林金钟｜复旦大学｜学者主页

精选作品

期刊论文

2026

Integrating multitemperature sample preparation with particle rebalancing addresses preferred orientation

Xin Su, Liuyan Yang, Caiying Zhang, Lei Qi, Ming-Dong Liu, Yun-Hui Liu, Peiyi Wang, Yong Li, Chun-Hui Li, Qing-Tao Shen, Jinzhong Lin

PNAS Nexus

DOI

2026

NAT10 governs development through the Xrp1-mediated stress response rather than its RNA acetylation activity

Lin Wang, Xue Zhao, Shuyang Gao, Yanhua Wang, Houguang Lu, Bo Peng, Tianyi Fan, Ying Cao, Jian‐Quan Ni, Guoliang Lu, Jinzhong Lin, Dong Yan

Science Advances

DOI

2026

mRNA-LNP delivery of individual longevity genes mitigates doxorubicin-induced progeroid phenotypes

Yifan Ju, Yu Zhang, X Zhao, Jinzhong Lin, Ye Wei

Protein & Cell

DOI

2025

Synergically enhanced anti-tumor immunity of in vivo panCAR by circRNA vaccine boosting

Yanyan Wang, Liangru Lin, Xinyue Wang, Jing Li, Qian Pan, Haomeng Kou, Jie Yin, Fei Gao, Xinyuan Liao, Chenchen Zhang, Qimeng Yin, Chengzhi Zhao, Xinyang Li, Jinzhong Lin, Yichi Xu, Min Qiu, Dan Luo, Liang Qu

Cell Reports Medicine

DOI

2025

Hydroxychloroquine-functionalized ionizable lipids mitigate inflammatory responses in mRNA therapeutics

Kepan Chen, Xuechun Li, Shuo Feng, Ye Li, Ting Jiang, Yan Liu, Na Guo, Xiaoling Zeng, Hongwei Yao, Min Qiu, Jing Lü, Jinzhong Lin

Journal of Controlled Release

DOI

2025

Modified mRNA Treatment Restores Cardiac Function in Desmocollin-2–Deficient Mouse Models of Arrhythmogenic Right Ventricular Cardiomyopathy

Yan Zou, Jing Lu, Zhipeng Lian, Jianguo Jia, Juan Shen, Qianhe Li, Jennifer Ming Jen Wong, Kejia Jin, Wendi Yan, Xin-yue Ren, Yang Zhang, Chenxing Huang, Huanjie Yang, Feng Huang, Jun Li, Junyu Zhai, Yamei Xu, Xialian Xu, Hang Yu, Yi Jin, Hui Gong, Jinzhong Lin, Junbo Ge, Yuxiang Dai

Circulation

DOI

2025

In Situ Delivery of Gasdermin E mRNA Promotes Antitumor Immunity via Creatine-Elicited Type I Interferon Signaling in Monocytes

Hanjun Li, Jing Lu, Shudan Tan, Ting Jiang, Xin He, Wen Qiao, Cegui Hu, Sumiya Dalangood, Jinzhong Lin, Jun Gui

Cancer Immunology Research

DOI

2025

The application of modified mRNA in the treatment and prospective vaccine development for cardiovascular diseases

Yan Zou, Jennifer Ming Jen Wong, Jinzhong Lin, Yuxiang Dai

Cardiology Plus

DOI

2024

Artificial intelligence-driven rational design of ionizable lipids for mRNA delivery

Wei Wang, Kepan Chen, Ting Shun Jiang, Yi‐Yang Wu, Zheng Wu, Hang Ying, Hang Yu, Jing Lu, Jinzhong Lin, Defang Ouyang

Nature Communications

DOI

2024

The ribosome termination complex remodels release factor RF3 and ejects GDP

Li Li, Mariia Yu. Rybak, Jinzhong Lin, Matthieu G. Gagnon

Nature Structural & Molecular Biology

DOI

2024

Synthetic macrolides overcoming MLSBK-resistant pathogens

Cong-Xuan Ma, Ye Li, Wentian Liu, Yun Li, Fei Zhao, Xiao-Tian Lian, Jing Ding, Simeng Liu, Xie-Peng Liu, Bing-Zhi Fan, Li-Yong Liu, Feng Xue, Jian Li, Jue-Ru Zhang, Xue Zhao, Xiao-Tong Pei, Jinzhong Lin, Jian‐Hua Liang

Cell Discovery

DOI

2024

NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity

Yan Xiao, Bo‐Hua Kuang, Shengsuo Ma, Ruihua Wang, Jinzhong Lin, Yi‐Xin Zeng, Xiaoduo Xie, Lin Feng

Journal of Biological Chemistry

DOI

2024

Modeling on in vivo disposition and cellular transportation of RNA lipid nanoparticles via quantum mechanics/physiologically-based pharmacokinetic approaches

Wei Wang, Shiwei Deng, Jinzhong Lin, Defang Ouyang

Acta Pharmaceutica Sinica B

DOI

2024

Effectiveness of a broad-spectrum bivalent mRNA vaccine against SARS-CoV-2 variants in preclinical studies

Jing Lü, Shudan Tan, Hao Gu, Kunpeng Liu, Wei Huang, Zhaoli Yu, Guoliang Lu, Zihan Wu, Xiaobo Gao, Jinghua Zhao, Zongting Yao, Yi Feng, Yantao Yang, Hu Wang, Xue Hu, Mingqing Lu, Wei Li, Hui Zhou, Hang Yu, Chao Shan, Jinzhong Lin

Emerging Microbes & Infections

DOI

2023

An mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine against SARS-CoV-2 variants

Wanbo Tai, Shengyong Feng, Benjie Chai, Shuaiyao Lu, Guangyu Zhao, Dong Chen, Wenhai Yu, Liting Ren, Huicheng Shi, Jing Lü, Zhuming Cai, Mujia Pang, Xu Tan, Penghua Wang, Jinzhong Lin, Qiangming Sun, Xiaozhong Peng, Gong Cheng

Nature Communications

DOI

2023

Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase

Zhaoli Yu, Zihan Wu, Ye Li, Qiang Hao, Xiaofeng Cao, Gregor M. Blaha, Jinzhong Lin, Guoliang Lu

Nucleic Acids Research

DOI

2023

Optimization of Strategy for Modified mRNA Inducing Cardiac-Specific Expression in Mice

Chenxing Huang, Jianguo Jia, Kejia Jin, Yan Zou, Shudan Tan, Jing Lu, Yi Zhun Zhu, Jinzhong Lin, Yuxiang Dai, Hui Gong

Journal of Cardiovascular Translational Research

DOI

2022

A scalable system for the fast production of RNA with homogeneous terminal ends

Yu‐Chen Chen, Yan Cheng, Jinzhong Lin

RNA Biology

DOI

2022

Reconstruction of the rRNA Sequences of LUCA, with Bioinformatic Implication of the Local Similarities Shared by Them

Yu Men, Guoliang Lu, Yanhui Wang, Jinzhong Lin, Qiang Xie

Biology

DOI

2022

Crystal structures and insights into precursor tRNA 5’-end processing by prokaryotic minimal protein-only RNase P

Yangyang Li, Shichen Su, Yanqing Gao, Guoliang Lu, Hehua Liu, Xi Chen, Zhiwei Shao, Yixi Zhang, Qiyuan Shao, Xin Zhao, Jie Yang, Chulei Cao, Jinzhong Lin, Jinbiao Ma, Jianhua Gan

Nature Communications

DOI

2022

Annealing synchronizes the 70 S ribosome into a minimum-energy conformation

Xiaofeng Chu, Xin Su, Mingdong Liu, Li Li, Tianhao Li, Yicheng Qin, Guoliang Lu, Lei Qi, Yunhui Liu, Jinzhong Lin, Qing-Tao Shen

Proceedings of the National Academy of Sciences

DOI

2022

Chemically modified in-vitro-transcribed mRNA encoding thrombopoietin stimulates thrombopoiesis in mice

Yu Zhang, Xiaodong Xi, Hang Yu, Liuyan Yang, Jinzhong Lin, Wen Yang, Junling Liu, Xuemei Fan, Yingjie Xu

Molecular Therapy — Nucleic Acids

DOI

2022

A Single Dose of Anti-HBsAg Antibody-Encoding mRNA-LNPs Suppressed HBsAg Expression: a Potential Cure of Chronic Hepatitis B Virus Infection

Binfan Chen, Yuchen Chen, Jian Li, Chunyu Wang, Wenping Song, Yumei Wen, Jinzhong Lin, Yanling Wu, Tianlei Ying

mBio

DOI

2022

RplI interacts with 5’ UTR of exsA to repress its translation and type III secretion system in Pseudomonas aeruginosa

Dan Wang, Xinxin Zhang, Liwen Yin, Qi Liu, Zhaoli Yu, Congjuan Xu, Zhenzhen Ma, Yushan Xia, Jing Shi, Yuehua Gong, Fang Bai, Zhihui Cheng, Weihui Wu, Jinzhong Lin, Yongxin Jin

PLoS Pathogens

DOI

2020

A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice

Jing Lu, Guoliang Lu, Shudan Tan, Jia Hui XIA, Hualong Xiong, Xiaofei Yu, Qingqing Qi, Xiang Yu, Li Li, Hang Yu, Ningshao Xia, Tianying Zhang, Yingjie Xu, Jinzhong Lin

Cell Research

DOI

2020

Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond

Ru‐Juan Liu, Tao Long, Hao Li, Jinghua Zhao, Jing Li, Mingzhu Wang, Andrés Palencia, Jinzhong Lin, S. Cusack, En‐Duo Wang

Nucleic Acids Research

DOI

2019

Structural basis for ribosome recycling by RRF and tRNA

Dejian Zhou, Takehito Tanzawa, Jinzhong Lin, Matthieu G. Gagnon

Nature Structural & Molecular Biology

DOI

2018

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

Jinzhong Lin, Dejian Zhou, Thomas A. Steitz, Yury S. Polikanov, Matthieu G. Gagnon

Annual Review of Biochemistry

DOI

2016

Natural selection on various sites of ribosomal proteins: a cladistic view

Haoyang Wu, Yang Liu, Yanhui Wang, Jinzhong Lin, Qiang Xie, Wenjun Bu

Zoological Systematics

2011

Structural diversity of eukaryotic 18S rRNA and its impact on alignment and phylogenetic reconstruction

Qiang Xie, Jinzhong Lin, Yan Qin, Jianfu Zhou, Wenjun Bu

Protein & Cell

会议论文

2019

核糖体的工作机理与人源体外翻译系统的全重构

林金钟

《中国生物化学与分子生物学会2019年全国学术会议暨学会成立四十周年论文集》

2019

原核生物翻译终止过程分子机理的研究

李丽，逯国亮，于朝丽，林金钟

《中国生物化学与分子生物学会2019年全国学术会议暨学会成立四十周年论文集》

2019

Reconstitution of human eukaryotic translation initiation factor 3 using a ribozyme-mediated polycistronic expression system

Yan Liu, Guoliang Lu, Jinzhong Lin

《中国生物化学与分子生物学会2019年全国学术会议暨学会成立四十周年》

2019

RNA Production using engineered ribozymes

Yuchen Chen, Yan Cheng, Jinzhong Lin

《中国生物化学与分子生物学会2019年全国学术会议暨学会成立四十周年》

2019

Biochemical characterization of cellular IRES using an in vitro reconstituted human cell-free translation system

Ye Li, Yan Liu, Shudan Tan, Jinghua Zhao, Zhaoli Yu, Li Li, Yuchen Chen, Jinzhong Lin

《中国生物化学与分子生物学会2019年全国学术会议暨学会成立四十周年论文集》

2013

A degenerate CCA-adding enzyme complex is involved in early assembly of yeast ribosome

Jinzhong Lin, Jing Lu, Keqiong Ye

《第四届中国结构生物学学术讨论会论文摘要集》

2009

Structural organization of box C/D RNA-guided RNA methyltransferase

Keqiong Ye, Ru Jia, Jinzhong Lin, Minghua Ju, Jin Peng, Anbi Xu, Liman Zhang

Abstracts of 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology

预印本

2025

Viral tRNA-like structure hijacks host ribosomes for poly(A)-independent translation

Guoliang Lu, Liming Wan, Yuchen Chen, Ye Li, Yajie Yan, Yan Liu, Jinzhong Lin

bioRxiv (Cold Spring Harbor Laboratory)

DOI

2024

Structural basis of translation in transcription-translation coupling

Jing Zhang, Guo‐Liang Lu, Wei Zhou, Vadim Molodtsov, Ziyun Cheng, Yu Zhang, Ruoxuan Li, Zhaoxuan Jiang, Mingxia Yang, Li Li, Huihui Shao, Wei Lin, Xiaogen Zhou, Richard H. Ebright, Jinzhong Lin, Chengyuan Wang

bioRxiv (Cold Spring Harbor Laboratory)

DOI

研究方向

核糖体结构与功能真核mRNA翻译起始及其调控核糖体靶向抗生素作用与耐药机制

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