张慧芳｜山西医科大学｜学者主页

2026

Association between plasma metal element profiles and cognitive impairment in occupationally aluminum-exposed workers at a large aluminum plant in northern China

Xin Guo, Fangyu Gao, Mujia Li, Baolong Pan, Feng Gao, Shanshan Wang, Jingsi Zhang, Xiaoting Lu, Jing Song, Linping Wang, Huifang Zhang, Qiao Niu

The Journal of Prevention of Alzheimer s Disease

DOI

2026

The AMPK-PGC-1α-SIRT3 axis mediates mitochondrial metabolic dysfunction and neuronal senescence induced by Al(mal)3 exposure in HT22 hippocampal neuronal cells

Huifang Zhang, Xinrong Gao, Zhaoya Jin, Yang Liu, Jinzhu Yin, Rui Zhang

Free Radical Biology and Medicine

DOI

2026

FTO-mediated m6A demethylation regulates PGC-1α-dependent mitochondrial biogenesis to attenuate aluminum-induced neuronal senescence

Zhaoya Jin, Shuai Li, Jinzhu Yin, Xiaoyu He, Ru Wang, Yang Liu, Huifang Zhang

Scientific Reports

DOI

2026

The association between mixed exposure to multiple metals and the risk of abnormally elevated blood glucose among aluminum factory workers

Yifeng Zhang, Yulu Xin, Mujia Li, Hao Xu, Xin Guo, Linping Wang, Huifang Zhang, Jinzhu Yin, Xiaoting Lu, Baolong Pan, Jing Song

Environmental Geochemistry and Health

DOI

2026

Integrated Assessment of Internal Metal Mixtures and Plasma Neurodegeneration Biomarkers in Relation to Mild Cognitive Impairment among Aluminum Workers

Shanshan Wang, Nan Shang, Wanying Chen, Shuhui Zhang, Jingsi Zhang, Huaxing Meng, Xin Guo, Baolong Pan, Chanting He, Xiaoting Lu, Jing Song, Linping Wang, Huifang Zhang, Q. L. Niu

Environmental Science & Technology

DOI

2025

FTO调控m6A甲基化修饰p16在铝致小鼠学习记忆损伤中的作用

杨鹤，向长鑫，王茹，刘洋，殷金珠，张慧芳

《环境与职业医学》

2025

A moderated mediation of tau phosphorylated sites in the association between occupational aluminum exposure and cognitive function

Yujun Ma, Guangsen Feng, Shihui Guo, Jing Song, Linping Wang, Huifang Zhang, Jinzhu Yin, Xiaoting Lu

NeuroToxicology

DOI

2025

The effects of occupational aluminum exposure on blood pressure and blood glucose in workers – A longitudinal study in northern China

Lingshan Xue, Shihui Guo, Jiaping Huan, Chenyang Li, Jing Song, Linping Wang, Huifang Zhang, Baolong Pan, Q. L. Niu, Xiaoting Lu, Jinzhu Yin

Toxicology Letters

DOI

2024

PGC-1α介导的线粒体生物发生在铝致小鼠学习记忆能力损伤中的作用研究

贺小玉，向长鑫，王茹，刘洋，殷金珠，张慧芳

《职业与健康》

2024

The interaction between plasma polymetals and lifestyle on cognitive dysfunction in occupational aluminum exposed workers: A cross-sectional study in China

Tianshu Wang, Lingshan Xue, Chenyang Li, Dan Zhao, Jiaping Huan, Xiao Han, Jing Song, Linping Wang, Huifang Zhang, Q. L. Niu, Baolong Pan, Jinzhu Yin, Xiaoting Lu

NeuroToxicology

DOI

2024

A Bayesian network for estimating hypertension risk due to occupational aluminum exposure

Le Zhao, Jinzhu Yin, Jiaping Huan, Xiao Han, Dan Zhao, Jing Song, Linping Wang, Huifang Zhang, Baolong Pan, Q. L. Niu, Xiaoting Lu

Chronic Diseases and Translational Medicine

DOI

2023

GSK-3β在铝致原代海马神经元网络电活动损伤的机制初探

卢丽媛，李萌，贺小玉，路小婷，秦小江，张慧芳

《毒理学杂志》

2023

STAT3调控NLRP3炎症小体在麦芽酚铝致BV2细胞炎症反应中的作用

王天枢，高丹，赵丹，宦佳萍，韩笑，宋静，王林平，张慧芳，牛侨，路小婷

《环境与职业医学》

2022

铝作业工人执行功能变化及其影响因素

韩笑，宦佳萍，高丹，赵丹，宋静，王林平，张慧芳，牛侨，路小婷

《中国职业医学》

2022

微小RNA-29a/PTEN通路在铝致神经元网络损伤中的作用及机制

向长鑫，韩颖超，李萌，卢丽媛，牛侨，张慧芳

《环境与职业医学》

2022

职业铝暴露和饮酒种类及其交互作用对工人认知功能的影响

宦佳萍，韩笑，高丹，赵丹，宋静，王林平，张慧芳，牛侨，路小婷

《环境与职业医学》

2022

GSK-3β调控DRP1在铝致原代海马神经元突起生长抑制中的作用

李萌，卢丽媛，贺小玉，向长鑫，蔡小亚，张慧芳

《环境与职业医学》

2022

Forecasting and analysis of the effect of lifestyle on cognitive dysfunction induced by occupational aluminum exposure based on Bayesian networks

Dan Zhao, Xiao Han, Jiaping Huan, Dan Gao, Tianshu Wang, Jing Song, Linping Wang, Huifang Zhang, Tiane Luo, Baolong Pan, Q. L. Niu, Xiaoting Lu

Environmental Toxicology and Pharmacology

DOI

2022

Effect of GSK-3β-mediated DRP1 on inhibition of primary hippocampal neuronal growth induced by aluminum

Meng Li, Liyuan LU, Xiaoyu HE, Changxin Xiang, Xiaoya Cai, Huifang Zhang

DOAJ (DOAJ: Directory of Open Access Journals)

DOI

2022

Effects of occupational aluminum exposure, types of alcohol consumption, and their interaction on cognitive function of workers

Jiaping Huan, Xiao HAN, Dan GAO, Dan Zhao, jing song, Linping Wang, Huifang Zhang, Q. L. Niu, Xiaoting Lu

DOAJ (DOAJ: Directory of Open Access Journals)

DOI

2022

Blood glucose mediated the effects of cognitive function impairment related to aluminum exposure in Chinese aluminum smelting workers

Shimeng Xu, Baolong Pan, Dan Gao, Yunwei Zhang, Jiaping Huan, Xiao Han, Jing Song, Linping Wang, Huifang Zhang, Q. L. Niu, Xiaoting Lu

NeuroToxicology

DOI

2021

麦芽酚铝通过GSK-3β调控CRMP2致小鼠海马神经元突起损伤的作用研究

张慧芳，韩颖超，蔡小亚，向长鑫，牛侨

《环境与职业医学》

DOI

2021

miR-29a and the PTEN–GSK3β axis are involved in aluminum-induced damage to primary hippocampal neuronal networks

Huifang Zhang, Xiaoya Cai, Changxin Xiang, Yingchao Han, Q. L. Niu

Ecotoxicology and Environmental Safety

DOI

2021

The GSK-3β/β-Catenin Signaling–Mediated Brain–Derived Neurotrophic Factor Pathway Is Involved in Aluminum-Induced Impairment of Hippocampal LTP In Vivo

Huifang Zhang, Yingchao Han, Ling Zhang, Xiaofang Jia, Q. L. Niu

Biological Trace Element Research

DOI

2020

代谢型谷氨酸受体1对麦芽酚铝致大鼠突触可塑性调节作用

李亚芹，潘宝龙，傅晔，李亮，薛星莉，张慧芳，牛侨

《中国职业医学》

2019

慢性铝染毒对大鼠海马突触可塑性及神经连接蛋白1表达的影响

张淑惠，张慧芳，徐义荣，王姗姗，赵宇卿，牛侨

《环境与职业医学》

2019

The Relationship between Plasma Al Levels and Multi-domain Cognitive Performance among In-service Aluminum-exposed Workers at the SH Aluminum Factory in China: A Cross-sectional Study

Shanshan Wang, Huaxing Meng, Nan Shang, Junhong Guo, Ting Zhang, Shuhui Zhang, Yuqing Zhao, Huifang Zhang, Qinli Zhang, Q. L. Niu

NeuroToxicology

DOI

2018

砷、氟暴露对子代大鼠空间学习记忆和海马CA1区长时程增强的影响

马文彦，张慧芳，张林，陈诗奇，田晓琳，阎小艳，张文平，仇玉兰

《毒理学杂志》

2017

[Impact of chronic aluminum exposure on NMDAR1 in the cortex and peripheral blood lymphocytes in rats].

Pei Ren, Pan Kang, Zhaoyang Li, Huifang Zhang, Q. L. Niu

PubMed

2016

Caspase-3 is Involved in Aluminum-Induced Impairment of Long-Term Potentiation in Rats Through the Akt/GSK-3β Pathway

Huifang Zhang, Xiaojuan Yang, Xiujun Qin, Q. L. Niu

Neurotoxicity Research

DOI

2016

Effects of perfluorooctane sulfonate and its alternatives on long-term potentiation in the hippocampus CA1 region of adult rats in vivo

Qian Zhang, Wei Liu, Q. L. Niu, Yu Wang, Huimin Zhao, Huifang Zhang, Jing Song, Shuji Tsuda, Norimitsu Saito

Toxicology Research

DOI

2015

铝电解职业人群认知功能和基因甲基化关系研究

杨晓娟，张慧芳，原宇宙，牛侨

《中国职业医学》

2013

麦芽酚铝对大鼠在体海马长时程增强影响

宋静，张慧芳，刘莹，牛侨

《中国公共卫生》

张慧芳

精选作品

期刊论文

Association between plasma metal element profiles and cognitive impairment in occupationally aluminum-exposed workers at a large aluminum plant in northern China

The AMPK-PGC-1α-SIRT3 axis mediates mitochondrial metabolic dysfunction and neuronal senescence induced by Al(mal)3 exposure in HT22 hippocampal neuronal cells

FTO-mediated m6A demethylation regulates PGC-1α-dependent mitochondrial biogenesis to attenuate aluminum-induced neuronal senescence

The association between mixed exposure to multiple metals and the risk of abnormally elevated blood glucose among aluminum factory workers

Integrated Assessment of Internal Metal Mixtures and Plasma Neurodegeneration Biomarkers in Relation to Mild Cognitive Impairment among Aluminum Workers

FTO调控m6A甲基化修饰p16在铝致小鼠学习记忆损伤中的作用

A moderated mediation of tau phosphorylated sites in the association between occupational aluminum exposure and cognitive function

The effects of occupational aluminum exposure on blood pressure and blood glucose in workers – A longitudinal study in northern China

PGC-1α介导的线粒体生物发生在铝致小鼠学习记忆能力损伤中的作用研究

The interaction between plasma polymetals and lifestyle on cognitive dysfunction in occupational aluminum exposed workers: A cross-sectional study in China

A Bayesian network for estimating hypertension risk due to occupational aluminum exposure

GSK-3β在铝致原代海马神经元网络电活动损伤的机制初探

STAT3调控NLRP3炎症小体在麦芽酚铝致BV2细胞炎症反应中的作用

铝作业工人执行功能变化及其影响因素

微小RNA-29a/PTEN通路在铝致神经元网络损伤中的作用及机制

职业铝暴露和饮酒种类及其交互作用对工人认知功能的影响

GSK-3β调控DRP1在铝致原代海马神经元突起生长抑制中的作用

Forecasting and analysis of the effect of lifestyle on cognitive dysfunction induced by occupational aluminum exposure based on Bayesian networks

Effect of GSK-3β-mediated DRP1 on inhibition of primary hippocampal neuronal growth induced by aluminum

Effects of occupational aluminum exposure, types of alcohol consumption, and their interaction on cognitive function of workers

Blood glucose mediated the effects of cognitive function impairment related to aluminum exposure in Chinese aluminum smelting workers

麦芽酚铝通过GSK-3β调控CRMP2致小鼠海马神经元突起损伤的作用研究

miR-29a and the PTEN–GSK3β axis are involved in aluminum-induced damage to primary hippocampal neuronal networks

The GSK-3β/β-Catenin Signaling–Mediated Brain–Derived Neurotrophic Factor Pathway Is Involved in Aluminum-Induced Impairment of Hippocampal LTP In Vivo

代谢型谷氨酸受体1对麦芽酚铝致大鼠突触可塑性调节作用

慢性铝染毒对大鼠海马突触可塑性及神经连接蛋白1表达的影响

The Relationship between Plasma Al Levels and Multi-domain Cognitive Performance among In-service Aluminum-exposed Workers at the SH Aluminum Factory in China: A Cross-sectional Study

砷、氟暴露对子代大鼠空间学习记忆和海马CA1区长时程增强的影响

[Impact of chronic aluminum exposure on NMDAR1 in the cortex and peripheral blood lymphocytes in rats].

Caspase-3 is Involved in Aluminum-Induced Impairment of Long-Term Potentiation in Rats Through the Akt/GSK-3β Pathway

Effects of perfluorooctane sulfonate and its alternatives on long-term potentiation in the hippocampus CA1 region of adult rats in vivo

铝电解职业人群认知功能和基因甲基化关系研究

麦芽酚铝对大鼠在体海马长时程增强影响

书籍章节

Aluminum-Induced Electrophysiological Variation, Synaptic Plasticity Impairment, and Related Mechanism

Aluminum-Induced Electrophysiological Variation, Synaptic Plasticity Impairment, and Related Mechanism

研究方向