邓万燕｜重庆医科大学｜学者主页

2026

神经损伤诱导蛋白1(NINJ1):从介导细胞质膜破裂到炎症性疾病治疗靶点

郑诗棋，张琪琦，杨丹，邓万燕

《中国科学:生命科学》

2026

Intratumoral Mycobacterium abscessus promotes cytidine deaminase mutagenesis in non-small cell lung cancer

Xun Li, Mei-Ting Li, Kepeng Ou, Panqi Gao, Anhua Xiao, J. Yang, Jia-Ning Li, Wan-Yan Deng, Mengjun Bie, Ai-Long Huang, Xiaofeng Shi, Quan-xin Long

Signal Transduction and Targeted Therapy

DOI

2025

ER-resident CCDC134 safeguards TLR4 maturation by maintaining gp96 stability

Yang Bai, Chao Zhang, Hao Liu, Fan Deng, Zeyu Wu, Wan-Yan Deng, Zengzhang Zheng, Rui Min, Sheng-Lin Mei, Hee-Kwon Kang, Huiqing Yu, You-Dong Pan, Judy Lieberman, Jing-Xia Zhao, Xing Liu

Proceedings of the National Academy of Sciences of the United States of America

DOI

2023

病原体逃逸宿主固有免疫的新策略：抑制细胞焦亡

杨茂艺，崔潇月，郑诗棋，马诗瑶，郑增长，邓万燕

《遗传》

2023

Inhibiting pyroptosis: novel immune evasion strategies for pathogens.

Maoyi Yang, Xiaoyan Cui, Shi-Zhong Zheng, Shilan Ma, Zengzhang Zheng, Wan-Yan Deng

Yi chuan = Hereditas

DOI

2023

A spacer design strategy for CRISPR‐Cas12f1 with single‐nucleotide polymorphism mutation resolution capability and its application in the mutations diagnosis of pathogens

Panqi Gao, Maoyi Yang, Y. Chen, Jun Yan, Miaomiao Han, Hai-Jun Deng, K. Qian, Jian-Dong Yang, Yao-Qin Lu, Ling Zhou, Ailong Huang, Xiao-Song Li, Wan-Yan Deng, Quan-xin Long

Journal of Medical Virology

DOI

2022

Gasdermin家族蛋白介导的细胞焦亡及其病理作用与靶向干预

白杨，邓万燕，闵睿，刘星

《药学进展》

2022

Mycobacterium tuberculosis Rv2387 Facilitates Mycobacterial Survival by Silencing TLR2/p38/JNK Signaling

Wu Li, Wan-Yan Deng, Nan Zhang, Huijuan Peng, Yi Xu

Pathogens

DOI

2022

Deficiency of GntR Family Regulator MSMEG_5174 Promotes Mycobacterium smegmatis Resistance to Aminoglycosides via Manipulating Purine Metabolism

Wan-Yan Deng, Zengzhang Zheng, Yi Chen, Mao-Yi Yang, Jun Yan, Wu Li, Jie Zeng, Jian-Ping Xie, S. Gong, H. Zeng

Frontiers in Microbiology

DOI

2022

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

Wan-Yan Deng, Yang Bai, Fan Deng, You-Dong Pan, S. Mei, Zengzhang Zheng, Rui Min, Zeyu Wu, Wu Li, R. Miao, Zhibin Zhang, T. Kupper, J. Lieberman, Xing Liu

Nature

DOI

2022

Author Correction: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

Wan-Yan Deng, Yang Bai, Fan Deng, You-Dong Pan, S. Mei, Zengzhang Zheng, Rui Min, Zeyu Wu, Wu Li, R. Miao, Zhibin Zhang, T. Kupper, J. Lieberman, Xing Liu

Nature

DOI

2021

The Lysosomal Rag-Ragulator Complex Licenses RIPK1 and Caspase-8-mediated Pyroptosis by Yersinia

Zengzhang Zheng, Wan-Yan Deng, Yang Bai, R. Miao, S. Mei, Zhi-Bin Zhang, You-Dong Pan, Yi Wang, Rui Min, Fan Deng, Ze-Yu Wu, Wu Li, Pengcheng Chen, Tianchi Ma, Xiwen Lou, J. Lieberman, Xing Liu

Science

DOI

2020

Gasdermins: pore-forming activities and beyond.

Zengzhang Zheng, Wan-Yan Deng, Xiwen Lou, Yang Bai, Junhong Wang, H. Zeng, S. Gong, Xing Liu

Acta Biochimica et Biophysica Sinica

DOI

2020

Mycobacterium tuberculosis Rv0341 Promotes Mycobacterium Survival in In Vitro Hostile Environments and within Macrophages and Induces Cytokines Expression

A. E. Abdalla, Shuang-Quan Yan, Jie Zeng, Wan-Yan Deng, Long-Xiang Xie, Jian-Ping Xie

Pathogens

DOI

2020

Mycobacterial ethambutol responsive genes and implications in antibiotics resistance

Xiao-hong Xiang, Zhen Gong, Wan-Yan Deng, Qingyu Sun, Jian-Ping Xie

Journal of drug targeting (Print)

DOI

2020

L-lysine potentiates aminoglycosides against Acinetobacter baumannii via regulation of proton motive force and antibiotics uptake

Wan-Yan Deng, Tiwei Fu, Zhen Zhang, Xiao Jiang, Jian-Ping Xie, Hang Sun, P. Hu, H. Ren, P. Zhou, Qi Liu, Q. Long

Emerging Microbes and Infections

DOI

2019

PE_PGRS62 promotes the survival of Mycobacterium smegmatis within macrophages via disrupting ER stress‐mediated apoptosis

Quan-xin Long, Xiao-hong Xiang, Qing-qin Yin, Shuang-Jiang Li, Wenmin Yang, Hang Sun, Qi Liu, Jian-Ping Xie, Wan-Yan Deng

Journal of Cellular Physiology

DOI

2018

The Biology and Role of Interleukin-32 in Tuberculosis

Wu Li, Wan-Yan Deng, Jian-Ping Xie

Journal of Immunological Research

DOI

2018

Expression and regulatory networks of Mycobacterium tuberculosis PE/PPE family antigens

Wu Li, Wan-Yan Deng, Jian-Ping Xie

Journal of Cellular Physiology

DOI

2017

CRISPR-Cas9系统抑制乙型肝炎病毒复制相关研究

邓万燕，孟田，钱克莉，蔡雪飞，邓海君，胡接力，黄爱龙，龙泉鑫

《重庆医科大学学报》

2017

Mycobacterium tuberculosis PE_PGRS41 Enhances the Intracellular Survival of M. smegmatis within Macrophages Via Blocking Innate Immunity and Inhibition of Host Defense

Wan-Yan Deng, Quan-xin Long, Jie Zeng, Ping Li, Wenmin Yang, Xin-Chun Chen, Jian-Ping Xie

Scientific Reports

DOI

2017

Comparative analysis of prophages in Streptococcus mutans genomes

Tiwei Fu, Xiangyu Fan, Q. Long, Wan-Yan Deng, Jinlin Song, E. Huang

PeerJ

DOI

2017

Histoplasma capsulatumヒト病原体のリジンスクシニル化のプロテオーム解析【Powered by NICT】

Long-Xiang Xie, Juan Li, Wan-Yan Deng, Zhao-Xiao Yu, W. Fang, Min Chen, W. Liao, Jian-Ping Xie, W. Pan

2017

Proteomic analysis of lysine succinylation of the human pathogen Histoplasma capsulatum.

Long-Xiang Xie, Juan Li, Wan-Yan Deng, Zhao-Xiao Yu, W. Fang, Min Chen, W. Liao, Jian-Ping Xie, W. Pan

Journal of Proteomics

DOI

2016

Global profiling of lysine acetylation in human histoplasmosis pathogen Histoplasma capsulatum.

Long-Xiang Xie, W. Fang, Wan-Yan Deng, Zhao-Xiao Yu, Juan Li, Min Chen, W. Liao, Jian-Ping Xie, W. Pan

International Journal of Biochemistry and Cell Biology

DOI

2016

Mycobacterium tuberculosis PE_PGRS18 enhances the intracellular survival of M. smegmatis via altering host macrophage cytokine profiling and attenuating the cell apoptosis

Wenmin Yang, Wan-Yan Deng, Jie Zeng, Sai Ren, Md Kaisar Ali, Yin-Zhong Gu, Yangyuling Li, Jian-Ping Xie

Apoptosis

DOI

2016

MicroRNAs play big roles in modulating macrophages response toward mycobacteria infection.

A. E. Abdalla, Xiang-Ke Duan, Wan-Yan Deng, Jie Zeng, Jian-Ping Xie

Infection, Genetics and Evolution

DOI

2016

Mycobacterium tuberculosis PPE32 promotes cytokines production and host cell apoptosis through caspase cascade accompanying with enhanced ER stress response

Wan-Yan Deng, Wenmin Yang, Jie Zeng, A. E. Abdalla, Jian-Ping Xie

OncoTarget

DOI

2016

Mycobacterium tuberculosis Rv1152 is a Novel GntR Family Transcriptional Regulator Involved in Intrinsic Vancomycin Resistance and is a Potential Vancomycin Adjuvant Target

Jie Zeng, Wan-Yan Deng, Wenmin Yang, Hongping Luo, Xiang-Ke Duan, Long-Xiang Xie, Ping Li, Rui Wang, Tiwei Fu, A. E. Abdalla, Jian-Ping Xie

Scientific Reports

DOI

2015

结核分枝杆菌PE/PPE家族蛋白的性质及其在与宿主细胞相互作用中的功能

邓万燕

《西南大学》

2015

PE11 (Rv1169c) selectively alters fatty acid components of Mycobacterium smegmatis and host cell interleukin-6 level accompanied with cell death

Wan-Yan Deng, Jie Zeng, Xiao-hong Xiang, Ping Li, Jian-Ping Xie

Frontiers in Microbiology

DOI

2014

Mycobacterium tuberculosis Rv3402c Enhances Mycobacterial Survival within Macrophages and Modulates the Host Pro-Inflammatory Cytokines Production via NF-Kappa B/ERK/p38 Signaling

Wu Li, Quan-Ju Zhao, Wan-Yan Deng, Tian Chen, Minqiang Liu, Jian-Ping Xie

PLoS ONE

DOI

2014

Mycobacterium biofilms: factors involved in development, dispersal, and therapeutic strategies against biofilm-relevant pathogens.

Xiao-hong Xiang, Wan-Yan Deng, Minqiang Liu, Jian-Ping Xie

Critical Reviews in Eukaryotic Gene Expression

DOI

2014

Mycobacterium tuberculosis Serine Protease Rv3668c Can Manipulate the Host–Pathogen Interaction via Erk-NF-κB Axis-Mediated Cytokine Differential Expression

Quan-Ju Zhao, Wu Li, Tian Chen, Ying He, Wan-Yan Deng, Hongping Luo, Jian-Ping Xie

Journal of Interferon and Cytokine Research

DOI

2014

Correction: Mycobacterium tuberculosis Rv3402c Enhances Mycobacterial Survival within Macrophages and Modulates the Host Pro-Inflammatory Cytokines Production via NF-Kappa B/ERK/p38 Signaling

Wu Li, Quan-Ju Zhao, Wanyan Deng, Tian Chen, Minqiang Liu, Jianping Xie, L. W., Zhaoqun Deng, Chen Liu

PLoS ONE

DOI

2014

Mycobacterium Tuberculosis PPE Family Protein Rv1808 Manipulates Cytokines Profile via Co-Activation of MAPK and NF-κB Signaling Pathways

Wan-Yan Deng, Wu Li, Jie Zeng, Quan-Ju Zhao, Chunmei Li, Yu-Zhong Zhao, Jian-Ping Xie

Cellular Physiology and Biochemistry

DOI

2013

The Mycobacterium DosR regulon structure and diversity revealed by comparative genomic analysis

Tian Chen, Li-Ming He, Wan-Yan Deng, Jian-Ping Xie

Journal of Cellular Biochemistry

DOI

2013

Comparative Genomic and Proteomic Anatomy of Mycobacterium Ubiquitous Esx Family Proteins: Implications in Pathogenicity and Virulence

Wan-Yan Deng, Xiao-hong Xiang, Jian-Ping Xie

Current Microbiology

DOI

2013

The underling mechanism of bacterial TetR/AcrR family transcriptional repressors.

Wan-Yan Deng, Chunmei Li, Jian-Ping Xie

Cellular Signalling

DOI

2013

Mycobacterium tuberculosis Biology Revealed by Proteome Profiling and Integration of Multi-omics Data—Proteomics Insight into M. tuberculosis Systems Biology

Wan-Yan Deng, Xiangyu Fan, Xiao-Zhen Wang, Ying He, Zi-hui Li, Jie Song, L. Ping, Lei Chang, D. Duong, Zong-De Zhang, Ping Xu, Jian-Ping Xie

DOI

2012

致病菌生物被膜形成的调节机制及潜在的药物靶标

石廷玉，邓万燕，谢建平

《药学学报》

2012

The Structure, Function, and Regulation of Mycobacterium FtsZ

Weiling Hong, Wan-Yan Deng, Jian-Ping Xie

Cell Biochemistry and Biophysics

DOI

2012

Ins and outs of Mycobacterium tuberculosis PPE family in pathogenesis and implications for novel measures against tuberculosis

Wan-Yan Deng, Jian-Ping Xie

Journal of Cellular Biochemistry

DOI

2012

NOD2 Signaling and Role in Pathogenic Mycobacterium Recognition, Infection and Immunity

Wan-Yan Deng, Jian-Ping Xie

Cellular Physiology and Biochemistry

DOI

2012

Insights into the distribution and functions of the eukaryotic GPI-like anchored genes among Mycobacterium from a comparative genomic perspective.

Wan-Yan Deng, Jie Zeng, Xiao-hong Xiang, Jian-Ping Xie

Critical Reviews in Eukaryotic Gene Expression

DOI

2012

The biology of Mycobacterium cord factor and roles in pathogen-host interaction.

Chunmei Li, Qing-Lin Du, Wan-Yan Deng, Jian-Ping Xie

Critical Reviews in Eukaryotic Gene Expression

DOI

2012

Novel insights into Mycobacterium antigen Ag85 biology and implications in countermeasures for M. tuberculosis.

Xiemei Tang, Wan-Yan Deng, Jian-Ping Xie

Critical Reviews in Eukaryotic Gene Expression

DOI

2012

[Regulatory mechanism underlying pathogen biofilm formation and potential drug targets].

Tingyu Shi, Wan-Yan Deng, Jian-Ping Xie

Yao xue xue bao = Acta pharmaceutica Sinica

2011

New insights into the pathogenesis of tuberculosis revealed by Mycobacterium marinum: the zebrafish model from the systems biology perspective.

Wan-Yan Deng, Xiemei Tang, Manmei Hou, Chunmei Li, Jian-Ping Xie

Critical Reviews in Eukaryotic Gene Expression

DOI

2011

Regulatory and pathogenesis roles of Mycobacterium Lrp/AsnC family transcriptional factors

Wan-Yan Deng, Honghai Wang, Jian-Ping Xie

Journal of Cellular Biochemistry

DOI

精选作品

期刊论文

神经损伤诱导蛋白1(NINJ1):从介导细胞质膜破裂到炎症性疾病治疗靶点

Intratumoral Mycobacterium abscessus promotes cytidine deaminase mutagenesis in non-small cell lung cancer

ER-resident CCDC134 safeguards TLR4 maturation by maintaining gp96 stability

病原体逃逸宿主固有免疫的新策略：抑制细胞焦亡

Inhibiting pyroptosis: novel immune evasion strategies for pathogens.

A spacer design strategy for CRISPR‐Cas12f1 with single‐nucleotide polymorphism mutation resolution capability and its application in the mutations diagnosis of pathogens

Gasdermin家族蛋白介导的细胞焦亡及其病理作用与靶向干预

Mycobacterium tuberculosis Rv2387 Facilitates Mycobacterial Survival by Silencing TLR2/p38/JNK Signaling

Deficiency of GntR Family Regulator MSMEG_5174 Promotes Mycobacterium smegmatis Resistance to Aminoglycosides via Manipulating Purine Metabolism

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

Author Correction: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

The Lysosomal Rag-Ragulator Complex Licenses RIPK1 and Caspase-8-mediated Pyroptosis by Yersinia

Gasdermins: pore-forming activities and beyond.

Mycobacterium tuberculosis Rv0341 Promotes Mycobacterium Survival in In Vitro Hostile Environments and within Macrophages and Induces Cytokines Expression

Mycobacterial ethambutol responsive genes and implications in antibiotics resistance

L-lysine potentiates aminoglycosides against Acinetobacter baumannii via regulation of proton motive force and antibiotics uptake

PE_PGRS62 promotes the survival of Mycobacterium smegmatis within macrophages via disrupting ER stress‐mediated apoptosis

The Biology and Role of Interleukin-32 in Tuberculosis

Expression and regulatory networks of Mycobacterium tuberculosis PE/PPE family antigens

CRISPR-Cas9系统抑制乙型肝炎病毒复制相关研究

Mycobacterium tuberculosis PE_PGRS41 Enhances the Intracellular Survival of M. smegmatis within Macrophages Via Blocking Innate Immunity and Inhibition of Host Defense

Comparative analysis of prophages in Streptococcus mutans genomes

Histoplasma capsulatumヒト病原体のリジンスクシニル化のプロテオーム解析【Powered by NICT】

Proteomic analysis of lysine succinylation of the human pathogen Histoplasma capsulatum.

Global profiling of lysine acetylation in human histoplasmosis pathogen Histoplasma capsulatum.

Mycobacterium tuberculosis PE_PGRS18 enhances the intracellular survival of M. smegmatis via altering host macrophage cytokine profiling and attenuating the cell apoptosis

MicroRNAs play big roles in modulating macrophages response toward mycobacteria infection.

Mycobacterium tuberculosis PPE32 promotes cytokines production and host cell apoptosis through caspase cascade accompanying with enhanced ER stress response

Mycobacterium tuberculosis Rv1152 is a Novel GntR Family Transcriptional Regulator Involved in Intrinsic Vancomycin Resistance and is a Potential Vancomycin Adjuvant Target

结核分枝杆菌PE/PPE家族蛋白的性质及其在与宿主细胞相互作用中的功能

PE11 (Rv1169c) selectively alters fatty acid components of Mycobacterium smegmatis and host cell interleukin-6 level accompanied with cell death

Mycobacterium tuberculosis Rv3402c Enhances Mycobacterial Survival within Macrophages and Modulates the Host Pro-Inflammatory Cytokines Production via NF-Kappa B/ERK/p38 Signaling

Mycobacterium biofilms: factors involved in development, dispersal, and therapeutic strategies against biofilm-relevant pathogens.

Mycobacterium tuberculosis Serine Protease Rv3668c Can Manipulate the Host–Pathogen Interaction via Erk-NF-κB Axis-Mediated Cytokine Differential Expression

Correction: Mycobacterium tuberculosis Rv3402c Enhances Mycobacterial Survival within Macrophages and Modulates the Host Pro-Inflammatory Cytokines Production via NF-Kappa B/ERK/p38 Signaling

Mycobacterium Tuberculosis PPE Family Protein Rv1808 Manipulates Cytokines Profile via Co-Activation of MAPK and NF-κB Signaling Pathways

The Mycobacterium DosR regulon structure and diversity revealed by comparative genomic analysis

Comparative Genomic and Proteomic Anatomy of Mycobacterium Ubiquitous Esx Family Proteins: Implications in Pathogenicity and Virulence

The underling mechanism of bacterial TetR/AcrR family transcriptional repressors.

Mycobacterium tuberculosis Biology Revealed by Proteome Profiling and Integration of Multi-omics Data—Proteomics Insight into M. tuberculosis Systems Biology

致病菌生物被膜形成的调节机制及潜在的药物靶标

The Structure, Function, and Regulation of Mycobacterium FtsZ

Ins and outs of Mycobacterium tuberculosis PPE family in pathogenesis and implications for novel measures against tuberculosis

NOD2 Signaling and Role in Pathogenic Mycobacterium Recognition, Infection and Immunity

Insights into the distribution and functions of the eukaryotic GPI-like anchored genes among Mycobacterium from a comparative genomic perspective.

The biology of Mycobacterium cord factor and roles in pathogen-host interaction.

Novel insights into Mycobacterium antigen Ag85 biology and implications in countermeasures for M. tuberculosis.

[Regulatory mechanism underlying pathogen biofilm formation and potential drug targets].

New insights into the pathogenesis of tuberculosis revealed by Mycobacterium marinum: the zebrafish model from the systems biology perspective.

Regulatory and pathogenesis roles of Mycobacterium Lrp/AsnC family transcriptional factors

会议论文

结核分枝杆菌蛋白Rv3402c的毒力研究

研究方向