章翔宇｜中国药科大学｜学者主页

2026

贝美前列素治疗眉毛稀少症的临床应用进展

黄夏梦，陈兆波，章翔宇，吕萍，黄雪群，黄自通，陈滔彬

《今日药学》

2026

Discovery of Novel Dual Small-Molecule Inhibitors Targeting SHP2 and NAMPT for Overcoming Resistance to Allosteric SHP2 Inhibition

Kaizhen Wang, Yijiao Liu, Zhiyi Zhang, Yingxin Hu, Yuhua Zhong, Sheng Jiang, Xiangyu Zhang, Kuojun Zhang, Tianyu Wang

Journal of Medicinal Chemistry

DOI

2025

Discovery, Synthesis, and Activity Evaluation of Novel Small-Molecule Inhibitors Targeting VISTA for Cancer Immunotherapy

Zhihao Qi, Yao Cheng, Kaizhen Wang, Shi Cai, Xiang Ni, Tianyu Wang, Kuojun Zhang, Sheng Jiang, Yibei Xiao, Xiangyu Zhang

Journal of Medicinal Chemistry

DOI

2024

Discovery of novel phenyl urea SHP2 inhibitors with anti-colon cancer and potential immunomodulatory effects

Kaizhen Wang, Xiangyu Zhang, Yingxin Hu, Jiazheng Guo, Guoqing Shen, Kuojun Zhang, Sheng Jiang, Tianyu Wang

European Journal of Medicinal Chemistry

DOI

2024

Discovery of small molecules for autophagy-lysosome degradation of immune checkpoint proteins

Kaizhen Wang, Kaizhen Wang, Zhihao Qi, Jiazheng Guo, Guoqing Shen, Xiang Ni, Sheng Jiang, Kuojun Zhang, Tianyu Wang, Xiangyu Zhang

European Journal of Medicinal Chemistry

DOI

2024

Discovery of Benzo[d]oxazoles as Novel Dual Small-Molecule Inhibitors Targeting PD-1/PD-L1 and VISTA Pathway

Kaizhen Wang, Shi Cai, Yao Cheng, Zhihao Qi, Xiang Ni, Kuojun Zhang, Yibei Xiao, Xiangyu Zhang, Tianyu Wang

Journal of Medicinal Chemistry

DOI

2024

Rising Star in Immunotherapy: Development and Therapeutic Potential of Small-Molecule Inhibitors Targeting Casitas B Cell Lymphoma-b (Cbl-b)

Lixin Zhou, Jiamei Yang, Kuojun Zhang, Tianyu Wang, Sheng Jiang, Xiangyu Zhang

Journal of Medicinal Chemistry

DOI

2024

Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours

Xiangyu Zhang

Natural Product Reports

DOI

2023

Discovery of Novel PD-L1 Inhibitors That Induce the Dimerization, Internalization, and Degradation of PD-L1 Based on the Fragment Coupling Strategy

Kaizhen Wang, Xiangyu Zhang, Yao Cheng, Zhihao Qi, Ke Ye, Kuojun Zhang, Sheng Jiang, Yi Liu, Yibei Xiao, Tianyu Wang

Journal of Medicinal Chemistry

DOI

2023

Novel Benzimidazoles as Potent Small-Molecule Inhibitors and Degraders of V-Domain Ig Suppressor of T-Cell Activation (VISTA)

Tianyu Wang, Kaizhen Wang, Yu Zhang, Kuojun Zhang, Shi Cai, Sheng Jiang, Yibei Xiao, Xiangyu Zhang

Journal of Medicinal Chemistry

DOI

2023

Recent advances of targeting nicotinamide phosphoribosyltransferase (NAMPT) for cancer drug discovery

He Tang, Lin Wang, Tianyu Wang, Jiamei Yang, Shuai Zheng, Jun Tong, Sheng Jiang, Xiangyu Zhang, Kuojun Zhang

European Journal of Medicinal Chemistry

DOI

2023

Design, synthesis, and evaluation of PD-1/PD-L1 small-molecule inhibitors bearing a rigid indane scaffold

Shi Cai, Kaizhen Wang, Zhihao Qi, Ke Ye, Xinyuan Zhou, Sheng Jiang, Kuojun Zhang, Xiangyu Zhang, Tianyu Wang

European Journal of Medicinal Chemistry

DOI

2023

Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors

Kuojun Zhang, Ke Ye, He Qi Tang, Zhihao Qi, Tianyu Wang, Jie Mao, Xiangyu Zhang, Sheng Jiang

Journal of Medicinal Chemistry

DOI

2023

Design, synthesis, biological evaluation of urea substituted 1,2,5-oxadiazole-3-carboximidamides as novel indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors

Ke Ye, Kaizheng Wang, Tianyu Wang, He Tang, Lin Wang, Wanheng Zhang, Wanheng Zhang, Sheng Jiang, Xiangyu Zhang, Kuojun Zhang

European Journal of Medicinal Chemistry

DOI

2023

Dual Nicotinamide Phosphoribosyltransferase (NAMPT) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors for the Treatment of Drug-Resistant Nonsmall-Cell Lung Cancer

Kaizhen Wang, Ke Ye, Xiangyu Zhang, Tianyu Wang, Zhihao Qi, Youjun Wang, Sheng Jiang, Kuojun Zhang

Journal of Medicinal Chemistry

DOI

2023

Beyond inhibition against the PD-1/PD-L1 pathway: development of PD-L1 inhibitors targeting internalization and degradation of PD-L1

Jiazheng Guo, Fengyi Yu, Kuojun Zhang, Sheng Jiang, Xiangyu Zhang, Tianyu Wang

RSC Medicinal Chemistry

DOI

2023

Discovery of diaminotriazine carboxamides as potent inhibitors of hematopoetic progenitor kinase 1

Lixin Zhou, Xiuquan Ye, Kaizhen Wang, Hongtao Shen, Tianyu Wang, Xiangyu Zhang, Sheng Jiang, Yibei Xiao, Kuojun Zhang

Bioorganic Chemistry

DOI

2022

The development of small-molecule inhibitors targeting HPK1

Lixin Zhou, Tianyu Wang, Kuojun Zhang, Xiangyu Zhang, Sheng Jiang

European Journal of Medicinal Chemistry

DOI

2022

Development of Inhibitors Targeting the V-Domain Ig Suppressor of T Cell Activation Signal Pathway

Shuai Zheng, Kuojun Zhang, Xiangyu Zhang, Yibei Xiao, Tianyu Wang, Sheng Jiang

Journal of Medicinal Chemistry

DOI

2022

Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer

Kuojun Zhang, Kaizhen Wang, Xiangyu Zhang, Zhenlong Qian, Wenbo Zhang, Xiao Zheng, Jiaying Wang, Yin Jiang, Wanheng Zhang, Zhiyu Lu, Haiping Hao, Sheng Jiang

Journal of Medicinal Chemistry

DOI

2020

Cyclin-dependent Kinase 7 Inhibitors in Cancer Therapy

Minmin Wang, Tianyu Wang, Xiangyu Zhang, Xiaoxing Wu, Sheng Jiang

Future Medicinal Chemistry

DOI

章翔宇

精选作品

期刊论文

贝美前列素治疗眉毛稀少症的临床应用进展

Discovery of Novel Dual Small-Molecule Inhibitors Targeting SHP2 and NAMPT for Overcoming Resistance to Allosteric SHP2 Inhibition

Discovery, Synthesis, and Activity Evaluation of Novel Small-Molecule Inhibitors Targeting VISTA for Cancer Immunotherapy

Discovery of novel phenyl urea SHP2 inhibitors with anti-colon cancer and potential immunomodulatory effects

Discovery of small molecules for autophagy-lysosome degradation of immune checkpoint proteins

Discovery of Benzo[d]oxazoles as Novel Dual Small-Molecule Inhibitors Targeting PD-1/PD-L1 and VISTA Pathway

Rising Star in Immunotherapy: Development and Therapeutic Potential of Small-Molecule Inhibitors Targeting Casitas B Cell Lymphoma-b (Cbl-b)

Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours

Discovery of Novel PD-L1 Inhibitors That Induce the Dimerization, Internalization, and Degradation of PD-L1 Based on the Fragment Coupling Strategy

Novel Benzimidazoles as Potent Small-Molecule Inhibitors and Degraders of V-Domain Ig Suppressor of T-Cell Activation (VISTA)

Recent advances of targeting nicotinamide phosphoribosyltransferase (NAMPT) for cancer drug discovery

Design, synthesis, and evaluation of PD-1/PD-L1 small-molecule inhibitors bearing a rigid indane scaffold

Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors

Design, synthesis, biological evaluation of urea substituted 1,2,5-oxadiazole-3-carboximidamides as novel indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors

Dual Nicotinamide Phosphoribosyltransferase (NAMPT) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors for the Treatment of Drug-Resistant Nonsmall-Cell Lung Cancer

Beyond inhibition against the PD-1/PD-L1 pathway: development of PD-L1 inhibitors targeting internalization and degradation of PD-L1

Discovery of diaminotriazine carboxamides as potent inhibitors of hematopoetic progenitor kinase 1

The development of small-molecule inhibitors targeting HPK1

Development of Inhibitors Targeting the V-Domain Ig Suppressor of T Cell Activation Signal Pathway

Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer

Cyclin-dependent Kinase 7 Inhibitors in Cancer Therapy

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