侯宇｜重庆医科大学｜学者主页

2026

Inhibition of nucleoporin 214 depletes leukemia stem cells by promoting heme catabolism and lipid peroxidation

Zhe Chen, Feng Wu, Wei Zhang, Wei Guo, Yan Li, Qiang Gong, Yue Wei, Linfeng Li, Tao Chen, Xueya Zhao, Jianwen Xiao, Hanqing Zeng, Jianchuan Deng, Huabing Li, Li Wang, Zufeng Guo, Yu Hou

Blood

DOI

2026

Phosphorylated DEK sustains leukemia stem cells by enabling PBX3-driven transcriptional reprogramming

Yufei Lei, Yanru Lai, Yan Li, Yuxing Wang, Haiqi Fan, Qiang Gong, Feng Wu, Qinrong Yan, Hanqing Zeng, Jianchuan Deng, Yu Hou, Zhe Chen

Blood

DOI

2026

MMRN1-EGFR drives sialylglycan-Siglec immune evasion in AML leukemia stem cells

Meixi Peng, Yongxiu Huang, Mengyun Zhang, Mengyun Zhang, Qinrong Yan, Lulu Li, Yaoqi Gui, Jingsong Cheng, Yanni Sun, Yi Mo, Wenqiong Xiang, Yongjie Zhang, Yongjie Zhang, Li Wang, Qin Wen, Xi Zhang, Yu Hou

Cell stem cell

DOI

2026

Silencing GPx1 Synergizes with Ionizing Radiation to Enhance the Elimination of Leukemia Stem Cells

Yaoqi Gui, Jingsong Cheng, Yi Mo, Yongxiu Huang, Meixi Peng, Yu Hou

Radiation Research

DOI

2026

Toosendanin suppresses acute myeloid leukemia by targeting DDX5/c-Myc axis to inhibit protein synthesis

Xianchao He, Zhiwei Chen, Jing Luo, Hongru Chen, Yu Hou, Dan Liu, Yuanyuan Liu

Journal of Translational Medicine

DOI

2025

Targeting KPNB1 suppresses AML cells by inhibiting HMGB2 nuclear import

Yuxin Xie, Runlong Zhao, Yingjiao Zheng, Yan Li, Feng Wu, Yufei Lei, Lei Li, Hanqing Zeng, Zhe Chen, Yu Hou

Oncogene

DOI

2025

Regulation of an lncRNA irf8 by the Ikzf1/Myb complex drives neutrophil development

Yuepeng He, Li Yang, Yibo Shao, Xue Song Huang, Jiangyong He, Shengnan Liu, Yalan Xiao, Zhigang Li, Yu Hou, Lingfei Luo, Fangying Zhao, Li Li

Proceedings of the National Academy of Sciences

DOI

2025

EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress

Lei Li, Yufei Lei, Yan Li, Yuxin Xie, Pusheng Hui, Xiaoyan Zang, Weiru Wu, Feng Wu, Jiankun Fan, Jianming Wang, Jieping Chen, Zhe Chen, Yu Hou

Nature Communications

DOI

2025

Single-cell sequencing reveals the expansion and diversity of T cell subsets in the bone marrow microenvironment of chronic myeloid leukemia

Chenjian Zhuo, Xin Dong, Xueya Zhao, Weiru Wu, Hao Zhou, Jing Feng, Lingbo Liu, Mingqian Feng, Chunjiang He, Yu Hou

Genes & Diseases

DOI

2024

Essential role of Dhx16-mediated ribosome assembly in maintenance of hematopoietic stem cells

Zhigang Li, Jiankun Fan, Yalan Xiao, Wei Wang, Changlin Zhen, Junbing Pan, Weiru Wu, Yuanyuan Liu, Zhe Chen, Qinrong Yan, Hanqing Zeng, Shuyu Luo, Lun Liu, Zhanhan Tu, Xueya Zhao, Yu Hou

Leukemia

DOI

2024

Inhibition of DEK restores hematopoietic stem cell function in Fanconi anemia

Zhe Chen, Feng Wu, Yan Li, Lei Li, Yufei Lei, Siwei Gao, Tao Chen, Yuxin Xie, Jianwen Xiao, Hanqing Zeng, Jianchuan Deng, Xueya Zhao, Yu Hou

The Journal of Experimental Medicine

DOI

2024

DDX21 at the Nexus of RNA Metabolism, Cancer Oncogenesis, and Host–Virus Crosstalk: Decoding Its Biomarker Potential and Therapeutic Implications

Yalan Xiao, Jiankun Fan, Zhigang Li, Yu Hou

International Journal of Molecular Sciences

DOI

2024

Epithelial membrane protein 1 in human cancer: a potential diagnostic biomarker and therapeutic target

Yuxin Xie, Feng Wu, Zhe Chen, Yu Hou

Biomarkers in Medicine

DOI

2024

A novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells

Huanhuan Qin, Meixi Peng, Jingsong Cheng, Zhenyu Wang, Yinghui Cui, Yongxiu Huang, Yaoqi Gui, Yanni Sun, Wenqiong Xiang, Xiaomei Huang, Ting Huang, Li Wang, Jieping Chen, Yu Hou

Cell Death and Disease

DOI

2024

Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening

Chengfang Zhou, Mei Kuang, Tao Yin, Jianming Wang, Jianming Wang, Yu Luo, Yinghao Fu, Zhe Chen, Yuanyuan Liu, Zhigang Li, Weiru Wu, Li Wang, Ying Dou, Junping Wang, Junping Wang, Yu Hou

Cell stem cell

DOI

2024

Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies

Jiankun Fan, Zhigang Li, Li Pei, Yu Hou

Genes & Diseases

DOI

2023

小分子化合物TIC10对白血病细胞的抑制作用

陈涛，李蕾，陈哲，侯宇

《中国实验血液学杂志》

2023

Targeting NUP214 Eradicates Leukemia Stem Cells By Inducing Ferroptosis

Zhe Chen, Feng Wu, Lei Li, Yu Hou

Blood

DOI

2023

Chromatin Remodeler DEK Is a Sensor to Replication Stress and Contributes to HSC Defects in Fanconi Anemia

Zhe Chen, Feng Wu, Lei Li, Yan Li, Xueya Zhao, Yu Hou

Blood

DOI

2023

The RNA Helicase DHX16 Is Required for the Maintenance of Hematopoietic Stem Cells

Zhigang Li, Jiankun Fan, Yuanze Zhou, Yu Hou

Blood

DOI

2023

Nynrin Preserves Hematopoietic Stem Cell Function Via the Ppif-Mediated Mitochondrial Permeability Transition

Chengfang Zhou, Mei Kuang, Jianming Wang, Yu Luo, Yu Hou

Blood

DOI

2023

Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin

Zhe Chen, Qian Guo, Shichen Huang, Lei Li, Feng Wu, Zhilong Liu, Zhigang Li, Tao Chen, Guanbin Song, Shuangnian Xu, Jieping Chen, Yu Hou

Genes & Diseases

DOI

2022

Targeting Mitochondrial Oxidative Phosphorylation Eradicates Acute Myeloid Leukemic Stem Cells

Meixi Peng, Yongxiu Huang, Ling Zhang, Xueya Zhao, Yu Hou

Frontiers in Oncology

DOI

2022

Molecular regulation of hematopoietic stem cell quiescence

Zhe Chen, Qian Guo, Guanbin Song, Yu Hou

Cellular and Molecular Life Sciences

DOI

2021

Laptm4b缺失对小鼠造血干祖细胞稳态维持的影响

周媛媛，王振坤，黄永秀，傅雪梅，张宪利，侯宇，鞠振宇，刘波

《中国实验血液学杂志》

DOI

2019

c-myc抑制剂10058-F4对Ph+ALL细胞凋亡的影响及相关机制研究

侯宇，廖芬芳，刘漫宇，王伟章

《广东药科大学学报》

DOI

2018

IGF1R抑制剂对慢性粒细胞白血病细胞增殖和凋亡的影响

程琳，吴清清，廖芬芳，侯宇，王伟章

《广东药科大学学报》

2017

鬼臼苦素抗Ph+急性淋巴细胞白血病细胞Sup-B15的作用及其机制

陈永恒，廖芬芳，程琳，侯宇，王伟章

《广东药科大学学报》

2015

Foxm1 is essential for quiescence and maintenance of hematopoietic stem cells

Yu Hou, Wen Li, Yue Sheng, Li-Ping Li, Yong Huang, Zhong-Hui Zhang, T. Zhu, D. Peace, John G. Quigley, Wen-Shu Wu, You-yang Zhao, Zhijian Qian

Nature Immunology

DOI

2014

FHL2 regulates hematopoietic stem cell functions under stress conditions

Yu Hou, Xiao-Qin Wang, Li-Ping Li, Rong Fan, Ju Chen, T. Zhu, Wen Li, Yan-Wen Jiang, N. Mittal, Wen-Shu Wu, D. Peace, Zhijian Qian

Leukemia

DOI

2013

Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.

Wen-Shu Li, Yu Hou, Ming Ming, Long Yu, A. Seba, Zhijian Qian

Blood

DOI

[Inhibitory Effect of Small Molecule Compound TIC10 on Leukemia].

Tao Chen, Lie Li, Zhe Chen, Yu Hou

PubMed

DOI

侯宇

精选作品

期刊论文

Inhibition of nucleoporin 214 depletes leukemia stem cells by promoting heme catabolism and lipid peroxidation

Phosphorylated DEK sustains leukemia stem cells by enabling PBX3-driven transcriptional reprogramming

MMRN1-EGFR drives sialylglycan-Siglec immune evasion in AML leukemia stem cells

Silencing GPx1 Synergizes with Ionizing Radiation to Enhance the Elimination of Leukemia Stem Cells

Toosendanin suppresses acute myeloid leukemia by targeting DDX5/c-Myc axis to inhibit protein synthesis

Targeting KPNB1 suppresses AML cells by inhibiting HMGB2 nuclear import

Regulation of an lncRNA irf8 by the Ikzf1/Myb complex drives neutrophil development

EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress

Single-cell sequencing reveals the expansion and diversity of T cell subsets in the bone marrow microenvironment of chronic myeloid leukemia

Essential role of Dhx16-mediated ribosome assembly in maintenance of hematopoietic stem cells

Inhibition of DEK restores hematopoietic stem cell function in Fanconi anemia

DDX21 at the Nexus of RNA Metabolism, Cancer Oncogenesis, and Host–Virus Crosstalk: Decoding Its Biomarker Potential and Therapeutic Implications

Epithelial membrane protein 1 in human cancer: a potential diagnostic biomarker and therapeutic target

A novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells

Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening

Post-transcriptional regulation of DEAD-box RNA helicases in hematopoietic malignancies

小分子化合物TIC10对白血病细胞的抑制作用

Targeting NUP214 Eradicates Leukemia Stem Cells By Inducing Ferroptosis

Chromatin Remodeler DEK Is a Sensor to Replication Stress and Contributes to HSC Defects in Fanconi Anemia

The RNA Helicase DHX16 Is Required for the Maintenance of Hematopoietic Stem Cells

Nynrin Preserves Hematopoietic Stem Cell Function Via the Ppif-Mediated Mitochondrial Permeability Transition

Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin

Targeting Mitochondrial Oxidative Phosphorylation Eradicates Acute Myeloid Leukemic Stem Cells

Molecular regulation of hematopoietic stem cell quiescence

Laptm4b缺失对小鼠造血干祖细胞稳态维持的影响

c-myc抑制剂10058-F4对Ph+ALL细胞凋亡的影响及相关机制研究

IGF1R抑制剂对慢性粒细胞白血病细胞增殖和凋亡的影响

鬼臼苦素抗Ph+急性淋巴细胞白血病细胞Sup-B15的作用及其机制

Foxm1 is essential for quiescence and maintenance of hematopoietic stem cells

FHL2 regulates hematopoietic stem cell functions under stress conditions

Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.

[Inhibitory Effect of Small Molecule Compound TIC10 on Leukemia].

研究方向