百晓学者学者目录

陈捷亮

副教授、副研究员、博士生导师、教授、研究员，复旦大学

精选作品

期刊论文

2026

乙型肝炎病毒感染的自然控制和清除

叶建宇，王冰，顾乐言，樊映廷，陈捷亮

《临床肝胆病杂志》

2026

Gut|功能性抗前S1抗体应答与慢性乙型肝炎病毒控制密切相关

王冰，陈捷亮，WANG B，LI Y，LI F

《临床肝胆病杂志》

2026

RNAi-mediated HBV antigen shutdown enhances the antiviral immune effects of PEGIFNα via T and B cell crosstalk remodeling

Wenjing Zai, Kongying Hu, Mengying He, Ziyang Song, Pan Gao, Chen Luo, Minxiang Xie, Asha Ashuo, Min Yang, Jieliang Chen, Zhenghong Yuan

Clinical and Molecular Hepatology

DOI

2026

Extracellular matrix-defined transcriptomic subtypes reveal a CXCL8-enriched fibrotic-inflammatory microenvironment and preliminary radiological associations in hepatocellular carcinoma

Guangyu Xu, Futeng Li, Zhaorun Li, Lu Wang, Jieliang Chen, Ti Zhang

Journal of Radiation Research and Applied Sciences

DOI

2026

Dysregulated BCR repertoire and metabolic state of HBsAg-specific B cells in chronic hepatitis B revealed by integrated single-cell analysis

Mengying He, Liangjun Shen, Yaming Li, Menghan Hao, Bing Wang, Yi Zhang, Min Wu, Zhanqing Zhang, Zhong Fang, Zhenghong Yuan, Jieliang Chen

Hepatology Communications

DOI

2026

An AAV-based bioluminescent reporter reveals dynamic YAP/TAZ–TEAD transcriptional activity during liver injury

Jianyu Ye, Chen Luo, Zhongning Yang, Yingting Fan, Leyan Gu, Guangyu Xu, Xiongfeng You, Yiqiu Feng, Haiyu Wang, Ruohan Jia, Yuan Zhenghong, Jieliang Chen

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI

2026

Functional anti-preS1 antibody responses associated with viral control in chronic hepatitis B

Bing Wang, Y T Li, Fahong Li, Yiqiu Feng, Menghan Hao, Ting Hua, Min Wu, Mengying He, Feifei Luo, Mengji Lu, Qiao Wang, Jiming Zhang, Zhenghong Yuan, M C Zhang, Jieliang Chen

Gut

DOI

2026

Cell-autonomous co-stimulatory function of membrane-bound CD100 promotes activation and differentiation of HBcAg-specific CD8+ T cells

Mengxiao Zhao, Liwei Chen, Yuhang Chen, L L Wang, Xuecheng Yang, Xuecheng Yang, Kathrin Sutter, Mengji Lu, Jieliang Chen, Xin Zheng, Dongliang Yang, Liang Wang, Liang Wang, Jia Liu

Frontiers in Immunology

DOI

2026

Generation of HBV cccDNA using single-stranded M13 phage DNA for authentic minichromosome functionality

Y T Li, Ting Hua, Menghan Hao, Liman Chen, Wenjun Huang, Zhong Fang, Asha Ashuo, Y T Li, Zhigang Yi, Hongzhou Gu, Zhenghong Yuan, Jieliang Chen

Journal of Virology

DOI

2026

Macrophage duality in liver diseases: heterogeneity, plasticity, and the quest for precision therapeutics

Liwei Chen, Yuehua Chen, Mengxiao Zhao, Xuecheng Yang, Kathrin Sutte, Mengji Lu, Jieliang Chen, Xin Zheng, Dongliang Yang, J Liu

Frontiers in Immunology

DOI

2026

Spatial-quantitative profiling of intrahepatic HBsAg heterogeneity and clustered distribution in chronic HBV infection

Mingzhu Xu, Ye Zheng, Min Wu, Yuyan Qian, Wei Lu, Pingzhao Zhang, Jiangxia Liu, Fahong Li, Shu Song, Jiming Zhang, Xiaonan Zhang, Zhanqing Zhang, Jieliang Chen, Zhenghong Yuan

JHEP Reports

DOI

2026

Structural and functional insights into HBx–Smc6 targeting for HBV inhibition

Tong Cheng, Jinhong Zhou, Wen Huang, Lili Du, Pengyu He, Renzheng Yang, Yan Gao, Menghan Hao, Kongying Hu, Jieliang Chen, Hongxia Wang, Zihe Rao, Zhenghong Yuan, Lanfeng Wang

Cell Research

DOI

2025

Interferon-α for Immune Modulation in Chronic Hepatitis B Toward Functional Cure

Asha Ashuo, Jia Liu, Zhenghong Yuan, Jieliang Chen

Viruses

DOI

2025

Residual viral expression in siRNA-treated HBV-replicating cell and mouse models

Mingzhu Xu, Yuyan Qian, Ziyang Song, Haiyu Wang, Lei Yue, Jiangxia Liu, Yaming Li, Wenjing Zai, Zhenghong Yuan, Jieliang Chen

Antiviral Research

DOI

2025

The Impact of Hepatitis B Surface Antigen Reduction via Small Interfering RNA Treatment on Natural and Vaccine (BRII-179)-Induced Hepatitis B Virus-Specific Humoral and Cellular Immune Responses

Yun Ji, Nina Le Bert, Grace Lai‐Hung Wong, Mark W. Douglas, Ariel Lee, Chong Zhu, Bing Wang, Jianxiang Lv, Dong Li, Ying Tan, Haiyan Ma, Jieliang Chen, Xiaofei Chen, Qing Zhu, Man‐Fung Yuen, Antonio Bertoletti

Gastroenterology

DOI

2024

机体应对病毒感染的内在之力——免疫力

冯忆秋，陈捷亮

《世界科学》

2024

Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy

Kongying Hu, Wenjing Zai, Mingzhu Xu, Haiyu Wang, Xinluo Song, Chao Huang, Jiangxia Liu, Juan Chen, Qiang Deng, Zhenghong Yuan, Jieliang Chen

mBio

DOI

2024

Liver mechanosignaling as a natural anti-hepatitis B virus mechanism

Jianyu Ye, Fahong Li, Ting Hua, Kewei Ma, Jinyu Wang, Zixin Zhao, Zhongning Yang, Chen Luo, Ruohan Jia, Yaming Li, Menghan Hao, Jian Huang Wu, Mengji Lu, Zhenghong Yuan, Jiming Zhang, Jieliang Chen

Nature Communications

DOI

2024

Hepatitis B surface antigen impairs TLR4 signaling by upregulating A20 expression in monocytes

Cong Wang, Chenlu Huang, Yaming Li, Jinjin Bai, Kuangjie Zhao, Zhong Fang, Jieliang Chen

Microbiology Spectrum

DOI

2024

Discovery of novel small molecules targeting hepatitis B virus core protein from marine natural products with HiBiT-based high-throughput screening

Chao Huang, Yang Jin, Panpan Fu, Kongying Hu, Mengxue Wang, Wenjing Zai, Ting Hua, Xinluo Song, Jianyu Ye, Yiqing Zhang, Gan Luo, Haiyu Wang, Jiangxia Liu, Jieliang Chen, Xu‐Wen Li, Zhenghong Yuan

Acta Pharmaceutica Sinica B

DOI

2024

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection

Wenjing Zai, Min Jae Yang, Kuan Jiang, Juan Guan, Huijing Wang, Kongying Hu, Chao Ran Huang, Jieliang Chen, Wei En Fu, Changyou Zhan, Zhenghong Yuan

Signal Transduction and Targeted Therapy

DOI

2024

Modulation of monocyte activity by hepatocellular MicroRNA delivery through HBsAg particles: Implications for pathobiology of chronic hepatitis B

Jin Li, Xiao Ma, Qinkao Xuan, Qiang Li, Min Wu, Bisheng Shi, Zhong Fang, Liang Chen, Jieliang Chen, Yu‐Mei Wen, Chuanwu Zhu, Li Zhu, Xiaonan Zhang, Zhenghong Yuan

Hepatology

DOI

2023

An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes

Yumeng Li, Asha Ashuo, Menghan Hao, Yaming Li, Jianyu Ye, Jiangxia Liu, Ting Hua, Zhong Fang, Jianhua Li, Zhenghong Yuan, Jieliang Chen

Emerging Microbes & Infections

DOI

2023

Genome-Wide Extrachromosomal Circular DNA Profiling of Paired Hepatocellular Carcinoma and Adjacent Liver Tissues

Jianyu Ye, Peixin Huang, Kewei Ma, Zixin Zhao, Ting Hua, Wenjing Zai, Jieliang Chen, Xiutao Fu

Cancers

DOI

2022

Hepatology|不同表观转录状态下HBV cccDNA微染色体的稳定性差异

王洋，陈捷亮，WANG Y，LI Y，ZAI W

《临床肝胆病杂志》

2022

英国等地不明原因儿童肝炎的暴发情况及病因

谢幼华，陈捷亮，王勇翔，袁正宏

《微生物与感染》

2022

HBV induced the discharge of intrinsic antiviral miRNAs in HBV-replicating hepatocytes via extracellular vesicles to facilitate its replication

Qiaofang Chu, Jianhua Li, Jieliang Chen, Zhenghong Yuan

Journal of General Virology

DOI

2022

Omicron XE emerges as SARS-CoV-2 keeps evolving

Kewei Ma, Jieliang Chen

The Innovation

DOI

2022

Monocytic MDSCs homing to thymus contribute to age-related CD8+ T cell tolerance of HBV

Zhong Fang, Yi Zhang, Zhaoqin Zhu, Cong Wang, Yao Hu, Xiuhua Peng, Dandan Zhang, Zhao Jun, Bisheng Shi, Zhongliang Shen, Min Wu, Chunhua Xu, Jieliang Chen, Xiaohui Zhou, Youhua Xie, Hui Yu, Xiaonan Zhang, Jianhua Li, Yunwen Hu, Maya Kozlowski, Antonio Bertoletti, Zhenghong Yuan

The Journal of Experimental Medicine

DOI

2022

Long-Term Hepatitis B Virus Infection Induces Cytopathic Effects in Primary Human Hepatocytes, and Can Be Partially Reversed by Antiviral Therapy

Wenjing Zai, Kongying Hu, Jianyu Ye, Jiahui Ding, Chao Bing Huang, Yaming Li, Zhong Fang, Min Wu, Cong Wang, Jieliang Chen, Zhenghong Yuan

Microbiology Spectrum

DOI

2022

Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection

Jonas Schuhenn, Toni Luise Meister, Daniel Tödt, Thilo Bracht, Karin Schork, Jean-Noël Billaud, Carina Elsner, Natalie Heinen, Zehra Karakoese, Sibylle Haid, Sriram Kumar, Linda Brunotte, Martin Eisenacher, Yunyun Di, Jocelyne M. Lew, Darryl Falzarano, Jieliang Chen, Zhenghong Yuan, Thomas Pietschmann, Bettina Wiegmann, Hendrik Beckert, Christian Taube, Vu Thuy Khanh Le‐Trilling, Mirko Trilling, Adalbert Krawczyk, Stephan Ludwig, Barbara Sitek, Eike Steinmann, Ulf Dittmer, Kerry J. Lavender, Kathrin Sutter, Stephanie Pfaender

Proceedings of the National Academy of Sciences

DOI

2022

Human hepatocyte-enriched miRNA-192-3p promotes HBV replication through inhibiting Akt/mTOR signalling by targeting ZNF143 in hepatic cell lines

Fahong Li, Yingying Deng, Shenyan Zhang, Beidi Zhu, Jun Wang, Jinyu Wang, Xueyu Wang, Zhenyu Zhao, Wanyu Deng, Richeng Mao, Zhongliang Shen, Jieliang Chen, Ruth Broering, Yong Lin, Mengji Lu, Jiming Zhang

Emerging Microbes & Infections

DOI

2022

Interferon Alpha Induces Cellular Autophagy and Modulates Hepatitis B Virus Replication

Jia Li, Thekla Kemper, Ruth Broering, Jieliang Chen, Zhenghong Yuan, Xueyu Wang, Mengji Lu

Frontiers in Cellular and Infection Microbiology

DOI

2021

两种抽提乙型肝炎病毒共价闭合环状DNA方法的效果比较

胡孔颖，金宇焘，叶建宇，宰文静，王洋，李雨檬，陈捷亮

《微生物与感染》

2021

HBV covalently closed circular DNA minichromosomes in distinct epigenetic transcriptional states differ in their vulnerability to damage

Yang Wang, Yumeng Li, Wenjing Zai, Kongying Hu, Yuanfei Zhu, Qiang Deng, Min Wu, Yaming Li, Jieliang Chen, Zhenghong Yuan

Hepatology

DOI

2021

Interferon and Hepatitis B: Current and Future Perspectives

Jianyu Ye, Jieliang Chen

Frontiers in Immunology

DOI

2020

实现慢性乙型肝炎治愈的战略计划及路径研究（美国国立卫生研究院2019年11月）

袁正宏课题组，岳蕾，唐怡洁，丁家惠，徐通，李畅，徐明珠，叶建宇，李雨檬，胡孔颖，王洋，宰文静，刘江霞，张小楠，陈捷亮，袁正宏

《肝脏》

DOI

2020

HBV cccDNA转录代谢调控机制及沉默清除策略

宰文静，陈捷亮，袁正宏

《临床肝胆病杂志》

2020

Functional Comparison of Interferon‐α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon‐α and Interferon‐γ Signaling

Jieliang Chen, Yaming Li, Fritz Lai, Yang Wang, Kathrin Sutter, Ulf Dittmer, Jianyu Ye, Wenjing Zai, Min Liu, Fang Shen, Min Wu, Kongying Hu, Baocun Li, Mengji Lu, Xiaonan Zhang, Jiming Zhang, Jianhua Li, Qingfeng Chen, Zhenghong Yuan

Hepatology

DOI

2020

Pathogenicity and transmissibility of 2019-nCoV—A quick overview and comparison with other emerging viruses

Jieliang Chen

Microbes and Infection

DOI

2020

Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent population

Zhigang Yi, Yun Ling, Xiaonan Zhang, Jieliang Chen, Kongying Hu, Yuyan Wang, Wuhui Song, Tianlei Ying, Rong Zhang, Hongzhou Lu, Zhenghong Yuan

Emerging Microbes & Infections

DOI

2019

干扰素和核苷(酸)类似物治疗对HBV cccDNA的影响与慢性乙型肝炎的功能性治愈

陈捷亮，袁正宏

《临床肝胆病杂志》

2019

AMPK and Akt/mTOR signalling pathways participate in glucose‐mediated regulation of hepatitis B virus replication and cellular autophagy

Xueyu Wang, Yong Lin, Thekla Kemper, Jieliang Chen, Zhenghong Yuan, Shi Liu, Ying Zhu, Ruth Broering, Mengji Lu

Cellular Microbiology

DOI

2019

Residues Asn118 and Glu119 of hepatitis B virus X protein are critical for HBx-mediated inhibition of RIG-I-MAVS signaling

Fan Wang, Fang Shen, Yang Wang, Ze Li, Jieliang Chen, Zhenghong Yuan

Virology

DOI

2019

Influence of interferon and nucleos(t)ide analogues on HBV cccDNA and functional cure of chronic hepatitis B

CHEN Jieliang

DOAJ (DOAJ: Directory of Open Access Journals)

2018

Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes

Zhenlan Yao, Xiaofang Jia, Dominik Andre Megger, Jieliang Chen, Yuyi Liu, Jianhua Li, Barbara Sitek, Zhenghong Yuan

Journal of Proteome Research

DOI

2018

Exosomes Exploit the Virus Entry Machinery and Pathway To Transmit Alpha Interferon-Induced Antiviral Activity

Zhenlan Yao, Yunsheng Qiao, Xiaofang Li, Jieliang Chen, Jiahui Ding, Lu Bai, Fang Shen, Bisheng Shi, Jia Liu, Lu Peng, Jianhua Li, Zhenghong Yuan

Journal of Virology

DOI

2018

Identification of Retinoic Acid Receptor Agonists as Potent Hepatitis B Virus Inhibitors via a Drug Repurposing Screen

Baocun Li, Yang Wang, Fang Shen, Min Wu, Yaming Li, Zhong Fang, Jianyu Ye, Li Wang, Lu Gao, Zhenghong Yuan, Jieliang Chen

Antimicrobial Agents and Chemotherapy

DOI

2018

In vitro studies identify a low replication phenotype for hepatitis B virus genotype H generally associated with occult HBV and less severe liver disease

Vitina Sozzi, Fang Shen, Jieliang Chen, Danni Colledge, Kathy Jackson, STEPHEN A LOCARNINI, Zhenghong Yuan, Peter A. Revill

Virology

DOI

2018

Establishment of Cre-mediated HBV recombinant cccDNA (rcccDNA) cell line for cccDNA biology and antiviral screening assays

Min Wu, Jin Li, Lei Yue, Lu Bai, Yaming Li, Jieliang Chen, Xiaonan Zhang, Zhenghong Yuan

Antiviral Research

DOI

2017

高压水动力法建立表面抗原表达缺失的乙型肝炎转染小鼠模型及初步评估

张毅，陈捷亮，方钟，徐国光，李军

《肝脏》

2017

乙型肝炎病毒与Ⅰ型干扰素系统相互作用新机制及治疗新策略的研究

陈捷亮，李建华，张小楠，邬敏，施碧胜，方钟，袁正宏

《复旦学报(医学版)》

2017

Hepatitis B virus sensitivity to interferon‐α in hepatocytes is more associated with cellular interferon response than with viral genotype

Fang Shen, Yaming Li, Yang Wang, Vitina Sozzi, Peter A. Revill, Jiangxia Liu, Lu Gao, Guang Yang, Mengji Lu, Kathrin Sutter, Ulf Dittmer, Jieliang Chen, Zhenghong Yuan

Hepatology

DOI

2017

Low hepatitis B virus–specific T‐cell response in males correlates with high regulatory T‐cell numbers in murine models

Anna D. Kosinska, Leila Pishraft‐Sabet, Weimin Wu, Zhong Fang, Marzena Lenart, Jieliang Chen, Kirsten K. Dietze, Cong Wang, Thekla Kemper, Yong Lin, Shiou‐Hwei Yeh, Jia Liu, Ulf Dittmer, Zhenghong Yuan, Michael Roggendorf, Mengji Lu

Hepatology

DOI

2017

Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line

Xiaofang Jia, Jieliang Chen, Dominik Andre Megger, Xiaonan Zhang, Maya Kozlowski, Lijun Zhang, Zhong Fang, Jin Li, Qiaofang Chu, Min Wu, Yaming Li, Barbara Sitek, Zhenghong Yuan

Molecular & Cellular Proteomics

DOI

2017

PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation

Wen Zhang, Jieliang Chen, Min Wu, Xiaonan Zhang, Min Zhang, Lei Yue, Yaming Li, Jiangxia Liu, Baocun Li, Fang Shen, Yang Wang, Lu Bai, Ulrike Protzer, Massimo Levrero, Zhenghong Yuan

Hepatology

DOI

2015

New insights into hepatitis B virus biology and implications for novel antiviral strategies

Jieliang Chen, Min Wu, Kuancheng Liu, Wen Zhang, Yaming Li, Xiaohui Zhou, Lu Bai, Zhenghong Yuan

National Science Review

DOI

2015

Hepatitis B virus spliced variants are associated with an impaired response to interferon therapy

Jieliang Chen, Min Wu, Fan Wang, Wen Zhang, Wei Wang, Xiaonan Zhang, Jiming Zhang, Yinghui Liu, Yi Liu, Yanling Feng, Ye Zheng, Yunwen Hu, Zhenghong Yuan

Scientific Reports

DOI

2015

Innate detection of hepatitis B and C virus and viral inhibition of the response

Zhigang Yi, Jieliang Chen, Maya Kozlowski, Zhenghong Yuan

Cellular Microbiology

DOI

2014

不同干扰素应答慢性乙型肝炎患者的基因组DNA甲基化谱差异分析

邬敏，张小楠，陈捷亮，袁正宏

《微生物与感染》

2014

Interplay between hepatitis B virus and the innate immune responses: implications for new therapeutic strategies

Jieliang Chen, Zhenghong Yuan

Virologica Sinica

DOI

2014

Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways

Yinghui Liu, Jianhua Li, Jieliang Chen, Yaming Li, Weixia Wang, Xiaoting Du, Wuhui Song, Wen Zhang, Li Lin, Zhenghong Yuan

Journal of Virology

DOI

2013

乙型肝炎病毒多聚酶蛋白拮抗Ⅰ型干扰素通路的机制研究

陈捷亮

《复旦大学》

2013

An Efficient Antiviral Strategy for Targeting Hepatitis B Virus Genome Using Transcription Activator-Like Effector Nucleases

Jieliang Chen, Wen Zhang, Junyu Lin, Fan Wang, Min Wu, Cuncun Chen, Ye Zheng, Xiuhua Peng, Jianhua Li, Zhenghong Yuan

Molecular Therapy

DOI

2013

Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity

Jianhua Li, Kuancheng Liu, Yang Liu, Yan Xu, Fei Zhang, Huijuan Yang, Jiangxia Liu, Tingting Pan, Jieliang Chen, Min Wu, Xiaohui Zhou, Zhenghong Yuan

Nature Immunology

DOI

2013

Hepatitis B Virus Surface Antigen Selectively Inhibits TLR2 Ligand–Induced IL-12 Production in Monocytes/Macrophages by Interfering with JNK Activation

Sen Wang, Zhiao Chen, Conghua Hu, Fangxing Qian, Yu‐Ming Cheng, Min Wu, Bisheng Shi, Jieliang Chen, Yunwen Hu, Zhenghong Yuan

The Journal of Immunology

DOI

2012

Hepatitis B Virus Polymerase Impairs Interferon-α–Induced STA Activation Through Inhibition of Importin-α5 and Protein Kinase C-δ

Jieliang Chen, Min Wu, Xiaonan Zhang, Wen Zhang, Zhanqing Zhang, Lixiang Chen, Jing He, Ye Zheng, Cuncun Chen, Fan Wang, Yunwen Hu, Xiaohui Zhou, Cong Wang, Yang Y. Xu, Mengji Lu, Zhenghong Yuan

Hepatology

DOI

2010

Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKϵ and DDX3

Shiyan Yu, Jieliang Chen, Min Wu, Hui Chen, Nobuyuki Kato, Zhenghong Yuan

Journal of General Virology

DOI

2009

不同来源人肝细胞系β干扰素诱生及其信号通路的比较

陈辉，邬敏，于士颜，陈捷亮，袁正宏

《微生物与感染》

2009

Hepatitis B virus polymerase interferes with interferon-β induction

Shiyan Yu, Jieliang Chen, Min Wu, Hui Chen, Zhenghong Yuan

Cytokine

DOI

书籍章节

2024

Analysis of HBV cccDNA Minichromosome Accessibility by MNase-qPCR and High-Throughput Sequencing

Kongying Hu, Wenjing Zai, Yang Wang, Jianyu Ye, Zhenghong Yuan, Jieliang Chen

Methods in molecular biology

DOI

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