彭丽洁｜暨南大学｜学者主页

期刊论文

2024

Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in Pancreatic Cancer Therapy.

Zifeng Tang, Jie Li, Lijie Peng, Fang Xu, Yi Tan, Xiao-Qiang He, Cheng-Jun Zhu, Zhi-Min Zhang, Zhang Zhang, Pinghua Sun, Ke Ding, Zhengqiu Li

Journal of Medicinal Chemistry

DOI

2023

Discovery of 3,5-diaryl-1H-pyrazol-based ureas as potent RET inhibitors.

Kaifu Wu, Rui He, Zongyang Li, Kong Qiu, Guo-Lan Xiao, Lijie Peng, Xiang-Bao Meng, Can-Hui Zheng, Zhang Zhang, Q. Cai

European journal of medicinal chemistry

DOI

2022

Discovery of Hexahydrofuro[3,2-b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant.

Shan Li, Hongfei Si, Xiao-Juan Song, Chong Lei, Xiao-Qiang He, Jie Wang, Yi-Ling Liu, Yang Zhou, Jian-Guo Song, Lijie Peng, Xia Tang, Shingpan Chan, Xiao-Mei Ren, Zhengchao Tu, Zhengqiu Li, Zhen Wang, Zhang Zhang, Ke Ding

Journal of Medicinal Chemistry

DOI

2022

Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors.

Zhen Zhang, Jie Li, Hao Chen, Jing Huang, Xiao-Juan Song, Zhengchao Tu, Zhang Zhang, Lijie Peng, Yang Zhou, Ke Ding

Journal of Medicinal Chemistry

DOI

2022

Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFRT790M/C797S Mutants.

Shanshan Li, Zhang Tao, Su-Jie Zhu, Chong Lei, Mengzhen Lai, Lijie Peng, Lin-jiang Tong, Zilu Pang, Xiaoyun Lu, Jian Ding, Xiao-Mei Ren, Cai-Hong Yun, Hua Xie, Ke Ding

ACS Medicinal Chemistry Letters

DOI

2022

Discovery of JND003 as a New Selective Estrogen-Related Receptor α Agonist Alleviating Nonalcoholic Fatty Liver Disease and Insulin Resistance

Liu-Feng Mao, Lijie Peng, Xiao-Mei Ren, Yi Chu, Tao Nie, Wanhua Lin, Xue-Bin Zhao, Andrew E. Libby, Yong Xu, Yu Chang, Chong Lei, K. Loomes, N. Wang, Jin-Song Liu, Moshe Levi, Dong-Hai Wu, X. Hui, Ke Ding

ACS Bio & Med Chem Au

DOI

2022

Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors

Jiaqian Xu, Lijie Peng, Cuiping Guo, Fang Xu, Dong Lin, Yi Tang, Zhengqiu Li

ChemBioChem

DOI

2022

Discovery of BRAF/HDAC Dual Inhibitors Suppressing Proliferation of Human Colorectal Cancer Cells

Ying-Jun Li, Yongjun Huang, Huimin Cheng, Fangye Xu, Ru-Xi Qi, Botao Dai, Yujian Yang, Zhengchao Tu, Lijie Peng, Zhang Zhang

Frontiers in Chemistry

DOI

2021

以药为本的有机化学课程教学改革

许芳，彭丽洁，张章，唐金山，陈河如

《药学教育》

DOI

2021

Development and application of novel electrophilic warheads in target identification and drug discovery.

Yue Liu, Shu-Min Lv, Lijie Peng, Cheng-Liang Xie, Li-Qian Gao, Hong-Yan Sun, Li-Gen Lin, Ke Ding, Zhengqiu Li

Biochemical Pharmacology

DOI

2019

Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation.

Lijie Peng, Zhensheng Zhang, Chong Lei, Shan Li, Z. Zhang, Xiao-Mei Ren, Yu Chang, Yan Zhang, Yong Xu, Ke Ding

ACS Medicinal Chemistry Letters

DOI

2018

Manganese-Catalyzed C−H Annulation of Ketimines with Allenes: Stereoselective Synthesis of 1-Aminoindanes

Chong Lei, Lijie Peng, Ke-Rong Ding

Advanced Synthesis and Catalysis

DOI

2017

基于优势资源建立和发展药学学科群的研究与实践

郭嘉亮，林静，彭丽洁，曾煦欣，孙平华

《基础医学教育》

2017

“双链”融合创新教学模式在药物化学实验教学中的应用

林静，郭嘉亮，彭丽洁，陈卫民，丁克，孙平华

《药学教育》

2016

4-Oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as New Axl Kinase Inhibitors.

Li Tan, Zhang Zhang, Dong-Lin Gao, Jin-Feng Luo, Zhengchao Tu, Zhengqiu Li, Lijie Peng, Xiao-Mei Ren, Ke Ding

Journal of Medicinal Chemistry

DOI

2015

2,7-二苯基-4H-吡啶并[1,2-a]嘧啶-4-酮类雌激素相关受体α(ERRα)转录功能抑制剂的合成及活性研究

李迎君，庄晓曦，彭丽洁，丁克

《中国科学:化学》

2015

提高实验课程中多媒体教学效果的实践与探索——以《药物化学实验》课程建设为例

孙平华，颜海波，郭嘉亮，林静，彭丽洁，陈卫民

《广东化工》

2015

Synthesis and biological evaluation of 2,7-diphenyl-4 H -pyrido[1,2- a ]-pyrimidin-4-ones as transcriptional function suppressors of estrogen-related receptor a (ERRα)

Ying-Jun Li, Ke-Rong Ding, Xiao-Xi Zhuang, Lijie Peng

DOI

2012

Recent advance in the design of small molecular modulators of estrogen-related receptors.

Xiaoyun Lu, Lijie Peng, Man Lv, Ke Ding

Current pharmaceutical design

DOI

2011

Identification of pyrido[1,2-α]pyrimidine-4-ones as new molecules improving the transcriptional functions of estrogen-related receptor α.

Lijie Peng, Xue-Fei Gao, Lei Duan, Xiao-Mei Ren, Dong-Hai Wu, Ke-Rong Ding

Journal of Medicinal Chemistry

DOI

2011

Structure-activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors.

Lijie Peng, Lei Duan, Xiaofeng Liu, M. Shen, Ying-Jun Li, Jia-Jie Yan, Honglin Li, Ke-Rong Ding

Bioorganic & Medicinal Chemistry Letters

DOI

2011

Sequential Hydration—Condensation—Double Cyclization of Pyridine-Substituted 2-Alkynylanilines: An Efficient Approach to Quinoline-Based Heterocycles.

Lijie Peng, Honggen Wang, Changlan Peng, Ke-Rong Ding, Qiang Zhu

DOI

2008

Compound as estrogen-related receptor modulator and application thereof

Ke-Rong Ding, Zhi-Wei Huang, Lijie Peng, Z. Kang, Xi Zhou

会议论文

2018

Estrogen related receptor(ERR) modulators as novel potential agents for metabolic disorders

Lijie Peng, Shilin Xu, Xiaoyun Lu, Xiaomei Ren, Ke Ding

《第11届世界华人药物化学研讨会（ISCMC 2018）》

2013

Targeting the Undruggable Tagert Identification of the First Class of Estrogen-Related ReceptorαAgonists

Lijie Peng, Xiaomei Ren, Xiaoyun Lu, Ke Ding

《2013年全国药物化学学术会议暨第四届中英药物化学学术会议会议指南》

彭丽洁

精选作品

期刊论文

Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in Pancreatic Cancer Therapy.

Discovery of 3,5-diaryl-1H-pyrazol-based ureas as potent RET inhibitors.

Discovery of Hexahydrofuro[3,2-b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant.

Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors.

Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFRT790M/C797S Mutants.

Discovery of JND003 as a New Selective Estrogen-Related Receptor α Agonist Alleviating Nonalcoholic Fatty Liver Disease and Insulin Resistance

Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors

Discovery of BRAF/HDAC Dual Inhibitors Suppressing Proliferation of Human Colorectal Cancer Cells

以药为本的有机化学课程教学改革

Development and application of novel electrophilic warheads in target identification and drug discovery.

Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation.

Manganese-Catalyzed C−H Annulation of Ketimines with Allenes: Stereoselective Synthesis of 1-Aminoindanes

基于优势资源建立和发展药学学科群的研究与实践

“双链”融合创新教学模式在药物化学实验教学中的应用

4-Oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as New Axl Kinase Inhibitors.

2,7-二苯基-4H-吡啶并[1,2-a]嘧啶-4-酮类雌激素相关受体α(ERRα)转录功能抑制剂的合成及活性研究

提高实验课程中多媒体教学效果的实践与探索——以《药物化学实验》课程建设为例

Synthesis and biological evaluation of 2,7-diphenyl-4 H -pyrido[1,2- a ]-pyrimidin-4-ones as transcriptional function suppressors of estrogen-related receptor a (ERRα)

Recent advance in the design of small molecular modulators of estrogen-related receptors.

Identification of pyrido[1,2-α]pyrimidine-4-ones as new molecules improving the transcriptional functions of estrogen-related receptor α.

Structure-activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors.

Sequential Hydration—Condensation—Double Cyclization of Pyridine-Substituted 2-Alkynylanilines: An Efficient Approach to Quinoline-Based Heterocycles.

Compound as estrogen-related receptor modulator and application thereof

会议论文

Estrogen related receptor(ERR) modulators as novel potential agents for metabolic disorders

Targeting the Undruggable Tagert Identification of the First Class of Estrogen-Related ReceptorαAgonists

研究方向