姜永帅｜哈尔滨医科大学｜学者主页

2026

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, 詹渊博, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu

Advanced Science

精选作品

期刊论文

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Beyond Stability: Rethinking Housekeeping Genes as Contributors to Rheumatoid Arthritis Pathogenesis

Trans‐ancestry meta‐analysis of genome‐wide association study identifies eight novel genetic loci in type 1 diabetes: A multi‐population study

Identification of HLA‐DQA1 and HLA‐DRB5 as Risk Factors for Multiple Sclerosis: An Epigenome‐Wide Methylation Haplotype Association Analysis

新医科背景下“医理”融合“统计遗传学”课程体系重构

IQI: Individualized Quantitative trait loci (QTL) Index

Computational Tools for Studying Genome Structural Variation

Plasma Protein Fluctuation Trajectories Over 15 Years Before Rheumatoid Arthritis Onset

Individualized co-expression-like index (iCKI) enables gene–gene interactions as individual biomarkers for complex disease

The hidden Markov model and its applications in bioinformatics analysis

Cheeta 1.0: A GPU-accelerated Ultra-large-scale Linkage Disequilibrium Analysis Software

基因组遗传大数据分析方法

A review of disease risk prediction methods and applications in the omics era

Effects of genetic variation on the structure of RNA and protein

The molecular subtypes of autoimmune diseases

Epigenome‐wide methylation haplotype association analysis identified HLA‐DRB1, HLA‐DRB5 and HLA‐DQB1 as risk factors for rheumatoid arthritis

Genome-wide identification of m6A-associated single nucleotide polymorphisms in complex diseases of nervous system.

Identification of novel meQTLs strongly associated with rheumatoid arthritis by large‐scale epigenome‐wide analysis

Mobile-Based and Self-Service Tool (iPed) to Collect, Manage, and Visualize Pedigree Data: Development Study

RABC: Rheumatoid Arthritis Bioinformatics Center

“双一流”背景下统计遗传学金课建设探索与思考

Contribution of structural accessibility to the cooperative relationship of TF-lncRNA in myopia

Ten Years of EWAS

Ten Years of EWAS (Adv. Sci. 20/2021)

统计遗传学在线开放课程建设助推创新人才培养

In silico drug repositioning based on drug-miRNA associations

Location deviations of DNA functional elements affected SNP mapping in the published databases and references

RIscoper: a tool for RNA-RNA interaction extraction from the literature

A Comparison of Co-methylation Relationships Between Rheumatoid Arthritis and Parkinson's Disease

Genome-Wide Haplotype Association Study

The Function Transformation Omics - Funomics.

EWASdb: epigenome-wide association study database

Comparison of the general co‐expression landscapes between human and mouse

EWAS: epigenome-wide association study software 2.0

LncRNA Structural Characteristics in Epigenetic Regulation

Multiple sclerosis risk pathways differ in Caucasian and Chinese populations.

Genome-wide pathway-based association analysis identifies risk pathways associated with Parkinson's disease.

Integrating genome-wide association studies and gene expression data highlights dysregulated multiple sclerosis risk pathways

全基因组数据分析软件PLINK在统计遗传学教学中的应用

CR1 rs3818361 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Chinese Population

Alzheimer’s Disease Variants with the Genome-Wide Significance are Significantly Enriched in Immune Pathways and Active in Immune Cells

Integrative analysis of genome-wide association studies and gene expression analysis identifies pathways associated with rheumatoid arthritis

PICALM rs3851179 Variant Confers Susceptibility to Alzheimer’s Disease in Chinese Population

Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma

Genetic Variants and Multiple Sclerosis Risk Gene SLC9A9 Expression in Distinct Human Brain Regions

EWAS: epigenome-wide association studies software 1.0 – identifying the association between combinations of methylation levels and diseases

The framework for population epigenetic study

Cell adhesion molecule pathway genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimer's disease brains.

CD33 rs3865444 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Chinese, European, and North American Populations

CLU rs9331888 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Caucasian But Not East Asian Populations

Analyzing large-scale samples confirms the association between rs16892766 polymorphism and colorectal cancer susceptibility

Identifying the Association Between Alzheimer’s Disease and Parkinson’s Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network

Genes with stable DNA methylation levels show higher evolutionary conservation than genes with fluctuant DNA methylation levels

The drug target genes show higher evolutionary conservation than non-target genes

Genome-wide haplotype association study identifies BLM as a risk gene for prostate cancer in Chinese population

A gene-based information gain method for detecting gene–gene interactions in case–control studies

Prioritization of rheumatoid arthritis risk subpathways based on global immune subpathway interaction network and random walk strategy.

Comparing the evolutionary conservation between human essential genes, human orthologs of mouse essential genes and human housekeeping genes

Analyzing large-scale samples highlights significant association between rs10411210 polymorphism and colorectal cancer.

Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson’s Disease Susceptibility

CLU rs2279590 polymorphism contributes to Alzheimer’s disease susceptibility in Caucasian and Asian populations

Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals

Pathway Analysis of Two Amyotrophic Lateral Sclerosis GWAS Highlights Shared Genetic Signals with Alzheimer’s Disease and Parkinson’s Disease

Analyzing 54,936 Samples Supports the Association Between CD2AP rs9349407 Polymorphism and Alzheimer’s Disease Susceptibility

Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer

Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks

MCPerm: A Monte Carlo Permutation Method for Accurately Correcting the Multiple Testing in a Meta-Analysis of Genetic Association Studies

The CLU Gene rs11136000 Variant is Significantly Associated with Alzheimer’s Disease in Caucasian and Asian Populations

Analyzing Large-Scale Samples Confirms the Association Between the ABCA7 rs3764650 Polymorphism and Alzheimer’s Disease Susceptibility

System Analysis of LWDH Related Genes Based on Text Mining in Biological Networks

An Updated Analysis with 85,939 Samples Confirms the Association Between CR1 rs6656401 Polymorphism and Alzheimer’s Disease

Prioritization of candidate genes for periodontitis using multiple computational tools.

Integrating Genome-Wide Association Study and Brain Expression Data Highlights Cell Adhesion Molecules and Purine Metabolism in Alzheimer’s Disease

Network-based analysis of genotype-phenotype correlations between different inheritance modes

RADB: a database of rheumatoid arthritis-related polymorphisms

Association between polymorphisms in the promoter region of interleukin-10 and susceptibility to inflammatory bowel disease

以学生为主体的医学统计学教学实践

HGPGD: The Human Gene Population Genetic Difference Database