百晓学者学者目录

谢琼

副教授、博士生导师、教授、硕士生导师、讲师，复旦大学

精选作品

期刊论文

2025

Discovery of potential VEGFR-2 inhibitors from natural products by virtual screening and molecular dynamics simulation.

Qiong Xie, Mengshi Luo, Mingyan Liu, Yuxin Xie, Di Li, Hong-Jing Dai, Xiao-Hua Chen

Physical Chemistry, Chemical Physics - PCCP

DOI

2025

Design, synthesis, and biological activity of novel para-substituted phenylamino and phenyl derivatives of northebaine as selective delta opioid receptor agonists

Denggao Zhang, Jiangwen Gui, Linghui Kong, Chuyuan Hu, Xinmeng Kou, Biying Wang, Shaoliang Duan, Min Liu, Zixiang Li, Jiawen Luo, Siyuan Tang, Hui Xiao, Zhenning Du, Qiong Xie, Jing‐Gen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li

Bioorganic & Medicinal Chemistry

DOI

2025

Structure–Activity Relationship of N -Cyclopropylmethyl-7α-[ para -(arylcarboxamido)phenyl]-6,14- endo ethano-tetrahydronorthebaines as Potent and Selective Kappa Opioid Receptor Agonists

Linghui Kong, Songyu Yao, Denggao Zhang, Jiangwen Gui, Baiyu Chen, Min Liu, Siyuan Tang, Chuyuan Hu, Shaoliang Duan, Biying Wang, Zixiang Li, Yiquan Shen, Yingjie Lan, Xiaoning Liu, Zhenning Du, Zihan Liu, Qiong Xie, Anan Liu, Jing‐Rui Chai, Jing‐Gen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li

Journal of Medicinal Chemistry

DOI

2025

Corrigendum to “Design, synthesis, and biological evaluation of novel BTK-targeting proteolysis targeting chimeras (PROTACs) with enhanced pharmacokinetic properties” [Eur. J. Med. Chem. 289 (2025) 117420]

Ying‐Hung Lin, Jing Liu, Xinjian Tian, Jin Wang, Huahua Su, Jianpin Xiang, Tao Cao, Yonghui Wang, Qiong Xie, Xufen Yu

European Journal of Medicinal Chemistry

DOI

2025

Structure–activity relationship analysis of meta-substituted N-cyclopropylmethyl-nornepenthones with mixed KOR/MOR activities

Siyuan Tang, Shuyang Hu, Lijing Feng, Linghui Kong, Jiangwen Gui, Ying Zhang, Zihan Liu, Zi-han Liu, Denggao Zhang, Xiao Liu, An-An Liu, Xiao Liu, Xiaoning Liu, Chuyuan Hu, Yingjie Lan, Xiaoning Liu, Xiaoning Liu, Zixiang Li, Panwen Liu, Panwen Liu, Shaoliang Duan, Wei Fu, Min Liu, Wei Li, Qiong Xie, Jinggen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li

European Journal of Medicinal Chemistry

DOI

2025

Design, synthesis, and biological evaluation of novel BTK-targeting proteolysis targeting chimeras (PROTACs) with enhanced pharmacokinetic properties

Ying‐Hung Lin, Jing Liu, Xinjian Tian, Jin Wang, Huahua Su, Jianpin Xiang, Tao Cao, Yonghui Wang, Qiong Xie, Xufen Yu

European Journal of Medicinal Chemistry

DOI

2025

Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice

Hui Zhang, Wei‐Xiang Ma, Qiong Xie, Lu-Lu Bu, Ling-xi Kong, Pingchuan Yuan, Ronghui Zhou, Yonghui Wang, Yonghui Wang, Lei Wu, Chen-yu Zhu, Zhi-lin Wang, Jun Han, Zhi‐Li Huang, Yi-qun Wang, Yi-qun Wang

Acta Pharmacologica Sinica

DOI

2024

Discovery of an Ortho-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect

Zixiang Li, Ru-Feng Ye, He Qian, Jiashuo Lu, Yanting Sun, Xiujian Sun, Siyuan Tang, Shuyang Hu, Jing‐Rui Chai, Linghui Kong, Xiaoning Liu, Jing Chen, Yun Hua Fang, Yingjie Lan, Qiong Xie, Jinggen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li

Journal of Medicinal Chemistry

DOI

2024

Subtle Structural Changes across the Boundary between A2AR/A2BR Dual Antagonism and A2BR Antagonism: A Novel Class of 2-Aminopyrimidine-Based Derivatives

Haojie Wang, Xinyu Yang, Yan Li, Shuyin Ze, Bo Feng, Yuan Weng, Aoqi Gao, Gaojie Song, Mingyao Liu, Qiong Xie, Yonghui Wang, Weiqiang Lü

Journal of Medicinal Chemistry

DOI

2024

Evaluation of XQ528 tartrate on embryo-fetus developmental toxicity in SD rats and genotoxicity

Yijun Tian, Wenjing Shi, Bin Zhang, Lijun Ren, Lang Yan, Qiong Xie, Xiao Chen, Tianbao Zhang, Zhuibai Qiu, Zhu Yuping

Drug and Chemical Toxicology

DOI

2024

Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A2 receptors

Yuan Weng, Xinyu Yang, Qiansen Zhang, Ying Chen, Yueming Xu, Chenyu Zhu, Qiong Xie, Yonghui Wang, Huaiyu Yang, Mingyao Liu, Weiqiang Lü, Gaojie Song

Science China Life Sciences

DOI

2023

Discovery of Biaryl Amide Derivatives as Potent, Selective, and Orally Bioavailable RORγt Agonists for Cancer Immunotherapy

Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Jian Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie

Journal of Medicinal Chemistry

DOI

2023

Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone

Linghui Kong, Kuan Ning, Xiao Liu, Jiashuo Lu, Baiyu Chen, Rongrong Ye, Zixiang Li, Shuang Jiang, Siyuan Tang, Jing‐Rui Chai, Siyuan Tang, Yingjie Lan, Xiaobo Mai, Qiong Xie, Jinggen Liu, Liming Shao, Wei Fu, Yujun Wang, Wei Li

European Journal of Medicinal Chemistry

DOI

2023

Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists

Lixue Lu, Song Chen, Mingcheng Yu, Ronghui Zhou, Siqi Guo, Jian Chen, Haojie Wang, Haojie Wang, Shijie Chen, Cheng Luo, Qiong Xie, Yonghui Wang

European Journal of Medicinal Chemistry

DOI

2023

Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategy

Song Chen, Zhendong Chen, Lixue Lu, Yunpeng Zhao, Ronghui Zhou, Qiong Xie, Yongzhi Shu, Jun Lin, Xufen Yu, Yonghui Wang

European Journal of Medicinal Chemistry

DOI

2023

Discovery of Pyridinone Derivatives as Potent, Selective, and Orally Bioavailable Adenosine A 2A Receptor Antagonists for Cancer Immunotherapy

Chenyu Zhu, Shuyin Ze, Ronghui Zhou, Xinyu Yang, Haojie Wang, Xiaolei Chai, Meimiao Fang, Mingyao Liu, Yonghui Wang, Weiqiang Lü, Qiong Xie

Journal of Medicinal Chemistry

DOI

2023

Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity

Nannan Sun, Mingcheng Yu, Zhengyuan Jiang, Feng Yang, Lixue Lu, Yuehan Xia, Yunpeng Zhao, Yafei Huang, Song Chen, Shijie Chen, Cheng Luo, Yonghui Wang, Qiong Xie

European Journal of Medicinal Chemistry

DOI

2023

Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia

Hui Ma, Jiayan Cui, Zehui Liu, Wenqing Fang, Sisi Lu, Shuying Cao, Yuanyuan Zhang, Jian Chen, Lixue Lu, Qiong Xie, Yonghui Wang, Ying Huang, Kongfei Li, Hongyan Tong, Jin Yan Huang, Weiqiang Lü

Oncogene

DOI

2023

Drug design education in China

Wei Fu, Wei Li, Boyu Chen, Junjie Zhang, Qiong Xie, Lu Zhou, Xuemei Zhang

Biochemistry and Molecular Biology Education

DOI

2023

Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library

Jinlei Wang, Ying Lin, Xiaoyu Xu, Yonghui Wang, Qiong Xie

SLAS DISCOVERY

DOI

2022

SLL-627 Is a Highly Selective and Potent κ Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity

Linghui Kong, Xuelian Shu, Siyuan Tang, Rongrong Ye, Huijiao Sun, Shuang Jiang, Zixiang Li, Jing‐Rui Chai, Yun Hua Fang, Yinjie Lan, Linqian Yu, Qiong Xie, Wei Fu, Yujun Wang, Wei Li, Zhuibai Qiu, Jinggen Liu, Liming Shao

Journal of Medicinal Chemistry

DOI

2022

Design, Synthesis, and Bioevaluation of 2-Aminopteridin-7(8H)-one Derivatives as Novel Potent Adenosine A2A Receptor Antagonists for Cancer Immunotherapy

Fazhi Yu, Chenyu Zhu, Shuyin Ze, Haojie Wang, Xinyu Yang, Mingyao Liu, Qiong Xie, Weiqiang Lü, Yonghui Wang

Journal of Medicinal Chemistry

DOI

2022

Cholinergic Neuron Targeting Nanosystem Delivering Hybrid Peptide for Combinatorial Mitochondrial Therapy in Alzheimer’s Disease

Kang Qian, Xiaoyan Bao, Yixian Li, Pengzhen Wang, Qian Guo, Peng Yang, Shuting Xu, Fazhi Yu, Ran Meng, Yunlong Cheng, Dongyu Sheng, Jinxu Cao, Minjun Xu, Jing Wu, Tianying Wang, Yonghui Wang, Qiong Xie, Wei Lü, Qizhi Zhang

ACS Nano

DOI

2022

RORγt agonist enhances anti-PD-1 therapy by promoting monocyte-derived dendritic cells through CXCL10 in cancers

Li Xia, Enming Tian, Mingcheng Yu, Chenglong Liu, Lian Shen, Yafei Huang, Zhongen Wu, Jinlong Tian, Ker Yu, Yonghui Wang, Qiong Xie, Di Zhu

Journal of Experimental & Clinical Cancer Research

DOI

2021

Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease

Jian Chen, Hui Ma, Zehui Liu, Jinlong Tian, Sisi Lu, Wenqing Fang, Shuyin Ze, Weiqiang Lü, Qiong Xie, Jin Yan Huang, Yonghui Wang

Journal of Medicinal Chemistry

DOI

2021

Discovery of novel BTK PROTACs for B-Cell lymphomas

Yunpeng Zhao, Yongzhi Shu, Jun Lin, Zhendong Chen, Qiong Xie, Yanning Bao, Lixue Lu, Nannan Sun, Yonghui Wang

European Journal of Medicinal Chemistry

DOI

2021

Discovery of an M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile

He Qian, Yuanyuan Wei, Xiao Liu, Rongrong Ye, Linghui Kong, Zixiang Li, Shuang Jiang, Linqian Yu, Jing‐Rui Chai, Qiong Xie, Wei Fu, Yujun Wang, Wei Li, Zhuibai Qiu, Jinggen Liu, Liming Shao

Journal of Medicinal Chemistry

DOI

2021

RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-β signaling in cancer

Enming Tian, Mingcheng Yu, Mei Feng, Lixue Lu, Chenglong Liu, Lian Shen, Yonghui Wang, Qiong Xie, Di Zhu

Pharmacological Research

DOI

2021

Agonist Lock Touched and Untouched Retinoic Acid Receptor-Related Orphan Receptor-γt (RORγt) Inverse Agonists: Classification Based on the Molecular Mechanisms of Action

Nannan Sun, Qiong Xie, Yongjun Dang, Yonghui Wang

Journal of Medicinal Chemistry

DOI

2021

Discovery of tert-amine-based RORγt agonists

Ruomeng Qiu, Mingcheng Yu, Juwen Gong, Jinlong Tian, Yafei Huang, Yonghui Wang, Qiong Xie

European Journal of Medicinal Chemistry

DOI

2021

Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based κ Opioid Receptor (κOR) Agonists Using the Strategy of Bridging

Xiao Liu, Shuang Jiang, Linghui Kong, Rongrong Ye, Xiao Li, Xuejun Xu, He Qian, Yuanyuan Wei, Zixiang Li, Huijiao Sun, Qiong Xie, Xu Xu, Yan Lu, Yujun Wang, Wei Li, Wei Fu, Zhuibai Qiu, Jinggen Liu, Liming Shao

ACS Chemical Neuroscience

DOI

2020

Discovery of tetrahydroquinolines and benzomorpholines as novel potent RORγt agonists

Yuehan Xia, Mingcheng Yu, Yunpeng Zhao, Li Xia, Yafei Huang, Nannan Sun, Meiqi Song, Huimin Guo, Yunyi Zhang, Di Zhu, Qiong Xie, Yonghui Wang

European Journal of Medicinal Chemistry

DOI

2020

Adenosine A2A Receptor Antagonists for Cancer Immunotherapy

Fazhi Yu, Chenyu Zhu, Qiong Xie, Yonghui Wang

Journal of Medicinal Chemistry

DOI

2020

Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists

Nannan Sun, Yafei Huang, Mingcheng Yu, Yunpeng Zhao, Jian Chen, Chenyu Zhu, Meiqi Song, Huimin Guo, Qiong Xie, Yonghui Wang

European Journal of Medicinal Chemistry

DOI

2020

Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with “short” and “long” inverse agonists

Mingcheng Yu, Feng Yang, Xiaoyu Ding, Nannan Sun, Zhengyuan Jiang, Yafei Huang, Yurong Yan, Chen Ying Zhu, Qiong Xie, Zhifeng Chen, Siqi Guo, Hualiang Jiang, Kaixian Chen, Cheng Luo, Xiaomin Luo, Shijie Chen, Yonghui Wang

Acta Pharmacologica Sinica

DOI

2019

抗阿尔茨海默病药物研发进展

郑易林，谢琼，肖立，李秋，徐丽丽，邵黎明

《药学进展》

2019

Discovery of a Highly Selective and Potent κ Opioid Receptor Agonist from N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message–Address Concept

Xiao Li, Yujun Wang, Mumei Zhang, Weiwei Wu, Linghui Kong, Yan Ma, Xuejun Xu, Xiao Liu, He Qian, Yuanyuan Qian, Huijiao Sun, Hai-hao Wu, Cheng Lin, Huoming Huang, Rongrong Ye, Shuang Jiang, Ru-Feng Ye, Congmin Yuan, Shengyang Fang, Dengqi Xue, Xicheng Yang, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie, Lan Zheng, Wei Fu, Wei Li, Zhuibai Qiu, Jinggen Liu, Liming Shao

Journal of Medicinal Chemistry

DOI

2019

Discovery of aryl-substituted indole and indoline derivatives as RORγt agonists

Yan Zhu, Nannan Sun, Mingcheng Yu, Huimin Guo, Qiong Xie, Yonghui Wang

European Journal of Medicinal Chemistry

DOI

2019

Discovery of N-indanyl benzamides as potent RORγt inverse agonists

Jinlong Tian, Nannan Sun, Mingcheng Yu, Xianfeng Gu, Qiong Xie, Liming Shao, Jin Liu, Li Liu, Yonghui Wang

European Journal of Medicinal Chemistry

DOI

2019

Effects of BIS-MEP on Reversing Amyloid Plaque Deposition and Spatial Learning and Memory Impairments in a Mouse Model of β-Amyloid Peptide- and Ibotenic Acid-Induced Alzheimer’s Disease

Yu Wang, Jia Xia, Mengjun Shen, Yifan Zhou, Zhe Wu, Yuhuan Shi, Jianrong Xu, Lina Hou, Rui Zhang, Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Yongfang Zhang, Hao Wang

Frontiers in Aging Neuroscience

DOI

2018

Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities

Xicheng Yang, Jian Hua Shen, Lulu Jiang, Wei Li, Mingcheng Yu, Guanxing Pan, Yurong Yan, Chenghan Zhang, Wanwan Jia, Xiao Li, Haihua Yu, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie, Lu Zhou, Liming Shao

European Journal of Medicinal Chemistry

DOI

2018

7β-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues

Huijiao Sun, Yuhua Wang, Congmin Yuan, Linghui Kong, Xuejun Xu, Yu-jun Wang, Hai-hao Wu, Cheng Lin, Yuanyuan Qian, Huoming Huang, Xiao Li, Xiao Liu, Qian He, Shengyang Fang, Dengqi Xue, Xicheng Yang, Hao Chen, Yi-lin Zheng, Lan Zheng, Linqian Yu, Qiong Xie, Wei Fu, Wei Li, Jing‐Gen Liu, Zhuibai Qiu, Li-ming Shao

Bioorganic & Medicinal Chemistry

DOI

2018

Discovery of novel 20S proteasome inhibitors by rational topology-based scaffold hopping of bortezomib

Yulong Xu, Xicheng Yang, Yiyi Chen, Hao Chen, Huijiao Sun, Wei Li, Qiong Xie, Linqian Yu, Liming Shao

Bioorganic & Medicinal Chemistry Letters

DOI

2018

Discovery of carbazole carboxamides as novel RORγt inverse agonists

Yafei Huang, Mingcheng Yu, Nannan Sun, Ting Ao Tang, Fazhi Yu, Xiaoxia Song, Qiong Xie, Wei Fu, Liming Shao, Yonghui Wang

European Journal of Medicinal Chemistry

DOI

2018

Palladium-Catalyzed Synthesis of β,β-Diaryl α,β-Unsaturated Ketones

Liming Shao, Yi-lin Zheng, Xiao Li, Qiong Xie

Synthesis

DOI

2018

Bis(9)-(−)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice

Yuhuan Shi, Wanying Huang, Yu Wang, Rui Zhang, Lina Hou, Jianrong Xu, Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Yongfang Zhang, Hao Wang

Translational Neurodegeneration

DOI

2018

Synthetic access to isoxazoline-functionalized isoquinolines via microwave-assisted iminoxyl radical-participated cascade cyclization of vinyl isocyanides

Yulong Xu, Hao Chen, Wei Li, Qiong Xie, Linqian Yu, Liming Shao

Organic & Biomolecular Chemistry

DOI

2017

Microwave‐Assisted Radical Insertion/Cyclization of Vinyl Isocyanides for the Synthesis of Multi‐Substituted Isoquinolines

Yulong Xu, Hao Chen, Wei Li, Qiong Xie, Linqian Yu, Liming Shao

ChemistrySelect

DOI

2017

Palladium‐Catalyzed Cascade Saegusa–Heck Reaction: Synthesis of β,β‐Diarylacroleins from Arylpropanals and Aryl Iodides

Xiao Li, Yilin Zheng, Qiong Xie, Liming Shao

European Journal of Organic Chemistry

DOI

2017

On-Water Silver(I)-Catalyzed Cycloisomerization of Acetylenic Free Amines/Amides towards 7-Azaindole/Indole/Isoquinolone Derivatives

Qiong Xie, Liming Shao, Hongpeng Sun, Xiao Li, Wei Li

Synthesis

DOI

2017

Microwave-assisted synthesis of hydroxyl-containing isoquinolines by metal-free radical cyclization of vinyl isocyanides with alcohols

Dengqi Xue, Hao Chen, Yulong Xu, Haihua Yu, Linqian Yu, Wei Li, Qiong Xie, Liming Shao

Organic & Biomolecular Chemistry

DOI

2017

Pharmacophore-based design and discovery of (−)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis

Qiong Xie, Zhaoxi Zheng, Biyun Shao, Wei Fu, Zheng Xia, Wei Li, Jian Qi Sun, Wei Zheng, Weiwei Zhang, Wei Sheng, Qihong Zhang, Hongzhuan Chen, Hao Wang, Zhuibai Qiu

Journal of Enzyme Inhibition and Medicinal Chemistry

DOI

2016

The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent κ-Opioid Agonistic Activities

Wei Li, Jian-Dong Long, Yuanyuan Qian, Yu Long, Xuejun Xu, Yujun Wang, Qing Shen, Zuoneng Wang, Xicheng Yang, Xiao Li, Hongpeng Sun, Yulong Xu, Yiyi Chen, Qiong Xie, Yonghui Wang, Li-Ming Shao, Jing‐Gen Liu, Zhuibai Qiu, Wei Fu

ACS Chemical Neuroscience

DOI

2016

Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands

Jian Hua Shen, Xicheng Yang, Mingcheng Yu, Xiao Li, Xunjie Zhang, Huijiao Sun, Hao Chen, Guan-xin Pan, Yurong Yan, Si-chen Wang, Wei Li, Lu Zhou, Qiong Xie, Linqian Yu, Yonghui Wang, Liming Shao

Acta Pharmacologica Sinica

DOI

2016

Microwave-Assisted Synthesis of Phenanthridines by Radical Insertion/Cyclization of Biphenyl Isocyanides

Yulong Xu, Yiyi Chen, Wei Li, Qiong Xie, Liming Shao

The Journal of Organic Chemistry

DOI

2015

(−)-Meptazinol–melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-β aggregation with high antioxidant potency for Alzheimer’s therapy

Shaobing Cheng, Wei Zheng, Ping Gong, Qiang Zhou, Qiong Xie, Lining Yu, Peiyi Zhang, Liangkang Chen, Juan Li, Jianxing Chen, Hailin Chen, Hongzhuan Chen

Bioorganic & Medicinal Chemistry

DOI

2015

ChemInform Abstract: A Convenient Aqueous Copper‐Catalyzed Synthesis of Quinazolinones.

Yulong Xu, Qiong Xie, Wei Li, Hongpeng Sun, Yonghui Wang, Liming Shao

ChemInform

DOI

2015

A convenient aqueous copper-catalyzed synthesis of quinazolinones

Yulong Xu, Qiong Xie, Wei Li, Hongpeng Sun, Yonghui Wang, Liming Shao

Tetrahedron

DOI

2014

Determination of Meserine, a new candidate for Alzheimer’s disease in mice brain by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic and tissue distribution study

Zhaoxi Zheng, Ya‐Bin Tang, Haoyu Lv, Jianrong Xu, Hengyi Zhao, Qiong Xie, Zhuibai Qiu, Hongzhuan Chen, Hao Wang

Analytical and Bioanalytical Chemistry

DOI

2014

Determination of a novel carbamate AChE inhibitor meserine in mouse plasma, brain and rat plasma by LC–MS/MS: Application to pharmacokinetic study after intravenous and subcutaneous administration

Ying Xie, Pan Jiang, Xin-xing Ge, Hao Wang, Biyun Shao, Qiong Xie, Zhuibai Qiu, Hongzhuan Chen

Journal of Pharmaceutical and Biomedical Analysis

DOI

2013

实验记录随堂检查与讨论制度在实验药物化学课程中的应用

李炜，王洁，谢琼，杨翠芬，王洋

《药学教育》

2013

Triple reuptake inhibitors: a patent review (2006 – 2012)

Liming Shao, Wěi Li, Qiong Xie, Hong Yin

Expert Opinion on Therapeutic Patents

DOI

2013

Meserine, a Novel Carbamate AC hE Inhibitor, Ameliorates Scopolamine‐Induced Dementia and Alleviates Amyloidogenesis of APP / PS 1 Transgenic Mice

Bi‐Yun Shao, Zheng Xia, Qiong Xie, Xin-xing Ge, Weiwei Zhang, Jian Sun, Pan Jiang, Hao Wang, Weidong Le, Zhuibai Qiu, Lu Yang, Hong‐Zhuan Chen

CNS Neuroscience & Therapeutics

DOI

2013

Theoretical and NMR investigations on the conformations of ( − )-meptazinol hydrochloride in solution

Wei Li, Lili Xu, Qiong Xie, Yan Xiang Chen, Meiyan Lu, Bo Chao, Xinghai Wang, Yun Tang, Zhuibai Qiu, Wanjia Fu, Choiwan Lau

Molecular Simulation

DOI

2012

Novel bis-(−)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property

Wei Zheng, Juan Li, Zhuibai Qiu, Zheng Xia, Wei Li, Lining Yu, Hailin Chen, Jianxing Chen, Yan Chen, Zhuqin Hu, Wei Zhou, Biyun Shao, Yong‐Yao Cui, Qiong Xie, Hongzhuan Chen

Toxicology and Applied Pharmacology

DOI

2011

6-甲氧基-1,2,3,9-四氢-4H-咔唑-4-酮肟的一锅合成

孙健，盛源，谢琼，仇缀百

《有机化学》

2011

Determination of Bis(9)-(−)-Meptazinol, a bis-ligand for Alzheimer's disease, in rat plasma by liquid chromatography–tandem mass spectrometry: Application to pharmacokinetics study

Xin-xing Ge, Xiaolin Wang, Pan Jiang, Ying Xie, Tao Jiang, Zhengxing Rong, Qizhi Zhang, Qiong Xie, Zhuibai Qiu, Hao Wang, Hongzhuan Chen

Journal of Chromatography B

DOI

2010

Synthesis and evaluation of κ-opioid receptor agonistic activity and antinociceptive effect of novel morphine analogues, 7α-phenyl-6α,14α-endo-etheno-tetrahydrothebaine with substituted o-, m- and p-amino group

Hong Yan Qi, Wei Li, Yu Lan Qiu, Yong‐Yao Cui, Jian Ma, Xiaoling Gao, Yi-bin Zeng, Jie Yang, Yun Tang, Xinghai Wang, Wei Sheng, Qiong Xie, Jing-geng Liu, Zhuibai Qiu, Hongzhuan Chen

Medicinal Chemistry Research

DOI

2010

3-[(3S)-3-Ethyl-1-methylazepan-3-yl]phenylN-(4-fluorophenyl)carbamate

Jian Qi Sun, Qiong Xie, Zhuibai Qiu

Acta Crystallographica Section E Structure Reports Online

DOI

2010

Interaction Between Serum Albumin and Four Flavones by Fluorescence Spectroscopy and Molecular Docking

Qian XU, Dandan Deng, Zhijuan Cao, Qiong Xie, Jianying Liang, Jianzhong Lu

Chinese Journal of Analytical Chemistry

DOI

2009

Highly selective and potent μ opioid ligands by unexpected substituent on morphine skeleton

Wei Li, Yimin Tao, Yun Tang, Xuejun Xu, Jie Chen, Wei Fu, Xinghai Wang, Bo Chao, Sheng Wei, Qiong Xie, Zhuibai Qiu, Jing‐Gen Liu

Bioorganic & Medicinal Chemistry Letters

DOI

2009

The Crystal Structure of a Complex of Acetylcholinesterase with a Bis-(−)-nor-meptazinol Derivative Reveals Disruption of the Catalytic Triad

Aviv Paz, Qiong Xie, Harry M. Greenblatt, Wei Fu, Yun Tang, Israel Silman, Zhuibai Qiu, Joel L. Sussman

Journal of Medicinal Chemistry

DOI

2009

1-Ethyl-4-hydroxy-9-azatricyclo[7.4.1.02,7]tetradeca-2,4,6-trien-8-one

Wei Zheng, Qiong Xie, Fang Li, Zhuibai Qiu

Acta Crystallographica Section E Structure Reports Online

DOI

2009

2-Methyl-1,2,3,4-tetrahydroisoquinolin-6-ylN-phenylcarbamate

Qihong Zhang, Qiong Xie, Jingmei Wang, Zhuibai Qiu

Acta Crystallographica Section E Structure Reports Online

DOI

2008

Bis-(−)-nor-meptazinols as Novel Nanomolar Cholinesterase Inhibitors with High Inhibitory Potency on Amyloid-β Aggregation

Qiong Xie, Hao Wang, Zheng Xia, Meiyan Lu, Weiwei Zhang, Xinghai Wang, Wei Fu, Yun Tang, Wei Sheng, Wei Li, Wei Zhou, Xu Zhu, Zhuibai Qiu, Hongzhuan Chen

Journal of Medicinal Chemistry

DOI

2006

QSAR study of 4-phenylpiperidine derivatives as μ opioid agonists by neural network method

Xinghai Wang, Yun Tang, Qiong Xie, Zhuibai Qiu

European Journal of Medicinal Chemistry

DOI

2006

Conformational re-analysis of (+)-meptazinol: an opioid with mixed analgesic pharmacophores

Wei Li, Xinghai Wang, Choiwan Lau, Yun Tang, Qiong Xie, Zhuibai Qiu

Acta Pharmacologica Sinica

DOI

2006

3D–QSAR studies of orvinol analogs as κ-opioid agonists

Wei Li, Yun Tang, Qiong Xie, Wei Sheng, Zhuibai Qiu

Journal of Molecular Modeling

DOI

2006

Design, Synthesis, and Bioavailability Evaluation of Coumarin‐Based Prodrug of Meptazinol.

Qiong Xie, Xiaolin Wang, Xinghai Wang, Zhiqiang Jiang, Zhuibai Qiu

ChemInform

DOI

2006

Investigation of the binding mode of (−)-meptazinol and bis-meptazinol derivatives on acetylcholinesterase using a molecular docking method

Qiong Xie, Yun Tang, Wei Li, Xinghai Wang, Zhuibai Qiu

Journal of Molecular Modeling

DOI

2005

多样性合成与向前合成分析在药物发现中的应用

王星海，谢琼，叶德泳

《药学进展》

2005

Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol

Qiong Xie, Xiaolin Wang, Xinghai Wang, Zhiqiang Jiang, Zhuibai Qiu

Bioorganic & Medicinal Chemistry Letters

DOI

研究方向

自身免疫病与肿瘤免疫治疗小分子药物发现药物化学新方法新技术（PROTAC、分子胶）

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