张永有｜厦门大学｜学者主页

2026

Af-CUT&Tag: a sensitive and antibody-free chromatin profiling method using genetically encoded tags and high-affinity binders fused to Tn5

Xindong Wang, Xusheng Deng, Lu-Gui Qiu, Junjia Liu, Hengxiang Shen, Hao-Ran Du, Weijie Li, Lin-Xuan Song, Wenhui Deng, Xiaoning Dong, Yi Han, Benchao Liu, Jialiang Huang, Zeng-Peng Li, Yongyou Zhang

Nature Communications

DOI

2026

Hub of life and death: Global regulation of ferroptosis by inter-organelle crosstalk

Yun-Jie Cai, Hualei Zheng, Yongyou Zhang

Ferroptosis and Oxidative Stress

DOI

2026

Ribosome-tethered in situ sequencing for single-cell translatome analysis

Meng Jiang, Xiao-Jie He, Yan-Xiu Liu, Benchao Liu, Zhao-Xiang Xie, Wei-Yan Ma, Ling-Yu Zhu, Chen Lin, Yongyou Zhang, Rongqin Ke

bioRxiv

DOI

2025

Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism

Dishu Zhou, Ying Chen, Panpan Liu, Kun Zhu, Juliet Holder-Haynes, S. Lloyd, Campfield La, Inna Astapova, S. Choa, Ying Xiong, Hosung Bae, Marlene Aguilar, Hong-Yuan Yang, Yu A. An, Zheng Sun, Mark A. Herman, Xia Gao, Liming Pei, Cholsoon Jang, Josh Rabinowitz, S. Mattar, Yongyou Zhang, Dong-Yin Guan

Cell Metabolism

DOI

2024

METTL17 coordinates ferroptosis and tumorigenesis by regulating mitochondrial translation in colorectal cancer

Hao Li, Kailun Yu, Huilong Hu, Xian-Dang Zhang, Siyu Zeng, Jiawen Li, Xiaoning Dong, Xusheng Deng, Jianhui Zhang, Yongyou Zhang

Redox Biology

DOI

2024

ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer

Junjia Liu, Xin-Yi Lu, Siyu Zeng, Rong Fu, Xindong Wang, Li Luo, Ting Huang, Xusheng Deng, Hualei Zheng, Shaoqian Ma, Dan Ning, Lili Zong, Shu-Hai Lin, Yongyou Zhang

Redox Biology

DOI

2024

YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response

Hao Li, Kailun Yu, Xian-Dang Zhang, Jiawen Li, Huilong Hu, Xusheng Deng, Siyu Zeng, Xiaoning Dong, Junru Zhao, Yongyou Zhang

Genes and Diseases

DOI

2024

Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer.

Hualei Zheng, Hui-Di Chen, Yun-Jie Cai, M. Shen, Xi-Lin Li, Yi Han, Xusheng Deng, Hongjie Cao, Junjia Liu, Hao Li, Benchao Liu, Ganlin Li, Xindong Wang, Hui Chen, Jingjing Hou, Shu-Hai Lin, Lili Zong, Yongyou Zhang

Molecules and Cells

DOI

2022

Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling

P. Guo, Qiang Chen, Kesong Peng, Jian-Yuan Xie, Junjia Liu, Wenjing Ren, Zhang-Wei Tong, Ming Li, Jian-Ming Xu, Yongyou Zhang, Chundong Yu, Ping-Li Mo

Oncogene

DOI

2021

15-PGDH regulates hematopoietic and gastrointestinal fitness during aging

W. Ho, Julianne N. P. Smith, Young Soo Park, Matthew Hadiono, Kelsey F. Christo, Alvin P. Jogasuria, Yongyou Zhang, Alyssia V. Broncano, L. Kasturi, D. Dawson, S. Gerson, S. Markowitz, Amar B. Desai

bioRxiv

DOI

2021

Structural Insights into Novel 15-Prostaglandin Dehydrogenase Inhibitors

Prema L Mallipeddi, Yongyou Zhang, Hongyun Li, S. Markowitz, B. Posner

Molecules

DOI

2020

Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling

Minghui Zhuo, Wenbo Chen, Shaohui Shang, P. Guo, Kesong Peng, Ming Li, Ping-Li Mo, Yongyou Zhang, Xing-Feng Qiu, Wen-Gang Li, Chundong Yu

Oncogene

DOI

2020

Profiling chromatin regulatory landscape: insights into the development of ChIP-seq and ATAC-seq

Shaoqian Ma, Yongyou Zhang

Molecular Biomedicine

DOI

2020

15-PGDH as a Negative Regulator of Age-Related Organ Fitness

W. Ho, Julianne N. P. Smith, Young Soo Park, Matthew Hadiono, Kelsey F. Christo, Alvin P. Jogasuria, Yongyou Zhang, Alyssia V. Broncano, L. Kasturi, D. Dawson, S. Gerson, S. Markowitz, Amar B. Desai

DOI

2018

A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independently of age, transplant dose and granulocyte colony-stimulating factor support

Amar B. Desai, Yongyou Zhang, Youngsoo Park, D. Dawson, Gretchen A. Larusch, L. Kasturi, D. Wald, J. Ready, S. Gerson, S. Markowitz

Haematologica

DOI

2017

Inhibitors of 15-Prostaglandin Dehydrogenase to Potentiate Tissue Repair

Monika I. Antczak, Yongyou Zhang, Changguan Wang, Jennifer Doran, J. Naidoo, Sukesh Voruganti, N. Williams, S. Markowitz, J. Ready

Journal of Medicinal Chemistry

DOI

2015

Inhibition of the Prostaglandin Degrading Enzyme 15-PGDH Potentiates Tissue Regeneration

Yongyou Zhang, Amar B. Desai, S. Yang, K. Bae, Monika I. Antczak, S. Fink, Shruti Tiwari, J. Willis, N. Williams, D. Dawson, D. Wald, Wei-Dong Chen, Zheng-He Wang, L. Kasturi, Gretchen A. Larusch, Lucy He, F. Cominelli, L. Di Martino, Z. Djuric, G. Milne, M. Chance, J. Sanabria, C. Dealwis, D. Mikkola, J. Naidoo, Shu-Guang Wei, H. Tai, S. Gerson, J. Ready, B. Posner, J. Willson, S. Markowitz

Science

DOI

2015

Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs.

S. Fink, D. Dawson, Yongyou Zhang, A. Kresak, E. Lawrence, Pei-Ying Yang, Yan-Wen Chen, J. Barnholtz-Sloan, J. Willis, L. Kopelovich, S. Markowitz

Carcinogenesis

DOI

2015

Abstract 2815: Sulindac reversal of 15-PGDH mediated resistance to colon tumor chemoprevention with NSAIDs

S. Fink, D. Dawson, Yongyou Zhang, A. Kresak, E. Lawrence, Pei-Ying Yang, Yan-Wen Chen, J. Barnholtz-Sloan, J. Willis, L. Kopelovich, S. Markowitz

DOI

2013

FGFR1 is Essential for Prostate Cancer Progression and Metastasis

Feng Yang, Yongyou Zhang, S. Ressler, M. Ittmann, G. Ayala, T. Dang, Fen Wang, D. Rowley

Cancer Research

DOI

2011

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

Da-Wang Zhou, Yongyou Zhang, Hongtan Wu, E. Barry, Yi Yin, E. Lawrence, Dawn Dawson, J. Willis, S. Markowitz, F. Camargo, J. Avruch

Proceedings of the National Academy of Sciences of the United States of America

DOI

2011

CKS1B (CDC28 protein kinase regulatory subunit 1B)

Yongyou Zhang

DOI

2011

FRS2α is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts

Xiang Lin, Yongyou Zhang, Le-Yuan Liu, W. Mckeehan, Yue-Mao Shen, Si-Yang Song, Fen Wang

International Journal on Biological Sciences

DOI

2008

Frs2α-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis

Jue Zhang, Yongshun Lin, Yongyou Zhang, Y. Lan, Chunhong Lin, A. Moon, R. Schwartz, James F. Martin, Fen Wang

Development

DOI

2008

Role of epithelial cell fibroblast growth factor receptor substrate 2α in prostate development, regeneration and tumorigenesis

Yongyou Zhang, Jue Zhang, Yongshun Lin, Y. Lan, Chunhong Lin, J. Xuan, M. Shen, W. Mckeehan, N. Greenberg, Fen Wang

Development

DOI

2008

Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death

Y. Lan, Yongyou Zhang, Jiang-Huai Wang, Chunhong Lin, M. Ittmann, Fen Wang

International Journal of Cancer

DOI

2008

Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.

Yongyou Zhang, K. Mckeehan, Yongshun Lin, Jue Zhang, Fen Wang

Molecular Endocrinology

DOI

2007

Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis

Yongshun Lin, Guo-Qin Liu, Yongyou Zhang, Ya-Ping Hu, Kai Yu, Chunhong Lin, K. Mckeehan, J. Xuan, D. Ornitz, M. Shen, N. Greenberg, W. Mckeehan, Fen Wang

Development

DOI

2007

Generation of an Frs2α conditional null allele

Yongshun Lin, Jue Zhang, Yongyou Zhang, Fen Wang

DOI

2007

Generation of an Frs2alpha conditional null allele.

Yongshun Lin, Jue Zhang, Yongyou Zhang, Fen Wang

Genesis

2004

Direct Cell Cycle Regulation by the Fibroblast Growth Factor Receptor (FGFR) Kinase through Phosphorylation-dependent Release of Cks1 from FGFR Substrate 2*

Yongyou Zhang, Yongshun Lin, Courtney A. Bowles, Fen Wang

Journal of Biological Chemistry

DOI

张永有

精选作品

期刊论文

Af-CUT&Tag: a sensitive and antibody-free chromatin profiling method using genetically encoded tags and high-affinity binders fused to Tn5

Hub of life and death: Global regulation of ferroptosis by inter-organelle crosstalk

Ribosome-tethered in situ sequencing for single-cell translatome analysis

Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism

METTL17 coordinates ferroptosis and tumorigenesis by regulating mitochondrial translation in colorectal cancer

ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer

YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response

Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer.

Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling

15-PGDH regulates hematopoietic and gastrointestinal fitness during aging

Structural Insights into Novel 15-Prostaglandin Dehydrogenase Inhibitors

Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling

Profiling chromatin regulatory landscape: insights into the development of ChIP-seq and ATAC-seq

15-PGDH as a Negative Regulator of Age-Related Organ Fitness

A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independently of age, transplant dose and granulocyte colony-stimulating factor support

Inhibitors of 15-Prostaglandin Dehydrogenase to Potentiate Tissue Repair

Inhibition of the Prostaglandin Degrading Enzyme 15-PGDH Potentiates Tissue Regeneration

Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs.

Abstract 2815: Sulindac reversal of 15-PGDH mediated resistance to colon tumor chemoprevention with NSAIDs

FGFR1 is Essential for Prostate Cancer Progression and Metastasis

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

CKS1B (CDC28 protein kinase regulatory subunit 1B)

FRS2α is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts

Frs2α-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis

Role of epithelial cell fibroblast growth factor receptor substrate 2α in prostate development, regeneration and tumorigenesis

Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death

Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.

Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis

Generation of an Frs2α conditional null allele

Generation of an Frs2alpha conditional null allele.

Direct Cell Cycle Regulation by the Fibroblast Growth Factor Receptor (FGFR) Kinase through Phosphorylation-dependent Release of Cks1 from FGFR Substrate 2*

研究方向