刘靖华｜南方医科大学｜学者主页

2026

训练免疫：脓毒症防治的免疫调控新策略

刘靖华

《感染、炎症、修复》

2026

细菌脂蛋白训练通过上调柠康酸保护内毒素血症小鼠的作用与机制

许秀娟，万彦彤，陈文翰，洪英濠，黄晓岚，闫征征，刘靖华

《中国临床解剖学杂志》

2025

Managing coagulation using the sonoclot analyzer in patients with disseminated intravascular coagulation

Peng Wan, Yan Geng, Lei Su, Jinghua Liu, Huasheng Tong, Zhifeng Liu, Wenda Chen, Baojun Yu, Na Peng

American Journal Of Critical Care，Vol. 340, No. 30

DOI

2025

VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2.

Liyan Lou, Jiang-Yun Shen, Jian-Zhao Zhang, Fu-Qi Mei, De-Yu Deng, De-Qi Wang, Yan-Qi Xu, Kangmin Chen, Bao-Li Cheng, Jinghua Liu, Xu Wang

Cell Reports

DOI

2025

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu, Jinghua Liu

Advanced Science

DOI

2023

中性粒细胞侧向荧光强度对重症中暑合并弥散性血管内凝血的早期诊断价值

陈文达，彭娜，刘帅，童华生，唐柚青，刘靖华，苏磊

《解放军医学杂志》

2023

Endothelial glycocalyx injury is involved in heatstroke-associated coagulopathy and protected by N-acetylcysteine

Na Peng, Yan Geng, Jiafu Ouyang, Shuai Liu, Fangfang Yuan, Yantong Wan, Wenda Chen, Baojun Yu, Youqing Tang, Lei Su, Huaping Liang, Jiang Huai Wang, Jinghua Liu

Frontiers in Immunology

DOI

2023

Knowledge mapping and research trends of IL-33 from 2004 to 2022: a bibliometric analysis

Jingyi Jin, Yantong Wan, Qiang Shu, Jinghua Liu, Dengming Lai

Frontiers in Immunology

DOI

2023

PVB exerts anti-inflammatory effects by inhibiting the activation of MAPK and NF-κB signaling pathways and ROS generation in neutrophils

Jiafu Ouyang, Yinghao Hong, Yantong Wan, Xiangyi He, Bingxuan Geng, Xinxing Yang, Jing Xiang, Junwei Cai, Zhenhua Zeng, Zhifeng Liu, Na Peng, Yong Jiang, Jinghua Liu

International Immunopharmacology

DOI

2023

Gene expression variability across cells and species shapes the relationship between renal resident macrophages and infiltrated macrophages

Xiangjun Ji, Junwei Cai, Lixin Liang, Tieliu Shi, Jinghua Liu

BMC Bioinformatics

DOI

2022

基础医学拔尖人才培养过程中SPBL实践

蔡军伟，徐佳，郭晓华，刘靖华，黄巧冰

《基础医学教育》

2022

Corrigendum: Bibliometric and visual analysis of neutrophil extracellular traps from 2004 to 2022

Yantong Wan, Junyi Shen, Jiafu Ouyang, Peng Dong, Yinghao Hong, Lixin Liang, Jinghua Liu

Frontiers in Immunology

DOI

2022

Bibliometric and visual analysis of neutrophil extracellular traps from 2004 to 2022

Yantong Wan, Junyi Shen, Jiafu Ouyang, Peng Dong, Yinghao Hong, Lixin Liang, Jinghua Liu

Frontiers in Immunology

DOI

2022

Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect

Piao Luo, Qian Zhang, Tianyu Zhong, Jia-Yun Chen, Junzhe Zhang, Ya Tian, Liuhai Zheng, Fan Yang, Lingyun Dai, Chang Zou, Zhijie Li, Jinghua Liu, Jigang Wang

Military Medical Research

DOI

2021

免疫训练——先天免疫记忆的发现和研究进展

苏婷，刘靖华

《中国免疫学杂志》

2021

Macrophage ICAM-1 functions as a regulator of phagocytosis in LPS induced endotoxemia

Hanhui Zhong, Haitao Lin, Qiongni Pang, Jinling Zhuang, Xiaolei Liu, Xiaolian Li, Jinghua Liu, Jing Yi Tang

Inflammation Research

DOI

2021

Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis

Zhengzheng Yan, Haihua Luo, Bingyao Xie, Tian Tian, Shan Li, Zhixia Chen, Jinghua Liu, Xuwen Zhao, Liyong Zhang, Yongqiang Deng, Timothy R. Billiar, Yong Jiang

Nature Communications

DOI

2021

Pinaverium Bromide Attenuates Lipopolysaccharide-Induced Excessive Systemic Inflammation via Inhibiting Neutrophil Priming

Xiaohuan Chen, Yun Liu, Hallie H. Dolin, Jinghua Liu, Yong Jiang, Zhixing K. Pan

The Journal of Immunology

DOI

2020

SETD4敲除对小鼠巨噬细胞功能及免疫细胞分化影响的初步研究

牛世贤，黄穗，李山，蔡军伟，常若水，郑肇萍，姜勇，刘靖华

《中国临床解剖学杂志》

DOI

2020

Protective effects of rolipram on endotoxic cardiac dysfunction via inhibition of the inflammatory response in cardiac fibroblasts

Jingjing Ji, Zhifeng Liu, Zhifeng Liu, Xinxin Hong, Zheying Liu, Jinghua Liu, Jinghua Gao, Jinghua Liu

BMC Cardiovascular Disorders

DOI

2019

BLP耐受通过上调MARCO增强巨噬细胞的吞噬能力

习大林，项静，蔡军伟，赵舒祺，吉晶晶，李月，苏婷，姜勇，刘靖华

《中国病理生理杂志》

2019

The novel methyltransferase SETD4 regulates TLR agonist-induced expression of cytokines through methylation of lysine 4 at histone 3 in macrophages

Yuyun Zhong, Ping Ye, Zhu-Zhong Mei, Sui Huang, Mengyi Huang, Yue Li, Shixian Niu, Shuqi Zhao, Junwei Cai, Juan Wang, Hequn Zou, Yong Jiang, Jinghua Liu

Molecular Immunology

DOI

2019

Data‐Independent Acquisition‐Based Quantitative Proteomics Analysis Reveals Dynamic Network Profiles during the Macrophage Inflammatory Response

Lei Li, Li Chen, Xinya Lu, Chenyang Huang, Haihua Luo, Jingmiao Jin, Zhu-Zhong Mei, Jinghua Liu, Cuiting Liu, Jun-Min Shi, Peng Chen, Yong Jiang

PROTEOMICS

DOI

2019

An Early Neutrophil Recruitment into the Infectious Site Is Critical for Bacterial Lipoprotein Tolerance–Afforded Protection against Microbial Sepsis

Wenting Chen, Shuqi Zhao, Michael Ita, Yue Li, Jingjing Ji, Yong Jiang, H. Paul Redmond, Jiang Huai Wang, Jinghua Liu

The Journal of Immunology

DOI

2019

Rab20 is critical for bacterial lipoprotein tolerization-enhanced bactericidal activity in macrophages during bacterial infection

Shuqi Zhao, Dalin Xi, Junwei Cai, Wenting Chen, Jing Xiang, Na Peng, Juan Wang, Yong Jiang, Zhu-Zhong Mei, Jinghua Liu

Science China Life Sciences

DOI

2019

Differences in Lipopolysaccharides-Induced Inflammatory Response Between Mouse Embryonic Fibroblasts and Bone Marrow-Derived Macrophages

Yue Li, Shixian Niu, Dalin Xi, Shuqi Zhao, Jiang Sun, Yong Jiang, Jinghua Liu

Journal of Interferon & Cytokine Research

DOI

2018

LPS的胞内受体Caspase-11的研究进展

罗炳生，刘靖华

《生物化学与生物物理进展》

2018

线粒体在NLRP3炎性小体激活过程中的双向调节作用

吴晓升，项静，刘靖华

《现代免疫学》

2018

SETD4对脂多糖诱导的AML12细胞IL-6转录的调控作用

孙江，李月，牛世贤，黄梦怡，钟玙沄，赵舒祺，罗海华，姜勇，刘靖华

《中国临床解剖学杂志》

2018

H3K4 Methylation Regulates LPS-Induced Proinflammatory Cytokine Expression and Release in Macrophages

Shuqi Zhao, Yuyun Zhong, Xiaoxia Fu, Yiqian Wang, Ping Ye, Junwei Cai, Yun Liu, Jiang Sun, Zhu-Zhong Mei, Yong Qing Jiang, Jinghua Liu

Shock

DOI

2018

Mig6 reduces inflammatory mediators production by regulating the activation of EGFR in LPS‐induced endotoxemia

Wenting Chen, Hanhui Zhong, Xiaofei Wang, Qiongni Pang, Jinling Zhuang, JIAN LI HU, Yeming Chen, Jijie Hu, Jinghua Liu, Jing Yi Tang

Journal of Cellular Physiology

DOI

2017

NF-κB activation is critical for bacterial lipoprotein tolerance-enhanced bactericidal activity in macrophages during microbial infection

Jinghua Liu, Jing Xiang, Xue Li, Siobhan Blankson, Shuqi Zhao, Junwei Cai, Yong Jiang, H. Paul Redmond, Jiang Huai Wang

Scientific Reports

DOI

2017

Screening cytokine/chemokine profiles in serum and organs from an endotoxic shock mouse model by LiquiChip

Jinghua Liu, Juan Wang, Haihua Luo, Zhijie Li, Tianyu Zhong, Jing Yi Tang, Yong Jiang

Science China Life Sciences

DOI

2017

Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma

Zhigang Li, Erica Fan, Jinghua Liu, Melanie J. Scott, Yuehua Li, Song Li, Wen Li Xie, Timothy R. Billiar, Mark A. Wilson, Yong Jiang, Ping Wang, Jie Fan

Cell Death and Disease

DOI

2016

microRNA作为脓毒症早期诊断生物标志物的研究进展

李韶威，刘靖华

《基础医学与临床》

2016

Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively

Zhu-Zhong Mei, Xinyu Chen, Shuiwang Hu, Ni Wang, Xiaoli Ou, Jing Wang, Haihua Luo, Jinghua Liu, Yong Jiang

Journal of Biological Chemistry

DOI

2014

组蛋白修饰对炎症反应的调控

梁燊，黄穗，刘靖华

《感染、炎症、修复》

2014

Role of testis‐specific high‐mobility‐group protein in transcriptional regulation of inducible nitric oxide synthase expression in the liver of endotoxic shock mice

Zhifeng Liu, Jinghua Liu, Juan Wang, Juan Wang, Jia Xu, Yawei Liu, Xuegang Sun, Lei Su, Jiang Huai Wang, Jiang Huai Wang, Yong Jiang

FEBS Journal

DOI

2013

巨噬细胞的极化及其调控的信号分子和转录因子

鲁宏伟，蔡军伟，刘靖华

《细胞与分子免疫学杂志》

2013

Preparation of histones and their effects on macrophages

Jinghua Liu

Zhongguo bingli shengli zazhi

2009

丝裂原活化的蛋白激酶在高迁移率族蛋白1诱导内皮细胞释放炎性细胞因子中的作用

钟田雨，唐靖，刘亚伟，李志杰，陈登宇，赵明哲，王蔚，刘靖华，姜勇

《南方医科大学学报》

2009

人CAT启动子红色荧光蛋白报告基因载体的构建及功能鉴定

姚琦，黄劭，刘亚伟，刘靖华，姜勇

《南方医科大学学报》

2009

Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine/chemokine production in endothelial cells via activation of both mitogen‐activated protein kinases and nuclear factor‐κB

Jinghua Liu, Shan‐Chao Zhao, Jing Yi Tang, Zhijie Li, Tianyu Zhong, Yawei Liu, Dengyu Chen, Mingzhe Zhao, Yusheng Li, Xiaowei Gong, Peng Deng, Jiang H. Wang, Yong Jiang

FEBS Journal

DOI

2008

两种细胞系中内源性C-反应蛋白的表达和定位分析

陈腾祥，李红梅，胡水旺，杨婷，刘亚伟，刘靖华，姜勇

《南方医科大学学报》

2008

Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes

Zhihui Zhao, Qing Li, Jiale Hu, Zhongjun Li, Jinghua Liu, Aihua Liu, Peng Deng, Lin Zhang, Xiaowei Gong, Kesen Zhao, Shuangquan Zhang, Yong Jiang

Glycoconjugate Journal

DOI

2007

脓毒症单核巨噬细胞特异性结合肽的筛选

丁宁，刘承武，李志杰，刘靖华，邓鹏，姜勇

《中国生物化学与分子生物学报》

2006

双色红外荧光技术在蛋白磷酸化检测中的应用

刘靖华，唐靖，蓝兴国，刘亚伟，李志杰，陈芳，邓鹏，姜勇

《南方医科大学学报》

2006

细胞穿透肽核靶向运输蛋白表达载体的构建及其蛋白转导功能的研究

李海玉，郭爱华，刘志锋，刘瑜，刘靖华，邓鹏，李志杰，刘亚伟，姜勇

《南方医科大学学报》

2006

用FRET技术研究TLR4和MD-2的相互作用

刘亚伟，刘靖华，唐靖，赵清，李建军，赵明哲，李志杰，王国军，钟田雨，邓鹏，姜勇

《南方医科大学学报》

2005

人可溶性晚期糖基化终产物受体的原核表达及活性鉴定

赵善超，姜勇，刘靖华，李志杰，邓鹏，张桂林，刘志强，张训，侯凡凡，郑少斌

《南方医科大学学报》

2005

HPC2真核表达载体的构建及其在HEK293细胞中的表达

谭康联，李志杰，刘靖华，黄浩，唐靖，邓鹏，姜勇

《南方医科大学学报》

2005

His标记的小鼠线粒体转录因子A的克隆和表达纯化及其多克隆抗体的制备

刘志锋，邵紫韫，徐佳，刘靖华，邓鹏，姜勇

《南方医科大学学报》

2005

Characterization of Cytokine/Chemokine Profiles of Severe Acute Respiratory Syndrome

Yong Jiang, Jun Xu, Chengzhi Zhou, Zhenguo Wu, Shu-qing Zhong, Jinghua Liu, Wei Luo, Tao Chen, Qinghe Qin, Peng Deng

American Journal of Respiratory and Critical Care Medicine

DOI

2004

人ARPC2基因的克隆与表达

龚小卫，彭毅，刘靖华，李志杰，邓鹏，秦清和，姜勇

《南方医科大学学报》

2003

信号肽-FRET荧光蛋白载体的构建及在NIH3T3细胞中的表达

孙学刚，宋革，刘靖华，安海燕，李红乐，邢飞跃，张丽华，姜勇

《南方医科大学学报》

2003

用T7噬菌体展示筛选系统筛选与p38相结合的蛋白

李志杰，刘靖华，龚小卫，秦清和，黄浩，邓鹏，王静珍，孙学刚，赵善超，刘亚伟，赵克森，姜勇

《南方医科大学学报》

2003

人晚期糖基化终产物受体胞质内段融合蛋白表达载体的构建与表达

赵善超，刘靖华，李志杰，秦清和，邓鹏，侯凡凡，姜勇

《南方医科大学学报》

2003

[Construction of vector of his-tagged cytoplasmic fragment of human toll like receptor 4 and its expression in E.coli].

Jinghua Liu, Xue-gang Sun, Zhijie Li, Qing-he Qin, Xiaowei Gong, Peng Deng, Yawei Liu, Jing-zhen Wang, Kesen Zhao, Yong Qing Jiang

PubMed

2001

TLR与天然免疫反应

刘靖华，赵克森

《免疫学杂志》

精选作品

期刊论文

训练免疫：脓毒症防治的免疫调控新策略

细菌脂蛋白训练通过上调柠康酸保护内毒素血症小鼠的作用与机制

Managing coagulation using the sonoclot analyzer in patients with disseminated intravascular coagulation

VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2.

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

中性粒细胞侧向荧光强度对重症中暑合并弥散性血管内凝血的早期诊断价值

Endothelial glycocalyx injury is involved in heatstroke-associated coagulopathy and protected by N-acetylcysteine

Knowledge mapping and research trends of IL-33 from 2004 to 2022: a bibliometric analysis

PVB exerts anti-inflammatory effects by inhibiting the activation of MAPK and NF-κB signaling pathways and ROS generation in neutrophils

Gene expression variability across cells and species shapes the relationship between renal resident macrophages and infiltrated macrophages

基础医学拔尖人才培养过程中SPBL实践

Corrigendum: Bibliometric and visual analysis of neutrophil extracellular traps from 2004 to 2022

Bibliometric and visual analysis of neutrophil extracellular traps from 2004 to 2022

Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect

免疫训练——先天免疫记忆的发现和研究进展

Macrophage ICAM-1 functions as a regulator of phagocytosis in LPS induced endotoxemia

Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis

Pinaverium Bromide Attenuates Lipopolysaccharide-Induced Excessive Systemic Inflammation via Inhibiting Neutrophil Priming

SETD4敲除对小鼠巨噬细胞功能及免疫细胞分化影响的初步研究

Protective effects of rolipram on endotoxic cardiac dysfunction via inhibition of the inflammatory response in cardiac fibroblasts

BLP耐受通过上调MARCO增强巨噬细胞的吞噬能力

The novel methyltransferase SETD4 regulates TLR agonist-induced expression of cytokines through methylation of lysine 4 at histone 3 in macrophages

Data‐Independent Acquisition‐Based Quantitative Proteomics Analysis Reveals Dynamic Network Profiles during the Macrophage Inflammatory Response

An Early Neutrophil Recruitment into the Infectious Site Is Critical for Bacterial Lipoprotein Tolerance–Afforded Protection against Microbial Sepsis

Rab20 is critical for bacterial lipoprotein tolerization-enhanced bactericidal activity in macrophages during bacterial infection

Differences in Lipopolysaccharides-Induced Inflammatory Response Between Mouse Embryonic Fibroblasts and Bone Marrow-Derived Macrophages

LPS的胞内受体Caspase-11的研究进展

线粒体在NLRP3炎性小体激活过程中的双向调节作用

SETD4对脂多糖诱导的AML12细胞IL-6转录的调控作用

H3K4 Methylation Regulates LPS-Induced Proinflammatory Cytokine Expression and Release in Macrophages

Mig6 reduces inflammatory mediators production by regulating the activation of EGFR in LPS‐induced endotoxemia

NF-κB activation is critical for bacterial lipoprotein tolerance-enhanced bactericidal activity in macrophages during microbial infection

Screening cytokine/chemokine profiles in serum and organs from an endotoxic shock mouse model by LiquiChip

Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma

microRNA作为脓毒症早期诊断生物标志物的研究进展

Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively

组蛋白修饰对炎症反应的调控

Role of testis‐specific high‐mobility‐group protein in transcriptional regulation of inducible nitric oxide synthase expression in the liver of endotoxic shock mice

巨噬细胞的极化及其调控的信号分子和转录因子

Preparation of histones and their effects on macrophages

丝裂原活化的蛋白激酶在高迁移率族蛋白1诱导内皮细胞释放炎性细胞因子中的作用

人CAT启动子红色荧光蛋白报告基因载体的构建及功能鉴定

Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine/chemokine production in endothelial cells via activation of both mitogen‐activated protein kinases and nuclear factor‐κB

两种细胞系中内源性C-反应蛋白的表达和定位分析

Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes

脓毒症单核巨噬细胞特异性结合肽的筛选

双色红外荧光技术在蛋白磷酸化检测中的应用

细胞穿透肽核靶向运输蛋白表达载体的构建及其蛋白转导功能的研究

用FRET技术研究TLR4和MD-2的相互作用

人可溶性晚期糖基化终产物受体的原核表达及活性鉴定

HPC2真核表达载体的构建及其在HEK293细胞中的表达

His标记的小鼠线粒体转录因子A的克隆和表达纯化及其多克隆抗体的制备

Characterization of Cytokine/Chemokine Profiles of Severe Acute Respiratory Syndrome

人ARPC2基因的克隆与表达

信号肽-FRET荧光蛋白载体的构建及在NIH3T3细胞中的表达

用T7噬菌体展示筛选系统筛选与p38相结合的蛋白

人晚期糖基化终产物受体胞质内段融合蛋白表达载体的构建与表达

[Construction of vector of his-tagged cytoplasmic fragment of human toll like receptor 4 and its expression in E.coli].

TLR与天然免疫反应

研究方向