百晓学者学者目录

柳满然

助理研究员、博士生导师、教授、讲师，重庆医科大学

精选作品

期刊论文

2026

VASN Enhances IGF2BP3 Stability via USP10 Deubiquitination to Promote Triple-negative Breast Cancer Paclitaxel Resistance

Hao Liu, Zexiu Lu, Maoshan Chen, Zhenghang Li, Jian Chen, Xingyu Yang, Xueying Wan, Gang Tu, Manran Liu, Lingfeng Tang

International Journal of Biological Sciences

DOI

2026

ACSL5 Mediates Adaptation to the Palmitic Acid–Enriched Pulmonary Microenvironment to Enhance Metastatic Breast Cancer Cell Survival and Lung Metastasis

Shanchun Chen, Chao Kai Chang, Xiaoqi Liu, Rui Wang, Yongcan Liu, Die Meng, Boxuan Wang, Yuhang Hai, Chaoqun Deng, Yanran Tong, Xiaojiang Cui, Siyang Wen, Guobing Yin, Manran Liu

Cancer Research

DOI

2026

Nerves Stimulate Cross-talk Between Gastric Cancer and Group 3 Innate Lymphoid Cells to Enhance Immunosuppression

Fangli Liao, Yanran Tong, Hua Sun, Sen Chen, Siyang Wen, Yan-e Du, Linshan Jiang, Tong Huang, Manran Liu, W. William Chen, Li-Ping Yang

Cancer Research

DOI

2026

MSLN-mediated activation of EGFR-ERK1/2 signaling drives liver metastasis in breast cancer

Jing Chen, Yongcan Liu, GuoWu Zhang, Die Meng, Chao Chang, Jian Chen, Boxuan Wang, Yanran Tong, Yuhang Hai, Ming Lei, Xingyu Yang, Yubi Gan, Chaoqun Deng, Peijin Dai, Manran Liu, Xi Tang

Cell Death Discovery

DOI

2026

The Ly6g high Neutrophil Subset Dictates Breast Cancer Lung Metastasis via CD8 + T Cell Death

Xueying Wan, Xiaoqi Liu, Yixuan Hou, Shanchun Chen, Yongcan Liu, Yongcan Liu, Chao Chang, Die Meng, Jing Chen, Xiaojiang Cui, Zhengrong Shi, Xueying Wan, Manran Liu

《癌症：英文版》

DOI

2025

CUEDC1 promotes glycolytic metabolism reprogramming through the CUEDC1/CACNG4/PI3K axis to promote ER-positive breast cancer growth

Zijian Lu, Ming Lei, Jian Chen, Ao Deng, Chao Chang, Jing Chen, Die Meng, Rui Wang, Xueying Wan, Gang Tu, Manran Liu, Lingfeng Tang

Cellular & Molecular Biology Letters

DOI

2025

PLA2G16‐Mediated Tetracosatetraenoic Acid Rewires Fatty Acid Oxidation to Impair CD8 + T Cell Immune Function in Promoting Breast Cancer Lung Metastasis

Yubi Gan, Die Meng, Lei Lang, Jing Luo, Peijin Dai, Chao Chang, Zijian Lu, Yuetong Guo, Rui Wang, Shan-Chun Chen, Xi Tang, Yixuan Hou, Dongmei Tan, Manran Liu

Advanced Science

DOI

2025

Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3‐dependent PDGFB signaling

Rui Tang, Yan Sun, Ao Deng, Jiahe Liu, Peijin Dai, Jing Chen, Chaoqun Deng, Hui Liu, Yuhang Hai, Yanran Tong, Yan-e Du, Manran Liu, Haojun Luo

《癌症：英文版》

DOI

2025

Circulating Tumor Microenvironment in Metastasis

Rui Tang, Shujuan Luo, Hui Liu, Yan Sun, Manran Liu, Lu Li, Haoyu Ren, Martin Kurt Angele, Nikolaus Börner, Ke‐Da Yu, Zufeng Guo, Guobing Yin, Haojun Luo

Cancer Research

DOI

2025

Corrigendum for “Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling” [eBioMedicine 41 (2019) 370–383]

Kexin Sun, Shifu Tang, Yixuan Hou, Lei Xi, Yanlin Chen, Jiali Yin, Meixi Peng, Maojia Zhao, Xiaojiang Cui, Manran Liu

EBioMedicine

DOI

2024

Microenvironmental G protein‐coupled estrogen receptor‐mediated glutamine metabolic coupling between cancer‐associated fibroblasts and triple‐negative breast cancer cells governs tumour progression

Chongwu He, Meixi Peng, Xiaoqiang Zeng, Hanzhi Dong, Zhengkui Sun, Jiawei Xu, Manran Liu, Liyan Liu, Yanxiao Huang, Zhiqiang Peng, Yuan Qiu, Chunling Jiang, Bin Xu, Tenghua Yu

Clinical and Translational Medicine

DOI

2024

Tryptophan 2,3‐dioxygenase‐positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine‐mediated ferroptosis resistance of metastatic cells and T cell dysfunction

Yongcan Liu, Shan-Chun Chen, Xueying Wan, Rui Wang, Haojun Luo, Chao Chang, Peijin Dai, Yubi Gan, Yuetong Guo, Yixuan Hou, Yan Sun, Yong Teng, Xiaojiang Cui, Manran Liu

《癌症：英文版》

DOI

2024

HnRNPA2B1 ISGylation Regulates m6A‐Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development

Ting Jin, Liping Yang, Chao Chang, Haojun Luo, Rui Wang, Yubi Gan, Yan Sun, Yuetong Guo, Rui Tang, Shan-Chun Chen, Die Meng, Peijin Dai, Manran Liu

Advanced Science

DOI

2024

ACSL4-Mediated Membrane Phospholipid Remodeling Induces Integrin β1 Activation to Facilitate Triple-Negative Breast Cancer Metastasis

Yuxiang Qiu, Xing Wang, Yan Sun, Ting Jin, Rui Tang, Xinyue Zhou, Ming Xu, Yubi Gan, Rui Wang, Haojun Luo, Manran Liu, Xi Tang

Cancer Research

DOI

2023

RGCC-mediated PLK1 activity drives breast cancer lung metastasis by phosphorylating AMPKα2 to activate oxidative phosphorylation and fatty acid oxidation

Shaojie Cheng, Xueying Wan, Liping Yang, Yilu Qin, Shan-Chun Chen, Yongcan Liu, Yan Sun, Yuxiang Qiu, Luyi Huang, Qizhong Qin, Xiaojiang Cui, Mingjun Wu, Manran Liu

Journal of Experimental & Clinical Cancer Research

DOI

2023

Oxidized ATM governs stemness of breast cancer stem cell through regulating ubiquitylation and acetylation switch

Xinyue Zhou, Xiaoqi Liu, Xueying Wan, Ming Xu, Rui Wang, Dan Yang, Meixi Peng, Ting Jin, Rui Tang, Manran Liu, Yixuan Hou

Biochemical and Biophysical Research Communications

DOI

2023

Hypoxia-induced circSTT3A enhances serine synthesis and promotes H3K4me3 modification to facilitate breast cancer stem cell formation

Ming Xu, Xiaoqi Liu, Xinyue Zhou, Yilu Qin, Liping Yang, Siyang Wen, Yuxiang Qiu, Shanchun Chen, Rui Tang, Yuetong Guo, Manran Liu, Yan Sun

Pharmacological Research

DOI

2023

Retraction Note: Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis

Meixi Peng, Dan Yang, Yixuan Hou, Shuiqing Liu, Maojia Zhao, Yilu Qin, Rui Chen, Yong Teng, Manran Liu

Cell Death and Disease

DOI

2023

TCF12 regulates exosome release from epirubicin-treated CAFs to promote ER+ breast cancer cell chemoresistance

Yuxiang Qiu, Xing Wang, Yan Sun, Yan-e Du, Guobing Yin, Haojun Luo, Siyang Wen, Lei Lang, Manran Liu, Xi Tang

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI

2022

Cancer-associated fibroblasts facilitate premetastatic niche formation through lncRNA SNHG5-mediated angiogenesis and vascular permeability in breast cancer

Huan Zeng, Yixuan Hou, Xinyue Zhou, Lei Lang, Haojun Luo, Yan Sun, Xueying Wan, Taixian Yuan, Rui Wang, Yongcan Liu, Rui Tang, Shaojie Cheng, Ming qing Xu, Manran Liu

Theranostics

DOI

2022

Breast cancer liver metastasis: Pathogenesis and clinical implications

Cuiwei Liu, Srivarshini Cherukupalli Mohan, Jielin Wei, Ekihiro Seki, Manran Liu, Reva Kakkar Basho, Armando E. Giuliano, Yanxia Zhao, Xiaojiang Cui

Frontiers in Oncology

DOI

2022

The Drosha-Independent MicroRNA6778-5p/GSK3β Axis Mediates the Proliferation of Gastric Cancer Cells

Mingjun Ren, Xing Li, Wan-Ping Wang, Wanying Bi, Wanjun Wu, Gui Jiang, Weiji Wang, Xingdong Liang, Manran Liu, Shifu Tang

Computational Intelligence and Neuroscience

DOI

2022

FOSL2 promotes VEGF-independent angiogenesis by transcriptionnally activating Wnt5a in breast cancer-associated fibroblasts: Erratum

Xueying Wan, Shengdong Guan, Yixuan Hou, Yilu Qin, Huan Zeng, Liping Yang, Yina Qiao, Shuiqing Liu, Qiao Li, Ting Jin, Yuxiang Qiu, Manran Liu

Theranostics

DOI

2021

MiR-4719通过靶向调控ARHGAP36抑制人乳腺癌细胞的迁移和和侵袭

李侨，邱宇翔，金婷，柳满然，侯懿烜

《南方医科大学学报》

2021

A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties

Shuiqing Liu, Yan Sun, Yixuan Hou, Liping Yang, Xueying Wan, Yilu Qin, Yongcan Liu, Rui Wang, Pengpeng Zhu, Yong Teng, Manran Liu

Journal of Hematology & Oncology

DOI

2021

A pseudo-targeted metabolomics study based on serum bile acids profiling for the differential diagnosis of benign and malignant breast lesions

Can Luo, Xiaoqing Zhang, Yifan He, Hong Chen, Manran Liu, Haoran Wang, Lingfeng Tang, Gang Tu, Min Ding

Steroids

DOI

2021

Hypoxia‐stimulated ATM activation regulates autophagy‐associated exosome release from cancer‐associated fibroblasts to promote cancer cell invasion

Lei Xi, Meixi Peng, Shuiqing Liu, Yongcan Liu, Xueying Wan, Yixuan Hou, Yilu Qin, Liping Yang, Shan-Chun Chen, Huan Zeng, Yong Teng, Xiaojiang Cui, Manran Liu

Journal of Extracellular Vesicles

DOI

2021

Long non-coding RNA Lnc-408 promotes invasion and metastasis of breast cancer cell by regulating LIMK1

Yina Qiao, Ting Jin, Shengdong Guan, Shaojie Cheng, Siyang Wen, Huan Zeng, Maojia Zhao, Liping Yang, Xueying Wan, Yuxiang Qiu, Qiao Li, Manran Liu, Yixuan Hou

Oncogene

DOI

2021

SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell survival via ameliorating oxidative stress

Qiao Li, Manran Liu, Yan Sun, Ting Jin, Pengpeng Zhu, Xueying Wan, Yixuan Hou, Gang Tu

Journal of Experimental & Clinical Cancer Research

DOI

2021

A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear β-catenin levels

Siyang Wen, Yilu Qin, Rui Wang, Liping Yang, Huan Zeng, Pengpeng Zhu, Qiao Li, Yuxiang Qiu, Shanchun Chen, Yongcan Liu, Yixuan Hou, Xi Tang, Manran Liu, Gang Tu

Cell Death and Disease

DOI

2021

Mirtronic miR-4646-5p promotes gastric cancer metastasis by regulating ABHD16A and metabolite lysophosphatidylserines

Liping Yang, Yixuan Hou, Yan-e Du, Qiao Li, Fanlin Zhou, Yu Li, Huan Zeng, Ting Jin, Xueying Wan, Shengdong Guan, Rui Wang, Manran Liu

Cell Death and Differentiation

DOI

2021

A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability

Pengpeng Zhu, Fang He, Yixuan Hou, Gang Tu, Qiao Li, Ting Jin, Huan Zeng, Yilu Qin, Xueying Wan, Yina Qiao, Yuxiang Qiu, Yong Teng, Manran Liu

Oncogene

DOI

2021

FOSL2 promotes VEGF-independent angiogenesis by transcriptionnally activating Wnt5a in breast cancer-associated fibroblasts

Xueying Wan, Shengdong Guan, Yixuan Hou, Yilu Qin, Huan Zeng, Liping Yang, Yina Qiao, Shuiqing Liu, Qiao Li, Ting Jin, Yuxiang Qiu, Manran Liu

Theranostics

DOI

2020

低氧下氧化型ATM通过胞内柠檬酸累积促进人乳腺癌细胞的迁移和侵袭

万雪颖，彭美茜，秦旖璐，朱鹏鹏，乔伊娜，杨丽萍，曾欢，柳满然

《中国细胞生物学学报》

2020

微RNA-374c-5p通过靶向LIMK1增强人乳腺癌MDA-MB-231/DDP细胞对顺铂的敏感性

乔伊娜，文思阳，孙可馨，阴嘉莉，万雪颖，曾欢，杨丽萍，柳满然

《肿瘤》

2020

GPER‐regulated lncRNA‐Glu promotes glutamate secretion to enhance cellular invasion and metastasis in triple‐negative breast cancer

Jiali Yin, Gang Tu, Meixi Peng, Huan Zeng, Xueying Wan, Yina Qiao, Yilu Qin, Manran Liu, Haojun Luo

The FASEB Journal

DOI

2020

A Novel Long Non‐Coding RNA lnc030 Maintains Breast Cancer Stem Cell Stemness by Stabilizing SQLE mRNA and Increasing Cholesterol Synthesis

Yilu Qin, Yixuan Hou, Shuiqing Liu, Pengpeng Zhu, Xueying Wan, Maojia Zhao, Meixi Peng, Huan Zeng, Qiao Li, Ting Jin, Xiaojiang Cui, Manran Liu

Advanced Science

DOI

2020

Effects of differential distributed-JUP on the malignancy of gastric cancer

Yanlin Chen, Liping Yang, Yilu Qin, Shuiqing Liu, Yina Qiao, Xueying Wan, Huan Zeng, Xiaoli Tang, Manran Liu, Yixuan Hou

Journal of Advanced Research

DOI

2020

Oxidized ATM promotes breast cancer stem cell enrichment through energy metabolism reprogram-mediated acetyl-CoA accumulation

Dan Yang, Meixi Peng, Yixuan Hou, Yilu Qin, Xueying Wan, Pengpeng Zhu, Shuiqing Liu, Liping Yang, Huan Zeng, Ting Jin, Yuxiang Qiu, Qiao Li, Manran Liu

Cell Death and Disease

DOI

2020

Drosha-independent miR-6778–5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism

Maojia Zhao, Yixuan Hou, Yan-e Du, Liping Yang, Yilu Qin, Meixi Peng, Shuiqing Liu, Xueying Wan, Yina Qiao, Huan Zeng, Xiaojiang Cui, Yong Teng, Manran Liu

Cancer Letters

DOI

2020

GPER mediates decreased chemosensitivity via regulation of ABCG2 expression and localization in tamoxifen-resistant breast cancer cells

Tenghua Yu, Hong Cheng, Zhijuan Ding, Zhiliang Wang, Lixia Zhou, Peng Zhao, Shengxing Tan, Xue Jun Xu, Xianming Huang, Manran Liu, Meixi Peng, Yuan Qiu

Molecular and Cellular Endocrinology

DOI

2020

Although c‑MYC contributes to tamoxifen resistance, it improves cisplatin sensitivity in ER‑positive breast cancer

Rui Chen, Shipeng Guo, Chengcheng Yang, Lu Sun, Beige Zong, Kang Li, Li Liu, Gang Tu, Manran Liu, Shengchun Liu

International Journal of Oncology

DOI

2019

敲低Drosha基因可抑制人胃癌HGC-27细胞的迁移和侵袭

陈燕林，赵茂嘉，席磊，杨丹，郎磊，阴嘉莉，柳满然

《基因组学与应用生物学》

DOI

2019

GPER促进乳腺癌相关成纤维细胞的有氧糖酵解

秦旖璐，余滕骅，文思阳，彭美茜，赵茂嘉，刘水清，吴诚义，柳满然

《基因组学与应用生物学》

DOI

2019

肿瘤相关成纤维细胞通过p38/MAPK信号通路促进人乳腺癌细胞迁移

付立新，席磊，陈燕林，杨丹，柳满然

《重庆医科大学学报》

DOI

2019

沉默CXCL1基因抑制三阴性乳腺癌细胞MDA-MB-231的迁移、侵袭的研究

杨诚诚，陶凯，喻浩宸，蹇磊，柳满然，刘胜春

《基因组学与应用生物学》

DOI

2019

CXCL1 stimulates migration and invasion in ER‑negative breast cancer cells via activation of the ERK/MMP2/9 signaling axis

Chengcheng Yang, Haochen Yu, Rui Chen, Kai Xiong Tao, Jian Lei, Meixi Peng, Xiaotian Li, Manran Liu, Shengchun Liu

International Journal of Oncology

DOI

2019

RETRACTED ARTICLE: Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis

Meixi Peng, Dan Yang, Yixuan Hou, Shuiqing Liu, Maojia Zhao, Yilu Qin, Rui Chen, Yong Teng, Manran Liu

Cell Death and Disease

DOI

2019

Autocrine TGF-β1/miR-200s/miR-221/DNMT3B regulatory loop maintains CAF status to fuel breast cancer cell proliferation

Xi Tang, Gang Tu, Guanglun Yang, Xing Wang, Linmin Kang, Liping Yang, Huan Zeng, Xueying Wan, Yina Qiao, Xiaojiang Cui, Manran Liu, Yixuan Hou

Cancer Letters

DOI

2019

Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling

Kexin Sun, Shifu Tang, Yixuan Hou, Lei Xi, Yanlin Chen, Jiali Yin, Meixi Peng, Maojia Zhao, Xiaojiang Cui, Manran Liu

EBioMedicine

DOI

2018

Drosha通过调控微RNA-195-5P促进胃癌细胞的迁移和侵袭

彭美茜，徐丽云，杨丹，赵茂嘉，秦旖璐，刘水清，曾欢，柳满然

《肿瘤》

2018

癌相关成纤维细胞miR-200c对乳腺癌细胞侵袭的影响

席磊，付立新，唐曦，杜艳娥，杨丹，陈燕林，柳满然，侯懿烜

《基因组学与应用生物学》

2018

敲低心肌连接斑株蛋白对人胃癌SGC-7901细胞的迁移和侵袭能力的影响及机制研究

陈燕林，席磊，杨丹，付立新，柳满然

《中国细胞生物学学报》

2018

Twist促进人三阴性乳腺癌细胞迁移和侵袭

张达容，王维莲，吴立翔，柳满然

《基础医学与临床》

2018

Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3–p38 MAPK signalling

Siyang Wen, Yixuan Hou, Lixin Fu, Lei Xi, Dan Yang, Maojia Zhao, Yilu Qin, Kexin Sun, Yong Teng, Manran Liu

Cancer Letters

DOI

2018

Primed atypical ductal hyperplasia-associated fibroblasts promote cell growth and polarity changes of transformed epithelium-like breast cancer MCF-7 cells via miR-200b/c-IKKβ signaling

Yan Sun, Dan Yang, Lei Xi, Yanlin Chen, Lixin Fu, Kexin Sun, Jiali Yin, Xiaotian Li, Shuiqing Liu, Yilu Qin, Manran Liu, Yixuan Hou

Cell Death and Disease

DOI

2018

ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion

Lei Lang, Yixuan Hou, Yanlin Chen, Gang Tu, Jing Tao, Dan Yang, Lei Xi, Lixin Fu, Kexin Sun, Jiali Yin, Rui Chen, Meixi Peng, Shuiqing Liu, Manran Liu

Cellular Physiology and Biochemistry

DOI

2017

肿瘤相关成纤维细胞中GPER介导HMGB1外分泌促进乳腺癌MCF-7细胞自噬及增殖

郭林英，余腾骅，张光君，尹恒，柳满然，涂刚

《肿瘤》

2017

Hedgehog信号通路调控Twist高表达乳腺肿瘤干细胞样细胞的富集及迁移

周明莉，唐石伏，张海龙，柳满然

《肿瘤》

2017

稳定干扰ITGB1抑制人乳腺癌BT549细胞迁移和侵袭

郎磊，周明莉，杨佳佳，孙可馨，阴嘉莉，席磊，陈燕林，柳满然

《基因组学与应用生物学》

2017

Nuclear Drosha enhances cell invasion via an EGFR-ERK1/2-MMP7 signaling pathway induced by dysregulated miRNA-622/197 and their targets LAMC2 and CD82 in gastric cancer

Liyun Xu, Yixuan Hou, Gang Tu, Yanlin Chen, Yan-e Du, Hailong Zhang, Siyang Wen, Xi Tang, Jiali Yin, Lei Lang, Kexin Sun, Guanglun Yang, Xiaoli Tang, Manran Liu

Cell Death and Disease

DOI

2017

GPER promotes tamoxifen-resistance in ER+ breast cancer cells by reduced Bim proteins through MAPK/Erk-TRIM2 signaling axis

Heng Yin, Qing Zhu, Manran Liu, Gang Tu, Qing Li, Jie Yuan, Siyang Wen, Guanglun Yang

International Journal of Oncology

DOI

2017

MiR-205/YAP1 in Activated Fibroblasts of Breast Tumor Promotes VEGF-independent Angiogenesis through STAT3 Signaling

Yan-e Du, Gang Tu, Guanglun Yang, Genyou Li, Dan Yang, Lei Lang, Lei Xi, Kexin Sun, Yanlin Chen, Kunxian Shu, Huadong Liao, Manran Liu, Yixuan Hou

Theranostics

DOI

2016

高表达ITGB1促进人乳腺上皮MCF10A细胞EMT及迁移

郎磊，周明莉，杨佳佳，杜燕娥，文思阳，柳满然

《基础医学与临床》

2016

Sox2下调表达对MDA-MB-231乳腺癌细胞β-catenin与转录中介因子γ的影响

李雄武，张徽，柳满然

《陆军军医大学学报》

2016

TGF-β信号通路调控Twist高表达型乳腺肿瘤细胞微球体的形成及迁移

郎磊，周明莉，徐丽云，杜燕娥，文思阳，柳满然

《肿瘤》

2016

共济失调毛细血管扩张突变基因沉默可抑制人乳腺癌细胞的迁移和侵袭

郎磊，杜燕娥，席磊，周明莉，孙可馨，阴嘉莉，陈燕林，柳满然

《肿瘤》

2016

稳定干扰ITGB3基因可促进人乳腺癌BT549细胞的增殖

文思阳，徐丽云，杜燕娥，郎磊，孙可馨，阴嘉莉，付立新，席磊，陈燕林，杨丹，柳满然

《肿瘤》

2016

他莫昔芬通过GPR30介导CAF外分泌CXCL16促进乳腺癌MCF-7细胞迁移及侵袭

吴晓安，郭林英，杜燕娥，柳满然，涂刚

《肿瘤》

2016

下调Drosha基因表达促进MGC-803胃癌细胞对表阿霉素的敏感性

徐丽云，陈燕林，文思阳，杜燕娥，唐曦，柳满然

《细胞与分子免疫学杂志》

2016

Dynamic monitoring of GPER-mediated estrogenic effects in breast cancer associated fibroblasts: An alternative role of estrogen in mammary carcinoma development

Haojun Luo, Manran Liu, Shujuan Luo, Tenghua Yu, Ching‐Yi Wu, Guanglun Yang, Gang Tu

Steroids

DOI

2015

c-Ski癌基因对肿瘤相关成纤维细胞活化的影响

杨得志，王黎阳，柳满然

《重庆医科大学学报》

2015

低氧诱导乳腺癌癌相关成纤维细胞能量代谢重塑细胞模型的构建

唐石伏，周明莉，孙一帆，王林春，刘春明，杨丽，唐曦，张海龙，高超，黄光明，渠海洋，杜燕娥，徐丽云，文思阳，郎磊，柳满然

《重庆医科大学学报》

2015

Twist促进乳腺癌细胞BT-549乳腺细胞小球形成及其迁移

周明莉，唐石伏，张海龙，杨丽，杨佳佳，柳满然

《细胞与分子免疫学杂志》

2015

他莫昔芬抑制G蛋白偶联雌激素受体沉默的乳腺癌相关成纤维细胞的增殖并促进其凋亡

严玉钊，余腾骅，涂刚，柳满然，袁杰，杨光伦

《细胞与分子免疫学杂志》

2015

Drosha水平与胃腺癌恶性程度及侵袭呈负相关

张海龙，徐丽云，周明莉，杜燕娥，文思阳，柳满然

《细胞与分子免疫学杂志》

2015

Cytoplasmic Drosha Is Aberrant in Precancerous Lesions of Gastric Carcinoma and Its Loss Predicts Worse Outcome for Gastric Cancer Patients

Hailong Zhang, Yixuan Hou, Liyun Xu, Zongyue Zeng, Siyang Wen, Yan-e Du, Kexin Sun, Jiali Yin, Lei Lang, Xiaoli Tang, Manran Liu

Digestive Diseases and Sciences

DOI

2015

Twist induces epithelial-mesenchymal transition and cell motility in breast cancer via ITGB1-FAK/ILK signaling axis and its associated downstream network

Jiajia Yang, Yixuan Hou, Mingli Zhou, Siyang Wen, Jian Zhou, Liyun Xu, Xi Tang, Yan-e Du, Ping Hu, Manran Liu

The International Journal of Biochemistry & Cell Biology

DOI

2015

LncRNA-Hh Strengthen Cancer Stem Cells Generation in Twist-Positive Breast Cancer via Activation of Hedgehog Signaling Pathway

Mingli Zhou, Yixuan Hou, Guanglun Yang, Hailong Zhang, Gang Tu, Yan-e Du, Siyang Wen, Liyun Xu, Xi Tang, Shifu Tang, Yang Li, Xiaojiang Cui, Manran Liu

Stem Cells

DOI

2015

[GPER silence inhibits the stimulation of growth and inhibition of apoptosis induced by tamoxifen in breast cancer-associated fibroblasts].

Yuzhao Yan, Tenghua Yu, Gang Tu, Manran Liu, Jie Yuan, Guanglun Yang

PubMed

2015

Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways

Li Yang, Yixuan Hou, Jie Yuan, Shifu Tang, Hailong Zhang, Qing Zhu, Yan-e Du, Mingli Zhou, Siyang Wen, Liyun Xu, Xi Tang, Xiaojiang Cui, Manran Liu

Oncotarget

DOI

2015

Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells

Jie Yuan, Manran Liu, Li Yang, Gang Tu, Qing Zhu, Maoshan Chen, Hong Cheng, Haojun Luo, Weijie Fu, Zhenhua Li, Guanglun Yang

Breast Cancer Research

DOI

2015

Oxidized ATM promotes abnormal proliferation of breast CAFs through maintaining intracellular redox homeostasis and activating the PI3K-AKT, MEK-ERK, and Wnt-β-catenin signaling pathways

Shifu Tang, Yixuan Hou, Hailong Zhang, Gang Tu, Li Yang, Yifan Sun, Lei Lang, Xi Tang, Yan-e Du, Mingli Zhou, Tenghua Yu, Liyun Xu, Siyang Wen, Chunming Liu, Manran Liu

Cell Cycle

DOI

2015

[Twist gene promotes the formation and migration of mammospheres of BT-549 breast cancer cells].

Mingli Zhou, Shifu Tang, Hailong Zhang, Yang Li, Jiajia Yang, Manran Liu

PubMed

2015

Cancer-associated fibroblasts: A multifaceted driver of breast cancer progression

Haojun Luo, Gang Tu, Zhimin Liu, Manran Liu

Cancer Letters

DOI

2014

GPR30介导雌激素对三阴性乳腺癌MDA-MB-468细胞系增殖的影响

余腾骅，罗浩军，严玉钊，吴诚义，柳满然，涂刚

《陆军军医大学学报》

2014

乳腺癌相关成纤维细胞miRNA表达的检测和分析

曾宗跃，胡萍，唐曦，张海龙，杜艳娥，文思阳，柳满然

《细胞与分子免疫学杂志》

2014

转录因子Twist基因慢病毒质粒构建及其促进乳腺肿瘤上皮细胞MCF-7上皮间质转化

胡萍，杨佳佳，黄翼，曾宗跃，唐曦，黄杰涛，柳满然

《重庆医科大学学报》

2014

高表达Twist基因促进人乳腺癌细胞MCF-7干细胞样细胞富集和迁移

周明莉，杨佳佳，唐石伏，杨丽，张海龙，杜燕娥，文思阳，柳满然

《陆军军医大学学报》

2014

人乳腺癌MCF-7他莫昔芬耐受细胞株EMT表型的鉴定及其机制的初步研究

袁杰，杨丽，陈茂山，朱庆，付伟杰，成宏，柳满然，杨光伦

《陆军军医大学学报》

2014

[Dectection and analysis of miRNA expression in breast cancer-associated fibroblasts].

Zongyue Zeng, Ping Hu, Xi Tang, Hailong Zhang, Yan-e Du, Siyang Wen, Manran Liu

PubMed

2014

The role of oxidized ATM in the regulation of oxidative stress-induced energy metabolism reprogramming of CAFs

Shifu Tang, Li Yang, Xi Tang, Manran Liu

Cancer Letters

DOI

2014

GPER mediates enhanced cell viability and motility via non-genomic signaling induced by 17β-estradiol in triple-negative breast cancer cells

Tenghua Yu, Manran Liu, Haojun Luo, Ching‐Yi Wu, Xi Tang, Shifu Tang, Ping Hu, Yuzhao Yan, Zhiliang Wang, Gang Tu

The Journal of Steroid Biochemistry and Molecular Biology

DOI

2014

GPER-mediated proliferation and estradiol production in breast cancer-associated fibroblasts

Haojun Luo, Guanglun Yang, Tenghua Yu, Shujuan Luo, Chengyi Wu, Yan Sun, Manran Liu, Gang Tu

Endocrine Related Cancer

DOI

2013

人乳腺癌相关成纤维细胞对MDA-MB-231细胞的影响

彭琼乐，杨得志，赵浏阳，王黎阳，孙艳，柳满然

《陆军军医大学学报》

2013

癌相关成纤维细胞在肿瘤发生发展中的作用

彭琼乐，孙艳，赵浏阳，王黎阳，彭惠民，柳满然

《生物医学工程学杂志》

2013

Twist基因逆转录病毒载体的构建及其诱导正常乳腺上皮细胞发生上皮间质转化

杨佳佳，胡萍，周明莉，黄杰涛，柳满然

《细胞与分子免疫学杂志》

2013

c-ski基因重组腺病毒质粒的构建及其对肿瘤相关成纤维细胞增殖的影响

王黎阳，赵浏阳，彭琼乐，孙艳，柳满然

《中国生物制品学杂志》

2013

microRNA与胃癌耐药的关系

袁泉，柳满然，曾宗跃，周旭春

《国际检验医学杂志》

2013

人乳腺癌微环境中癌相关成纤维细胞的生物学特征

彭琼乐，罗浩军，孙艳，韩明利，王黎阳，赵浏阳，柳满然

《肿瘤》

2013

MCF-7细胞他莫昔芬耐药过程中F-actin细胞骨架的重构促进细胞迁移

李振华，涂刚，李维东，莫志强，杨光伦，罗浩军，柳满然

《陆军军医大学学报》

2013

Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the β-Catenin/TCF/LEF-1 pathway in gastric cancer cells

Xiaoli Tang, Dong Zheng, Ping Hu, Zongyue Zeng, Ming Li, Lynne D. Tucker, Renée Monahan, Murray B. Resnick, Manran Liu, Bharat Ramratnam

Nucleic Acids Research

DOI

2013

GPR30 as an initiator of tamoxifen resistance in hormone-dependent breast cancer

Zhiqiang Mo, Manran Liu, Fangfang Yang, Haojun Luo, Zhenhua Li, Gang Tu, Guanglun Yang

Breast Cancer Research

DOI

2013

LncRNA expression signatures of twist-induced epithelial-to-mesenchymal transition in MCF10A cells

Ping Hu, Jiajia Yang, Yixuan Hou, Hailong Zhang, Zongyue Zeng, Liuyang Zhao, Tenghua Yu, Xi Tang, Gang Tu, Xiaojiang Cui, Manran Liu

Cellular Signalling

DOI

2013

c‐Ski activates cancer‐associated fibroblasts to regulate breast cancer cell invasion

Liyang Wang, Yixuan Hou, Yan Sun, Liuyang Zhao, Xi Tang, Ping Hu, Jiajia Yang, Zongyue Zeng, Guanglun Yang, Xiaojiang Cui, Manran Liu

Molecular Oncology

DOI

2013

Biological Characteristics and Genetic Heterogeneity between Carcinoma-Associated Fibroblasts and Their Paired Normal Fibroblasts in Human Breast Cancer

Qiongle Peng, Liuyang Zhao, Yixuan Hou, Yan Sun, Liyang Wang, Haojun Luo, Huimin Peng, Manran Liu

PLoS ONE

DOI

2012

乳腺癌前病变组织原代成纤维细胞生物学特征初步研究

孙艳，彭琼乐，王黎阳，赵浏阳，袁泉，李俊，柳满然

《陆军军医大学学报》

2012

人端粒酶蛋白催化亚单位基因逆转录病毒真核表达质粒的构建及其对人乳腺癌相关成纤维细胞增殖的影响

彭琼乐，王黎阳，赵浏阳，孙艳，柳满然，彭惠民

《中国生物制品学杂志》

2012

人乳腺癌相关成纤维细胞的原代培养及其生物学特性

彭琼乐，孙艳，赵浏阳，王黎阳，柳满然，彭惠民

《中国生物制品学杂志》

2012

MiRNA expression analysis of cancer-associated fibroblasts and normal fibroblasts in breast cancer

Liuyang Zhao, Yan Sun, Yixuan Hou, Qiongle Peng, Liyang Wang, Haojun Luo, Xi Tang, Zongyue Zeng, Manran Liu

The International Journal of Biochemistry & Cell Biology

DOI

2012

Antagonism of miR-21 Reverses Epithelial-Mesenchymal Transition and Cancer Stem Cell Phenotype through AKT/ERK1/2 Inactivation by Targeting PTEN

Mingli Han, Manran Liu, Yimeng Wang, Xin Chen, Jianli Xu, Yan Sun, Liuyang Zhao, Hongbo Qu, Yuanming Fan, Chun‐Ying Wu

PLoS ONE

DOI

2012

MiR‐21 regulates epithelial‐mesenchymal transition phenotype and hypoxia‐inducible factor‐1α expression in third‐sphere forming breast cancer stem cell‐like cells

Mingli Han, Yimeng Wang, Manran Liu, Xiaokai Bi, Junjie Bao, Ni Zeng, Zhi-kun Zhu, Zhiqiang Mo, Chengyi Wu, Xin Chen

Cancer Science

DOI

2011

Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells

Han Ming-li, Manran Liu, Yimeng Wang, Zhiqiang Mo, Xiaokai Bi, Zhirong Liu, Yuanming Fan, Xin Chen, Chun‐Ying Wu

Molecular and Cellular Biochemistry

DOI

2010

The Canonical NF-κB Pathway Governs Mammary Tumorigenesis in Transgenic Mice and Tumor Stem Cell Expansion

Manran Liu, Toshiyuki Sakamaki, Mathew Craig Casimiro, Nicole E. Willmarth, Andrew A. Quong, Xiaoming Ju, John O. Ojeifo, Xuanmao Jiao, Wen-Shuz Yeow, Sanjay Katiyar, Lawrence A. Shirley, David A. Joyce, Michael P. Lisanti, Christopher Albanese, Richard G. Pestell

Cancer Research

DOI

2009

p21 CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo

Manran Liu, Mathew Craig Casimiro, Chenguang Wang, Lawrence A. Shirley, Xuanmao Jiao, Sanjay Katiyar, Xiaoming Ju, Zhiping Li, Zuoren Yu, Jie Zhou, Michael D. Johnson, Paolo M. Fortina, Terry Hyslop, Jolene J. Windle, Richard G. Pestell

Proceedings of the National Academy of Sciences

DOI

会议论文

2018

Oxidized ATM-mediated EMR plays a pivotal role in BCSC enrichment and stemness maintenance

柳满然

《中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议》

2016

TGF-β信号通路调节乳腺肿瘤干细胞样细胞富集及迁移

周明莉，柳满然，刘华伟

《第七届中国临床微生物学大会暨微生物学与免疫学论坛论文汇编》

2015

基质miR-200s介导CAF活化和ECM重塑促进乳腺癌细胞的侵袭转移

柳满然

《贯通研究与实践——2015第八届世界癌症大会》

2010

GPR30、CTGF及FN在原发性乳腺癌中的表达与关联(英文)

罗浩军，杨光伦，柳满然，彭琼乐，涂刚

《第四届中—法乳腺癌高级学术论坛论文集》

预印本

2023

Targeting hypoxia-induced circSTT3A decreases breast cancer stem cell formation via degradation of PGK1 protein and serine synthesis

Ming Xu, Manran Liu, Xinyue Zhou, Yilu Qin, Liping Yang, Siyang Wen, Yuxiang Qiu, Ting Jin, Shangchun Chen, Rui Tang, Yuetong Guo, Yan Sun

bioRxiv (Cold Spring Harbor Laboratory)

DOI

2021

Oxidized ATM Protein Kinase Promotes the Proliferation of Breast CAF Through Upregulating the SCD1 Gene Expression by Activating Core Proliferation-Related Pathways

Xing Li, Mingjun Ren, Wanying Bi, Wanjun Wu, Gui Jiang, Limin Li, Yu Lu, Hongli Yu, Manran Liu, Xin Tu, Shifu Tang

Research Square

DOI

研究方向

乳腺肿瘤及胃癌转移、药物耐受与标志物肿瘤微环境与癌细胞互作肿瘤代谢、免疫及信号传导机制

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