张明明｜哈尔滨医科大学｜学者主页

2026

基于组学技术的近视发病机制及中医药防治研究进展

叶姗姗，亢泽峰，张明明，晏鑫，臧玉玲

《中国中医基础医学杂志》

DOI

2026

类风湿关节炎时间生物学机制研究进展

谷贺，耿诗雨，唐欣欣，李丹，王志强，张明明，白杰，冯星，王亚静，刘东生，张晓刚

《免疫学杂志》

DOI

2026

Beyond Stability: Rethinking Housekeeping Genes as Contributors to Rheumatoid Arthritis Pathogenesis

Wenhua Lv, Hao Tang, Ruijie Zhang, Mingming Zhang, Yongshuai Jiang

International Journal of Rheumatic Diseases

DOI

2025

Long-term air pollutants exposure on risk of psoriasis: the mediating role of accelerated biological aging among 284,544 participants

Jie Gao, Jiarong He, Wenbo Zhao, Jing Cui, Qi Zhang, Ping Yang, Fan Yang, Yuquan Chen, Mingming Zhang

Journals Of Gerontology Series A-Biological Sciences And Medical Sciences，Vol. 800, No. 80

DOI

2025

基于生物信息学分析整合素α 11在胃癌组织中的表达及临床意义

何光耀，牛佳乐，赵克晗，张明明

《肿瘤学杂志》

2025

以创新人才培养为导向的生物信息学专业基础课与专业课对接模式研究——以“数据结构”课程为例

石洪波，张明明，赵文媛

《黑龙江教育(理论与实践)》

2025

新医科背景下“医理”融合“统计遗传学”课程体系重构

张明明，吕洪超，石洪波，尚振伟，吕文华，张瑞杰，姜永帅

《医学教育研究与实践》

DOI

2024

性类固醇激素与近视之间的因果关系：一项孟德尔随机化研究

李宝花，亢泽峰，张明明，侯昕玥，王健全，李丹玉，刘梦雨，师宜鹏

《眼科新进展》

2023

重构生物信息学专业基础课教学内容培养学生创新能力——以“数据结构”课程为例

石洪波，张明明，赵文媛

《黑龙江教育(理论与实践)》

2022

后GWAS时代的原发性胆汁性胆管炎的遗传学研究

邱方，王婵，张明明，史兴娟，刘向东

《临床肝胆病杂志》

2021

“双一流”背景下统计遗传学金课建设探索与思考

张明明，姜永帅，张瑞杰

《黑龙江教育(理论与实践)》

2014

Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo

Mingming Zhang, Fang Cai, Shuting Zhang, Si Zhang, Wei-Hong Song

Scientific Reports

DOI

2014

Ubiquitin carboxyl-terminal hydrolase l1 in alzheimer's disease

Mingming Zhang

DOI

2014

Upregulation of SET Expression by BACE1 and its Implications in Down Syndrome

Xiaozhu Zhang, Yi-Li Wu, Xiaoling Duan, Wei Chen, Haiyan Zou, Mingming Zhang, Shuting Zhang, Fang Cai, Wei-Hong Song

Molecular Neurobiology

DOI

2014

Down‐regulation of MIF by NFκB under hypoxia accelerated neuronal loss during stroke

Si Zhang, Odysseus Zis, P. Ly, Yi-Li Wu, Shuting Zhang, Mingming Zhang, Fang Cai, R. Bucala, W. Shyu, Wei-Hong Song

The FASEB Journal

DOI

2013

Targeting nascent soluble Aβ42 for potential Alzheimer drug development

Mingming Zhang, L. Hausmann, Wei-Hong Song

Journal of Neurochemistry

DOI

2013

Biological function of Presenilin and its role in AD pathogenesis

Shuting Zhang, Mingming Zhang, Fang Cai, Wei-Hong Song

Translational Neurodegeneration

DOI

2013

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.

P. Ly, Yi-Li Wu, Haiyan Zou, Ruitao Wang, Wei-Hui Zhou, Ayae Kinoshita, Mingming Zhang, Yi Yang, Fang Cai, J. Woodgett, Wei-Hong Song

Journal of Clinical Investigation

DOI

2012

基于SVM的药物靶点预测方法及其应用

尚振伟，李晋，姜永帅，张明明，吕洪超，张瑞杰

《现代生物医学进展》

2012

Control of BACE1 degradation and APP processing by ubiquitin carboxyl‐terminal hydrolase L1

Mingming Zhang, Yu Deng, Ya-Wen Luo, Shuting Zhang, Haiyan Zou, Fang Cai, K. Wada, Wei-Hong Song

Journal of Neurochemistry

DOI

2011

NF‐κB signaling inhibits ubiquitin carboxyl‐terminal hydrolase L1 gene expression

Ruitao Wang, Mingming Zhang, Wei-Hui Zhou, P. Ly, Fang Cai, Wei-Hong Song

Journal of Neurochemistry

DOI

2010

统计遗传学精品课建设探索与实践

张明明，张瑞杰，李晋，吕洪超

《科学技术创新》

2009

生物信息学专业《统计遗传学》课程建设探索与实践

李晋，张瑞杰，张明明，吕洪超

《科学技术创新》

张明明

精选作品

期刊论文

基于组学技术的近视发病机制及中医药防治研究进展

类风湿关节炎时间生物学机制研究进展

Beyond Stability: Rethinking Housekeeping Genes as Contributors to Rheumatoid Arthritis Pathogenesis

Long-term air pollutants exposure on risk of psoriasis: the mediating role of accelerated biological aging among 284,544 participants

基于生物信息学分析整合素α 11在胃癌组织中的表达及临床意义

以创新人才培养为导向的生物信息学专业基础课与专业课对接模式研究——以“数据结构”课程为例

新医科背景下“医理”融合“统计遗传学”课程体系重构

性类固醇激素与近视之间的因果关系：一项孟德尔随机化研究

重构生物信息学专业基础课教学内容培养学生创新能力——以“数据结构”课程为例

后GWAS时代的原发性胆汁性胆管炎的遗传学研究

“双一流”背景下统计遗传学金课建设探索与思考

Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo

Ubiquitin carboxyl-terminal hydrolase l1 in alzheimer's disease

Upregulation of SET Expression by BACE1 and its Implications in Down Syndrome

Down‐regulation of MIF by NFκB under hypoxia accelerated neuronal loss during stroke

Targeting nascent soluble Aβ42 for potential Alzheimer drug development

Biological function of Presenilin and its role in AD pathogenesis

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.

基于SVM的药物靶点预测方法及其应用

Control of BACE1 degradation and APP processing by ubiquitin carboxyl‐terminal hydrolase L1

NF‐κB signaling inhibits ubiquitin carboxyl‐terminal hydrolase L1 gene expression

统计遗传学精品课建设探索与实践

生物信息学专业《统计遗传学》课程建设探索与实践

研究方向

精选作品

期刊论文

基于组学技术的近视发病机制及中医药防治研究进展

类风湿关节炎时间生物学机制研究进展

Beyond Stability: Rethinking Housekeeping Genes as Contributors to Rheumatoid Arthritis Pathogenesis

Long-term air pollutants exposure on risk of psoriasis: the mediating role of accelerated biological aging among 284,544 participants

基于生物信息学分析整合素α 11在胃癌组织中的表达及临床意义

以创新人才培养为导向的生物信息学专业基础课与专业课对接模式研究——以“数据结构”课程为例

新医科背景下“医理”融合“统计遗传学”课程体系重构

性类固醇激素与近视之间的因果关系：一项孟德尔随机化研究

重构生物信息学专业基础课教学内容 培养学生创新能力——以“数据结构”课程为例

后GWAS时代的原发性胆汁性胆管炎的遗传学研究

“双一流”背景下统计遗传学金课建设探索与思考

Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo

Ubiquitin carboxyl-terminal hydrolase l1 in alzheimer's disease

Upregulation of SET Expression by BACE1 and its Implications in Down Syndrome

Down‐regulation of MIF by NFκB under hypoxia accelerated neuronal loss during stroke

Targeting nascent soluble Aβ42 for potential Alzheimer drug development

Biological function of Presenilin and its role in AD pathogenesis

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.

基于SVM的药物靶点预测方法及其应用

Control of BACE1 degradation and APP processing by ubiquitin carboxyl‐terminal hydrolase L1

NF‐κB signaling inhibits ubiquitin carboxyl‐terminal hydrolase L1 gene expression

统计遗传学精品课建设探索与实践

生物信息学专业《统计遗传学》课程建设探索与实践

研究方向

重构生物信息学专业基础课教学内容培养学生创新能力——以“数据结构”课程为例