付国｜厦门大学｜学者主页

2026

PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells.

Keling Huang, Xiaoxue Li, Wenhua Liang, Shu-Yao Wu, You-Qiong Ye, Yan Lu, Junke Zheng, Weifang Wang, Qifan Zheng, Guo Fu, Song Gao, Feng Wang

Science immunology

DOI

2025

Themis dominates T cell exhaustion by regulation of TCR and PD-1 signaling

Jian Tang, X. Jia, Tao-Ling Zeng, Yuzhou Bao, Yanyan Hu, Junchen Dong, Xiaozheng Xu, Xiao-Lei Chen, Yongchao Liu, Jia-Yu Wang, B. Hou, Yuzhen Zhu, Guo Fu, Qifan Zheng, Yonglin Chen, Wanyun Li, Tong Ren, Lei Zhang, Shan Jiang, Yu Cong, Minxue Quan, Chaonan Yan, Shuo Lin, Ning Wang, Siyi Liu, Cheng-Hao Huang, Lichao Hou, J. Teijaro, J. Brzostek, N. Gautam, Changchun Xiao, Yan Wang, Gang Li, Bing Xu, E. Hui, Hong-Rui Wang, Nicholas R. J. Gascoigne, Guo Fu

bioRxiv

DOI

2025

T cell heterogeneity in asthma pathogenesis: from immunological mechanisms to biological targeted therapies

Qifeng Gan, Yuzhen Zhu, Yuxin Guo, Guo Fu, Xiaobin Zhang

Frontiers in Immunology

DOI

2025

p38 signaling enhances short-lived effector cell differentiation and weakens central memory CD8+ T-cell formation

Lichen Hu, Huaipeng Lin, Yubing Fu, Danying Li, Cong Yu, Wanyun Li, Zexu Wang, Lei Zhang, Guo Fu, Nengming Xiao, Jiahuai Han, Jianfeng Wu

The Journal of Immunology

DOI

2025

Themis differentially regulates T follicular helper cell differentiation during early and late stages of chronic viral infection

Yuzhen Zhu, Yuzhou Bao, Ning Wang, Qifeng Gan, Jian Tang, Cong Yu, Bowen Hou, Minxue Quan, Chaonan Yan, Siyi Liu, Shuo Lin, Xiaobin Zhang, Yanping Du, Lichao Hou, Nicholas R. J. Gascoigne, Bing Xu, Guo Fu, Qi‐Fan Zheng

Frontiers in Immunology

DOI

2023

SHP-1 Regulates CD8+ T Cell Effector Function but Plays a Subtle Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific Nonredundant Functional Relay.

B. Hou, Yanyan Hu, Yuzhen Zhu, Xiaocui Wang, Wanyun Li, Jian Tang, X. Jia, Jia-Yu Wang, Yu Cong, Minxue Quan, Hong-Ying Yang, Haiping Zheng, Yuzhou Bao, Xiao-Lei Chen, Hong-Rui Wang, Bing Xu, Nicholas R. J. Gascoigne, Guo Fu

Journal of Immunology

DOI

2023

Themis suppresses the effector function of CD8+ T cells in acute viral infection

Jian Tang, Xian Jia, Jian Li, Junchen Dong, Jiayu Wang, Wanyun Li, Yuzhen Zhu, Yanyan Hu, Bowen Hou, Chunjie Lin, Cong Yu, Tong Ren, Changsheng Yan, Hongying Yang, Qian Lai, Haiping Zheng, Yuzhou Bao, Namrata Gautam, Hongrui Wang, Bing Xu, Xiao Lei Chen, Qing Li, Nicholas R. J. Gascoigne, Guo Fu

Cellular and Molecular Immunology

DOI

2023

MHC class II regulation of CD8+ T cell tolerance and implications in autoimmunity and cancer immunotherapy

Xiaojuan Zhou, Xian Jia, Zhe Huang, Chao Yang, Jiali Li, Wangnan Xie, Xiaoyu He, Wei Ying, Chenfeng Liu, Yun Liu, Kunyu Liao, Yazhen Hong, Xiao Lei Chen, Tianying Zhang, Ningshao Xia, Wen‐Hsien Liu, Guo Fu, Changchun Xiao

Cell Reports

DOI

2023

Spatial proteomics of immune microenvironment in nonalcoholic steatohepatitis-associated hepatocellular carcinoma

Meiyi Li, Lina Wang, Liang Cong, Chi Chun Wong, Xiang Zhang, Huarong Chen, Tao Zeng, Bin Li, Xian Jia, Jihui Huo, Yuhua Huang, Xiaoxue Ren, Sui Peng, Guo Fu, Lixia Xu, Joseph J.�Y. Sung, Ming Kuang, Xiaoxing Li, Jun Qing Yu

Hepatology

DOI

2023

Integration of Protein Nanocage with CpG Motifs: A Virus‐Mimicked Core‐Shell Nanostructure to Ignite Antitumor Immunity

Qiang Zhang, Junchen Dong, Jiaping Wang, Jiayu Wang, Chufan Wang, Yao Li, Xiao Lei Chen, Xiumin Wang, Wenjun Shan, Guo Fu, Lei Ren

Small

DOI

2022

[The Effect of KRAS on Proliferation and Apoptosis of T-ALL Cell Lines].

Zi-Yang Liu, Y. Shu, Guo Fu, Hong-Yu Su, D. Zhu, Lan Zeng, De-Yu Ma, L. Zou

Zhongguo shi yan xue ye xue za zhi

DOI

2022

Oncolytic virus expressing PD-1 inhibitors activates a collaborative intratumoral immune response to control tumor and synergizes with CTLA-4 or TIM-3 blockade

Fei Ju, Yong Luo, Chaolong Lin, Xian Jia, Zilong Xu, Rui Tian, Yanhua Lin, Min Zhao, Ya‐Ting Chang, Xiaoxuan Huang, Shaopeng Li, Wenfeng Ren, Yaning Qin, Mengqin Yu, Jizong Jia, Jinle Han, Wenxin Luo, Jun Zhang, Guo Fu, Xiangzhong Ye, Chenghao Huang, Ningshao Xia

Journal for ImmunoTherapy of Cancer

DOI

2022

Themis is indispensable for IL-2 and IL-15 signaling in T cells

Yongchao Liu, Cong Yu, Yujia Niu, Yuan Yin, Fancheng Tan, Qian Lai, Yanyan Hu, Bowen Hou, Jian Li, Chunjie Lin, Haiping Zheng, Junchen Dong, Jian Tang, Qinwei Chen, Joanna Brzostek, Xueqin Zhang, Xiao Lei Chen, Hongrui Wang, Nicholas R. J. Gascoigne, Bing Xu, Shuhai Lin, Guo Fu

Science Signaling

DOI

2021

[Induction of mouse T lymphocyte differentiation in vitro by thymic organoids].

M. Gong, Guo Fu, Y. Shu, D. Zhu, T. Jiang, Haobiao Wang, Zi-Yang Liu, Hong-Yu Su, L. Zou

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

2021

Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt

Chenfeng Liu, Lei Ma, Yuxuan Wang, Jiayi Zhao, Pengda Chen, Xian Chen, Yingxin Wang, Yanyan Hu, Yun Liu, Xian Jia, Zhang‐Hua Yang, Xingzhi Yin, Jianfeng Wu, Suqin Wu, Haiping Zheng, Xiaohong Ma, Xiufeng Sun, Ying He, Lianghua Lin, Yubing Fu, Kunyu Liao, Xiaojuan Zhou, Shan Jiang, Guofeng Fu, Guofeng Fu, Jian Tang, Wei Han, Xiao Lei Chen, Wenzhu Fan, Yazhen Hong, Jiahuai Han, Xiangyang Huang, Boan Li, Changchun Xiao, Changchun Xiao, Guo Fu, Guo Fu, Wen‐Hsien Liu

Science Advances

DOI

2020

Review for "Deep phenotypical characterization of human CD3 + CD56 + T cells by mass cytometry"

Guo Fu

DOI

2019

ARRB1-promoted NOTCH1 degradation is suppressed by oncomiR miR-223 in T cell acute lymphoblastic leukemia

Y. Shu, Yi Wang, Wenjia Lv, D. Peng, Juan Li, Hang Zhang, Guangjie Jiang, Bigen Yang, Shan Liu, Jia Zhang, Yan-Hua Chen, Shi Tang, Ke-Xing Wan, Jun Yuan, Wei Guo, Guo Fu, Xinkun Qi, Zhi-Dai Liu, Hai-Yan Liu, Chao-Xu Yang, Ling-Huan Zhang, Fang Liu, Jie Yu, Penghui Zhang, B. Qu, Hui Zhao, Tong-Chuan He, Lin Zou

Cancer Research

DOI

2019

Correction: Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T-cell malignancies

Jinqi Huang, Stepanov Alexey, Jian Jian Li, Terri M. Jones, Geramie Grande, Lacey Douthit, Jun Xie, Danna Chen, Xiaolei Wu, Maschan Michael, Changchun Xiao, Jiangning Zhao, Xuehua Xie, Jia Xie, Xiao Lei Chen, Guo Fu, Gabibov Alexander, Chi‐Meng Tzeng

Leukemia

DOI

2019

Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T-cell malignancies

Jinqi Huang, Stepanov Alexey, Jian Li, Terri M. Jones, Geramie Grande, Lacey Douthit, Jun Xie, Danna Chen, Xiaolei Wu, Maschan Michael, Changchun Xiao, Jiangning Zhao, Xuehua Xie, Jia Xie, Xiao Lei Chen, Guo Fu, Gabibov Alexander, Chi‐Meng Tzeng

Leukemia

DOI

2019

Bioengineered Nanocage from HBc Protein for Combination Cancer Immunotherapy

Wenjun Shan, Haiping Zheng, Guofeng Fu, Guofeng Fu, Chenfeng Liu, Zizhen Li, Yuhan Ye, Jie Zhao, Dan Xu, Liping Sun, Xin Wang, Xiao Lei Chen, Shengli Bi, Lei Ren, Guo Fu, Guo Fu

Nano Letters

DOI

2018

ARRB1-Induced NOTCH1 Degradation Is Inhibited By Mir-223 in T-ALL

Lin Zou, Y. Shu, Yi Wang, Wen-Qiong Lv, Danyi Peng, Hang Zhang, Guangjie Jiang, Shan Liu, Yan-Hua Chen, Shi Tang, Guo Fu, Xinkun Qi, Zhi-Dai Liu, Hai-Yan Liu, Chao Yang, Fangjie Liu, Jie Yu, Penghui Zhang, B. Qu, Hui Zhao, Tong-Chuan He

Blood

DOI

2018

Patient's T Cell Functionality Determines Blinatumomab-Mediated Killing of B-ALL Leukemia Cells

Hong Xia Yin, Xian Jia, Xiaojie Guo, Yong Zhou, Manman Deng, Jian Li, Yan Qiu, Limin Lu, En‐Tzu Tang, Xiaolei Chen, Guo Fu, Mingqiang Zhang, Bing Xu, Ruibao Ren, Zhi‐Qiang Du

Blood

DOI

2017

The RIP3-RIP1-NF-κB signaling axis is dispensable for necroptotic cells to elicit cross-priming of CD8+ T cells

Junming Ren, Xian Jia, Yihao Zhao, Wenke Shi, Jiongcong Lu, Yingying Zhang, Jianfeng Wu, Bo Liang, Rui Wu, Guo Fu, Jiahuai Han

Cellular and Molecular Immunology

DOI

2016

A miR-155–Peli1–c-Rel pathway controls the generation and function of T follicular helper cells

Wen‐Hsien Liu, Seung Goo Kang, Zhe Huang, Cheng-Jang Wu, Hyun Yong Jin, Christian J. Maine, Yi Liu, Jovan Shepherd, Mohsen Sabouri-Ghomi, Alicia González-Martín, Shunbin Xu, Alexander Hoffmann, Ye Zheng, Li‐Fan Lu, Nengming Xiao, Guo Fu, Changchun Xiao

The Journal of Experimental Medicine

DOI

2000

多发性硬化患者血清TGF←β1的检测及其临床意义

何志义，吕昌龙，刘凤芝，付国，王刚

《中国免疫学杂志》

1999

多发性硬化患者血清sIL-6R水平观察

何志义，吕昌龙，刘风芝，王钢，付国，李绍英

《免疫学杂志》

付国

精选作品

期刊论文

PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T cells.

Themis dominates T cell exhaustion by regulation of TCR and PD-1 signaling

T cell heterogeneity in asthma pathogenesis: from immunological mechanisms to biological targeted therapies

p38 signaling enhances short-lived effector cell differentiation and weakens central memory CD8+ T-cell formation

Themis differentially regulates T follicular helper cell differentiation during early and late stages of chronic viral infection

SHP-1 Regulates CD8+ T Cell Effector Function but Plays a Subtle Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific Nonredundant Functional Relay.

Themis suppresses the effector function of CD8+ T cells in acute viral infection

MHC class II regulation of CD8+ T cell tolerance and implications in autoimmunity and cancer immunotherapy

Spatial proteomics of immune microenvironment in nonalcoholic steatohepatitis-associated hepatocellular carcinoma

Integration of Protein Nanocage with CpG Motifs: A Virus‐Mimicked Core‐Shell Nanostructure to Ignite Antitumor Immunity

[The Effect of KRAS on Proliferation and Apoptosis of T-ALL Cell Lines].

Oncolytic virus expressing PD-1 inhibitors activates a collaborative intratumoral immune response to control tumor and synergizes with CTLA-4 or TIM-3 blockade

Themis is indispensable for IL-2 and IL-15 signaling in T cells

[Induction of mouse T lymphocyte differentiation in vitro by thymic organoids].

Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt

Review for "Deep phenotypical characterization of human CD3 + CD56 + T cells by mass cytometry"

ARRB1-promoted NOTCH1 degradation is suppressed by oncomiR miR-223 in T cell acute lymphoblastic leukemia

Correction: Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T-cell malignancies

Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T-cell malignancies

Bioengineered Nanocage from HBc Protein for Combination Cancer Immunotherapy

ARRB1-Induced NOTCH1 Degradation Is Inhibited By Mir-223 in T-ALL

Patient's T Cell Functionality Determines Blinatumomab-Mediated Killing of B-ALL Leukemia Cells

The RIP3-RIP1-NF-κB signaling axis is dispensable for necroptotic cells to elicit cross-priming of CD8+ T cells

A miR-155–Peli1–c-Rel pathway controls the generation and function of T follicular helper cells

多发性硬化患者血清TGF←β1的检测及其临床意义

多发性硬化患者血清sIL-6R水平观察

预印本

Revealing the Evolution of the Tumor Immune Microenvironment in Follicular Lymphoma Patients Progressing Within 24 Months Using Single-cell Imaging Mass Cytometry

书籍章节

A Carrier Strategy for Mass Cytometry Analysis of Small Numbers of Cells

研究方向