百晓学者学者目录

张长城

教授，三峡大学

个人简介

张长城，医学博士，博士后，三峡大学二级教授，博士研究生导师，入选湖北省“楚天英才计划”医疗卫生人才、三峡学者。主要研究方向为代谢与衰老相关机理及药物防治机制、生殖衰退机理及药物防治机理。主持国家级科研项目7项，作为主要完成人获湖北省科技进步一等奖2项，发表研究论文100余篇。

精选作品

期刊论文

2026

淫羊藿苷对高脂饮食诱导小鼠睾丸支持细胞紧密连接功能损伤的保护作用及机制

卯润敏，高子惠，赵海霞，李广森，付国庆，张长城

《天然产物研究与开发》

2026

High‐Fat Diet Induces Inflammatory Injury in Mice Sertoli Cells via the IRE1α / TRAF2 Axis to Activate the NF ‐ κB Signaling Pathway

Zihui Gao, Li Li, Xuliang Luo, Guoqing Fu, 毛润民, Yanan Qu, Jianming Sun, Haixia Zhao, Changcheng Zhang

The FASEB Journal

DOI

2026

ERα maintains the junctional function of testicular Sertoli cells by activating the PKR pathway via upregulation of c-Fos

Xiaoyu Ma, Zhaojun Yu, Yanna Yang, Zhili Yao, Jie Wu, Yanfen Fang, Jianming Sun, Jianmin Mao, Haixia Zhao, Changcheng Zhang

Molecular and Cellular Endocrinology

DOI

2025

淫羊藿苷通过调节mTORC1和mTORC2平衡改善衰老所致小鼠睾丸支持细胞紧密连接损伤

程窈婷，张长城，付国庆，王坦，毛剑敏，孙建明，赵海霞

《中国药理学通报》

2025

基于NF-κB/NLRP3信号通路研究高脂饮食对睾丸支持细胞紧密连接功能损伤的作用及机制

卯润敏，赵海霞，段海丽，高子惠，屈亚男，付国庆，毛剑敏，孙建明，张长城

《中国药理学通报》

2025

Corrigendum to “Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling” [J Ginseng Res, 2021 May;45(3):408–419]

Yan Ming Gao, Ding Yuan, Liyue Gai, Xuelian Wu, Yue Shi, Yumin He, Chaoqi Liu, Changcheng Zhang, Gang Zhou, Chengfu Yuan

Journal of Ginseng Research

DOI

2025

Retraction: Chikusetsu saponin IVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of NLRP3 inflammasome activation and NF-κB signaling

Chengfu Yuan, Chaoqi Liu, Ting Wang, Yumin He, Zhiyong Zhou, Yaoyan Dun, Haixia Zhao, Dongming Ren, Junjie Wang, Changcheng Zhang, Ding Yuan

Oncotarget

DOI

2024

D-半乳糖对小鼠睾丸TM4支持细胞连接功能损伤及淫羊藿素的改善作用研究

姚志丽，赵海霞，马小玉，付国庆，吴杰，宋来新，张长城

《中国药理学通报》

2024

Icariin alleviates the injury of Sertoli cell junction function by upregulating PKR pathway via ERα/c-fos signaling in aged mice

Xiaoyu Ma, Kaili Zhu, Zhili Yao, Ding Yuan, Jie Wu, Changcheng Zhang, Haixia Zhao

Journal of Ethnopharmacology

DOI

2023

基于Nrf2信号通路探讨黄精对自然衰老大鼠睾丸生精功能衰退的保护作用

赵海霞，叶勇，张长城，杨圆，张艳，韩岚

《中药材》

DOI

2023

从内质网应激研究高脂饮食对小鼠睾丸生精细胞凋亡的影响

周本文，张长城，邓何，陈思敏，常言语，杨焱娜，付国庆，袁丁，赵海霞

《中国药理学通报》

2023

棕榈酸诱导小鼠精原细胞株GC-1细胞凋亡的作用机制

邓何，赵海霞，周本文，常言语，陈思敏，杨焱娜，付国庆，张长城

《中国药理学通报》

2023

雌激素受体α下调导致小鼠睾丸TM4支持细胞连接功能损伤的作用机制

杨焱娜，张长城，常言语，周本文，陈思敏，邓何，赵海霞

《中国药理学通报》

2023

微囊藻毒素亮氨酸精氨酸(MC-LR)损伤睾丸支持细胞免疫反应及细胞生物学行为的机制研究进展

朱凯丽，张长城，邬小平，刘尚雨，赵雪怡，袁丁，赵海霞

《细胞与分子免疫学杂志》

2023

全氟辛酸诱导小鼠睾丸生精细胞凋亡过程中内质网应激途径的研究

陈思敏，赵海霞，杨圆，杨焱娜，周本文，常言语，邓何，张长城

《生态毒理学报》

2023

从肾脾相关理论探讨高脂饮食对男性生殖功能的影响

张长城，唐小涵，闫俊，郭煜晖

《湖北中医杂志》

2023

竹节参总皂苷减轻高脂饮食诱导的小鼠睾丸支持细胞连接功能损伤

周本文，张长城，邓何，陈思敏，常言语，杨焱娜，付国庆，袁丁，赵海霞

《南方医科大学学报》

2023

Saponins from Panax japonicus improve neuronal mitochondrial injury of aging rats

Cheng Fan, Jinxin Wang, Zhang-E. Xiong, Shanshan Hu, Ao-jia Zhou, Ding Yuan, Changcheng Zhang, Zhi-Yong Zhou, Ting Wang

Pharmaceutical Biology

DOI

2023

[The mechanism of microcystin leucine-arginine (MC-LR)-induced injury of Sertoli cell immune response and biological behavior].

Kaili Zhu, Changcheng Zhang, Xiaoping Wu, Shangyu Liu, Xueyi Zhao, Ding Yuan, Haixia Zhao

PubMed

2023

Wuzi Yanzong administration alleviates Sertoli cell injury by recovering AKT/mTOR-mediated autophagy and the mTORC1–mTROC2 balance in aging-induced testicular dysfunction

Yanyu Chang, He Deng, Yumin He, Benwen Zhou, Ding Yuan, Jie Wu, Changcheng Zhang, Haixia Zhao

Journal of Ethnopharmacology

DOI

2023

Perfluorooctanoic acid induces tight junction injury of Sertoli cells by blocking autophagic flux

Yuan Yang, Guoqing Fu, Xueyi Zhao, Xiaoping Wu, Kaili Zhu, Shangyu Liu, Ding Yuan, Jie Wu, Ting Wang, Changcheng Zhang, Haixia Zhao

Food and Chemical Toxicology

DOI

2023

Changes of Colon in Rats with Different Ages in Response to Lipopolysaccharide

Yanli Li, Yuhui Guo, Liu Aoqi, Chengquan Ma, Zhengguo Xiong, Ding Yuan, Changcheng Zhang, Jihong Zhang, Yaoyan Dun

Current Medicinal Chemistry

DOI

2023

Redox metabolism maintains the leukemogenic capacity and drug resistance of AML cells

Dan Huang, Changcheng Zhang, Ming Xiao, Xie Li, Wei-Cai Chen, Yu Jiang, Ya-Min Yuan, Yaping Zhang, Ye-Jun Zou, Lei Deng, Yang Wang, Yuying Sun, Wenping Dong, Zhuo Zhang, Li Xie, Zhuo Yu, Chi-Qi Chen, Li-Gen Liu, Jing Wang, Yi Yang, Jie Yang, Yu-Zheng Zhao, Jun-Ke Zheng

Proceedings of the National Academy of Sciences of the United States of America

DOI

2022

淫羊藿苷通过激活ATF6/c-fos信号通路改善自然衰老大鼠睾丸支持细胞功能减退的研究

朱凯丽，张长城，刘尚雨，赵雪怡，邬小平，袁丁，赵海霞

《中国药学杂志》

2022

乙醇雄性生殖损伤及中药保护的研究进展

邬小平，赵海霞，朱凯丽，赵雪怡，刘尚雨，张长城

《中药材》

DOI

2022

淫羊藿苷对博来霉素诱导的GC-1细胞DNA损伤的保护作用

赵雪怡，赵海霞，杨圆，杨思琪，袁丁，张长城

《中国细胞生物学学报》

2022

Relief Effects of Icariin on Inflammation-Induced Decrease of Tight Junctions in Intestinal Epithelial Cells

Yanli Li, Jie Liu, Pawin Pongkorpsakol, Zhengguo Xiong, Li Li, Xuemei Jiang, Haixia Zhao, Ding Yuan, Changcheng Zhang, Yuhui Guo, Yaoyan Dun

Frontiers in Pharmacology

DOI

2022

Changes in the tight junctions of the testis during aging: Role of the p38 MAPK/MMP9 pathway and autophagy in Sertoli cells

Qiongyan Ma, Xu You, Kaili Zhu, Xueyi Zhao, Ding Yuan, Ting Wang, Yaoyan Dun, Jie Wu, Dongming Ren, Changcheng Zhang, Haixia Zhao

Experimental Gerontology

DOI

2022

The Role of LncRNA TUG1 in Obesity-related Diseases

Mengzhen Xue, Fangqi Xia, Yaqi Wang, Leiqi Zhu, Yuanyang Li, Dengke Jia, Yan Ming Gao, Yue Shi, Changcheng Zhang, Yumin He, Chaoqi Liu, Ding Yuan, Chengfu Yuan

Mini-Reviews in Medicinal Chemistry

DOI

2022

Icariin attenuates perfluorooctane sulfonate-induced testicular toxicity by alleviating Sertoli cell injury and downregulating the p38MAPK/MMP9 pathway

Yan Zhang, Xiaoping Wu, Kaili Zhu, Shangyu Liu, Yuan Yang, Ding Yuan, Ting Wang, Yumin He, Yaoyan Dun, Jie Wu, Changcheng Zhang, Haixia Zhao

Food & Function

DOI

2021

Protective effects of saponins from Panax japonicus on neurons of the colon myenteric plexus in aging rats through reduction of α-synuclein through endoplasmic reticulum stress

Yuhui Guo, Zhihao Cheng, Jie Liu, Yumin He, Zhengguo Xiong, Ding Yuan, Yaoyan Dun, Changcheng Zhang

Geriatrics & Gerontology International，Vol. 210, No. 10

DOI

2021

三种GC-1细胞DNA损伤模型的建立及比较分析

杨思琪，赵海霞，尤旭，马琼艳，杨圆，张艳，叶勇，吴杰，袁丁，张长城

《中国药理学通报》

2021

肾气丸对自然衰老大鼠睾丸支持细胞紧密连接功能损伤的保护作用及其机制研究

张艳，张长城，杨圆，吴杰，袁丁，赵海霞

《中药新药与临床药理》

DOI

2021

五子衍宗方对衰老大鼠睾丸支持细胞紧密连接损伤的保护作用及机制

马琼艳，张长城，杨圆，张艳，吴杰，袁丁，赵海霞

《中成药》

2021

Activation of NLRP3-Caspase-1 pathway contributes to age-related impairments in cognitive function and synaptic plasticity

Ting Wang, Bo Ruan, Jinxin Wang, Zhiyong Zhou, Xulan Zhang, Changcheng Zhang, Haixia Zhao, Yuan‐Jian Yang, Ding Yuan

Neurochemistry International

DOI

2021

The dynamic changes of Nrf2 mediated oxidative stress, DNA damage and base excision repair in testis of rats during aging

Haixia Zhao, Laixin Song, Na Ma, Chaoqi Liu, Yaoyan Dun, Zhiyong Zhou, Ding Yuan, Changcheng Zhang

Experimental Gerontology

DOI

2021

Saponins from Panax japonicus alleviate HFD-induced impaired behaviors through inhibiting NLRP3 inflammasome to upregulate AMPA receptors

Jinxin Wang, Dongfan Wang, Zhiyong Zhou, Xulan Zhang, Changcheng Zhang, Yumin He, Chaoqi Liu, Chengfu Yuan, Ding Yuan, Ting Wang

Neurochemistry International

DOI

2021

Common markers of testicular Sertoli cells

Xu You, Qian Chen, Ding Yuan, Changcheng Zhang, Haixia Zhao

Expert Review of Molecular Diagnostics

DOI

2021

The preventive effect of total saponins from Panax japonicus on inflammation and insulin resistance in adipose tissue of mice induced by a high-fat diet

Yue Shi, Zhengtai Liu, Liyue Gai, Yan Ming Gao, Yumin He, Chaoqi Liu, Changcheng Zhang, Gang Zhou, Ding Yuan, Chengfu Yuan

Journal of Functional Foods

DOI

2021

Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway

Jie Zheng, Shanshan Hu, Jinxin Wang, Xulan Zhang, Ding Yuan, Changcheng Zhang, Chaoqi Liu, Ting Wang, Zhiyong Zhou

Pharmaceutical Biology

DOI

2021

Caloric restriction ameliorates high-fat diet induced cognitive deficits through attenuating neuroinflammation via the TREM2-PI3K/AKT signaling pathway

Rui Wang, Zhiyong Zhou, Dongfan Wang, Qingqing Zhao, Changcheng Zhang, Chaoqi Liu, Haixia Zhao, Chengfu Yuan, Ding Yuan, Ting Wang

Food & Function

DOI

2021

Saponins from Panax japonicus attenuate cognitive impairment in ageing rats through regulating microglial polarisation and autophagy

Xuejiao Pi, Qingqing Zhao, Jinxin Wang, Xu-lan Zhang, Ding Yuan, Shanshan Hu, Yumin He, Changcheng Zhang, Zhi-Yong Zhou, Ting Wang

Pharmaceutical Biology

DOI

2020

增龄对大鼠睾丸自噬水平和血睾屏障完整性的影响

尤旭，赵海霞，马琼艳，杨思琪，张艳，杨圆，叶勇，袁丁，张长城

《中国药理学通报》

2020

Panax notoginseng Saponins Attenuate Neuroinflammation through TXNIP-Mediated NLRP3 Inflammasome Activation in Aging Rats

Zhiyong Zhou, Menghan He, Qingqing Zhao, Dongfan Wang, Changcheng Zhang, Chaoqi Liu, Haixia Zhao, Yaoyan Dun, Yumin He, Chengfu Yuan, Ding Yuan, Ting Wang

Current Pharmaceutical Biotechnology

DOI

2020

[D-galactose (D-gal) disrupts barrier function of murine TM4 sertoli cells via activation of p38MAPK signaling pathway].

Yuan Yang, Changcheng Zhang, Yan Zhang, Siqi Yang, Yong Ye, Jie Wu, Ding Yuan, Haixia Zhao

PubMed

2020

MiR-155/GSK-3β mediates anti-inflammatory effect of Chikusetsusaponin IVa by inhibiting NF-κB signaling pathway in LPS-induced RAW264.7 cell

Yi Xin, Qin Yuan, Chaoqi Liu, Changcheng Zhang, Ding Yuan

Scientific Reports

DOI

2020

Chlorogenic Acid Suppresses miR‐155 and Ameliorates Ulcerative Colitis through the NF‐κB/NLRP3 Inflammasome Pathway

Junhao Zeng, Dengqing Zhang, Xiaoyu Wan, Yuanling Bai, Chengfu Yuan, Ting Wang, Ding Yuan, Changcheng Zhang, Chaoqi Liu

Molecular Nutrition & Food Research

DOI

2020

Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR‐34a/Cyclin‐Dependent Kinase 6

Yue Qin, Li Duan, Yumin He, Chengfu Yuan, Ting Wang, Ding Yuan, Changcheng Zhang, Chaoqi Liu

Molecular Nutrition & Food Research

DOI

2020

Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling

Yan Ming Gao, Ding Yuan, Liyue Gai, Xuelian Wu, Yue Shi, Yumin He, Chaoqi Liu, Changcheng Zhang, Gang Zhou, Chengfu Yuan

Journal of Ginseng Research

DOI

2020

Icariin Improves Age-Related Testicular Dysfunction by Alleviating Sertoli Cell Injury via Upregulation of the ERα/Nrf2-Signaling Pathway

Haixia Zhao, Xu You, Qian Chen, Siqi Yang, Qiongyan Ma, Yumin He, Chaoqi Liu, Yaoyan Dun, Jie Wu, Changcheng Zhang, Ding Yuan

Frontiers in Pharmacology

DOI

2020

Changes of Wnt/β-catenin signalling, BMP2, and BMP4 in the jejunum during ageing in rats

Yaoyan Dun, Jing Chen, Jie Liu, Yuhui Guo, Changcheng Zhang, Ding Yuan

Arab Journal of Gastroenterology

DOI

2019

淫羊藿总黄酮改善自然衰老大鼠睾丸支持细胞分泌功能衰退的作用

陈茜，张长城，韩贵芳，马娜，袁丁，赵海霞

《中国药理学与毒理学杂志》

2019

竹节参总皂苷改善高脂饮食诱导的小鼠睾丸生殖功能障碍

马琼艳，张长城，杨思琪，尤旭，杨圆，张艳，叶勇，袁丁，赵海霞

《中国药理学通报》

2019

淫羊藿苷激活Nrf2/HO-1信号通路减轻自然衰老大鼠睾丸生殖细胞DNA损伤研究

尤旭，赵海霞，杨思琪，马琼艳，张艳，杨圆，叶勇，袁丁，张长城

《中草药》

2019

Saponins of Panax japonicus Confer Neuroprotection against Brain Aging through Mitochondrial Related Oxidative Stress and Autophagy in Rats

Jingzhi Wan, Rui Wang, Zhi-yong Zhou, Lili Deng, Changcheng Zhang, Chaoqi Liu, Haixia Zhao, Chengfu Yuan, Yumin He, Yaoyan Dun, Ding Yuan, Ting Wang

Current Pharmaceutical Biotechnology

DOI

2019

Decline in testicular function in ageing rats: Changes in the unfolded protein response and mitochondrial apoptotic pathway

Haixia Zhao, Na Ma, Qian Chen, Xu You, Chaoqi Liu, Ting Wang, Ding Yuan, Changcheng Zhang

Experimental Gerontology

DOI

2019

[Improved effects of saponins from Panax japonicus on decline of cognitive function in natural aging rats via NLRP3 inflammasome pathway].

Bo Ruan, Rui Wang, Yuan‐Jian Yang, Dongfan Wang, Jiawen Wang, Changcheng Zhang, Ding Yuan, Zhi-Yong Zhou, Ting Wang

PubMed

DOI

2019

[Triterpene saponins in Panax japonicus and their ~(13)C-NMR spectroscopic characteristics].

Yumin He, Ke Ai, HE Chun-xi, Changcheng Zhang, Ding Yuan, San-Jin Cai

PubMed

DOI

2019

Distinct expression patterns of aging effects on the UPRER signaling pathway in rat colon and regulatory role of saponins from Panax japonicus.

Yaoyan Dun, Zhihao Cheng, Jie Liu, Yuhui Guo, Yumin He, Zhengguo Xiong, Ding Yuan, Changcheng Zhang

PubMed

2018

三七总皂苷与淫羊藿总黄酮联合对自然衰老大鼠睾丸生殖功能衰退的影响

杜丽娜，王超，王芳，韩泽宇，袁丁，张长城，赵海霞

《中国中医药信息杂志》

2018

肾气丸对自然衰老大鼠睾丸生殖功能衰退的保护作用及机制研究

韩泽宇，王芳，王超，杜丽娜，袁丁，张长城，赵海霞

《中国新药杂志》

2018

竹节参总皂苷对自然衰老大鼠生殖功能减退的保护作用

王芳，韩泽宇，杜丽娜，王超，袁丁，张长城，赵海霞

《中国新药杂志》

2018

淫羊藿总黄酮通过AMPK/SIRT1/NFκB信号通路减轻自然衰老大鼠睾丸组织炎症反应

韩贵芳，张长城，陈茜，马娜，袁丁，赵海霞

《天然产物研究与开发》

2018

齐墩果酸对自然衰老大鼠睾丸DNA损伤保护作用及机制研究

马娜，张长城，陈茜，刘珍财，韩贵芳，刘静，袁丁，赵海霞

《天然产物研究与开发》

2018

Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling

Luo-Pei Wang, Ding Yuan, Jie Zheng, Xue-Cui Wu, Juntao Wang, Xiu Liu, Yumin He, Changcheng Zhang, Chaoqi Liu, Ting Wang, Zhiyong Zhou

Phytomedicine

DOI

2018

Protective effect of Wuzi Yanzong recipe on testicular dysfunction through inhibition of germ cell apoptosis in ageing rats via endoplasmic reticulum stress

Haixia Zhao, Na Ma, Zhaoqi Liu, Ting Wang, Chengfu Yuan, Yumin He, Yaoyan Dun, Zhiyong Zhou, Ding Yuan, Changcheng Zhang

Andrologia

DOI

2018

[Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-β1/Smad3 signaling pathway in aging rats].

Yanan Song, Luo-Pei Wang, Jie Zheng, Changcheng Zhang, Ting Wang, Ding Yuan, Zhi-Yong Zhou

PubMed

DOI

2018

[Protective effect of Wuzi Yanzong recipe on testicular germ cell apoptosis in natural ageing rats through endoplasmic reticulum stress].

Na Ma, Changcheng Zhang, Qian Chen, Qiongyan Ma, Xu You, Siqi Yang, Ding Yuan, Haixia Zhao

PubMed

DOI

2018

[Protective effects of total saponins of Panax japonicas on non-alcoholic fatty liver disease through regulating expression of miR-199-5p].

Xiong Hai-Rong, Cong Li, HE Chun-xi, Yumin He, Chengfu Yuan, Ting Wang, Changcheng Zhang, Ding Yuan, Chaoqi Liu

PubMed

DOI

2018

Chikusetsusaponin V Inhibits LPS-Activated Inflammatory Responses via SIRT1/NF-κB Signaling Pathway in RAW264.7 Cells

Qin Yuan, Dengqing Zhang, Chaoqi Liu, Changcheng Zhang, Ding Yuan

Inflammation

DOI

2018

[Protective effect of Wuzi Yanzong recipe on testicular DNA oxidative damage in natural ageing rats].

Na Ma, Haixia Zhao, Qian Chen, Xu You, Qiongyan Ma, Siqi Yang, Ding Yuan, Changcheng Zhang

PubMed

DOI

2018

[Protective effect of Wuzi Yanzong recipe on testicular DNA damage and apoptosis in natural ageing rats].

Na Ma, Haixia Zhao, Qian Chen, Guifang Han, Zhen-Cai Liu, Ding Yuan, Changcheng Zhang

PubMed

DOI

2018

[Decline of secretory function of TM4 Sertoli cells stimulated by D-galactose in mice and its mechanism].

Qian Chen, Haixia Zhao, Na Ma, Xu You, Siqi Yang, Qiongyan Ma, Ding Yuan, Changcheng Zhang

PubMed

2018

[Protective effects of total saponins of Panax japonicas on HepG2 cell apoptosis induced with palmitic acid].

Hao Tu, Qin Zhou, Xun Zhang, Ting Wang, Chengfu Yuan, Changcheng Zhang, Ding Yuan, Zhaoqi Liu

PubMed

DOI

2017

五子衍宗方对自然衰老大鼠睾丸损伤的保护作用及其机制研究

刘珍财，赵海霞，马娜，陈茜，袁丁，张长城

《中药材》

DOI

2017

[Effect of saponins extracted from Panax japonicus on inhibiting cardiomyocyte apoptosis by AMPK/Sirt1/NF-κB signaling pathway in aging rats].

Yanan Song, Ding Yuan, Changcheng Zhang, Luo-Pei Wang, Yumin He, Ting Wang, Zhi-Yong Zhou

PubMed

DOI

2017

Panax notoginseng saponins attenuate cardiomyocyte apoptosis through mitochondrial pathway in natural aging rats

Zhiyong Zhou, Jiao Wang, Yanan Song, Yumin He, Changcheng Zhang, Chaoqi Liu, Haixia Zhao, Yaoyan Dun, Ding Yuan, Ting Wang

Phytotherapy Research

DOI

2017

Chikusetsu saponin IVa ameliorates high fat diet-induced inflammation in adipose tissue of mice through inhibition of NLRP3 inflammasome activation and NF-κB signaling

Chengfu Yuan, Chaoqi Liu, Ting Wang, Yumin He, Zhiyong Zhou, Yaoyan Dun, Haixia Zhao, Dongming Ren, Junjie Wang, Changcheng Zhang, Ding Yuan

Oncotarget

DOI

2017

[Protective effect of total saponins of Panax notoginseng combined with total flavonoids of epimedium on D-galactose-incuced senescence of H9c2 cell].

Jin Li, Lili Deng, Zhi-Yong Zhou, Ding Yuan, Changcheng Zhang, Ting Wang

PubMed

DOI

2017

Regulatory effects of saponins from Panax japonicus on colonic epithelial tight junctions in aging rats

Yaoyan Dun, Min Liu, Jing Chen, Danli Peng, Haixia Zhao, Zhiyong Zhou, Ting Wang, Chaoqi Liu, Yuhui Guo, Changcheng Zhang, Ding Yuan

Journal of Ginseng Research

DOI

2017

Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways

Yuan‐Jian Yang, Ting Wang, Lili Deng, Ding Yuan, Zhi-yong Zhou, Jingzhi Wan, Changcheng Zhang, Chaoqi Liu, Yaoyan Dun, Haixia Zhao, Bo Zhao

Neural Regeneration Research

DOI

2016

淫羊藿总黄酮对自然衰老大鼠睾丸细胞凋亡及p-P53、p-P38表达的影响

宋来新，赵海霞，袁丁，王拥军，张长城

《中药材》

DOI

2016

三七总皂苷对自然衰老大鼠睾丸炎症反应和生殖细胞凋亡的影响

刘静，张长城，韩贵芳，刘珍财，袁丁，赵海霞

《中药新药与临床药理》

2016

Oleanolic acid rejuvenates testicular function through attenuating germ cell DNA damage and apoptosis via deactivation of NF-κB, p53 and p38 signalling pathways

Haixia Zhao, Jing Liu, Laixin Song, Zhencai Liu, Guifang Han, Ding Yuan, Ting Wang, Yaoyan Dun, Zhiyong Zhou, Zhaoqi Liu, Yongjun Wang, Changcheng Zhang

Journal of Pharmacy and Pharmacology

DOI

2016

Preventive effects of total saponins of Panax japonicus on fatty liver fibrosis in mice

Ding Yuan, Tingting Xiang, Yuanxiu Huo, Chaoqi Liu, Ting Wang, Zhiyong Zhou, Yaoyan Dun, Haixia Zhao, Changcheng Zhang

Archives of Medical Science

DOI

2016

[The preventive effect of total saponins of Panax japonicus on nonsteroidal anti-inflammatory drug-induced enteropathy].

Ying Mei, Zhaozhao Xiao, Jinwu Feng, Ting Wang, Changcheng Zhang, Ding Yuan, Chaoqi Liu

PubMed

2016

Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through Sirt1/PGC-1α/Mn-SOD signaling pathways

Jingzhi Wan, Lili Deng, Changcheng Zhang, Qin Yuan, Jing Liu, Yaoyan Dun, Zhiyong Zhou, Haixia Zhao, Chaoqi Liu, Yuan Ding, Ting Wang

Canadian Journal of Physiology and Pharmacology

DOI

2016

Vaccine adjuvant ginsenoside Rg1 enhances immune responses against hepatitis B surface antigen in mice

Yuan Ding, Qin Yuan, Qianqian Cui, Chaoqi Liu, Zhiyong Zhou, Hai-Xia Zhao, Yaoyan Dun, Ting Wang, Changcheng Zhang

Canadian Journal of Physiology and Pharmacology

DOI

2015

精原干细胞与睾丸生殖衰老的研究进展

彭奔，李靳，刘苗苗，张长城

《现代生物医学进展》

2015

精原干细胞niche的研究进展

李靳，彭奔，刘苗苗，邓丽丽，张长城

《现代生物医学进展》

2015

MiRNA-194 Regulates Palmitic Acid-Induced Toll-Like Receptor 4 Inflammatory Responses in THP-1 Cells

Huiqun Tian, Chaoqi Liu, Xiaohua Zou, Wei Wu, Changcheng Zhang, Ding Yuan

Nutrients

DOI

2015

Saponins from P anax japonicus attenuate D-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats

Ting Wang, Guojie Di, Li Yang, Yaoyan Dun, Zhiwei Sun, Jingzhi Wan, Ben Peng, Chaoqi Liu, Xiong Guangrun, Changcheng Zhang, Ding Yuan

Journal of Pharmacy and Pharmacology

DOI

2015

Icariin Intervenes in Cardiac Inflammaging through Upregulation of SIRT6 Enzyme Activity and Inhibition of the NF-Kappa B Pathway

Yang Chen, Tao Sun, Junzhen Wu, Bill Kalionis, Changcheng Zhang, Ding Yuan, Jianhua Huang, Waijiao Cai, Hong Fang, Shijin Xia

BioMed Research International

DOI

2014

Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-κB, Sirt1 and mitogen-activated protein kinase signalling pathways and inhibition of inflammation

Na Wei, Changcheng Zhang, Haibo He, Ting Wang, Zhaoqi Liu, Guangyao Liu, Zhiwei Sun, Zhiyong Zhou, Cai-hong Bai, Ding Yuan

Journal of Pharmacy and Pharmacology

DOI

2014

Chikusetsu Saponin V Attenuates MPP+-Induced Neurotoxicity in SH-SY5Y Cells via Regulation of Sirt1/Mn-SOD and GRP78/Caspase-12 Pathways

Ding Yuan, Jingzhi Wan, Lili Deng, Changcheng Zhang, Yaoyan Dun, Yanwen Dai, Zhi-Yong Zhou, Chaoqi Liu, Ting Wang

International Journal of Molecular Sciences

DOI

2013

五子衍宗方对实验性隐睾小鼠复位固定术后生精功能恢复的影响

曾晓，袁丁，王婷，刘苗苗，狄国杰，张海滨，李靳，刘朝奇，张长城

《中国中医基础医学杂志》

2013

Protective Effects of Total Flavonoids from Epimedium on the Male Mouse Reproductive System Against Cyclophosphamide‐Induced Oxidative Injury by Up‐Regulating the Expressions of SOD3 and GPX1

Ding Yuan, Hongwu Wang, Haibo He, Liangliang Jia, Yumin He, Ting Wang, Xiao Zeng, Yuzhou Li, Shouchao Li, Changcheng Zhang

Phytotherapy Research

DOI

2011

Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats

Haibo He, Jia Ming Stella Xu, Yuanqing Xu, Changcheng Zhang, Hongwu Wang, Yumin He, Ting Wang, Yuan Ding

Journal of Ethnopharmacology

DOI

2011

[Effects of polysaccharides isolated from Panax japonicus on immunosuppression mice].

Changcheng Zhang, Haixia Zhao, Meijie Jiang, Hongwu Wang, Yu-min He, Xiao Rong Zeng, Ding Yuan

PubMed

2011

The Development of Extraction,Separation and Assay of Polysaccharides

Changcheng Zhang

Shipin yanjiu yu kaifa

2011

Immuno-regulation Effects of Wuzi Yanzong Decoction on Immunosuppression Mice

Changcheng Zhang

Zhongguo shiyan fangjixue zazhi

2010

五子衍宗汤对环磷酰胺致小鼠生精障碍保护作用的研究

张长城，贾亮亮，许佳，孙志伟，曾晓，何毓敏，袁丁，王洪武

《中国中医基础医学杂志》

DOI

2010

The pharmacological research advance of Icariin.

Jia Liangliang, Yuan Ding, Hongwu Wang, Yumin He, Changcheng Zhang

Xiandai shengwu yixue jinzhan

2010

Immunoregulatory Effects of Total Flavones of Epimedium on Immunosuppression Mice

Changcheng Zhang

Tianjin yiyao

2010

Research Advances on Panax japonicus and its Approximation Varieties in Tujia Nationality

Changcheng Zhang

《农业科学与技术：英文版》

2009

Effect of total saponins of Panax Japonicus on expression of serum TNF-α and IL-1β in rheumatoid arthritis rats.

Ding Yuan, Jao Qi, Changcheng Zhang

Shandong yiyao

2009

Determination of Oleanolic Acid in Panax japonicus by RP-HPLC

Yanwen Liu, Changcheng Zhang

Zhongguo yaofang

2008

精原干细胞移植技术及其应用的研究进展

姜美杰，张小鹏，张长城

《中国计划生育学杂志》

2008

Inhibitory Effect of Total Saponins of Panax japonicus on the Proliferation of Synoviocytes in Collagen-induced Arthritis Rats

Changcheng Zhang

Lishizhen Medicine and Materia Medica Research

2008

Determination of total saponins and oleanolic acid in traditional Chinese medicine Rhizoma Panacis Japonici

Changcheng Zhang

Huaxi yaoxue zazhi

2008

Inhibitory Effect of Saponins of Spina Gleditsiae on the Proliferation of PC-3 Cell

Changcheng Zhang

Tianjin yiyao

2008

Research Progress on the Anti-inflammatory Effects of Saponins

Changcheng Zhang

Lishizhen Medicine and Materia Medica Research

2004

精索静脉曲张性不育的病机探讨

张长城，周安方

《中国中医基础医学杂志》

2003

实验性精索静脉曲张对大鼠睾丸生精细胞凋亡的影响

张长城，周安方，张茂林，曹继刚

《中华男科学杂志》

2003

[Effects of experimental varicocele on the apoptosis of spermatogenic cells in rats].

Changcheng Zhang, An-fang Zhou, Maolin Zhang, Jigang Cao

PubMed

研究方向

代谢与衰老相关机理及药物防治机制生殖衰退机理及药物防治机理

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