唐梦帆｜南京中医药大学｜学者主页

2026

ESCO2 Interacts with TRF1/2 and Facilitates Telomere Maintenance

Jiahui Guo, Jingjing Ji, Jinfeng Liu, Mengfan Tang

International Journal of Molecular Sciences

2026

CHK1 is an integral regulator of DNA replication in human cells

Siting Li, Dandan Zhu, Mengfan Tang, Min Huang, Xu Feng, Litong Nie, Huimin Zhang, Ling Yin, Sarah Keast, Chang Yang, Tiantian Ma, Junjie Chen

Cell Death and Disease

DOI

2025

USP37 counteracts HLTF to protect damaged replication forks and promote survival of BRCA1-deficient cells and PARP inhibitor resistance

Mengfan Tang, Siting Li, Ziqiang Zhu, Chao Wang, Shuai Ding, Huimin Zhang, Min Huang, Sarah Keast, Zhen Chen, Ling Yin, Litong Nie, Dan Su, Xu Feng, Junjie Chen

Nucleic Acids Research

DOI

2025

Cell cycle progression of under-replicated cells

Min Huang, Chang Yang, Li-Tong Nie, Hui-Min Zhang, Dan-Dan Zhu, Chao Wang, Jeong-Min Park, Mrinal Srivastava, Elina A. Mosa, Siting Li, Mengfan Tang, Xu Feng, Sarah Keast, F. Stossi, Jun-Jie Chen

Nucleic Acids Research

DOI

2024

Systematic investigation of BRCA1-A, -B, and -C complexes and their functions in DNA damage response and DNA repair

Siting Li, Mengfan Tang, Yun Xiong, Xu Feng, Chao Wang, Litong Nie, Min Huang, Huimin Zhang, Ling Yin, Dandan Zhu, Chang Yang, Tiantian Ma, Junjie Chen

Oncogene

DOI

2024

DePARylation is critical for S phase progression and cell survival

Li-Tong Nie, Chao Wang, Min Huang, Xiaoguang Liu, Xu Feng, Mengfan Tang, Siting Li, Q. Hang, Hong-Qi Teng, Xi Shen, Li Ma, Bo-Yi Gan, Jun-Jie Chen

eLife

DOI

2024

In vivo CRISPR screens identify Mga as an immunotherapy target in triple-negative breast cancer

Xu Feng, Chang Yang, Yuan-Jian Huang, Dan Su, Chao Wang, Lori L. Wilson, Ling Yin, Mengfan Tang, Siting Li, Zhen Chen, Dan-Dan Zhu, Shimin Wang, Sheng-Zhe Zhang, Jie Zhang, Hui-Min Zhang, Li-Tong Nie, Min Huang, Jae-Il Park, Traver Hart, Da-Di Jiang, Kui-Rong Jiang, Jun-Jie Chen

Proceedings of the National Academy of Sciences of the United States of America

DOI

2024

Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy

Ling Yin, Xiao-Ding Hu, Guangsheng Pei, Mengfan Tang, You-Liang Zhou, Hui-Min Zhang, Min Huang, Siting Li, Jie Zhang, C. Citu, Zhongming Zhao, B. Debeb, Xu Feng, Jun-Jie Chen

Life Science Alliance

DOI

2023

CRISPR/Cas9-Mediated Genome Editing in Cancer Therapy

Shuai Ding, Jinfeng Liu, Xin Han, Mengfan Tang

International Journal of Molecular Sciences

DOI

2023

RAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons

Hui-Min Zhang, Yun Xiong, Yi-Lun Sun, Jeong-Min Park, Dan Su, Xu Feng, Sarah Keast, Mengfan Tang, Min Huang, Chao Wang, Mrinal Srivastava, Chang Yang, Dan-Dan Zhu, Zhen Chen, Siting Li, Ling Yin, Y. Pommier, Jun-Jie Chen

Science Advances

DOI

2023

Genome-Wide CRISPR Screens Reveal ZATT as a Synthetic Lethal Target of TOP2-Poison Etoposide That Can Act in a TDP2-Independent Pathway

Jeong-Min Park, Hui-Min Zhang, Li-Tong Nie, Chao Wang, Min Huang, Xu Feng, Mengfan Tang, Zhen Chen, Yun Xiong, Namsoo Lee, Siting Li, Ling Yin, Traver Hart, Jun-Jie Chen

International Journal of Molecular Sciences

DOI

2023

FACS-based genome-wide CRISPR screens define key regulators of DNA damage signaling pathways

Min Huang, F. Yao, Li-Tong Nie, Chao Wang, Dan Su, Hui-Min Zhang, Siting Li, Mengfan Tang, Xu Feng, Bing Yu, Zhen Chen, Shimin Wang, Ling Yin, Li-Sha Mou, Traver Hart, Jun-Jie Chen

Molecules and Cells

DOI

2022

Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells

Mengfan Tang, Zhen Chen, Chao Wang, Xu Feng, Namsoo Lee, Min Huang, Hui-Min Zhang, Siting Li, Yun Xiong, Jun-Jie Chen

Journal of Biological Chemistry

DOI

2022

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Li-Tong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Hui-Min Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Jun-Jie Chen

Science Advances

DOI

2022

TDP1-independent pathways in the process and repair of TOP1-induced DNA damage

Hui-Min Zhang, Yun Xiong, Dan Su, Chao Wang, Mrinal Srivastava, Mengfan Tang, Xu Feng, Min Huang, Zhen Chen, Jun-Jie Chen

Nature Communications

DOI

2022

Integrated screens uncover a cell surface tumor suppressor gene KIRREL involved in Hippo pathway

Chao Wang, Xu Feng, Dan Su, Zhen Chen, Shimin Wang, Mengfan Tang, Min Huang, Li-Tong Nie, Hui-Min Zhang, Siting Li, Ling Yin, Randy L. Johnson, Traver Hart, Jun-Jie Chen

Proceedings of the National Academy of Sciences of the United States of America

DOI

2021

Ubiquitylation in DNA double-strand break repair

Mengfan Tang, Siting Li, Jun-Jie Chen

DNA Repair

DOI

2021

Comprehensive analysis of the host-virus interactome of SARS-CoV-2

Zhen Chen, Chao Wang, Xu Feng, Li-Tong Nie, Mengfan Tang, Hui-Min Zhang, Yun Xiong, S. Swisher, Mrinal Srivastava, Jun-Jie Chen

bioRxiv

DOI

2021

Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation.

Wei-Xiang Bian, Mengfan Tang, Hua Jiang, Wenyan Xu, Wanyu Hao, Yue Sui, Ying-Nan Hou, Li-Tong Nie, Hui-Min Zhang, Chao Wang, Nan Li, Jiadong Wang, Jun Qin, Lianfeng Wu, Xianjue Ma, Jun-Jie Chen, Wenqi Wang, Xu Li

Developmental Cell

DOI

2021

Interactomes of SARS‐CoV‐2 and human coronaviruses reveal host factors potentially affecting pathogenesis

Zhen Chen, Chao Wang, Xu Feng, Li-Tong Nie, Mengfan Tang, Hui-Min Zhang, Yun Xiong, S. Swisher, Mrinal Srivastava, Jun-Jie Chen

EMBO Journal

DOI

2021

Genetic vulnerabilities upon inhibition of DNA damage response

Chao Wang, Mengfan Tang, Zhen Chen, Li-Tong Nie, Siting Li, Yun Xiong, Klaudia Szymonowicz, Jeong-Min Park, Hui-Min Zhang, Xu Feng, Min Huang, Dan Su, Traver Hart, Jun-Jie Chen

Nucleic Acids Research

DOI

2021

Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2

Mengfan Tang, Guangsheng Pei, Dan Su, Chao Wang, Xu Feng, Mrinal Srivastava, Zhen Chen, Zhong-Ming Zhao, Jun-Jie Chen

Nucleic Acids Research

DOI

2020

Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation

Li-Tong Nie, Chao Wang, Nan Li, Xu Feng, Namsoo Lee, Dan Su, Mengfan Tang, Fan Yao, Jun-Jie Chen

Molecular & Cellular Proteomics

DOI

2020

AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair*

Zhen Chen, Chao Wang, Antrix Jain, Mrinal Srivastava, Mengfan Tang, Hui-Min Zhang, Xu Feng, Li-Tong Nie, Dan Su, Yun Xiong, Sung-Yun Jung, J. Qin, Jun-Jie Chen

Molecular & Cellular Proteomics

DOI

2020

CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions

Dan Su, Xu Feng, Medina Colic, Yunfei Wang, Chun-Chao Zhang, Chao Wang, Mengfan Tang, Traver Hart, Jun-Jie Chen

DNA Repair

DOI

2020

Genome-wide CRISPR screen uncovers a synergistic effect of combining Haspin and Aurora kinase B inhibition

Min Huang, Xu Feng, Dan Su, Gang Wang, Chao Wang, Mengfan Tang, A. Paulucci-Holthauzen, Traver Hart, Jun-Jie Chen

Oncogene

DOI

2020

C17orf53 is identified as a Novel Gene Involved in Inter-strand Crosslink Repair

Chao Wang, Zhen Chen, Dan Su, Mengfan Tang, Li-Tong Nie, Hui-Min Zhang, Xu Feng, Rui Wang, Xi Shen, Mrinal Srivastava, M. McLaughlin, Traver Hart, Lei Li, Jun-Jie Chen

DNA Repair

DOI

2020

HMCES safeguards replication from oxidative stress and ensures error‐free repair

Mrinal Srivastava, Dan Su, Hui-Min Zhang, Zhen Chen, Mengfan Tang, Li-Tong Nie, Jun-Jie Chen

EMBO Reports

DOI

2020

ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways

Xu Feng, Anthony T. Tubbs, Chun-Chao Zhang, Mengfan Tang, Sriram Sridharan, Chao Wang, Dadi Jiang, Dan Su, Hui-Min Zhang, Zhen Chen, Li-Tong Nie, Yun Xiong, Min Huang, A. Nussenzweig, Jun-Jie Chen

EMBO Journal

DOI

2020

FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function

Mengfan Tang, Xu Feng, Guangsheng Pei, Mrinal Srivastava, Chao Wang, Zhen Chen, Siting Li, Hui-Min Zhang, Zhong-Ming Zhao, Xu Li, Jun-Jie Chen

Cell Reports

DOI

2020

Extracellular signal-regulated kinases associate with and phosphorylate DHPS to promote cell proliferation

Chao Wang, Zhen Chen, Li-Tong Nie, Mengfan Tang, Xu Feng, Dan Su, Hui-Min Zhang, Yun Xiong, Jeong-Min Park, Jun-Jie Chen

Oncogenesis

DOI

2019

Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics

Zhen Chen, Caoqi Lei, Chao Wang, Nan Li, Mrinal Srivastava, Mengfan Tang, Hui-Min Zhang, Jong-Min Choi, Sung-Yun Jung, J. Qin, Jun-Jie Chen

Nature Communications

DOI

2019

SLX4IP acts with SLX4 and XPF–ERCC1 to promote interstrand crosslink repair

Hui-Min Zhang, Zhen Chen, Yin Ye, Zu Ye, D. Cao, Yun Xiong, Mrinal Srivastava, Xu Feng, Mengfan Tang, Chao Wang, J. Tainer, Jun-Jie Chen

Nucleic Acids Research

DOI

2018

Replisome Dynamics and Their Functional Relevance upon DNA Damage through the PCNA Interactome

Mrinal Srivastava, Zhen Chen, Hui-Min Zhang, Mengfan Tang, Chao Wang, Sung-Yun Jung, Jun-Jie Chen

Cell Reports

DOI

2018

Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition

Chao Wang, Gang Wang, Xu Feng, Peter D. A. Shepherd, Jie Zhang, Mengfan Tang, Zhen Chen, Mrinal Srivastava, M. McLaughlin, N. Navone, G. T. Hart, Jun-Jie Chen

Oncogene

DOI

2017

53BP1: keep an eye on merotely

Mengfan Tang, Jun-Jie Chen

OncoTarget

DOI

2016

Daxx/Atrx复合体在DNA低甲基化细胞中通过提升H3K9三甲基化保护串联重复序列

Quanyuan He, Hyeung Kim, Rui Huang, Weisi Lu, Mengfan Tang, Fengtao Shi, Dong Yang, Xiya Zhang, Junjiu Huang, Dan Liu, 松阳洲

《科学新闻》

2016

Proteomic Analysis Reveals a Novel Mutator S (MutS) Partner Involved in Mismatch Repair Pathway*

Zhen Chen, Mykim Tran, Mengfan Tang, Wenqi Wang, Zihua Gong, Jun-Jie Chen

Molecular & Cellular Proteomics

DOI

精选作品

期刊论文

ESCO2 Interacts with TRF1/2 and Facilitates Telomere Maintenance

CHK1 is an integral regulator of DNA replication in human cells

USP37 counteracts HLTF to protect damaged replication forks and promote survival of BRCA1-deficient cells and PARP inhibitor resistance

Cell cycle progression of under-replicated cells

Systematic investigation of BRCA1-A, -B, and -C complexes and their functions in DNA damage response and DNA repair

DePARylation is critical for S phase progression and cell survival

In vivo CRISPR screens identify Mga as an immunotherapy target in triple-negative breast cancer

Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy

CRISPR/Cas9-Mediated Genome Editing in Cancer Therapy

RAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons

Genome-Wide CRISPR Screens Reveal ZATT as a Synthetic Lethal Target of TOP2-Poison Etoposide That Can Act in a TDP2-Independent Pathway

FACS-based genome-wide CRISPR screens define key regulators of DNA damage signaling pathways

Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

TDP1-independent pathways in the process and repair of TOP1-induced DNA damage

Integrated screens uncover a cell surface tumor suppressor gene KIRREL involved in Hippo pathway

Ubiquitylation in DNA double-strand break repair

Comprehensive analysis of the host-virus interactome of SARS-CoV-2

Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation.

Interactomes of SARS‐CoV‐2 and human coronaviruses reveal host factors potentially affecting pathogenesis

Genetic vulnerabilities upon inhibition of DNA damage response

Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2

Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation

AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair*

CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions

Genome-wide CRISPR screen uncovers a synergistic effect of combining Haspin and Aurora kinase B inhibition

C17orf53 is identified as a Novel Gene Involved in Inter-strand Crosslink Repair

HMCES safeguards replication from oxidative stress and ensures error‐free repair

ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways

FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function

Extracellular signal-regulated kinases associate with and phosphorylate DHPS to promote cell proliferation

Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics

SLX4IP acts with SLX4 and XPF–ERCC1 to promote interstrand crosslink repair

Replisome Dynamics and Their Functional Relevance upon DNA Damage through the PCNA Interactome

Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition

53BP1: keep an eye on merotely

Daxx/Atrx复合体在DNA低甲基化细胞中通过提升H3K9三甲基化保护串联重复序列

Proteomic Analysis Reveals a Novel Mutator S (MutS) Partner Involved in Mismatch Repair Pathway*

研究方向