百晓学者学者目录

陈实

副教授、博士生导师、教授、讲师，武汉大学

精选作品

期刊论文

2026

Phage hijacks host phosphorothioate DNA modification machinery to circumvent bacterial Ssp defences

Yifei Wang, Haoyi Yang, Lixu Jiang, Yashi Ge, Yuhang Zhong, Hui Chu, Kuo Zhang, Kadierya Kuerban, Yuan Nong, Haiyan Gao, Congrui Xu, Xiaoyu Li, Shi Chen, Lianrong Wang

Nature Microbiology

DOI

2025

DNA硫修饰基础理论突破驱动合成生物学系统创新

帅玉婷，韩照晰，贺新义，王连荣，陈实，邓子新，刘光

《生物工程学报》

DOI

2025

Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells

Shi Chen, Yuanyuan He, Lejun Lv, Bei Liu, Cheng Li, Hongkui Deng, Jun Xu

Science China Life Sciences

2025

Microneedle Patches Loaded with cRGD-Modified pH-Sensitive Hydroxycamptothecin Liposomes for Melanoma Therapy

Xiaoju Zhou, Chengyuan Wang, Haojie Ke, Rui Zhang, Xiaoya Yu, Wei Li, Shi Chen, Lianrong Wang

Molecular Pharmaceutics

DOI

2025

Microglial Membrane‐Coated Biomimetic Nanoplatform for Enhanced Blood–Brain Barrier Penetration and Targeted Photodynamic Therapy in Orthotopic Glioblastoma

Jie Li, Xiaoyu Xu, Yuhang Zhao, Xuan Wu, Siyu Chen, Siyu Chen, Jiange Xu, Rong Xiao, Jing Ping Tang, Xuechuan Hong, Shi Chen, Shi Chen, Zhiqiang Li, Meijia Gu

Advanced Healthcare Materials

DOI

2025

Mechanistic insights into JSS1_004-mediated antagonism of the DndBCDE-FGH restriction system and engineering applications

Yu He, Susu Jiang, Fang Wang, Junwu Bi, Shi-Pian Li, Fuliang Yin, Shi Chen, Chao Chen, Lianrong Wang

mBio

DOI

2025

Diagnosis of Drug-Resistant Tuberculosis: Rapid Evaluation of Drug Susceptibility with Nanopore Targeted Sequencing

Jun Chen, Qijing Fan, Shiwei Gong, Jianjian Guo, Youyi Rao, Lifeng Chen, Ying Wang, Rui Jin Liao, Zhengbin Zhang, Chang Liu, Ming Hua Wu, Shi Chen, Yi Ren

Clinical Chemistry

DOI

2025

Top-down bioinspired nanotheranostics with AIE luminogens

Xiaoyu Xu, Luojia Chen, Liupiaopiao Yang, Baoping Li, Yujin Kim, Changyu Yoon, Jiyoung Yoo, Lianrong Wang, Shi Chen, Meijia Gu, Jong Seung Kim

Coordination Chemistry Reviews

DOI

2025

Illuminating oral health: AIEgens for phototheranostics

Jingyuan Chen, Wenhao Yan, Xinyu Wang, Chen Gao, Ziyu Hong, Zhiqiang Li, Lin Wang, Qihang Ding, Shi Chen, Zhen Cheng, Meijia Gu

Cell Biomaterials

DOI

2025

A DNA phosphorothioation pathway via adenylated intermediate modulates Tdp machinery

Tianchen An, Qian Tan, Lixu Jiang, Li Liu, Xing Yu Jiang, Liying Liu, Xiaofei Chang, Xihao Tian, Zixin Deng, Shuai Gao, Lianrong Wang, Shi Chen

Nature Chemical Biology

DOI

2024

A widespread phage-encoded kinase enables evasion of multiple host antiphage defence systems

Susu Jiang, Chao Chen, Wanqiu Huang, Yue He, Xuan Du, Yi Wang, Hongda Ou, Zixin Deng, Congrui Xu, Lixu Jiang, Lianrong Wang, Shi Chen

Nature Microbiology

DOI

2024

Molecular basis of the phosphorothioation-sensing antiphage defense system IscS–DndBCDE–DndI

Yaqian Tang, Dan Wu, Yueying Zhang, Xuan Liu, Hui Chu, Qian Tan, Lixu Jiang, Shi Chen, Geng Wu, Lianrong Wang

Nucleic Acids Research

DOI

2024

Overcoming Bacteriophage Contamination in Bioprocessing: Strategies and Applications

Xuan Zou, Ziran Mo, Lianrong Wang, Shi Chen, Sang Yup Lee

Small Methods

DOI

2024

Endo‐Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1 ‐Null Rat Hippocampus

Yajie Wang, Yuting Yang, Ying Cai, Ayikaimaier Aobulikasimu, Yuexin Wang, Chuanwei Hu, Zhikang Miao, Yue Shao, Mengna Zhao, Yue Hu, Chang Xu, Xinjun Chen, Zhiqiang Li, Jincao Chen, Lianrong Wang, Shi Chen

Advanced Science

DOI

2024

The Guardian of Vision: Intelligent Bacteriophage‐Based Eyedrops for Clinical Multidrug‐Resistant Ocular Surface Infections

Luojia Chen, Mingyu Wu, Si‐Ling Chen, Si‐Ling Chen, Rui Hu, Yifei Wang, Weijuan Zeng, Shun Feng, Min Ke, Lianrong Wang, Shi Chen, Shi Chen, Meijia Gu

Advanced Materials

DOI

2024

The Compromised Fanconi Anemia Pathway in Prelamin A‐Expressing Cells Contributes to Replication Stress‐Induced Genomic Instability

Pengqing Nie, Cheng Zhang, Fengyi Wu, Shi Chen, Lianrong Wang

Advanced Science

DOI

2024

C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport

Yachen Wu, Wenzhong Zheng, Guofeng Xu, Lijun Zhu, Zhiqiang Li, Jincao Chen, Lianrong Wang, Shi Chen

Cell Death and Differentiation

DOI

2023

A Membrane‐Targeted Photosensitizer Prevents Drug Resistance and Induces Immune Response in Treating Candidiasis

Mingyu Wu, Xiaoyu Xu, Rui Min Hu, Qingrong Chen, Luojia Chen, Yuncong Yuan, Jie Li, Li Zhou, Shun Feng, Lianrong Wang, Shi Chen, Meijia Gu

Advanced Science

DOI

2023

Aggregation-induced emission: recent applications in infectious diseases

Meijia Gu, Luojia Chen, Rui Hu, Qingrong Chen, Jianbo Liu, Lianrong Wang, Shi Chen

Science China Chemistry

DOI

2023

A DNA phosphorothioation-based Dnd defense system provides resistance against various phages and is compatible with the Ssp defense system

Susu Jiang, Ke Chen, Yingying Wang, Yueying Zhang, Yaru Tang, Wanqiu Huang, Xiaolin Xiong, Shi Chen, Chao Chen, Lianrong Wang

mBio

DOI

2023

Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats

Yajie Wang, Zhikang Miao, Chang Xu, Ying Cai, Yuting Yang, Yue Hu, Mengna Zhao, Yue Shao, Zhiqiang Li, Jincao Chen, Shi Chen, Lianrong Wang

Cell Death and Disease

DOI

2023

Engineered Phage with Aggregation‐Induced Emission Photosensitizer in Cocktail Therapy against Sepsis (Adv. Mater. 6/2023)

Mingyu Wu, Luojia Chen, Qingrong Chen, Rui Hua Hu, Xiaoyu Xu, Yifei Wang, Jie Li, Shun Feng, Changjiang Dong, Xiao‐Lian Zhang, Zhiqiang Li, Lianrong Wang, Shi Chen, Meijia Gu

Advanced Materials

DOI

2023

The DNA Phosphorothioation Restriction-Modification System Influences the Antimicrobial Resistance of Pathogenic Bacteria

Congrui Xu, Jing Rao, Yuqing Xie, Jiajun Lu, Zhiqiang Li, Changjiang Dong, Lianrong Wang, Jinghong Jiang, Chao Chen, Shi Chen

Microbiology Spectrum

DOI

2022

Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE

Haiyan Gao, Xinqi Gong, Jinchuan Zhou, Yubing Zhang, Jinsong Duan, Yue Wei, Liuqing Chen, Zixin Deng, Jiawei Wang, Shi Chen, Geng Wu, Lianrong Wang

Nature Communications

DOI

2022

Systematic strategies for developing phage resistant Escherichia coli strains

Xuan Zou, Xiaohong Xiao, Ziran Mo, Yashi Ge, Xing Yu Jiang, Ruolin Huang, Mengxue Li, Zixin Deng, Shi Chen, Lianrong Wang, Sang Yup Lee

Nature Communications

DOI

2022

The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex

Dan Wu, Yaqian Tang, Siwei Chen, Yue He, Yue He, Xiaofei Chang, Wenzhong Zheng, Zixin Deng, Zhiqiang Li, Lianrong Wang, Geng Wu, Shi Chen, Shi Chen

Nature Catalysis

DOI

2022

Engineered Phage with Aggregation‐Induced Emission Photosensitizer in Cocktail Therapy against Sepsis

Mingyu Wu, Luojia Chen, Qingrong Chen, Rui Hu, Xiaoyu Xu, Yifei Wang, Jie Li, Shun Feng, Changjiang Dong, Xiao‐Lian Zhang, Zhiqiang Li, Lianrong Wang, Shi Chen, Meijia Gu

Advanced Materials

DOI

2022

Microfluidics-Assisted Fluorescence Mapping of DNA Phosphorothioation

Qinqin Huang, Xingxiang Chen, Xingxiang Chen, Qian‐Fang Meng, Ludan Yue, Wei Jiang, Xingzhong Zhao, Lang Rao, Xiaoyuan Shawn Chen, Xiaoyuan Shawn Chen, Shi Chen

Analytical Chemistry

DOI

2022

DDX18 prevents R-loop-induced DNA damage and genome instability via PARP-1

Wen-Ling Lin, Jung-Kuei Chen, Xuemei Wen, Wei He, Geovanny A. Zarceno, Yutian Chen, Shi Chen, Tanya T. Paull, Hung‐wen Liu

Cell Reports

DOI

2022

Simultaneous Photodynamic Eradication of Tooth Biofilm and Tooth Whitening with an Aggregation‐Induced Emission Luminogen

Meijia Gu, Susu Jiang, Xiaoyu Xu, Mingyu Wu, Chao Chen, Yuncong Yuan, Qingrong Chen, Yidan Sun, Luojia Chen, Chao Shen, Peng Guo, Shujie Liu, Engui Zhao, Shi Chen, Sijie Chen

Advanced Science

DOI

2022

Involvement of the DNA Phosphorothioation System in TorR Binding and Anaerobic TMAO Respiration in Salmonella enterica

You Tang, Yue Hong, Li Liu, Xuan Du, Yaqi Ren, Susu Jiang, Wanjing Liu, Chao Chen, Zixin Deng, Lianrong Wang, Shi Chen

mBio

DOI

2022

C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α

Wenzhong Zheng, Kexin Wang, Yachen Wu, Yan Ge, Chi Zhang, Zhiqiang Li, Lianrong Wang, Shi Chen

Theranostics

DOI

2021

AIFM1, negatively regulated by miR-145-5p, aggravates hypoxia-induced cardiomyocyte injury

Wugang Zhou, LV Ji, Xuqin Liu, Dan Tu, Ning-ning Shi, Wangmu Yangqu, Shi Chen, Pingjin Gao, Hong Zhu, Cheng‐Chao Ruan

Biomedical Journal

DOI

2021

SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System

Shiwei Wang, Mengping Wan, Ruolin Huang, Yujing Zhang, Yuqing Xie, Yue Wei, Mustafa Ahmad, Dan Wu, Yue Hong, Zixin Deng, Shi Chen, Zhiqiang Li, Lianrong Wang

mBio

DOI

2021

Single-molecule optical mapping of the distribution of DNA phosphorothioate epigenetics

Yue Wei, Qinqin Huang, Xihao Tian, Mingmin Zhang, Junkai He, Xingxiang Chen, Chao Chen, Zixin Deng, Zhiqiang Li, Shi Chen, Lianrong Wang

Nucleic Acids Research

DOI

2021

Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner

Cheng Zhang, Pengqing Nie, Chunliu Zhou, Yue Hu, Suling Duan, Meijia Gu, Dongxu Jiang, Yunfu Wang, Zixin Deng, Jincao Chen, Shi Chen, Lianrong Wang

Cell Death and Disease

DOI

2020

Epigenetic competition reveals density-dependent regulation and target site plasticity of phosphorothioate epigenetics in bacteria

Xiaolin Wu, Bo Cao, Patricia Aquino, Tsu-Pei Chiu, Chao Chen, Susu Jiang, Zixin Deng, Shi Chen, Remo Rohs, Lianrong Wang, James E. Galagan, Peter C. Dedon

Proceedings of the National Academy of Sciences

DOI

2020

Advances in drug development for targeted therapies for glioblastoma

Yan Ge, Yunfu Wang, Jincao Chen, Wenzhong Zheng, Changzhen Liu, Shi Chen, Lianrong Wang, Jie Luo, Zhiqiang Li

Medicinal Research Reviews

DOI

2020

Structural Analysis of an l -Cysteine Desulfurase from an Ssp DNA Phosphorothioation System

Liqiong Liu, Susu Jiang, Xing Mai, Chao Chen, Chongde Lai, Na Li, Guangfeng Liu, Dan Wu, Haiyan Gao, Liang Hong, Pan Tan, Shi Chen, Zixin Deng, Geng Wu, Lianrong Wang

mBio

DOI

2020

SspABCD–SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities

Xiaolin Xiong, Geng Wu, Yue Wei, Liqiong Liu, Yubing Zhang, Rui Su, Xianyue Jiang, Mengxue Li, Haiyan Gao, Xihao Tian, Yizhou Zhang, Li Hu, Si Chen, You Tang, Susu Jiang, Ruolin Huang, Zhiqiang Li, Yunfu Wang, Zixin Deng, Jiawei Wang, Peter C. Dedon, Shi Chen, Lianrong Wang

Nature Microbiology

DOI

2019

基因组学技术解码天然产物合成

池淏甜，陈实

《生物工程学报》

DOI

2019

A new type of DNA phosphorothioation-based antiviral system in archaea

Lei Xiong, Siyi Liu, Si Chen, Si Chen, Yao Xiao, Bochen Zhu, Yali Gao, Yujing Zhang, Beibei Chen, Jie Luo, Zixin Deng, Xiangdong Chen, Lianrong Wang, Shi Chen, Shi Chen

Nature Communications

DOI

2019

Advances in CRISPR-Cas systems for RNA targeting, tracking and editing

Fei Wang, Lianrong Wang, Xuan Zou, Suling Duan, Zhiqiang Li, Zixin Deng, Jie Luo, Sang Yup Lee, Shi Chen

Biotechnology Advances

DOI

2019

The Biological Applications of Two Aggregation‐Induced Emission Luminogens

Meijia Gu, Zixuan Zeng, Xing Mai, Yige Xiong, Zixin Deng, Shi Chen, Lianrong Wang

Biotechnology Journal

DOI

2019

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

Zhiqiang Deng, Junghyun Lim, Qian Wang, Kerry Purtell, Shuai Wu, Gloria M. Palomo, Haiyan Tan, Giovanni Manfredi, Yanxiang Zhao, Junmin Peng, Bo Hu, Shi Chen, Zhenyu Yue

Autophagy

DOI

2019

Sam50–Mic19–Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact

Junhui Tang, Kuan Zhang, Jun Dong, Chaojun Yan, Chao Hu, Hongchao Ji, Liangyi Chen, Shi Chen, Huabin Zhao, Zhiyin Song

Cell Death and Differentiation

DOI

2019

Gut microbiome interventions in human health and diseases

Pengqing Nie, Zhiqiang Li, Yimeng Wang, Yubing Zhang, Mengna Zhao, Jie Luo, Shiming Du, Zixin Deng, Jincao Chen, Yunfu Wang, Shi Chen, Lianrong Wang

Medicinal Research Reviews

DOI

2018

肠道微生物组与宿主的表观遗传修饰

熊智，王连荣，陈实

《微生物学报》

2018

Surgery-free video-oculography in mouse models: enabling quantitative and short-interval longitudinal assessment of vestibular function

Xiaojie Yang, Shiyue Zhou, Jiaojiao Wu, Qun Liao, Changquan Wang, Minghua Liu, Lei Qu, Yuan Zhang, Cheng Cheng, Renjie Chai, Kun Zhang, Xiaojie Yu, Pingbo Huang, Lian Liu, Wei Xiong, Shi Chen, Fangyi Chen

Neuroscience Letters

DOI

2018

Tight control of genomic phosphorothioate modification by the ATP‐modulated autoregulation and reusability of DndB

Sisi Xia, Jun Chen, Liqiong Liu, Yue Wei, Zixin Deng, Lianrong Wang, Shi Chen

Molecular Microbiology

DOI

2018

Engineering and modification of microbial chassis for systems and synthetic biology

Haotian Chi, Xiaoli Wang, Yue Shao, Ying Qin, Zixin Deng, Lianrong Wang, Shi Chen

Synthetic and Systems Biotechnology

DOI

2018

Genetic mechanisms of arsenic detoxification and metabolism in bacteria

Ge Yan, Xingxiang Chen, Shiming Du, Zixin Deng, Lianrong Wang, Shi Chen

Current Genetics

DOI

2018

DNA phosphorothioate modification—a new multi-functional epigenetic system in bacteria

Lianrong Wang, Susu Jiang, Zixin Deng, Peter C. Dedon, Shi Chen

FEMS Microbiology Reviews

DOI

2018

Recent Advances in the Genomic Profiling of Bacterial Epigenetic Modifications

Liqiong Liu, Yizhou Zhang, Dongxu Jiang, Shiming Du, Zixin Deng, Lianrong Wang, Shi Chen

Biotechnology Journal

DOI

2018

Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology

Fenglei Jian, Dan Chen, Li Chen, Chaojun Yan, Bin Lü, Yushan Zhu, Shi Chen, Anbing Shi, David C. Chan, Zhiyin Song

Cell Reports

DOI

2018

Signature Arsenic Detoxification Pathways in Halomonas sp. Strain GFAJ-1

Shuangju Wu, Lianrong Wang, Rui Gan, Tong Tong, Hao Bian, Zhiqiang Li, Shiming Du, Zixin Deng, Shi Chen

mBio

DOI

2018

Gemin5 plays a role in unassembled‐U1 sn RNA disposal in SMN ‐deficient cells

Dongxu Jiang, Xuan Zou, Cheng Zhang, Jincao Chen, Zhiqiang Li, Yunfu Wang, Zixin Deng, Liangrong Wang, Shi Chen

FEBS Letters

DOI

2018

Occurrence, evolution, and functions of DNA phosphorothioate epigenetics in bacteria

Tong Tong, Si Chen, Lianrong Wang, You Tang, Jae Yong Ryu, Susu Jiang, Xiaolin Wu, Chao Chen, Jie Luo, Zixin Deng, Zhiqiang Li, Sang Yup Lee, Shi Chen

Proceedings of the National Academy of Sciences

DOI

2018

Gelatin Nanoparticle-Coated Silicon Beads for Density-Selective Capture and Release of Heterogeneous Circulating Tumor Cells with High Purity

Qinqin Huang, Xinghuan Wang, Chunhui Yuan, Zhaobo He, Lang Rao, Bo Cai, Bolei Chen, Susu Jiang, Zhiqiang Li, Jincao Chen, Wei Liu, Feng Guo, Zheng Ao, Shi Chen, Xingzhong Zhao

Theranostics

DOI

2017

微生物基因组:浩瀚的海洋

陈实

《微生物学报》

2017

细菌CRISPR-Cas系统的研究进展

胡丽，陈实

《微生物学报》

2017

单分子实时测序及其在微生物表观遗传学中的应用

葛元洁，陈实

《微生物学通报》

2017

Nanotechnology-Based Strategies for Early Cancer Diagnosis Using Circulating Tumor Cells as a Liquid Biopsy

Qinqin Huang, Yin Wang, Xingxiang Chen, Yimeng Wang, Zhiqiang Li, Shiming Du, Lianrong Wang, Shi Chen

Nanotheranostics

DOI

2017

Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?

Zhiqiang Deng, Patricia Sheehan, Shi Chen, Zhenyu Yue

Molecular Neurodegeneration

DOI

2017

Synthetic Genomics: From DNA Synthesis to Genome Design

Lianrong Wang, Susu Jiang, Chao Chen, Wei He, Xiaolin Wu, Fei Wang, Tong Tong, Xuan Zou, Zhiqiang Li, Jie Luo, Zixin Deng, Shi Chen

Angewandte Chemie International Edition

DOI

2017

Synthetische Genomik: von der DNA‐Synthese zu Designer‐Genomen

Lianrong Wang, Susu Jiang, Chao Chen, Wei He, Xiaolin Wu, Fei Wang, Tong Tong, Xuan Zou, Zhiqiang Li, Jie Luo, Zixin Deng, Shi Chen

Angewandte Chemie

DOI

2017

Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes

Chao Chen, Lianrong Wang, Si Chen, Xiaolin Wu, Meijia Gu, Xi Chen, Susu Jiang, Yunfu Wang, Zixin Deng, Peter C. Dedon, Shi Chen

Proceedings of the National Academy of Sciences

DOI

2017

Behavioral methods for the functional assessment of hair cells in zebrafish

Qin Yang, Peng Sun, Shi Chen, Hongzhe Li, Fangyi Chen

Frontiers of Medicine

DOI

2017

Genome Engineering and Modification Toward Synthetic Biology for the Production of Antibiotics

Xuan Zou, Lianrong Wang, Zhiqiang Li, Jie Luo, Yunfu Wang, Zixin Deng, Shiming Du, Shi Chen

Medicinal Research Reviews

DOI

2017

Autophagy Receptors and Neurodegenerative Diseases

Zhiqiang Deng, Kerry Purtell, Véronik Lachance, Mitchell S. Wold, Shi Chen, Zhenyu Yue

Trends in Cell Biology

DOI

2016

基因组磷硫酰化修饰的研究进展及展望

高雅丽，邓子新，陈实

《微生物学报》

2016

SAMM 50 Affects Mitochondrial Morphology through the Association of Drp1 in Mammalian Cells

Shuo Liu, Yali Gao, Cheng Zhang, Han Li, Shiyi Pan, Xiaoli Wang, Shiming Du, Zixin Deng, Lianrong Wang, Zhiyin Song, Shi Chen

FEBS Letters

DOI

2016

Testis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76

Xiaoli Wang, Han Li, Guolong Fu, Yunfu Wang, Shiming Du, Long Yu, Youheng Wei, Shi Chen

Scientific Reports

DOI

2016

Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology

Yajie Wang, Fengyi Wu, Haining Pan, Wenzhong Zheng, Chi Ting Feng, Yunfu Wang, Zixin Deng, Lianrong Wang, Jie Luo, Shi Chen

Scientific Reports

DOI

2015

Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure

Cheng-Li Ding, Zhifei Wu, Lei Haley Huang, Yajie Wang, Jie Xue, Si Chen, Zixin Deng, Lianrong Wang, Zhiyin Song, Shi Chen

Scientific Reports

DOI

2014

Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences

Bo Cao, Chao Chen, Michael S. DeMott, Qiuxiang Cheng, Tyson A. Clark, Xiaolin Xiong, Xiaoqing Zheng, Vincent L. Butty, Stuart S. Levine, George Yuan, Matthew Boitano, Khai Luong, Yi Song, Xiufen Zhou, Zixin Deng, Stephen W. Turner, Jonas Korlach, Delin You, Lianrong Wang, Shi Chen, Peter C. Dedon

Nature Communications

DOI

2014

Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance

Yanlian Chen, Zhiqiang Deng, Shuai Jiang, Qian Hu, Haiying Liu, Zhou Songyang, Wenbin Ma, Shi Chen, Yong Bo Zhao

Nucleic Acids Research

DOI

2014

Tssk4 is essential for maintaining the structural integrity of sperm flagellum

Xiaoli Wang, Youheng Wei, Guolong Fu, Haitao Li, Hexige Saiyin, Gang Lin, Zhugang Wang, Shi Chen, Long Yu

Molecular Human Reproduction

DOI

2014

DNA phosphorothioate modifications influence the global transcriptional response and protect DNA from double-stranded breaks

Rui Gan, Xiaolin Wu, Wei He, Zhenhua Liu, Shuangju Wu, Chao Chen, Si Chen, Qianrong Xiang, Zixin Deng, Dequan Liang, Shi Chen, Lianrong Wang

Scientific Reports

DOI

2014

In Vivo Mutational Characterization of DndE Involved in DNA Phosphorothioate Modification

Chongde Lai, Xiaolin Wu, Chao Chen, Teng Huang, Xiaolin Xiong, Shuangju Wu, Meijia Gu, Zixin Deng, Xi Chen, Shi Chen, Lianrong Wang

PLoS ONE

DOI

2014

PINK1 and Its Familial Parkinson's Disease-Associated Mutation Regulate Brain Vascular Endothelial Inflammation

Wang Yunfu, Liu Guangjian, Ping Zhong, Sun Yanpeng, Fang Xiaoxia, Wei Ming Hu, Yuan Jiang, Hu Jingquan, Wang Songlin, Zhang Hongyan, Liu Yong, Shi Chen

Journal of Molecular Neuroscience

DOI

2011

DNA phosphorothioation is widespread and quantized in bacterial genomes

Lianrong Wang, Shi Chen, Kevin L. Vergin, Stephen J. Giovannoni, Simon W. Chan, Michael S. DeMott, Koli Taghizadeh, Otto X. Cordero, Michael Cutler, Sonia C. Timberlake, Eric J. Alm, Martin F. Polz, Jarone Pinhassi, Zixin Deng, Peter C. Dedon

Proceedings of the National Academy of Sciences

DOI

2008

基因工程FR-008/杀念菌素脱羧衍生物发酵过程优化

杨亮，毛相朝，周文瑜，陈实，沈亚领，邓子新，魏东芝

《中国抗生素杂志》

预印本

2024

Recent Advances in Phototheranostics of Oral Diseases

Jingyuan Chen, Wenhao Yan, Xinyu Wang, Chen Gao, Ziyu Hong, Zhiqiang Li, Lin Wang, Shi Chen, Zhen Cheng, Meijia Gu, Qihang Ding

DOI

书籍章节

2011

Phosphorothioation: An Unusual Post-Replicative Modification on the DNA Backbone

Lianrong Wang, Shi Chen, Zixin Deng

InTech eBooks

DOI

研究方向

基因组修饰编辑与合成生物学宿主抗病原防御与表观遗传机制工程细胞与创新药物设计改造

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