Blood Substitutes and Biotechnology

DOI

2011

A Novel Hemoglobin‐Based Oxygen Carrier, Polymerized Porcine Hemoglobin, Inhibits H2O2‐Induced Cytotoxicity of Endothelial Cells

Wei Zhang, Kunping Yan, Penggao Dai, Jingjing Tian, Hongli Zhu, Chao Chen

Artificial Organs

DOI

2011

Pharmacodynamic Study of Polymerized Porcine Hemoglobin (pPolyHb) in a Rat Model of Exchange Transfusion

Hongli Zhu, Xiaodong Dang, Kunping Yan, Penggao Dai, Chao Luo, Jun Ma, Yan Li, Thomas Ming Swi Chang, Chao Chen

Artificial Cells Blood Substitutes and Biotechnology

DOI

2010

The Immunological Properties of Stroma-free Polyhemolysate Containing Catalase and Superoxide Dismutase Activities Prepared by Polymerized Bovine Stroma-free Hemolysate

Hongli Zhu, Qianqian Du, Chao Chen, Thomas Ming Swi Chang

Artificial Cells Blood Substitutes and Biotechnology

DOI

2009

氦氖激光、紫外复合诱变天麻素产生菌华根霉LN-A的原生质体

韩文霞，刘迪，陈二方，曹海燕，詹花，朱宏莉

《微生物学通报》

2007

静息细胞法转化天麻素的研究

朱宏莉，张嘉，宋纪蓉，陈邦，孙伟，马震宇

《西北大学学报(自然科学版)》

2006

微生物转化法合成天麻素

朱宏莉，宋纪蓉，黄建新，张嘉，马震宇，杨明琰

《药学学报》

DOI

2006

根霉LN-1生物合成天麻素条件研究

朱宏莉，宋纪蓉，黄建新，徐抗震，张嘉，罗娜，马敏

《化学工程》

2006

金磁微粒介导的盐酸克伦特罗多克隆抗体的纯化

汪慧蓉，朱宏莉，惠文利，张志锋，陈超，崔亚丽

《西北农林科技大学学报(自然科学版)》

2006

链亲和素-磁性微粒的制备及其应用

张志锋，朱宏莉，唐一通，崔婷，耿婷婷，陈超，崔亚丽

《中国科学:化学》

2005

竹叶总黄酮的提取和纯化工艺的研究

朱宏莉，韦海洪，宋纪蓉，陈邦，任静

《食品科学》

2005

氦-氖激光诱变细菌细胞及原生质体选育果胶酶高产菌株

朱宏莉，郭爱莲，宋纪蓉，杨秀芳，张嘉，张晓瑞

《光子学报》

2005

4-氨基-1,2,4-三唑-5-酮硫代脲酸甲酯的合成及表征

黄洁，宋纪蓉，任莹辉，徐抗震，朱宏莉

《中国现代应用药学》

2003

“微生物学”多媒体课件的开发及应用

黄建新，李斌，朱宏莉，刘建玲

《高等理科教育》

2002

紫外、氦氖激光等复合诱变产果胶酶细菌ZH1的研究

郭爱莲，朱宏莉

《光子学报》

2000

氧化亚铁硫杆菌的分离及其生长条件的研究

孙先锋，郭爱莲，朱宏莉，张志杰

《西北大学学报(自然科学版)》

1999

He-Ne激光诱变黑曲霉Sx的原生质体

郭爱莲，郭廷巍，朱宏莉，郎惠云，马洪军

《光子学报》

1999

He-Ne激光、紫外线诱变氧化亚铁硫杆菌及耐砷菌株的选育

郭爱莲，孙先锋，朱宏莉，郎惠云

《光子学报》

1998

西安地区河流水质的卫生细菌学调查和建议

郭爱莲，宁东俊，韩芳桥，朱宏莉

《西北大学学报(自然科学版)》

精选作品

期刊论文

Integrating Machine-learning and Ultra-high-throughput Screening for Enzyme spaces exploration

De novo design of metalloproteases for targeted amyloid-β cleavage

Proteus: Exploring Protein Structure Generation for Enhanced Designability and Efficiency

Ferrous hemoglobin and hemoglobin‐based oxygen carriers acting as a peroxidase can inhibit oxidative damage to endothelial cells caused by hydrogen peroxide

HPLC method for Residual 2-Bromoethylamine Hydrobromide in Hemoglobin-based Oxygen Carriers Derived with 4-Methoxybenzenesulfonyl Chloride

Study of the pharmacokinetics of polymerized porcine hemoglobin (pPolyHb)

Glutaraldehyde-polymerized hemoglobin and tempol (PolyHb-tempol) has superoxide dismutase activity that can attenuate oxidative stress on endothelial cells induced by superoxide anion

The effect of pPolyHb on hemodynamic stability and mesenteric microcirculation in a rat model of hemorrhagic shock

Study of the effects of polymerized porcine hemoglobin (pPolyHb) in an acute anemia rat model

Effects of resuscitation with polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and oxygen delivery in a rat model of hemorrhagic shock

Study of the inflammatory response of immunocytes to polymerized porcine hemoglobin (pPolyHb).

The protective effect of polymerized porcine hemoglobin (pPolyHb) on transient focal cerebral ischemia/reperfusion injury

Pretreatment with pPolyHb attenuates H 2 O 2 -induced endothelial cell injury through inhibition of JNK/p38 MAPK pathway by upregulation of heme oxygenase-1

人工氧载体在器官保存中的应用研究

邻二氮菲-铁(Ⅲ)测定血红蛋白氧载体中巯基抗氧化剂含量

三氯乙酸沉淀法结合姜黄素法测定血红蛋白氧载体中残余硼

Immune Safety Evaluation of Polymerized Porcine Hemoglobin (pPolyHb): A Potential Red Blood Cell Substitute

A Novel Hemoglobin‐Based Oxygen Carrier, Polymerized Porcine Hemoglobin, Inhibits H2O2‐Induced Cytotoxicity of Endothelial Cells

Pharmacodynamic Study of Polymerized Porcine Hemoglobin (pPolyHb) in a Rat Model of Exchange Transfusion

The Immunological Properties of Stroma-free Polyhemolysate Containing Catalase and Superoxide Dismutase Activities Prepared by Polymerized Bovine Stroma-free Hemolysate

氦氖激光、紫外复合诱变天麻素产生菌华根霉LN-A的原生质体

静息细胞法转化天麻素的研究

微生物转化法合成天麻素

根霉LN-1生物合成天麻素条件研究

金磁微粒介导的盐酸克伦特罗多克隆抗体的纯化

链亲和素-磁性微粒的制备及其应用

竹叶总黄酮的提取和纯化工艺的研究

氦-氖激光诱变细菌细胞及原生质体选育果胶酶高产菌株

4-氨基-1,2,4-三唑-5-酮硫代脲酸甲酯的合成及表征

“微生物学”多媒体课件的开发及应用

紫外、氦氖激光等复合诱变产果胶酶细菌ZH1的研究

氧化亚铁硫杆菌的分离及其生长条件的研究

He-Ne激光诱变黑曲霉Sx的原生质体

He-Ne激光、紫外线诱变氧化亚铁硫杆菌及耐砷菌株的选育

西安地区河流水质的卫生细菌学调查和建议

书籍章节

Immune Safety Evaluation of Polymerized Porcine Hemoglobin (pPolyHb) — Potential Red Blood Cell Substitutes

Glutaraldehyde Polymerized Porcine Hemoglobin: Preparation, Safety Evaluation and Pharmacodynamics Study

研究方向