古双喜｜武汉工程大学｜学者主页

2026

糖羟基的选择性氧化反应研究进展

杨其昌，张筱睿，吕剑，古双喜

《有机化学》

2026

Design, synthesis and evaluation of NTM-006-derived analgesics with enhanced potency

Qinlan Mu, Hao Zhou, Quaowei Li, Yikun Chen, Yuanyuan Zhu, Rong Liu, Luanyuan Tian, Shuangxi Gu

Bioorganic & Medicinal Chemistry Letters

DOI

2026

Uracil derivatives as non-nucleoside inhibitors targeting HIV-1 reverse transcriptase

J. Paul Chen, Gongming Yang, Luanyuan Tian, Yuanyuan Zhu, Shuangshuang Zhang, Shuangxi Gu

European Journal of Medicinal Chemistry

DOI

2026

Bis(trifluoromethanesulfonyl)imide (TFSI)‐Catalyzed Regioselective N 1 ‐Alkylation of Benzotriazoles

Hua Mei, Xiaoqiong Fu, Huaiyu Huang, Haifeng Wang, Shuang‐Xi Gu

European Journal of Organic Chemistry

DOI

2026

Iron-Catalyzed Regioselective Phosphorylation of trans -Vicinal Diols in Glycosides

Jiaxue Yao, Zongquan Wang, Jing Chen, Man Zhang, Jian Lyu, Nianyu Huang, Shuang‐Xi Gu

Organic Letters

DOI

2026

CDK4/6-Based Drug Research and Development: A Four-Year Update

Miao-Xia Pu, Wen-Bo Xu, Li Ding, Shuang‐Shuang Zhang, Luan-Yuan Tian, Shuang-Xi Gu

Anti-Cancer Agents in Medicinal Chemistry

DOI

2026

Engineering and design of artificial enzymes for non-natural biocatalysis in whole cells

Hanchen Zhao, Qiqi Liu, Juan Guo, Shuangxi Gu

Biotechnology Advances

DOI

2026

Coumarin derivatives as HIV-1 inhibitors: mechanistic insights and structure-activity relationships

Xiaohui Lin, Xijun Sheng, Hao Zhou, Xiongbin Xu, Luanyuan Tian, Shuangxi Gu

Medicinal Chemistry Research

DOI

2026

A Catalyst-Free Synthesis Platform for Functionalized Sulfur-Containing Molecules via Cyclic Sulfonium Salts

Xiaoqiong Fu, Huaiyu Huang, Xuyang Gong, Hui Li, Yue Wang, Kaiwen Zhang, Hongwei Li, Haifeng Wang, Shuangxi Gu

The Journal of Organic Chemistry

DOI

2025

PROTACs在抗病毒药物研发中的应用

蒲苗霞，张双双，王海峰，朱园园，古双喜

《中国药科大学学报》

2025

达普司他的合成新工艺（英文）

许志勇，林晓慧，朱园园，张双双，龙姣，古双喜

《有机化学》

2025

席夫碱型荧光探针对氨基酸化学选择性识别研究进展

彭澳霈，李扬，朱园园，吴广文，古双喜

《有机化学》

2025

Discovery of novel imidazo[1,2-b]pyridazine derivatives as potent covalent inhibitors of CDK12/13

Meng Xia, Ziteng Li, Hanrui Jiang, Yuan‐Qing Li, Linghao Hu, Yingwen He, Siqi Huang, Lei Tang, Cheng Luo, Shuang‐Xi Gu, Hong Ding, Mingliang Wang

European Journal of Medicinal Chemistry

DOI

2025

Application of deuterium in research and development of drugs

Jiong Chen, Yuan‐Yuan Zhu, Lu Huang, Shuang‐Shuang Zhang, Shuang‐Xi Gu

European Journal of Medicinal Chemistry

DOI

2025

NIR-II organic fluorophores integrated with blood–brain barrier-penetrating strategies for brain disease theranostics

Xiaobo Wang, Yuying Tan, Jierui Yan, Min Chen, Na Xie, Sha Wu, Fuhan Fan, Luming Qi, Shuang‐Xi Gu, Kun Qian, Xianli Meng, Qihang Ding, Ya Hou, Zhen Xiang Cheng, Yang Li

Coordination Chemistry Reviews

DOI

2025

Enantioselective Copper-Catalyzed N–H Insertion Reaction of Pyrazoles and α-Diazo Phosphates

Lewan Li, Mengxiang Luo, Yuqing Zhang, Huan Li, Xuyang Gong, Ruiqi Liao, Hua Huang, Xiaoqiong Fu, Jian Lyu, Shuang‐Xi Gu, Haifeng Wang

Organic Letters

DOI

2025

Iron-Catalyzed Aerobic Hydration of Glycal: A Route toward Deoxy Sugars/Glycosides

Qichang Yang, Zongquan Wang, Jiaxue Yao, Qiang Zhang, Haifeng Wang, Jian Lyu, Shuang‐Xi Gu

The Journal of Organic Chemistry

DOI

2025

Palladium-Catalyzed Carbene Se–H Insertion Reaction for C–Se Bond Formation

Xuyang Gong, Feifei Zhao, Xiaoqiong Fu, Hua Huang, Wenbo Xu, Man Zhang, Haifeng Wang, Shuangshuang Zhang, Shuang‐Xi Gu

The Journal of Organic Chemistry

DOI

2025

Enantioselective Construction of Heteroatom Stereocenters via N -Heterocyclic Carbene Catalysis

Jiong Chen, Cai Liu, Yuanyuan Zhu, Gongming Yang, Shuang‐Xi Gu

CCS Chemistry

DOI

2025

Recent Advances in Catalytic Atroposelective Synthesis of Seven‐ and Eight‐Membered Rings with Inherent Chirality

Cai Liu, Jiong Chen, Yuanyuan Zhu, Gongming Yang, Shuang‐Xi Gu

Advanced Synthesis & Catalysis

DOI

2025

Enantioselective recognition of amino acids in water using emission-tunable chiral fluorescent probes

Yixin Zhang, Fang-Qi Zhang, Ao-Pei Peng, Tao Jiang, Ya-Xi Meng, Yang Li, Shuang‐Xi Gu, Yuan‐Yuan Zhu

Chinese Chemical Letters

DOI

2025

Recent Advances in Transition Metal‐Catalyzed Asymmetric Synthesis of P‐chiral Organophosphorus Compounds (2020–Present)

Baixue Liu, Fan Feng, Jiao Long, Shuang‐Xi Gu

Chinese Journal of Chemistry

DOI

2025

Efficient synergistic recognition of D/L-cysteine and zinc ions using a chiral chemosensor

Ao-Pei Peng, Yu-Li Liang, Guangwen Wu, Jie Zeng, Yang Li, Shuang‐Xi Gu, Yuan‐Yuan Zhu

Sensors and Actuators B Chemical

DOI

2025

Tandem SNAr/Aldol Condensation of Oxindoles with o-Haloacetophenones Enables Modular Assembly of 2,3-Fused Indolines Bearing a Quaternary Carbon

Zi-Xia Zheng, Kai-Heng Yu, Ziyuan Liu, Qun Cai, Ziyi Yuan, Feng‐Cheng Jia, Shuang‐Xi Gu

The Journal of Organic Chemistry

DOI

2025

Chemoselective and enantioselective fluorescent recognition of basic amino acids: A review

Fang-Qi Zhang, Zhiyong Xu, Li Yang, Yuan‐Yuan Zhu, Shuang‐Xi Gu

Dyes and Pigments

DOI

2025

Typical Cases of Continuous Flow Chemistry in Pharmaceutical Synthesis in 2023–2024

Kang‐Bo Feng, Yuanyuan Zhu, Shuang‐Xi Gu, Jiao Long, Haifeng Wang

Asian Journal of Organic Chemistry

DOI

2025

A fluorescent probe for enantioselective recognition of amino acids in solutions, cells and zebrafishes

Shiwei Fu, Zong-Xing Huang, Chuan-Zhi Ni, Fang-Qi Zhang, Li Yang, Yuan‐Yuan Zhu, Qi Sun, Shuang‐Xi Gu

Dyes and Pigments

DOI

2025

Strain-release driven α,β-difunctionalization of cyclopropanols with bromonaphthols

Feng‐Cheng Jia, Lei-Xiao Luo, Yao-Hui Chen, Qian Xiang, Xiao‐Qiang Hu, Shuang‐Xi Gu

Organic Chemistry Frontiers

DOI

2025

Carbene-catalytic enantioselective synthesis of chiral macrocycles

Huikun Yan, Yuan‐Yuan Zhu, Gongming Yang, Shuang-Xi Gu

Chemical Science

DOI

2024

质量源于设计在缬沙坦胶囊处方开发中的应用

张晓娟，宋如顺，张双双，古双喜

《中国医药工业杂志》

2024

博舒替尼合成路线图解

张锦，张双双，龙姣，朱园园，古双喜

《中国药物化学杂志》

2024

基于连续流动化学的三组分有机合成实验设计

王海峰，王睿，古双喜

《化工时刊》

2024

阿托吉泮的合成研究进展

张锋，肖梦鑫，张双双，龙姣，朱园园，廖杰，古双喜

《武汉工程大学学报》

2024

水溶性荧光探针在氨基酸分子识别中的研究进展

余康，许志勇，安建平，朱园园，古双喜

《化学试剂》

2024

测定氨基酸浓度和对映体组成的手性荧光探针（英文）

李非凡，余康，倪传志，朱园园，曾婕，古双喜

《有机化学》

2024

全连续流反应技术在药物合成中的新进展(2019～2022)

冯康博，陈炯，古双喜，王海峰，陈芬儿

《有机化学》

2024

镍催化1,3-二烯的不对称氢官能团化反应研究进展

龙姣，刘白雪，张双双，朱园园，古双喜

《有机化学》

2024

连续流动化学在“高等有机化学实验”教学中的应用研究

王海峰，古双喜

《化工时刊》

2024

HIV-1逆转录酶抑制剂的新进展（2021—2023年）

曾依，周家琪，鲍怡翎，刘佳仪，张双双，古双喜

《药学进展》

2024

布洛芬的连续流合成研究进展

戴俊涛，冯康博，廖杰，龙姣，张双双，朱园园，古双喜

《武汉工程大学学报》

2024

Design, synthesis, and biological evaluation of dithiocarbamate derivatives as SARS-CoV-2 Mpro inhibitors

Jin-Qi Peng, Ya-Qi Xiao, Jiao Long, Shuang‐Shuang Zhang, Yuan‐Yuan Zhu, Shuang‐Xi Gu

Bioorganic & Medicinal Chemistry Letters

DOI

2024

Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors (2019–2023)

Mu-Zi Nie, Shuang‐Shuang Zhang, Shuang‐Xi Gu, Jiao Long, Yuan‐Yuan Zhu

European Journal of Medicinal Chemistry

DOI

2024

Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review

Ya-Qi Xiao, Jiao Long, Shuang‐Shuang Zhang, Yuan‐Yuan Zhu, Shuang‐Xi Gu

Bioorganic Chemistry

DOI

2024

UiO-67: A versatile metal-organic framework for diverse applications

Zhou Ji, Shuang‐Xi Gu, Yuqin Xiang, Yun Xiong, Genyan Liu

Coordination Chemistry Reviews

DOI

2024

Convergent Assembly of 1,4-Benzothiazide Spiroindolinones via [4 + 2] Spiroannulation Under Open-Air Conditions

Wenxiang Hu, Kai-Heng Yu, Feng‐Cheng Jia, Shuang‐Xi Gu

The Journal of Organic Chemistry

DOI

2024

Preparation of (S)‐3,3′‐Bis(1‐pyrrolidinylmethyl)‐5,5′,6,6′, 7,7′,8,8′‐octahydro‐1,1'‐bi‐2‐naphthol

Yu Hong, Yuan‐Yuan Zhu, Shuang‐Xi Gu

Organic Syntheses

DOI

2024

Modular Assembly of Six‐Membered Carbocyclic Spirooxindoles via Peterson Olefination/Michael Addition/C(sp3) Arylation Cascade

Feng‐Cheng Jia, Zi‐Yi Yuan, Na Luo, Shuang‐Xi Gu, Xiao‐Qiang Hu

Chinese Journal of Chemistry

DOI

2024

A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells

Chuan-Zhi Ni, Ruo-Ming Li, Fang-Qi Zhang, Qu-Ao-Wei Li, Yuan‐Yuan Zhu, Jie Zeng, Shuang‐Xi Gu

Chinese Chemical Letters

DOI

2024

Degradation mechanism of antibiotics by flower-like Bi2S3 sensitized anatase/rutile TiO2 coupled with SiO2 photonic crystals

Ruizhen Liu, Huaiyuan Jiang, Ping Li, Jianfei Yin, Zhengrui Xu, Xiaoyu Chen, Jian Cheng, Shuang‐Xi Gu, Renliang Lyu

Journal of Water Process Engineering

DOI

2023

泼尼松磷酸酯二钠的合成及其在水中的溶解度测定

李屈澳薇，龚智华，陈炯，张双双，古双喜

《中国药物化学杂志》

2023

Quinolines and isoquinolines as HIV-1 inhibitors: Chemical structures, action targets, and biological activities

Sha Hu, Jiong Chen, Jin-Xu Cao, Shuang‐Shuang Zhang, Shuang‐Xi Gu, Fen-Er Chen

Bioorganic Chemistry

DOI

2023

Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities

Wei Ming, Wen-Long Lu, Christophe C. Pannecouque, Jiong Chen, Haifeng Wang, Ya-Qi Xiao, Sha Hu, Shuang‐Xi Gu, Yuan‐Yuan Zhu, Fen-Er Chen

European Journal of Medicinal Chemistry

DOI

2023

Chemodivergent Synthesis of Sulfonamide and Sulfones from N-Tosylhydrazones by Switching Catalyst and Temperature

Jingru Jin, Chunyan Li, Rui Wang, Zhimin Xia, Qiongjiao Yan, Wei Wang, Shuang‐Xi Gu, Haifeng Wang, Fen‐Er Chen

Organic Letters

DOI

2023

Chiral amino acid recognition in water: A BINOL-based fluorescent probe

Mengxin Sun, Chuan-Zhi Ni, Fang-Qi Zhang, Yuan‐Yuan Zhu, Jie Zeng, Shuang‐Xi Gu

Chinese Chemical Letters

DOI

2023

Iridium-Catalyzed Intramolecular Asymmetric Allylation of Vinyl Benzoxazinones for the Synthesis of Chiral 4H-3,1-Benzoxazines via Kinetic Resolution

Chenzong Li, Xun Xiang, Xianghe Zhang, Zhao‐Lin He, Shuang‐Xi Gu, Xiu‐Qin Dong

Organic Letters

DOI

2023

Recent Advances in the Chemical Synthesis of β-Nicotinamide Mononucleotide

Wei Ming, Sha Hu, Ye Liu, Qu-Ao-Wei Li, Yuan‐Yuan Zhu, Shuang-Xi Gu

Current Organic Chemistry

DOI

2023

E3 ligase ligand optimization of Clinical PROTACs

Hanrui Jiang, Huan Xiong, Shuang-Xi Gu, Mingliang Wang

Frontiers in Chemistry

DOI

2022

拟肽类冠状病毒主蛋白酶抑制剂的研究进展

刘玉，明巍，李陈宗，朱园园，古双喜

《药学学报》

DOI

2022

临床应用中的新型冠状病毒肺炎治疗药物研究进展

刘烨，明巍，朱园园，古双喜

《中国新药杂志》

2022

磷酸酯类前药的合成方法与应用

龚智华，胡莎，金学平，余磊，朱园园，古双喜

《化学进展》

2022

手性药物及其中间体光学纯度的测定方法与应用

李陈宗，朱园园，古双喜

《分析试验室》

2022

新型冠状病毒肺炎（COVID-19）临床治疗化学药物述评

明巍，肖雅琪，胡莎，朱园园，古双喜

《武汉工程大学学报》

2022

手性化合物绝对构型确定的方法与应用

葛锐，朱园园，王海峰，古双喜

《有机化学》

2022

Synthesis and Characterization of Related Substances of Torasemide

Jiong Chen, Wei Ming, De-Hua Fan, Shuang-Xi Gu

Pharmaceutical Fronts

DOI

2022

Meet the Editorial Board Member

Shuang-Xi Gu

Mini-Reviews in Medicinal Chemistry

DOI

2021

选择性转染重排酪氨酸激酶抑制剂概述及其专利研究

黄璐，古双喜，洪怡

《中国医药工业杂志》

DOI

2021

米拉贝隆合成路线图解

陈炯，黄璐，古双喜

《中国药物化学杂志》

DOI

2021

流动化学在卤化反应中的应用

刘玎，朱园园，古双喜，陈芬儿

《有机化学》

2021

改进的(S)-3,3'-二(吡咯烷甲基)-八氢联萘酚合成方法

符世玮，葛锐，汤佳凡，明巍，古双喜

《武汉工程大学学报》

DOI

2021

Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents

Yu Jin Hong, Yuan‐Yuan Zhu, Qiuqin He, Shuang‐Xi Gu

Bioorganic & Medicinal Chemistry

DOI

2021

Advances in the development of HIV integrase strand transfer inhibitors

Yue Wang, Shuang‐Xi Gu, Qiuqin He, Renhua Fan

European Journal of Medicinal Chemistry

DOI

2021

A naphthimide-based ratiometric fluorescent probe for selective and visual detection of phosgene in solution and the gas phase

Zhiqiang Xu, Yabin Luo, Yu Jin Hong, Ziru Liu, Ming-Xing Zhang, Shuang‐Xi Gu, Jun Yin

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy

DOI

2020

用于COVID-19潜在治疗的小分子药物及专利研究

黄璐，古双喜

《中国医药工业杂志》

DOI

2020

一种曼尼希类反应的有机合成实验设计

古双喜，张珩，徐志强，刘根炎，朱园园

《实验技术与管理》

DOI

2020

二苯基嘧啶类化合物抗癌活性的研究进展

古双喜，王超，曹爽，王海峰

《武汉工程大学学报》

DOI

2020

新型稠环嘧啶类HIV-1 NNRTIs的设计、合成、抗病毒活性与初步成药性研究

古双喜

《合成化学》

2020

托匹司他的合成研究进展

卢文龙，陈炯，古双喜，徐志强

《合成化学》

DOI

2020

Recent discoveries in HIV-1 reverse transcriptase inhibitors

Shuang‐Xi Gu, Yuan‐Yuan Zhu, Chao Wang, Haifeng Wang, Genyan Liu, Shuang Cao, Lu Huang

Current Opinion in Pharmacology

DOI

2020

Small organic molecule-based nanoparticles with red/near-infrared aggregation-induced emission for bioimaging and PDT/PTT synergistic therapy

Mengqian Yang, Jingran Deng, Huifang Su, Shuang‐Xi Gu, Jie Zhang, Aiguo Zhong, Fengshou Wu

Materials Chemistry Frontiers

DOI

2020

Bromination of α‐Diazo Phenylacetate Derivatives Using Cobalt(II) Bromide

Haifeng Wang, Xiangli Sun, Manman Hu, Xiaoyi Zhang, Lele Xie, Shuang‐Xi Gu

Advanced Synthesis & Catalysis

DOI

2020

Asymmetric catalysis in synthetic strategies for chiral benzothiazepines

Haifeng Wang, Shuang‐Xi Gu, Qiongjiao Yan, Li Ding, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2020

Natural Occurrence, Biological Functions, and Analysis of D-Amino Acids

Shuang‐Xi Gu, Haifeng Wang, Yuan‐Yuan Zhu, Fen‐Er Chen

Pharmaceutical Fronts

DOI

2020

Virtual Screening and Optimization of Novel mTOR Inhibitors for Radiosensitization of Hepatocellular Carcinoma

Yingqi Feng, Shuang‐Xi Gu, Yong-Shou Chen, Xudong Gao, Yixin Ren, Jianchao Chen, Yinying Lu, Heng Zhang, Shuang Cao

Drug Design Development and Therapy

DOI

2020

Anticancer activity evaluation of indazolyl-substituted piperidin-4-yl-aminopyrimidines

Chao Wang, Xiao-Wen Liu, Ting Xiao, Zhi‐Qiang Xu, Shuang Cao, Haifeng Wang, Qiongjiao Yan, Shuang‐Xi Gu, Yuan‐Yuan Zhu

Medicinal Chemistry Research

DOI

2019

氨基酸手性荧光识别及光学组成测定实验设计

朱园园，王子君，古双喜，张珩

《实验技术与管理》

DOI

2019

Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities

Ting Xiao, Jia-Fan Tang, Ge Meng, Christophe C. Pannecouque, Yuan‐Yuan Zhu, Genyan Liu, Zhiqiang Xu, Fengshou Wu, Shuang‐Xi Gu, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2019

Recent progress in HIV-1 inhibitors targeting the entrance channel of HIV-1 non-nucleoside reverse transcriptase inhibitor binding pocket

Shuang‐Xi Gu, Ting Xiao, Yuan‐Yuan Zhu, Genyan Liu, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2019

Cover Feature: Biphasic Enantioselective Fluorescent Recognition of Amino Acids by a Fluorophilic Probe (Chem. Eur. J. 33/2019)

Yuan‐Yuan Zhu, Xuedan Wu, Mehdi A. Abed, Shuang‐Xi Gu, Lin Pu

Chemistry - A European Journal

DOI

2019

Biphasic Enantioselective Fluorescent Recognition of Amino Acids by a Fluorophilic Probe

Yuan‐Yuan Zhu, Xuedan Wu, Mehdi A. Abed, Shuang‐Xi Gu, Lin Pu

Chemistry - A European Journal

DOI

2018

Insights into the key structural features of N1-ary-benzimidazols as HIV-1 NNRTIs using molecular docking, molecular dynamics, 3D-QSAR, and pharmacophore modeling

Wenjie Wang, Yafeng Tian, Youlan Wan, Shuang‐Xi Gu, Xiu-Lian Ju, Xiaogang Luo, Genyan Liu

Structural Chemistry

DOI

2018

Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors

Shuang‐Xi Gu, Huan-Huan Lu, Genyan Liu, Xiu-Lian Ju, Yuan‐Yuan Zhu

European Journal of Medicinal Chemistry

DOI

2018

Docking-based 3D-QSAR and pharmacophore studies on diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Genyan Liu, Youlan Wan, Wenjie Wang, Sai Fang, Shuang‐Xi Gu, Xiu-Lian Ju

Molecular Diversity

DOI

2018

Application of 3D-QSAR, Pharmacophore, and Molecular Docking in the Molecular Design of Diarylpyrimidine Derivatives as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors

Genyan Liu, Wenjie Wang, Youlan Wan, Xiu-Lian Ju, Shuang‐Xi Gu

International Journal of Molecular Sciences

DOI

2018

In silico studies of diarylpyridine derivatives as novel HIV-1 NNRTIs using docking-based 3D-QSAR, molecular dynamics, and pharmacophore modeling approaches

Youlan Wan, Yafeng Tian, Wenjie Wang, Shuang‐Xi Gu, Xiu-Lian Ju, Genyan Liu

RSC Advances

DOI

2018

Free Amino Acid Recognition: A Bisbinaphthyl-Based Fluorescent Probe with High Enantioselectivity

Yuan‐Yuan Zhu, Xuedan Wu, Shuang‐Xi Gu, Lin Pu

Journal of the American Chemical Society

DOI

2017

富马酸喹硫平的合成研究进展

张旬，古双喜，肖婷，朱园园，巨修练

《中国医药工业杂志》

2017

“三对接一促进式”制药类专业核心课程改革

王凯，张秀兰，张珩，蒋尹华，高有智，侯敏，古双喜

《药学教育》

2017

Design and synthesis of hybrids of diarylpyrimidines and diketo acids as HIV-1 inhibitors

Ping Xue, Huan-Huan Lu, Yuan‐Yuan Zhu, Xiu-Lian Ju, Christophe C. Pannecouque, Xiaojiao Zheng, Genyan Liu, Xiulan Zhang, Shuang‐Xi Gu

Bioorganic & Medicinal Chemistry Letters

DOI

2017

Structural modifications of diarylpyrimidines (DAPYs) as HIV-1 NNRTIs: Synthesis, anti-HIV activities and SAR

Huan-Huan Lu, Ping Xue, Yuan‐Yuan Zhu, Xiu-Lian Ju, Xiaojiao Zheng, Xun Zhang, Ting Xiao, Christophe C. Pannecouque, Tingting Li, Shuang‐Xi Gu

Bioorganic & Medicinal Chemistry

DOI

2016

制药工程“卓越计划”导向下的物理化学教学模式构建

朱园园，张珩，古双喜

《科技资讯》

2016

Advances in rationally designed dual inhibitors of HIV-1 reverse transcriptase and integrase

Shuang‐Xi Gu, Ping Xue, Xiu-Lian Ju, Yuan‐Yuan Zhu

Bioorganic & Medicinal Chemistry

DOI

2015

4-[(4-氯-2-嘧啶基)氨基]苯腈的合成

巨修练，乔恒，古双喜，朱园园

《武汉工程大学学报》

2015

A novel family of diarylpyrimidines (DAPYs) featuring a diatomic linker: Design, synthesis and anti-HIV activities

Shuang‐Xi Gu, Heng Qiao, Yuan‐Yuan Zhu, Qi-Chao Shu, Hui Liu, Xiu-Lian Ju, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Bioorganic & Medicinal Chemistry

DOI

2015

Simple and Efficient One-Step Synthesis of a Highly Enantioselective Catalyst 3,3′-Di(pyrrolidinylmethyl)-H 8 BINOL

Shuang‐Xi Gu, Wencai Huang, Xuedan Wu, Jun Ying, Lin Pu

Synthetic Communications

DOI

2014

盐酸文拉法辛合成路线图解

古双喜，李婷婷，朱园园

《中国医药工业杂志》

2014

N-碘代丁二酰亚胺在有机合成中的应用

古双喜，乔恒，孙克，段婷，巨修练

《化学试剂》

2014

1-溴-6-氰基-2-萘酚的合成

朱园园，古双喜，段婷，巨修练

《精细化工》

2014

药物制剂专业英语教学改革探索

古双喜，张珩，王凯，张秀兰，黎莉

《科技资讯》

2014

制药工程专业生产实习新模式的探索与实践

古双喜，张珩，王凯，田琦峰，高友智

《药学教育》

2014

HIV-1抑制剂依曲韦林的合成

古双喜，乔恒，段婷，朱园园，陈金芳，巨修练

《武汉工程大学学报》

2014

氯沙坦的合成工艺研究进展

古双喜，段婷，乔恒，巨修练

《精细化工》

2014

Reduction of the 3,4,9,10-perylenediimides and the formation of eletrodeposited films based on their radical anions

Yuanyuan Zhu, Shuang‐Xi Gu

Materials Research Express

DOI

2014

Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors

Shuang‐Xi Gu, Yuan‐Yuan Zhu, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Medicinal Chemistry Research

DOI

2014

3D-QASR and molecular docking study of diarylpyrimidines as HIV-1 reverse transcriptase

Li Ye, Shuang‐Xi Gu, Cheng Qian, Xiu-Lian Ju

WIT transactions on biomedicine and health

DOI

2014

A Scalable One-Pot Process for the Synthesis of Florfenicol Phosphodiester

Shuang‐Xi Gu, Jiawen Du, Xiu-Lian Ju, Qing-Ping Chen

Organic Process Research & Development

DOI

2013

马来酸罗格列酮合成研究进展

古双喜，段婷，乔恒，陈金芳，巨修练

《武汉工程大学学报》

精选作品

期刊论文

糖羟基的选择性氧化反应研究进展

Design, synthesis and evaluation of NTM-006-derived analgesics with enhanced potency

Uracil derivatives as non-nucleoside inhibitors targeting HIV-1 reverse transcriptase

Bis(trifluoromethanesulfonyl)imide (TFSI)‐Catalyzed Regioselective N 1 ‐Alkylation of Benzotriazoles

Iron-Catalyzed Regioselective Phosphorylation of trans -Vicinal Diols in Glycosides

CDK4/6-Based Drug Research and Development: A Four-Year Update

Engineering and design of artificial enzymes for non-natural biocatalysis in whole cells

Coumarin derivatives as HIV-1 inhibitors: mechanistic insights and structure-activity relationships

A Catalyst-Free Synthesis Platform for Functionalized Sulfur-Containing Molecules via Cyclic Sulfonium Salts

PROTACs在抗病毒药物研发中的应用

达普司他的合成新工艺（英文）

席夫碱型荧光探针对氨基酸化学选择性识别研究进展

Discovery of novel imidazo[1,2-b]pyridazine derivatives as potent covalent inhibitors of CDK12/13

Application of deuterium in research and development of drugs

NIR-II organic fluorophores integrated with blood–brain barrier-penetrating strategies for brain disease theranostics

Enantioselective Copper-Catalyzed N–H Insertion Reaction of Pyrazoles and α-Diazo Phosphates

Iron-Catalyzed Aerobic Hydration of Glycal: A Route toward Deoxy Sugars/Glycosides

Palladium-Catalyzed Carbene Se–H Insertion Reaction for C–Se Bond Formation

Enantioselective Construction of Heteroatom Stereocenters via N -Heterocyclic Carbene Catalysis

Recent Advances in Catalytic Atroposelective Synthesis of Seven‐ and Eight‐Membered Rings with Inherent Chirality

Enantioselective recognition of amino acids in water using emission-tunable chiral fluorescent probes

Recent Advances in Transition Metal‐Catalyzed Asymmetric Synthesis of P‐chiral Organophosphorus Compounds (2020–Present)

Efficient synergistic recognition of D/L-cysteine and zinc ions using a chiral chemosensor

Tandem SNAr/Aldol Condensation of Oxindoles with o-Haloacetophenones Enables Modular Assembly of 2,3-Fused Indolines Bearing a Quaternary Carbon

Chemoselective and enantioselective fluorescent recognition of basic amino acids: A review

Typical Cases of Continuous Flow Chemistry in Pharmaceutical Synthesis in 2023–2024

A fluorescent probe for enantioselective recognition of amino acids in solutions, cells and zebrafishes

Strain-release driven α,β-difunctionalization of cyclopropanols with bromonaphthols

Carbene-catalytic enantioselective synthesis of chiral macrocycles

质量源于设计在缬沙坦胶囊处方开发中的应用

博舒替尼合成路线图解

基于连续流动化学的三组分有机合成实验设计

阿托吉泮的合成研究进展

水溶性荧光探针在氨基酸分子识别中的研究进展

测定氨基酸浓度和对映体组成的手性荧光探针（英文）

全连续流反应技术在药物合成中的新进展(2019～2022)

镍催化1,3-二烯的不对称氢官能团化反应研究进展

连续流动化学在“高等有机化学实验”教学中的应用研究

HIV-1逆转录酶抑制剂的新进展（2021—2023年）

布洛芬的连续流合成研究进展

Design, synthesis, and biological evaluation of dithiocarbamate derivatives as SARS-CoV-2 Mpro inhibitors

Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors (2019–2023)

Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review

UiO-67: A versatile metal-organic framework for diverse applications

Convergent Assembly of 1,4-Benzothiazide Spiroindolinones via [4 + 2] Spiroannulation Under Open-Air Conditions

Preparation of (S)‐3,3′‐Bis(1‐pyrrolidinylmethyl)‐5,5′,6,6′, 7,7′,8,8′‐octahydro‐1,1'‐bi‐2‐naphthol

Modular Assembly of Six‐Membered Carbocyclic Spirooxindoles via Peterson Olefination/Michael Addition/C(sp3) Arylation Cascade

A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells

Degradation mechanism of antibiotics by flower-like Bi2S3 sensitized anatase/rutile TiO2 coupled with SiO2 photonic crystals

泼尼松磷酸酯二钠的合成及其在水中的溶解度测定

Quinolines and isoquinolines as HIV-1 inhibitors: Chemical structures, action targets, and biological activities

Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities

Chemodivergent Synthesis of Sulfonamide and Sulfones from N-Tosylhydrazones by Switching Catalyst and Temperature

Chiral amino acid recognition in water: A BINOL-based fluorescent probe

Iridium-Catalyzed Intramolecular Asymmetric Allylation of Vinyl Benzoxazinones for the Synthesis of Chiral 4H-3,1-Benzoxazines via Kinetic Resolution

Recent Advances in the Chemical Synthesis of β-Nicotinamide Mononucleotide

E3 ligase ligand optimization of Clinical PROTACs

拟肽类冠状病毒主蛋白酶抑制剂的研究进展

临床应用中的新型冠状病毒肺炎治疗药物研究进展

磷酸酯类前药的合成方法与应用

手性药物及其中间体光学纯度的测定方法与应用

新型冠状病毒肺炎（COVID-19）临床治疗化学药物述评

手性化合物绝对构型确定的方法与应用

Synthesis and Characterization of Related Substances of Torasemide

Meet the Editorial Board Member

选择性转染重排酪氨酸激酶抑制剂概述及其专利研究

米拉贝隆合成路线图解

流动化学在卤化反应中的应用

改进的(S)-3,3'-二(吡咯烷甲基)-八氢联萘酚合成方法

Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents

Advances in the development of HIV integrase strand transfer inhibitors

A naphthimide-based ratiometric fluorescent probe for selective and visual detection of phosgene in solution and the gas phase

用于COVID-19潜在治疗的小分子药物及专利研究

一种曼尼希类反应的有机合成实验设计

二苯基嘧啶类化合物抗癌活性的研究进展

新型稠环嘧啶类HIV-1 NNRTIs的设计、合成、抗病毒活性与初步成药性研究

托匹司他的合成研究进展

Recent discoveries in HIV-1 reverse transcriptase inhibitors