李继喜｜复旦大学｜学者主页

期刊论文

2026

程序性细胞死亡在神经退行性疾病中的机制及其治疗潜能

GENG LU, 潘佳松, 李继喜

《中国科学:生命科学》

2026

Convergent TBK1 loss of function drives gasdermin E dependent pyroptosis and motor neuron degeneration across ALS genotypes.

Zi-Han Qi, Xue-He Liu, Lu Geng, Xiao-Ni Liu, Si-Qi Dong, Jia-Tong Li, Wen-Yi Hua, Yi-Fan Deng, Suo-Mei Lai, Yu-Hao Wang, Yu-Hong Xia, Yu Han, Dong-Qin Zhu, Xiang Zhang, Jin-Song Li, Jixi Li, Xiang-Jun Chen

Cell Death and Differentiation

DOI

2026

Mechanisms of programmed cell death in neurodegenerative diseases and their therapeutic potential

Lu Geng, Jiasong Pan, Jixi Li

Scientia Sinica Vitae

DOI

2025

RING1 dictates GSDMD-mediated inflammatory response and host susceptibility to pathogen infection

Yuanyuan Li, Wenqing Gao, Yuxin Qiu, Jiasong Pan, Qingqing Guo, Xue-He Liu, Lu Geng, Yajie Shen, Yi-Fan Deng, Zhi-Dong Hu, Suhua Li, Shanshan Liu, Adi Idris, Jin-Qing Huang, Hua Yang, Bao-Xue Ge, Xiaoyong Fan, Xiang-Jun Chen, Jixi Li

Cell Death and Differentiation

DOI

2025

The Mycobacterium tuberculosis ESX effector promotes pyroptosis-dependent pathogenicity and dissemination

Yajie Shen, Yifan He, Anke Chen, Yuanyuan Li, Yuhui Gao, Xue-He Liu, Lu Geng, Meng Ye, Yuxin Qiu, Lu Zhang, Yicheng Sun, Hua Yang, Jixi Li

bioRxiv

DOI

2025

Peptides alleviate cognitive impairment by inhibiting and disassembling amyloid-β aggregates in Alzheimer’s disease

Wenqing Gao, Bao-Cai Gao, Sen Wang, Dirong Wu, Pucheng Mei, Lu Geng, Chuhao Li, Yuanyuan Li, Xue-He Liu, Jiasong Pan, Jing Huang, Yi-Fan Deng, Xiangjun Chen, H. Saiyin, Hongbo Yu, Suhua Li, Qiuxin Zhang, Bing Xu, Fang Huang, Ming Chen, Hao Wu, Jixi Li

bioRxiv

DOI

2025

Necroptotic signaling orchestrates glioblastoma malignancy and potentiates temozolomide response

Yuanyuan Li, Yuxin Qiu, Wenqing Gao, Lu Geng, Ze-Rui Wu, Teng Zhang, Jiasong Pan, Jiang-Long Lu, Dan-Feng Zhang, Adi Idris, Li-Jun Hou, Zhi-Peng Su, Jixi Li

Cell Death and Disease

DOI

2025

Gasdermin E couples mitochondrial damage to pyroptotic neurodegeneration in Parkinson’s disease

Jiasong Pan, Lu Geng, Xue-He Liu, Ying-Lei Wang, Ning Fang, Feiyan Xie, Yajie Shen, Yi-Fan Deng, Yu Han, Suhua Li, Wenyong Xiong, Hua He, Ning-Yi Shao, Jian Wang, Jixi Li

bioRxiv

DOI

2025

Structural and functional characterization of P1L, an anti-apoptotic Bcl-2-like protein from monkeypox virus

Menglin Ye, Anke Chen, Jin Ding, Jixi Li

Biochemical and Biophysical Research Communications

DOI

2024

Transcription factor Sp1 transcriptionally enhances GSDME expression for pyroptosis

Jiasong Pan, Yuanyuan Li, Wenqing Gao, Qizhou Jiang, Lu Geng, Jin Ding, Suhua Li, Jixi Li

Cell Death and Disease

DOI

2024

ZBP1 condensate formation synergizes Z-NAs recognition and signal transduction

Feiyan Xie, Dirong Wu, Jing Huang, Xue-He Liu, Yanfang Shen, Jin-Qing Huang, Zhi-Peng Su, Jixi Li

Cell Death and Disease

DOI

2023

HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation

Erpeng Wu, Wen-tian He, Chenlu Wu, Zhangcheng Chen, Shuigeng Zhou, Xia-lian Wu, Zhiheng Hu, Kelong Jia, Jiasong Pan, Limin Wang, Jie Qin, Dan Liu, Jun-xia Lu, Hua-Yi Wang, Jixi Li, Sheng Wang, Liming Sun

Cell Research

DOI

2023

MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease

Lu Geng, Wenqing Gao, H. Saiyin, Yuanyuan Li, Yu Zeng, Zhi-Fei Zhang, Xue Li, Zuolong Liu, Qian Gao, Ping An, Ning Jiang, Xiao-Fei Yu, Xiang-Jun Chen, Suhua Li, Lei Chen, Boxun Lu, Aiqun Li, Guo-Yuan Chen, Yi-Dong Shen, Hai-Bing Zhang, Mei Tian, Zhuo-Hua Zhang, Jixi Li

Molecular Neurodegeneration

DOI

2023

Systematic pan-cancer analysis identifies gasdermin B as an immunological and prognostic biomarker for kidney renal clear cell carcinoma

Xue-He Liu, Feiyan Xie, Jin Ding, Suhua Li, Jixi Li

Frontiers in Oncology

DOI

2021

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

Wenqing Gao, Yuanyuan Li, Xue-He Liu, Sen Wang, Pucheng Mei, Zijun Chen, Kewei Liu, Suhua Li, Xuefan Xu, J. Gan, Jiaxue Wu, C. Ji, C. Ding, Xing Liu, Yu-Ping Lai, Hou-Sheng H. He, J. Lieberman, Hao Wu, Xiang-Jun Chen, Jixi Li

Cell Death and Differentiation

DOI

2021

E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis

Pucheng Mei, Feiyan Xie, Jiasong Pan, Sen Wang, Wenqing Gao, Rui Ge, Bao-Cai Gao, Si-Qi Gao, Xiang-Jun Chen, Yong-Ming Wang, Jiaxue Wu, C. Ding, Jixi Li

Cell Death and Differentiation

DOI

2020

Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation

Zijun Chen, Zheng-Yang Li, Xiaojian Hu, Feiyan Xie, Si-Yun Kuang, Bowen Zhan, Wenqing Gao, Xiang-Jun Chen, Si-Qi Gao, Yang Li, Yong-Ming Wang, Feng Qian, C. Ding, J. Gan, C. Ji, Xuefan Xu, Zheng Zhou, Jin-Qing Huang, Hou-Sheng H. He, Jixi Li

Advancement of science

DOI

2018

重新认识细胞焦亡

杨慧，李继喜

《科学》

2018

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

Miguel Mompeán, Wenbo Li, Jixi Li, Ségolène Laage, Ansgar B. Siemer, Günes Bozkurt, Hao Wu, Ann E. McDermott

Cell

DOI

2017

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

Si-Yun Kuang, Jun Zheng, Hui Yang, Suhua Li, Shu-Yan Duan, Yanfang Shen, C. Ji, J. Gan, Xue-Wei Xu, Jixi Li

Proceedings of the National Academy of Sciences of the United States of America

DOI

2017

Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling

Anni Kleino, Nancy F. Ramia, Günes Bozkurt, Yanfang Shen, Himani Nailwal, Jing Huang, Johanna Napetschnig, Monique Gangloff, Francis Ka-Ming Chan, Hao Wu, Jixi Li, Neal S. Silverman

Immunity

DOI

2015

Structural Biology of Innate Immunity

Qian Yin, Tian‐Min Fu, Jixi Li, Hao Wu

Annual Review of Immunology

DOI

2014

Structural basis of cell apoptosis and necrosis in TNFR signaling

Jing Huang, Shaoning Yu, Chaoneng Ji, Jixi Li

APOPTOSIS

DOI

2004

Over-expression of Bim α3, a novel isoform of human Bim, result in cell apoptosis

Jin-Zhong Chen, Chao-Neng Ji, Shaohua Gu, Jixi Li, En-Peng Zhao, Yan Xin Huang, Lu Huang, Kang Ying, Yi Xie, Yu-Min Mao

The International Journal of Biochemistry & Cell Biology

DOI

会议论文

2021

Phase separation of Gasdermin D regulates pyroptotic cell death

Wenqing Gao, Yuanyuan Li, Jixi Li

《2021年全国生物相分离和相变学术研讨会》

DOI

预印本

2025

NINJ1 promotes lung adenocarcinoma progression via activation of the PI3K-AKT signaling axis and suppression of cell death pathways

Jixi Li, Xuehe Liu, Zihan Qi, Yajie Shen, Yanjie Zhang, Feiyan Xie, Yuhong Xia, Weichen Yu, Quanhui Dai, Bing Tian Zhao, Jian Ding

Research Square

DOI

李继喜

精选作品

期刊论文

程序性细胞死亡在神经退行性疾病中的机制及其治疗潜能

Convergent TBK1 loss of function drives gasdermin E dependent pyroptosis and motor neuron degeneration across ALS genotypes.

Mechanisms of programmed cell death in neurodegenerative diseases and their therapeutic potential

RING1 dictates GSDMD-mediated inflammatory response and host susceptibility to pathogen infection

The Mycobacterium tuberculosis ESX effector promotes pyroptosis-dependent pathogenicity and dissemination

Peptides alleviate cognitive impairment by inhibiting and disassembling amyloid-β aggregates in Alzheimer’s disease

Necroptotic signaling orchestrates glioblastoma malignancy and potentiates temozolomide response

Gasdermin E couples mitochondrial damage to pyroptotic neurodegeneration in Parkinson’s disease

Structural and functional characterization of P1L, an anti-apoptotic Bcl-2-like protein from monkeypox virus

Transcription factor Sp1 transcriptionally enhances GSDME expression for pyroptosis

ZBP1 condensate formation synergizes Z-NAs recognition and signal transduction

HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation

MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease

Systematic pan-cancer analysis identifies gasdermin B as an immunological and prognostic biomarker for kidney renal clear cell carcinoma

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis

Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation

重新认识细胞焦亡

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling

Structural Biology of Innate Immunity

Structural basis of cell apoptosis and necrosis in TNFR signaling

Over-expression of Bim α3, a novel isoform of human Bim, result in cell apoptosis

会议论文

Phase separation of Gasdermin D regulates pyroptotic cell death

预印本

NINJ1 promotes lung adenocarcinoma progression via activation of the PI3K-AKT signaling axis and suppression of cell death pathways

研究方向