百晓学者学者目录

陈思

副教授、博士生导师、硕士生导师，海南大学

精选作品

期刊论文

2026

抗菌肽在牛大肠杆菌病防治中的应用

许会会，张东，张如，倪佳，高阳，陈思，杨艳玲

《动物医学进展》

2026

布鲁菌双重TaqMan荧光定量PCR检测方法的建立及初步应用

彭海涛，高阳，刘雨欣，顾德媛，张东，张如，许会会，陈思，杨艳玲

《畜牧兽医学报》

2026

冬季小学期教学助力动物科学专业课程建设探索

荀文娟，陈思，谭振，周华金，姜爱良，邓凯平，王锋

《黑龙江动物繁殖》

2026

羊源肺炎克雷伯菌可视化LAMP检测方法的建立

陈益妹，王子莹，吴丽莉，兰凤，焦玉清，章昱，黄紫荆，陈思，陈巧玲，满初日嘎，杜丽，王凤阳，高宏岩

《动物医学进展》

2026

溶血性曼氏杆菌MH-HN0721株感染条件下山羊支气管上皮细胞的转录组分析

吴丽莉，杨映雪，王子莹，景卉，高宏岩，满初日嘎，杜丽，陈思，王凤阳，陈巧玲

《中国兽医学报》

2026

Identification of the Potential chi-miR-148a-5p-PTGS2 Regulatory Axis Mediating TNF and IL-17 Signaling Pathways in Caprine Bronchial Epithelial Cells Challenged with Klebsiella Pneumoniae

Yimei Chen, Zhenxing Gong, Hui Jing, Hao Duan, Hejie Qian, Tengjiao Li, Shihua Niu, Lili Wu, Ziying Wang, Mengqi Zhang, Yiwen Cheng, Churiga Man, Qiaoling Chen, Li Du, Si Chen, Hongyan Gao, Fengyang Wang

Veterinary Sciences

DOI

2026

Genomic characterization and immunoinformatics analysis of the Brucella melitensis vaccine strain BA0711

Mengqi Zhang, Yiwen Cheng, Zhenghang Yin, Shihua Niu, Li Han, Hui Jing, Lianjie Liao, Yuqiu Yan, Zijing Huang, Li Du, Hongyan Gao, Churiga Man, Fengyang Wang, Qiaoling Chen, Si Chen

BMC Genomics

DOI

2026

TBC1D14 positively regulates autophagy induced by Brucella melitensis vaccine strain BA0711 in Sheep Leydig Cells

Yiwen Cheng, Shihua Niu, Z D Zhang, Hejie Qian, Zijing Huang, Hui Jing, Lianjie Liao, Churiga Man, Hongyan Gao, Qiaoling Chen, Li Du, Si Chen, Fengyang Wang

Microbial Pathogenesis

DOI

2026

A potassium-based single-atom catalyst enables acute lung injury immunotherapy in mice by inhibiting macrophage pyroptosis

Xiang-Yu Lu, Xuan Shi, Yan-Min Jian, Cai Sun, Li-Jie Mao, Si Chen, Yuanru Zhao, Fang Huang, Ji Lu, Zhiyi Song, Guanning Liu, Xin Li, Yong-Jun Chen, Ke Li, Xin Lv, Jian-Lin Shi

Nature Communications

DOI

2025

多杀性巴氏杆菌感染小鼠肝脏转录组分析

黄惠娴，陈巧玲，王雪梅，蒋俊明，刘志勇，陈思，王凤阳，杜丽

《中国动物传染病学报》

DOI

2025

1株山羊源D型多杀性巴氏杆菌的全基因组测序及生物学特性分析

张振兴，陈珍，陈巧玲，程逸文，陈思，满初日嘎，杜丽，王凤阳

《中国动物传染病学报》

DOI

2025

山羊源K57荚膜型肺炎克雷伯菌毒力基因检测及遗传进化分析

何美荣，廖连杰，何秋仪，潘浩举，杨映雪，陈韬羽，李昊洋，蒋俊明，陈巧玲，高宏岩，陈思，杜丽，王凤阳，满初日嘎

《中国畜牧兽医》

DOI

2025

羊布鲁菌外膜囊泡蛋白质组学分析及免疫原性评价

刘雨欣，陈思，高阳，顾德媛，彭海涛，张东，张如，许会会，刘亚乔，杨艳玲

《畜牧兽医学报》

2025

海南黑山羊SAA3基因多态位点筛查与生物信息学分析

陈祥英，陈韬羽，高宏岩，陈思，满初日嘎，杜丽，王凤阳，陈巧玲

《现代畜牧兽医》

DOI

2025

Development of a 5K Liquid-Phase Genome-Wide Breeding Chip for Xinglong Buffalo

Yuqing Jiao, Junming Jiang, Shiyuan Li, Taoyu Chen, Xinjun Qiu, Ke Cui, Boling Li, Si Chen, Qiaoling Chen, Li Du, Churiga Man, Lianbin Li, Fengyang Wang, Hongyan Gao

Animals

DOI

2025

Risk Assessment of Global Animal Melioidosis Under Current and Future Climate Scenarios

Suya Li, Le Xu, Yuqing Jiao, Shiyuan Li, Yingxue Yang, Feng Lan, Si Chen, Churiga Man, Li Du, Qiaoling Chen, Fengyang Wang, Hongyan Gao

Animals

DOI

2025

Cuproptosis: mechanisms and nanotherapeutic strategies in cancer and beyond.

Li-Jie Mao, Ji Lu, Xinyu Wen, Zhiyi Song, Cai Sun, Yuanru Zhao, Fang Huang, Si Chen, Dong-Yang Jiang, W. Che, Cheng Zhong, Chen Yu, Ke Li, Xiang-Yu Lu, Jian-Lin Shi

Chemical Society Reviews

DOI

2024

山羊NPC1基因核心启动子鉴定与转录调控分析

李崇瑞，陈思，翟哲，王雪梅，吴艳茹，刘志勇，蒋俊明，满初日嘎，杜丽，王凤阳

《中国动物传染病学报》

2024

海南黑山羊ATG16L2基因启动子区多态性研究

王欢，陈韬羽，吴慧，蒙勇，李世元，钱和洁，牛世华，满初日嘎，陈巧玲，高宏岩，杜丽，王凤阳，陈思

《畜牧兽医学报》

2024

Predicting Tuberculosis Risk in Cattle, Buffaloes, Sheep, and Goats in China Based on Air Pollutants and Meteorological Factors

Le Xu, Suya Li, Hong Li, Haoju Pan, Shiyuan Li, Yingxue Yang, Yuqing Jiao, Feng Lan, Si Chen, Qiaoling Chen, Li Du, Churiga Man, Fengyang Wang, Hongyan Gao

Animals

DOI

2024

The genome landscape of the Xinglong buffalo

Yuan Chai, Shiyuan Li, Hui Wu, Yong Qiang Meng, Yujing Fu, Hong Li, Guansheng Wu, Junming Jiang, Taoyu Chen, Yuqing Jiao, Qiaoling Chen, Li Du, Lianbin Li, Churiga Man, Si Chen, Hongyan Gao, Wenguang Zhang, Fengyang Wang

BMC Genomics

DOI

2024

Development and validation of a 5K low-density SNP chip for Hainan cattle

Huan Wang, Hui Wu, Wencan Zhang, Junming Jiang, Hejie Qian, Churiga Man, Hongyan Gao, Qiaoling Chen, Li Du, Si Chen, Fengyang Wang

BMC Genomics

DOI

2024

Development and verification of a 10K liquid chip for Hainan black goat based on genotyping by pinpoint sequencing of liquid captured targets

Yong Qiang Meng, Wencan Zhang, Yiwen Cheng, Yanru Wu, Haotian Wu, Meirong He, Si Chen, Churiga Man, Hongyan Gao, Li Du, Qiaoling Chen, Fengyang Wang

BMC Genomic Data

DOI

2024

Sheep and goat pathogen database: a pathogen data integration and analysis database of sheep and goat infectious diseases

Haoju Pan, Zizhuo Jiao, Hong Li, Suya Li, Le Xu, Shiyuan Li, Yong Meng, Yujing Fu, Taoyu Chen, Qiaoling Chen, Si Chen, Li Du, Churiga Man, Fengyang Wang, Hongyan Gao

Frontiers in Microbiology

DOI

2024

High Fe-Loading Single-Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

Si Chen, Fang Huang, Li-Jie Mao, Zhimin Zhang, Han Lin, Qixin Yan, Xiang-Yu Lu, Jian-Lin Shi

Nano-Micro Letters

DOI

2024

Dual-Site Biomimetic Cu/Zn-MOF for Atopic Dermatitis Catalytic Therapy via Suppressing FcγR-Mediated Phagocytosis.

Fang Huang, Xiang-Yu Lu, L. Kuai, Y. Ru, Jing-Si Jiang, Jian-Kun Song, Si Chen, Li-Jie Mao, Yongyong Li, Bin Li, Hai-Qing Dong, Jian-Lin Shi

Journal of the American Chemical Society

DOI

2024

Single-Atom Catalysts with Isolated Cu1-N4 Sites for Atopic Dermatitis Cascade Catalytic Therapy via Activating PPAR Signaling.

L. Kuai, Fang Huang, Li-Jie Mao, Y. Ru, Jing-Si Jiang, Jian-Kun Song, Si Chen, Ke Li, Yongyong Li, Hai-Qing Dong, Xiang-Yu Lu, Bin Li, Jian-Lin Shi

Small

DOI

2023

ORFV感染条件下RSAD2影响宿主细胞免疫反应的研究

蒋俊明，刘志勇，程逸文，吴慧，潘浩举，陈巧玲，高宏岩，满初日嘎，陈思，王凤阳，杜丽

《中国兽医学报》

2023

羊源产酸克雷伯菌的分离鉴定及感染小鼠的转录组学研究

李旭博，蒋俊明，何美荣，李昊洋，李虹，陈思，陈巧玲，满初日嘎，杜丽，王凤阳，高宏岩

《中国畜牧兽医》

2023

Integrated Analysis of Transcriptome and Metabolome Profiles in the Longissimus Dorsi Muscle of Buffalo and Cattle

Guansheng Wu, Xinjun Qiu, Zizhuo Jiao, Weijie Yang, Haoju Pan, Hong Li, Zhengyu Bian, Qiang Geng, Hui Chen Wu, Junming Jiang, Yuanyuan Chen, Yiwen Cheng, Qiaoling Chen, Si Chen, Churiga Man, Li Du, Lianbin Li, Fengyang Wang

Current Issues in Molecular Biology

DOI

2023

Whole-genome analyses reveal the genomic diversity and selection signatures of Hainan cattle

Si Chen, Chencheng Chang, Ke Cui, Weijie Yang, Boling Li, Shiheng Ni, Wencan Zhang, Wencan Zhang, Shiyuan Li, Xubo Li, Guansheng Wu, Lianbin Li, Qiaoling Chen, Churiga Man, Li Du, Wenguang Zhang, Wenguang Zhang, Fengyang Wang

Livestock Science

DOI

2023

Predicting Risk Areas of Classical Scrapie in China Based on Environmental Suitability

Hong Li, Haoju Pan, Le Xu, Suya Li, Shiyuan Li, Si Chen, Churiga Man, Li Du, Qiaoling Chen, Jianhua Xiao, Hongbin Wang, Fengyang Wang, Hongyan Gao

Transboundary and Emerging Diseases

DOI

2023

Overexpression of Pasteurella multocida OmpA induces transcriptional changes and its possible implications for the macrophage polarization

Yang Xiao-hong, Qiaoyu Fu, Wencan Zhang, Qi An, Zhenxing Zhang, Hong Li, Xiangying Chen, Zhen Chen, Yiwen Cheng, Si Chen, Churiga Man, Li Du, Si Chen, Fengyang Wang

Microbial Pathogenesis

DOI

2023

Association between INHA gene polymorphisms and litter size in Hainan black goats

Zhengyu Bian, Kunpeng Li, Si Chen, Churiga Man, Fengyang Wang, Lianbin Li

PeerJ

DOI

2023

Clearance of bacteria from lymph nodes in sheep immunized with Brucella suis S2 vaccine is associated with M1 macrophage activation

Si Chen, Yuanyuan Chen, Zizhuo Jiao, Chengqiang Wang, Dantong Zhao, Yongbin Liu, Wenguang Zhang, Shihua Zhao, Bin Yang, Qinan Zhao, Shaoyin Fu, Xiaolong He, Qiaoling Chen, Churiga Man, Guoying Liu, Xuefeng Wei, Li Du, Fengyang Wang

Veterinary Research

DOI

2023

Activation of MyD88-Dependent TLR Signaling Modulates Immune Response of the Mouse Heart during Pasteurella multocida Infection

Qiaoyu Fu, Junming Jiang, Xubo Li, Zhe Zhai, Xuemei Wang, Chongrui Li, Qiaoling Chen, Churiga Man, Li Du, Fengyang Wang, Si Chen

Microorganisms

DOI

2023

Profiling Chromatin Accessibility Responses in Goat Bronchial Epithelial Cells Infected with Pasteurella multocida

Qiaoling Chen, Zhen Chen, Zhenxing Zhang, Haoju Pan, Hong Li, Xubo Li, Qi An, Yiwen Cheng, Si Chen, Churiga Man, Li Du, Fengyang Wang

International Journal of Molecular Sciences

DOI

2023

Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1

Xiang-Yu Lu, L. Kuai, Fang Huang, Jing-Si Jiang, Jian-Kun Song, Yiqiong Liu, Si Chen, Li-Jie Mao, Wei Peng, Ying Luo, Yongyong Li, Hai-Qing Dong, Bin Li, Jian-Lin Shi

Nature Communications

DOI

2023

Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

Si Chen, Piao Zhu, Li-Jie Mao, Wencheng Wu, Han Lin, De-Liang Xu, Xiang-Yu Lu, Jian-Lin Shi

Advances in Materials

DOI

2022

海南黑山羊MBL2基因的转录调控元件的筛选与分析

王雪梅，翟哲，陈巧玲，吴艳茹，吴昊天，黄惠娴，刘志勇，李崇瑞，满初日嘎，王凤阳，杜丽，陈思

《畜牧兽医学报》

2022

多杀性巴氏杆菌攻毒小鼠肺脏的转录组分析

陈杰，陈巧玲，陈思，程逸文，刘志勇，李彬，刘昂，满初日嘎，王凤阳，杜丽，李昌，金宁一

《基因组学与应用生物学》

2022

布鲁氏菌脂多糖刺激山羊支气管上皮细胞的全转录组分析

吴昊天，张振兴，陈思，刘志勇，安琪，陈杰，程逸文，刘昂，何美荣，蒋俊明，陈巧玲，王凤阳，杜丽，满初日嘎

《基因组学与应用生物学》

2022

绵羊CCL19基因启动子活性分析及其转录调控元件筛选

翟哲，陈思，吴艳茹，王雪梅，李崇瑞，刘志勇，陈巧玲，王凤阳，杜丽，李昌，金宁一

《中国畜牧兽医》

2022

羊多杀性巴氏杆菌与布鲁氏菌双重套式PCR检测方法的建立及应用

吴昊天，满初日嘎，刘昂，何美荣，侯思梦，李崇瑞，杜丽，陈巧玲，陈思，王凤阳，李昌，金宁一

《动物医学进展》

2022

羊源A型多杀性巴氏杆菌的分离鉴定及生物学特性分析

张振兴，陈巧玲，程逸文，刘志勇，蒋俊明，陈思，满初日嘎，杜丽，王凤阳

《黑龙江畜牧兽医》

2022

First Report and Comparative Genomic Analysis of Mycoplasma capricolum subsp. capricolum HN-B in Hainan Island, China

Zhenxing Zhang, Meirong He, Junming Jiang, Xubo Li, Haoyang Li, Wencan Zhang, Si Chen, Li Du, Churiga Man, Qiaoling Chen, Hongyan Gao, Fengyang Wang

Microorganisms

DOI

2022

First Report and Comparative Genomic Analysis of a Mycoplasma mycoides Subspecies capri HN-A in Hainan Island

Zhenxing Zhang, Junming Jiang, Meirong He, Haoyang Li, Yiwen Cheng, Qi An, Si Chen, Li Du, Churiga Man, Qiaoling Chen, Lianbin Li, Fengyang Wang

Microorganisms

DOI

2022

Up-Regulation of Interleukin-10 in Splenic Immune Response Induced by Serotype A Pasteurellamultocida

Haoyang Li, Meirong He, Yiwen Cheng, Junming Jiang, Weijie Yang, Zhenxing Zhang, Qi An, Si Chen, Churiga Man, Li Du, Fengyang Wang, Qiaoling Chen

Genes

DOI

2022

Microbiological Characteristics and Pathogenesis of Klebsiella pneumoniae Isolated from Hainan Black Goat

Meirong He, Haoyang Li, Zhenxing Zhang, Junming Jiang, Hong Li, Weijie Yang, Yiwen Cheng, Hongyan Gao, Qiaoling Chen, Li Du, Si Chen, Churiga Man, Fengyang Wang

Veterinary Sciences

DOI

2022

Whole-Genome Sequencing Reveals the Genomic Characteristics and Selection Signatures of Hainan Black Goat

Qiaoling Chen, Yuan Chai, Wencan Zhang, Yiwen Cheng, Zhenxing Zhang, Zhenxing Zhang, Si Chen, Churiga Man, Li Du, Wenguang Zhang, Fengyang Wang

Genes

DOI

2022

Effects of Pasteurella multocida on Histopathology, miRNA and mRNA Expression Dynamics in Lung of Goats

Wencan Zhang, Zizhuo Jiao, Huixian Huang, Yanru Wu, Haotian Wu, Zhiyong Liu, Zhenxing Zhang, Qi An, Yiwen Cheng, Si Chen, Churiga Man, Li Du, Fengyang Wang, Qiaoling Chen

Animals

DOI

2022

The mRNA and miRNA profiles of goat bronchial epithelial cells stimulated by Pasteurella multocida strains of serotype A and D

Qi An, Si Chen, Luyin Zhang, Zhenxing Zhang, Yiwen Cheng, Haotian Wu, Ang Liu, Zhen Chen, Bin Li, Jie Chen, Yiying Zheng, Churiga Man, Fengyang Wang, Qiaoling Chen, Li Du

PeerJ

DOI

2022

Downregulation of Three Novel miRNAs in the Lymph Nodes of Sheep Immunized With the Brucella suis Strain 2 Vaccine

Si Chen, Chengqiang Wang, Qiaoling Chen, Dantong Zhao, Yongbin Liu, Shihua Zhao, Shaoyin Fu, Xiaolong He, Bin Yang, Qinan Zhao, Qi An, Zhenxing Zhang, Yiwen Cheng, Churiga Man, Guoying Liu, Xuefeng Wei, Wenguang Zhang, Li Du, Fengyang Wang

Frontiers in Veterinary Science

DOI

2021

猪流行性腹泻病毒入胞机制研究现状

陈思，张丽颖，蒋洪忠，任林柱

《动物医学进展》

DOI

2021

羊源多杀性巴氏杆菌重组酶聚合酶扩增诊断方法的建立

刘昂，程逸文，安琪，张振兴，李彬，陈杰，陈巧玲，杜丽，满初日嘎，王凤阳，陈思

《中国畜牧兽医》

DOI

2021

羊源D型多杀性巴氏杆菌感染小鼠脾脏转录组分析

李彬，陈巧玲，程逸文，陈杰，张振兴，安琪，黄惠娴，刘志勇，翟哲，满初日嘎，王凤阳，杜丽，陈思

《中国畜牧兽医》

2021

Integrated mRNA-seq and miRNA-seq analysis of goat fibroblasts response to Brucella Melitensis strain M5-90

Baobao Li, Si Chen, Chengqiang Wang, Qiaoling Chen, Churiga Man, Qi An, Zhenxing Zhang, Zhiyong Liu, Li Du, Fengyang Wang

PeerJ

DOI

2021

Genome-Wide Differential Expression Profiling of Pulmonary circRNAs Associated With Immune Reaction to Pasteurella multocida in Goats

Qiaoling Chen, Zhenxing Zhang, Si Chen, Jie Chen, Yiwen Cheng, Ang Liu, Bin Li, Zhen Chen, Yiying Zheng, Manchuriga Ga, Li Du, Fengyang Wang

Frontiers in Veterinary Science

DOI

2020

绵羊MMP-2基因多态性与产羔数的关联分析

陈思，狄冉，刘秋月，王翔宇，储明星

《中国草食动物科学》

2020

绵羊FLI-1基因多态性与产羔数的关联分析

陈思，狄冉，刘秋月，王翔宇，储明星

《中国草食动物科学》

预印本

2026

PRNP variation and Bayesian allele-frequency risk-background analysis in goats

Jingcheng Yang, Hong Li, Churiga Man, Si Chen, Q Chen, Li Du, Fengyang Wang, Hongyan Gao

SSRN Electronic Journal

DOI

2025

Construction of an Evaluation Model for the Protective Efficacy of Ovine Brucellosis Vaccines

Shihua Niu, Yong Meng, Churiga Man, Wei-Wei Wu, Wenxin Zheng, Dongling Wu, Changsuo Zhang, Chuanyu He, Jian Cao, Hailong Zhao, Huan Wang, Mengqi Zhang, Guowen He, Jun Chen, Li Zhang, Dan Tian, Qiaoling Chen, Hongyan Gao, Li Du, Si Chen, Fengyang Wang

Research Square

DOI

2023

Pasteurella Multocida Infection Induced Mice Acute Lung Injury and Saa3 Activation

Yiwen Cheng, Zhenxing Zhang, Yuanyuan Chen, Haoyang Li, Meirong He, Qi An, Simeng Hou, Si Chen, Churiga Man, Li Du, Qiaoling Chen, Fengyang Wang

SSRN Electronic Journal

DOI

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