薛玉花｜厦门大学｜学者主页

2025

Stabilization of AFF1 by PARylation ensures transcriptional restart after DNA damage

Feifeng Zhu, Huanyi Fu, Wenxuan Zhu, Chengyu Li, Min Yang, Zeming Feng, Yangqing Shao, Zhuo Li, Yafei Guo, Mengting Huang, Yitong Zhang, Yaohui He, Yi Lu, Zhibing Wu, Qiang Zhou, Huipeng Jiao, Jun Huang, Long Zhang, Yuhua Xue, Huasong Lu

Nature Chemical Biology

DOI

2025

PRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub

Xinyu Wang, Yuhua Xue, Lin Li, Jin‐Wen Song, Lei Jia, Li Lian Xu, Miao Fan, Lu Lu, Wen Su, Jingwan Han, Dandan Lin, Rongdiao Liu, Xiang Gao, Yafei Guo, Zixun Xiang, Chunjing Chen, Leilei Wan, Huihui Chong, Yuxian He, Fu‐Sheng Wang, Kaihu Yao, Qiang Zhou, Dan Yu

Nature Communications

DOI

2023

Ozone exposure affects corneal epithelial fate by promoting mtDNA leakage and cGAS/STING activation

Kai Fan, Nuo Dong, Meichai Fang, Zixun Xiang, Lan Zheng, Mengyuan Wang, Yukuan Shi, Gang Tan, Li Cheng, Yuhua Xue

Journal of Hazardous Materials

DOI

2023

Clickable corneal neovascularization therapy with ROS-responsive polydopamine silica nanoparticles loaded with fenofibrate

Kai Fan, Lixue Yu, Yuehuang Wu, Lan Zheng, Xiuqin Yang, Jingwei Lin, Mengyuan Wang, Yingyue Ye, Ruimiao Lin, Quancheng Chen, Zeyu Liu, Yuhua Xue, Jingjing Xie, Cheng Li

Materials & Design

DOI

2023

Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction

Guo‐Liang Wang, Guoliang Wang, Lina Xu, Ruize Shi, Yingyue Ye, Baihui Zeng, Xiuqin Yang, Zhen Liu, Zhen Liu, Shu‐Rong Wang, Yuhua Xue, Cheng Li

The Ocular Surface

DOI

2023

Quantitative Proteomics of the CDK9 Interactome Reveals a Function of the HSP90-CDC37-P-TEFb Complex for BETi-Induced HIV-1 Latency Reactivation

Cong Wang, Chunjing Chen, Zhenrui Pan, Yaohui He, Zhanming Zhang, Rongdiao Liu, Yuhua Xue, Qiang Zhou, Xiang Gao

Journal of Proteome Research

DOI

2023

Decellularized squid mantle scaffolds as tissue‐engineered corneal stroma for promoting corneal regeneration

Honghua Kang, Yi Han, Mengyi Jin, Lan Zheng, Zhen Liu, Zhen Liu, Yuhua Xue, Zuguo Liu, Zuguo Liu, Cheng Li

Bioengineering & Translational Medicine

DOI

2022

The synthesis of PROTAC molecule and new target KAT6A identification of CDK9 inhibitor iCDK9

Mingtao Ao, Jun Wu, Yin Cao, Yaohui He, Yuxiang Zhang, Xiang Gao, Yuhua Xue, Meijuan Fang, Zhen Wu

Chinese Chemical Letters

DOI

2022

Phenotypic and Transcriptomics Analyses Reveal Underlying Mechanisms in a Mouse Model of Corneal Bee Sting

Yanzi Wang, Honghua Kang, Mengyi Jin, Guoliang Wang, Weifang Ma, Zhen Liu, Yuhua Xue, Cheng Li

Toxins

DOI

2022

Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage

Huanyi Fu, Rongdiao Liu, Zixuan Jia, Ran Li, Feifeng Zhu, Wenxuan Zhu, Yangqing Shao, Yiyang Jin, Yuhua Xue, Jun Huang, Kunxin Luo, Xiang Gao, Huasong Lu, Qiang Zhou

Nature Cell Biology

DOI

2022

Polystyrene microplastic particles: In vivo and in vitro ocular surface toxicity assessment

Xiaoping Zhou, Guoliang Wang, Xiaoya An, Jun Wu, Kai Fan, Lina Xu, Cheng Li, Yuhua Xue

Environmental Pollution

DOI

2022

Polyphenol Extracts from Grape Seeds and Apple Can Reactivate Latent HIV-1 Transcription through Promoting P-TEFb Release from 7SK snRNP

Cong Wang, Huiru Wang, Zhenrui Pan, Jun Wu, Yafei Guo, Jıng Zhang, Zixun Xiang, Wei Lu, Yuhua Xue

Disease Markers

DOI

2021

A natural product targets BRD4 to inhibit phase separation and gene transcription

Cong Wang, Huasong Lu, Xiangzhong Liu, Xiang Gao, Wenjing Tian, Haifeng Chen, Yuhua Xue, Qiang Zhou

iScience

DOI

2021

Real-time confocal microscopy imaging of corneal cytoarchitectural changes induced by different stresses

Guoliang Wang, Xiaoya An, Xiaoping Zhou, Mengyi Jin, Xuemei Wang, Rongrong Zong, Zhen Liu, Zuguo Liu, Yuhua Xue, Cheng Li

Experimental Eye Research

DOI

2021

Novel Cell Culture Paradigm Prolongs Mouse Corneal Epithelial Cell Proliferative Activity in vitro and in vivo

Xiaoya An, Guoliang Wang, Mengyi Jin, Xiaoping Zhou, Shu-Bin Gao, Jingyao Chen, Peter Sol Reinach, Zuguo Liu, Yuhua Xue, Cheng Li

Frontiers in Cell and Developmental Biology

DOI

2021

Phenotypic and transcriptomic changes in the corneal epithelium following exposure to cigarette smoke

Mengyi Jin, Yanzi Wang, Xiaoya An, Honghua Kang, Yixin Wang, Guo‐Liang Wang, Yang Gao, Shui-Ping Wu, Peter Sol Reinach, Zuguo Liu, Yuhua Xue, Cheng Li

Environmental Pollution

DOI

2021

Resveratrol Promotes HIV-1 Tat Accumulation via AKT/FOXO1 Signaling Axis and Potentiates Vorinostat to Antagonize HIV-1 Latency

Zeming Feng, Zhengrong Yang, Xiang Gao, Yuhua Xue, Xiaohui Wang

Current HIV Research

DOI

2020

Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2

Jun Wu, Yuhua Xue, Xiang Gao, Qiang Zhou

Nucleic Acids Research

DOI

2020

Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors

Hongyu Hu, Jun Wu, Mingtao Ao, Xiaoping Zhou, Boqun Li, Zhenzhen Cui, Tong Wu, Lijuan Wang, Yuhua Xue, Zhen Wu, Meijuan Fang

Bioorganic Chemistry

DOI

2020

Protective Effects Oncorneal Endothelium During Intracameral Irrigation Using N-(2)-l-alanyl-l-Glutamine

Mengyi Jin, Yanzi Wang, Yixin Wang, Yunpeng Li, Guoliang Wang, Xuezhi Liu, Yuhua Xue, Zuguo Liu, Cheng Li

Frontiers in Pharmacology

DOI

2020

Polyphenols from Polygonum cuspidatum Reactivate Latent HIV

Shuiyuan Yang, Wenjing Tian, Zhenrui Pan, Ting Lin, Guanghui Wang, Qiang Zhou, Yuhua Xue, Haifeng Chen

Chemistry of Natural Compounds

DOI

2020

ELL-associated factors EAF1/2 negatively regulate HIV-1 transcription through inhibition of Super Elongation Complex formation

Rongdiao Liu, Chunjing Chen, Yun Li, Qingqing Huang, Yuhua Xue

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

DOI

2020

Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription

Dan Tang, Chunjing Chen, Ga Liao, Jiaming Liu, Banghua Liao, Qingqing Huang, Qianqian Chen, Jiahui Zhao, Hui Jiang, Jinsong Duan, Jin Huang, Kunjie Wang, Jiawei Wang, Cuiyan Zhou, Wendan Chu, Wenqi Li, Bo Sun, Zhonghan Li, Lunzhi Dai, Xianghui Fu, Wei Cheng, Yuhua Xue, Shiqian Qi

Cell Discovery

DOI

2020

JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes

Schuyler Lee, Haolin Liu, Ryan C. Hill, Chunjing Chen, Xia Hong, Fran Crawford, Molly C. Kingsley, Qianqian Zhang, Xinjian Liu, Zhongzhou Chen, Andreas Lengeling, Kathrin Maria Bernt, Philippa Marrack, John W. Kappler, Qiang Zhou, Chuan‐Yuan Li, Yuhua Xue, Kirk Charles Hansen, Gongyi Zhang

eLife

DOI

2020

Author response: JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes

DOI

2019

A complex between DYRK1A and DCAF7 phosphorylates the C-terminal domain of RNA polymerase II to promote myogenesis

Dan Yu, Claudia Cattoglio, Yuhua Xue, Qiang Zhou

Nucleic Acids Research

DOI

2019

The role of autophagy in the pathogenesis of exposure keratitis

Guoliang Wang, Yuhua Xue, Yanzi Wang, Fei Dong, Mei Shen, Rongrong Zong, Zuguo Liu, Cheng Li

Journal of Cellular and Molecular Medicine

DOI

2018

Epithelial dysplasia in pterygium postoperative granuloma

Guoliang Wang, Nuo Dong, Yanzi Wang, Jing Li, Fei Dong, Mani Vimalin Jeyalatha, Jingwen Wu, Mei Shen, Qichen Yang, Pei Chen, Yuhua Xue, Zuguo Liu, Cheng Li

Experimental Eye Research

DOI

2018

Design, synthesis, and biological evaluation of AV6 derivatives as novel dual reactivators of latent HIV-1

Mingtao Ao, Zhenrui Pan, Yuqing Qian, Bowen Tang, Zeming Feng, Hua Fang, Zhen Wu, Jingwei Chen, Yuhua Xue, Meijuan Fang

RSC Advances

DOI

2017

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter

Jun Wu, Mingtao Ao, Rui Shao, Huiru Wang, Diao Yu, Meijuan Fang, Xiang Gao, Zhen Wu, Qiang Zhou, Yuhua Xue

Scientific Reports

DOI

2017

Menin mediates Tat-induced neuronal apoptosis in brain frontal cortex of SIV-infected macaques and in Tat-treated cells

Jun Wang, Yu Zhang, Qiping Xu, Jinhua Qiu, Honghua Zheng, Xiang Ye, Yuhua Xue, Yongmei Yin, Zhou Zhang, Ying Liu, Yanling Hao, Qiang Wei, Wei Wang, Kazuyasu Mori, Shuji Izumo, Ryuji Kubota, Yiming Shao, Hui Qin Xing

Oncotarget

DOI

2015

Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription

Huasong Lu, Zichong Li, Wei Zhang, Ursula Schulze‐Gahmen, Yuhua Xue, Qiang Zhou

Nucleic Acids Research

DOI

2015

A Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb’s Release from 7SK snRNP

Cong Wang, Shuiyuan Yang, Huasong Lu, Hongchao You, Man Ni, Wenjun Shan, Ting Lin, Xiang Gao, Haifeng Chen, Qiang Zhou, Yuhua Xue

PLoS ONE

DOI

2015

Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

Huasong Lu, Yuhua Xue, Guoying Karen Yu, Carolina Arias, Julie Lin, Susan K. Fong, Michel Faure, Ben Weisburd, Xiao‐Dan Ji, Alexandre Mercier, James C. Sutton, Kunxin Luo, Zhenhai Gao, Qiang Zhou

eLife

DOI

2015

Author response: Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

Huasong Lu, Yuhua Xue, Guoying Karen Yu, Carolina Arias, Julie Lin, Susan K. Fong, Michel Faure, Ben Weisburd, Xiao‐Dan Ji, Alexandre Mercier, James C. Sutton, Kunxin Luo, Zhenhai Gao, Qiang Zhou

DOI

2015

Correction: Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

Hua-Song Lu, Yuhua Xue, Guo-Ying Yu, C. Arias, Julie Lin, Susan Fong, M. Faure, Benjamin Weisburd, Xiaodan Ji, A. Mercier, J. Sutton, K. Luo, Zhen-Hai Gao, Qiang Zhou

eLife

DOI

2014

Transcription Factor Brd4, a Potential Marker of Corneal Epithelial Stem Cells

Cheng Li, Yuhua Xue, Wei Shan Li, Zuguo Liu

Investigative Ophthalmology & Visual Science

2014

Mechanism and factors that control HIV-1 transcription and latency activation

Rongdiao Liu, Jun Fa Wu, Rui Shao, Yuhua Xue

Journal of Zhejiang University SCIENCE B

DOI

2014

Fibrin glue-assisted for the treatment of corneal perforations using glycerin-cryopreserved corneal tissue.

Nuo Dong, Cheng Li, Wensheng Chen, Wen-Juan Qin, Yuhua Xue, Huping Wu

PubMed

DOI

2013

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation

Huasong Lu, Zichong Li, Yuhua Xue, Ursula Schulze‐Gahmen, Jeffrey R. Johnson, Nevan J. Krogan, Tom Alber, Qiang Zhou

Proceedings of the National Academy of Sciences

DOI

2013

Viral–Host Interactions That Control HIV-1 Transcriptional Elongation

Huasong Lu, Zichong Li, Yuhua Xue, Qiang Zhou

Chemical Reviews

DOI

2013

Hypoxia affects in vitro proliferation and differentiation of mouse corneal epithelial progenitor cell

Nuo Dong, Wenjuan Qin, Yuhua Xue, Cheng Li, Zuguo Liu

In Vitro Cellular & Developmental Biology - Animal

DOI

2012

Mutual Information Analysis Reveals Coevolving Residues in Tat That Compensate for Two Distinct Functions in HIV-1 Gene Expression

Siddharth S. Dey, Yuhua Xue, Marcin P. Joachimiak, Gregory D. Friedland, John Burnett, Qiang Zhou, Adam P. Arkin, David V. Schaffer

Journal of Biological Chemistry

DOI

2011

NOVEL MECHANISM AND HOST COFACTORS FOR REGULATION OF HIV‐1 TRANSCRIPTION

Qiang Zhou, Nanhai He, Min Liu, Yuhua Xue, Caleb K. Chan, Joanne H. Hsu

DOI

2011

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin

Nanhai He, Caleb K. Chan, Bijan Sobhian, S. Chou, Yuhua Xue, Min Liu, T. Alber, M. Benkirane, Qiang Zhou

Proceedings of the National Academy of Sciences of the United States of America

DOI

2010

HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription

Nanhai He, Min Liu, Joanne H. Hsu, Yuhua Xue, Seemay Chou, Alma L. Burlingame, Nevan J. Krogan, Tom Alber, Qiang Zhou

Molecular Cell

DOI

2009

A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP

Yuhua Xue, Zhiyuan Yang, Rui-Chuan Chen, Qiang Zhou

Nucleic Acids Research

DOI

精选作品

期刊论文

Stabilization of AFF1 by PARylation ensures transcriptional restart after DNA damage

PRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub

Ozone exposure affects corneal epithelial fate by promoting mtDNA leakage and cGAS/STING activation

Clickable corneal neovascularization therapy with ROS-responsive polydopamine silica nanoparticles loaded with fenofibrate

Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction

Quantitative Proteomics of the CDK9 Interactome Reveals a Function of the HSP90-CDC37-P-TEFb Complex for BETi-Induced HIV-1 Latency Reactivation

Decellularized squid mantle scaffolds as tissue‐engineered corneal stroma for promoting corneal regeneration

The synthesis of PROTAC molecule and new target KAT6A identification of CDK9 inhibitor iCDK9

Phenotypic and Transcriptomics Analyses Reveal Underlying Mechanisms in a Mouse Model of Corneal Bee Sting

Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage

Polystyrene microplastic particles: In vivo and in vitro ocular surface toxicity assessment

Polyphenol Extracts from Grape Seeds and Apple Can Reactivate Latent HIV-1 Transcription through Promoting P-TEFb Release from 7SK snRNP

A natural product targets BRD4 to inhibit phase separation and gene transcription

Real-time confocal microscopy imaging of corneal cytoarchitectural changes induced by different stresses

Novel Cell Culture Paradigm Prolongs Mouse Corneal Epithelial Cell Proliferative Activity in vitro and in vivo

Phenotypic and transcriptomic changes in the corneal epithelium following exposure to cigarette smoke

Resveratrol Promotes HIV-1 Tat Accumulation via AKT/FOXO1 Signaling Axis and Potentiates Vorinostat to Antagonize HIV-1 Latency

Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2

Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors

Protective Effects Oncorneal Endothelium During Intracameral Irrigation Using N-(2)-l-alanyl-l-Glutamine

Polyphenols from Polygonum cuspidatum Reactivate Latent HIV

ELL-associated factors EAF1/2 negatively regulate HIV-1 transcription through inhibition of Super Elongation Complex formation

Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription

JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes

Author response: JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes

A complex between DYRK1A and DCAF7 phosphorylates the C-terminal domain of RNA polymerase II to promote myogenesis

The role of autophagy in the pathogenesis of exposure keratitis

Epithelial dysplasia in pterygium postoperative granuloma

Design, synthesis, and biological evaluation of AV6 derivatives as novel dual reactivators of latent HIV-1

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter

Menin mediates Tat-induced neuronal apoptosis in brain frontal cortex of SIV-infected macaques and in Tat-treated cells

Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription

A Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb’s Release from 7SK snRNP

Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

Author response: Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

Correction: Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

Transcription Factor Brd4, a Potential Marker of Corneal Epithelial Stem Cells

Mechanism and factors that control HIV-1 transcription and latency activation

Fibrin glue-assisted for the treatment of corneal perforations using glycerin-cryopreserved corneal tissue.

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation

Viral–Host Interactions That Control HIV-1 Transcriptional Elongation

Hypoxia affects in vitro proliferation and differentiation of mouse corneal epithelial progenitor cell

Mutual Information Analysis Reveals Coevolving Residues in Tat That Compensate for Two Distinct Functions in HIV-1 Gene Expression

NOVEL MECHANISM AND HOST COFACTORS FOR REGULATION OF HIV‐1 TRANSCRIPTION

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin

HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription

A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP

会议论文

Poly(ADP-ribosylation) of P-TEFb disrupts phase separation to inhibit global transcription upon genotoxic stress

预印本

PP2B and PP1α cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+signaling

研究方向