周翔｜武汉大学｜学者主页

2026

核酸修饰驱动的分子医学:现状、挑战与机遇

黄艳，朱凌，翁小成，陈鹏，周翔，杨俊林

《中国科学:化学》

2026

Targeted detection method for locus-specific m 6 A modifications in low-abundance transcripts based on chemical conversion

Ting Liu, Xin Fang, Yue Lu, Xiumin Liu, Ruiqi Zhao, Xiang Zhou, Xiaocheng Weng

Chemical Communications

DOI

2026

Photocatalytic Proximity Labeling Maps RNA and Protein Subcellular Landscapes

Meihan Hou, Linao Ren, Xi Xin, Rongjie Zhu, Shengda Xie, Yaqian Liu, Xiaocheng Weng, Xiang Zhou, Yuhao Du

JACS Au

DOI

2026

Metal–Organic Framework as a Bioorthogonal Catalyst for Gene Editing

Z H Chen, Xingyu Liu, Wanyue Sang, Li Li, 肖京城, Gaoli Hu, L H Zhou, Qianqian Qi, Chen Peng, J Y Huang, Wei Xiong, Zikun Li, Nuo Chen, Enci Zhang, Lilei Yu, Huaidong Jiang, Tian Tian, Xiang Zhou, Hexiang Deng

Journal of the American Chemical Society

DOI

2026

Development of the First YTHDC1 Degrader with Improved Antileukemia Activity

Zhongpao Xie, Yuanyuan Zhang, Weicai Song, Qianqian Qi, Wei Xiong, Xingyu Liu, Xiaocheng Weng, Xiang Zhou, Tian Tian

JACS Au

DOI

2026

Simultaneous single-base resolution profiling of 5mC and 5hmC using BRIGHT-seq

Xiaochen Xue, Ziang Lu, Wei Yang, Shaoqing Han, Zhiying Wang, Yifan Jin, Xingxing Li, Xiang Zhou, Yafen Wang, Xiaocheng Weng

National Science Review

DOI

2026

Harnessing a single molecule for dual bioorthogonal regulation of RNA function and m6A methylation

Wei Xiong, Enyi Zhou, Qianqian Qi, Xingyu Liu, Kaisong Zhang, Siqi Huang, Moran Li, Chao Wang, Xiang Zhou, Tian Tian

Nucleic Acids Research

DOI

2026

Chemical-Assisted Ligation-qPCR for Locus-Specific Detection of RNA N 4 -Acetylcytidine and 5-Formylcytidine

Zhiying Wang, Xiumin Liu, Xinyue Guo, Xiaochen Xue, Xiang Zhou, Yafen Wang

Analytical Chemistry

DOI

2026

Advantages and Challenges of G-Quadruplexes in Regulating Alternative Splicing

Haiyan Huang, Xiang Zhou

JACS Au

DOI

2026

Dynamic Control of RNA Structure and Function through Bioorthogonal Staudinger Chemistry

Li Zhu, Wei Xiong, Silin Yang, Qianqian Qi, Xingyu Liu, Xiang Zhou, Tian Tian

ACS Chemical Biology

DOI

2026

Nanobody-Tethered Transposition for Dual Profiling of Histone Modification and DNA Methylation

Jizhou Liu, Jindi Zhou, Ziang Lu, Guorun Tang, Zhiying Wang, Yelin Lan, Xiang Zhou, Guan‐Zheng Luo, Wang Yc, Xiaocheng Weng

JACS Au

DOI

2025

A catalyst-free bioorthogonal reaction for malononitrile addition to azodicarboxylates

Hong-Gui Huang, Xingyu Liu, Qianqian Qi, Hannan Chen, Haiyan Zhang, Kaisong Zhang, Xinyan Xu, Yunting Zhao, Xiang Zhou, Wen‐Bo Liu, Tian Tian

Nature Communications

DOI

2025

Mechanistic Insights into the Borane-Mediated Conversion of 5-Carboxylcytosine to Dihydrouracil in DNA Enable an Efficient Labeling Method Using Alkoxyamines

Cong Ding, Zipeng Wang, Bingwen Li, Jiangtian Shao, Ying Chun Tang, Wei Yang, Xiaocheng Weng, Zhi‐Xiang Yu, Xiang Zhou, Yibin Liu

Journal of the American Chemical Society

DOI

2025

Whole-genome methylation profiling of extracellular vesicle DNA in gastric cancer identifies intercellular communication features

Bingqian Lin, Zhenna Jiao, Shouquan Dong, Weikai Yan, Jinting Jiang, DU Yan-fang, Xiaocheng Weng, Hongling Wang, Zhiyuan Hu, Yibin Liu, Xiang Zhou

Nature Communications

DOI

2025

Author Correction: In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes

Jing Mo, Zonggui Chen, Manman Cui, Xin Fang, Ruichao Li, Shanshan Qin, Zhenlin Zhou, Mei Sun, Jinjun Wu, Chuan He, Fang Wang, Haojian Zhang, Xiang Zhou, Xiaocheng Weng

Nature Chemical Biology

DOI

2025

In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes

Jing Mo, Zonggui Chen, Manman Cui, Xin Fang, Ruichao Li, Shanshan Qin, Zhenlin Zhou, Mei Sun, Jinjun Wu, Chuan He, Fang Wang, Haojian Zhang, Xiang Zhou, Xiaocheng Weng

Nature Chemical Biology

DOI

2025

Single-cell imaging of N 4-acetylcytidine-modified RNA using fluorine metabolic labeling mediated proximity ligation assay

Qi Wang, Yuhao Du, Shen Yan, Ziang Lu, Yongling Tang, Feng Xiao, Fuling Zhou, Xiang Zhou

Nucleic Acids Research

DOI

2025

Developments of the mDZ-RhoBAST Probe for Super-Resolution Imaging of FTO Demethylation in Live Cells

Xiaolu Zhou, Xiaolu Zhou, Huihui Gao, Limin Xiang, Hui Liu, Xiang Zhou, Xiang Zhou

Journal of the American Chemical Society

DOI

2025

Unveiling the clinical significance of RNA pseudouridine in colorectal cancer

Jiehua Li, Xuanfei Li, Xiaole Zhao, Xiaochen Xue, Panpan Xia, Lilan Fan, Hongling Wang, Xiaocheng Weng, Yafen Wang, Shaoqing Han, Xiang Zhou

Science China Life Sciences

DOI

2025

Innovative Chemical Strategies for Advanced CRISPR Modulation

Xingyu Liu, Enyi Zhou, Qianqian Qi, Wei Xiong, Tian Tian, Xiang Zhou

Accounts of Chemical Research

DOI

2025

Selict-seq profiles genome-wide off-target effects in adenosine base editing

Kexin Yuan, Xi Xin, Shaoqing Han, Jingyu Han, Bin Zhao, Qi Wei, Xiang Zhou

Nucleic Acids Research

DOI

2025

Enhanced or reversible RNA N6-methyladenosine editing by red/far-red light induction

Heng Yuan Tang, Shaoqing Han, Yang Jie, Xin Quan Jiang, Yi Zhang, Junran Peng, Fang Wang, Xiang Li, Xiang Zhou, Wei Jiang, Xiaocheng Weng

Nucleic Acids Research

DOI

2025

Customized Controllable Pyrophosphate Nanosensor Based on Lanthanide Metal–Organic Frameworks for Accurate and Sensitive Detection of Nucleic Acids

Long Yu, Yumin Feng, Qianqian Yuan, Shuang Peng, Yuxiu Xiao, Gaosong Wu, Xiang Zhou

Analytical Chemistry

DOI

2025

NSUN2-mediated HCV RNA m5C Methylation Facilitates Viral RNA Stability and Replication

Zhu-Li Li, Yan Xie, Yafen Wang, Jing Wang, Xiang Zhou, Xiao‐Lian Zhang

Genomics Proteomics & Bioinformatics

DOI

2025

Strategic base modifications refine RNA function and reduce CRISPR–Cas9 off-targets

Kaisong Zhang, Wei Hua Shen, Yunting Zhao, Xinyan Xu, Xingyu Liu, Qianqian Qi, Siqi Huang, Tian Tian, Xiang Zhou

Nucleic Acids Research

DOI

2024

Unraveling the Cleavage Reaction of Hydroxylamines with Cyclopropenones Considering Biocompatibility

Tianying Zeng, Quan Wu, Yongjie Liu, Qianqian Qi, Wei Shen, Wei Gu, Yuanyuan Zhang, Wei Xiong, Zhongpao Xie, Xiaotian Qi, Tian Tian, Xiang Zhou

Journal of the American Chemical Society

DOI

2024

Reducing CRISPR-Cas9 off-target effects by optically controlled chemical modifications of guide RNA

Qianqian Qi, Xingyu Liu, Wei Xiong, Kaisong Zhang, Wei Shen, Yuanyuan Zhang, Xinyan Xu, Cheng Zhong, Yan Zhang, Tian Tian, Xiang Zhou

Cell chemical biology

DOI

2024

Unveiling a Potent Small Molecule Disruptor for RNA G-Quadruplexes Tougher Than DNA G-Quadruplex Disruption

Xingyu Liu, Qianqian Qi, Wei Xiong, Wei Hua Shen, Kaisong Zhang, Ruochen Fan, Yuanyuan Zhang, Yunting Zhao, Xinyan Xu, Min Li, Enyi Zhou, Tian Tian, Xiang Zhou

ACS Chemical Biology

DOI

2024

Rapid degradation of DHX36 revealing its transcriptional role by interacting with G‐quadruplex

Ziang Lu, Jinglei Xu, Yuqi Chen, Yuanyuan Zhou, Xiaolu Zhou, Xiaolu Zhou, Qi Wang, Qi Wei, Shaoqing Han, Ruiqi Zhao, Xiaocheng Weng, Xiao‐Lian Zhang, Xiang Zhou, Xiang Zhou

Aggregate

DOI

2024

Programmable Lanthanide Metal–Organic Framework for Ultra-Efficient Nucleic Acids Extraction and Interaction Analysis

Long Yu, Qi Xu, Yuqing Sun, Yuhao Wang, Yongling Tang, Qianqian Yuan, Shuang Peng, Gaosong Wu, Yuxiu Xiao, Xiang Zhou

Analytical Chemistry

DOI

2024

HCV 5-Methylcytosine Enhances Viral RNA Replication through Interaction with m5C Reader YBX1

Zhu-Li Li, Yan Xie, Yuke Xie, Hongliang Chen, Xiang Zhou, Min Liu, Xiao‐Lian Zhang

ACS Chemical Biology

DOI

2024

A bisulfite-assisted and ligation-based qPCR amplification technology for locus-specific pseudouridine detection at base resolution

Xin Fang, Ruiqi Zhao, Yafen Wang, Mei Sun, Jin Xu, Shengrong Long, Jing Mo, Hudan Liu, Xiang Li, Fang Wang, Xiang Zhou, Xiaocheng Weng

Nucleic Acids Research

DOI

2024

Developing nucleoside tailoring strategies against SARS-CoV-2 via ribonuclease targeting chimera

Yuan‐Qin Min, Wei Xiong, Wei Shen, Xingyu Liu, Qianqian Qi, Yuanyuan Zhang, Ruochen Fan, Fang Fu, Heng Xue, Hang Yang, Xiulian Sun, Yun‐Jia Ning, Tian Tian, Xiang Zhou

Science Advances

DOI

2024

Identification of G-quadruplex-interacting proteins in living cells using an artificial G4-targeting biotin ligase

Ziang Lu, Shengjie Xie, Haomiao Su, Shaoqing Han, Haiyan Huang, Xiang Zhou

Nucleic Acids Research

DOI

2024

Regulating CRISPR /Cas9 Using Streptavidin‐Biotin Interactions†

Wei Shen, Wei Xiong, Qianqian Qi, Xingyu Liu, Zhongpao Xie, Yuanyuan Zhang, Jinxuan Hou, Tian Tian, Xiang Zhou

Chinese Journal of Chemistry

DOI

2024

Cellular Metabolic Labeling of Nucleic Acids and Its Applications

Zhiyong He, Xiang Zhou, Xiang Zhou

Israel Journal of Chemistry

DOI

2024

Recent advances in design strategies of aptamer‐based liquid biopsy

Bingqian Lin, Jinting Jiang, Xiang Zhou

Journal of Polymer Science

DOI

2024

Locus-specific detection of pseudouridine with CRISPR-Cas13a

Mei Sun, Xin De Fang, Bingqian Lin, Jing Mo, Fang Wang, Xiang Zhou, Xiaocheng Weng

Chemical Communications

DOI

2024

Steric hindrance of N 6 -methyl in m 6 A and its application for specific loci detection

Xiaoyi Xie, Qi Wei, Jingyu Han, Xin Fang, Wei Yang, Xiang Zhou, Yafen Wang, Xiaocheng Weng

Chemical Communications

DOI

2024

Exonuclease-assisted enrichment and base resolution analysis of pseudouridine in single-stranded RNA

Xin Fang, Ziang Lu, Yafen Wang, Ruiqi Zhao, Jing Mo, Wei Yang, Mei Sun, Xiang Zhou, Xiaocheng Weng

Chemical Science

DOI

2023

核酸修饰与编辑的化学生物学前沿专辑

周翔，伊成器，季泉江

《高等学校化学学报》

2023

Circulating nucleic acids as liquid biopsies for disease prediction, screening and diagnosis

Yuqing Sun, Yongling Tang, Long Yu, Yuhao Wang, Shuang Peng, Xiang Zhou

Science China Chemistry

DOI

2023

Preface: special issue celebrating the 130th anniversary of Wuhan University

Xiang Zhou, Zhen Li, Xiaocheng Wen, Qianqian Li

Science China Chemistry

DOI

2023

中国蛋白质、核酸与糖类等的合成、修饰、功能与调控领域发展现状和未来挑战

周翔，俞飚，刘磊

《科学观察》，Vol. 18, No. 5

下载原文

2023

Method for the extraction of circulating nucleic acids based on MOF reveals cell-free RNA signatures in liver cancer

Yuqing Sun, Haixin Yu, Shaoqing Han, Ruoxi Ran, Ying Zhen Yang, Yongling Tang, Yuhao Wang, Wenhao Zhang, Heng Yuan Tang, Boqiao Fu, Boshi Fu, Xiaocheng Weng, Song‐Mei Liu, Hexiang Deng, Shuang Peng, Xiang Zhou

National Science Review

DOI

2023

Antibody-Free Fluorine-Assisted Metabolic Sequencing of RNA N 4‑Acetylcytidine

Shen Yan, Ziang Lu, Wei Yang, Jinglei Xu, Yafen Wang, Wei Xiong, Rongjie Zhu, Linao Ren, Zhaoxin Chen, Qi Wei, Song‐Mei Liu, Tian Feng, Bi‐Feng Yuan, Xiaocheng Weng, Yuhao Du, Xiang Zhou

Journal of the American Chemical Society

DOI

2023

Detection, Clinical Application, and Manipulation of RNA Modifications

Jing Mo, Xiaocheng Weng, Xiang Zhou

Accounts of Chemical Research

DOI

2023

Nanoporous Crystalline Materials for the Recognition and Applications of Nucleic Acids

Long Yu, Yuhao Wang, Yuqing Sun, Yongling Tang, Yuxiu Xiao, Gaosong Wu, Shuang Peng, Xiang Zhou

Advanced Materials

DOI

2023

G-quadruplex in hepatitis B virus pregenomic RNA promotes its translation

Jingjing Wang, Haiyan Huang, Kaitao Zhao, Yan Teng, Li Zhao, Zaichao Xu, Yingcheng Zheng, Lu Zhang, Conghui Li, Yurong Duan, Kaiwei Liang, Xiang Zhou, Xiaoming Cheng, Yuchen Xia

Journal of Biological Chemistry

DOI

2023

Disease Diagnosis Based on Nucleic Acid Modifications

Xiaochen Xue, Zhiying Wang, Yafen Wang, Xiang Zhou

ACS Chemical Biology

DOI

2023

Isonitrile-Tetrazine Click-and-Release Chemistry for Controlling RNA-Guided Nucleic Acid Cleavage

Huimin Ji, Wei Xiong, Shaoyuan Guo, Shaoru Wang, Xiwen Xing, Tian Tian, Xiang Zhou

ACS Chemical Biology

DOI

2023

Transcriptome-wide profiling of A-to-I RNA editing by Slic-seq

Qi Wei, Shaoqing Han, Kexin Yuan, Zhiyong He, Yuqi Chen, Xi Xin, Jingyu Han, Shen Yan, Yingying Chen, Bi‐Feng Yuan, Xiaocheng Weng, Xiang Zhou

Nucleic Acids Research

DOI

2023

Mesoporous Metal–Organic Frameworks for Catalytic RNA Deprotection and Activation

Jin Liu, Xingyu Liu, Qi Liu, Jing Cao, Xinheng Lv, Shaoru Wang, Tian Tian, Xiang Zhou, Hexiang Deng

Angewandte Chemie

DOI

2023

Extremely Large 3D Cages in Metal–Organic Frameworks for Nucleic Acid Extraction

Gaoli Hu, Qi Liu, Yi Zhou, Wei Yan, Yuqing Sun, Shuang Peng, Chengbin Zhao, Xiang Zhou, Hexiang Deng

Journal of the American Chemical Society

DOI

2023

Utilizing Epigenetic Modification as a Reactive Handle To Regulate RNA Function and CRISPR-Based Gene Regulation

Qianqian Qi, Xingyu Liu, Fang Fu, Wei Hua Shen, Shuangyu Cui, Shen Yan, Yutong Zhang, Yuhao Du, Tian Tian, Xiang Zhou

Journal of the American Chemical Society

DOI

2023

The Transcriptome-Wide Mapping of 2-Methylthio-N6-isopentenyladenosine at Single-Base Resolution

Zhentian Fang, Ziang Lu, Shaoqing Han, Yuanyuan Zhou, Wei Yang, Xiao‐Lian Zhang, Xiang Zhou

Journal of the American Chemical Society

DOI

2023

A CRISPR-Cas and Tat Peptide with Fluorescent RNA Aptamer System for Signal Amplification in RNA Imaging

Heng Yuan Tang, Junran Peng, Xin Quan Jiang, Shuang Peng, Fang Wang, Xiaocheng Weng, Xiang Zhou

Biosensors

DOI

2023

NSUN2-mediated m 5 C methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections

Hongyun Wang, Jiangpeng Feng, Cong Zeng, Jiejie Liu, Zhiying Fu, Dehe Wang, Yafen Wang, Lu Zhang, Jiali Li, Ao Jiang, Miao He, Yuanyuan Cao, Kun Yan, Hao Tang, Deyin Guo, Ke Xu, Xiang Zhou, Li Zhou, Ke Lan, Yu Zhou, Yu Zheng Chen

Emerging Microbes & Infections

DOI

2023

Chemical Control of CRISPR Gene Editing via Conditional Diacylation Crosslinking of Guide RNAs

Huajun Lei, Tianying Zeng, Xiaofang Ye, Ruochen Fan, Wei Xiong, Tian Tian, Xiang Zhou

Advanced Science

DOI

2023

Engineered aptamers for molecular imaging

Bingqian Lin, Feng Xiao, Jinting Jiang, Zhengjia Zhao, Xiang Zhou

Chemical Science

DOI

2023

Transcriptome-wide identification of single-stranded RNA binding proteins

Ruiqi Zhao, Xin Fang, Zhibiao Mai, Xi Chen, Jing Mo, Yingying Lin, Rui Xiao, Xichen Bao, Xiaocheng Weng, Xiang Zhou

Chemical Science

DOI

2023

N6‐methyladenine profiling of low‐input multiplex clinical samples on transcriptome reveals RNA modifications implicated in type 2 diabetes and acute myocardial infarction

Shanshan Qin, Kun Yang, Shaoqing Han, Yushu Yuan, Jing Mo, Meng-Yao Xiao, Yin Yang, Yafen Wang, Xin Fang, Fang Wang, Wei Zhang, Song‐Mei Liu, Xiaocheng Weng, Xiang Zhou

Clinical and Translational Medicine

DOI

2022

The development of an iridium(III) complex functionalized G-quadruplex probe for the stability of G-quadruplex and lifetime image in cytoplasm

Shaokang Jia, Wenjin Wang, Shanshan Qin, Shengjie Xie, Lisi Zhan, Qi Wei, Ziang Lu, Xiaolu Zhou, Xiaolu Zhou, Cong Chen, Kun Chen, Shen Yan, Cai‐Ping Tan, Zong‐Wan Mao, Xiang Zhou, Xiang Zhou

Chinese Chemical Letters

DOI

2022

Construction of an Autocatalytic Hybridization Assembly Circuit for Amplified In Vivo MicroRNA Imaging

Huimin Wang, Yuqiu He, Jie Wei, Hong Wang, Kang Ma, Yangjie Zhou, Xiaoqing Liu, Xiang Zhou, Fuan Wang

Angewandte Chemie

DOI

2022

Recent Advances in Exosomal miRNA Biosensing for Liquid Biopsy

Bingqian Lin, Jinting Jiang, Jingxuan Jia, Xiang Zhou

Molecules

DOI

2022

G-quadruplex-guided RNA engineering to modulate CRISPR-based genomic regulation

Xingyu Liu, Shuangyu Cui, Qianqian Qi, Huajun Lei, Yutong Zhang, Wei Shen, Fang Fu, Tian Tian, Xiang Zhou

Nucleic Acids Research

DOI

2022

Determination of 5‐Formyluracil via Oxime‐Based Nucleotide‐Metal Coordination

Kaiyuan Zhang, Boshi Fu, Guangrong Zou, Wei Yang, Shen Yan, Tian Tian, Xiang Zhou

ChemBioChem

DOI

2022

N 6 -Methyladenosine and Its Implications in Viruses

Yafen Wang, Xiang Zhou

Genomics Proteomics & Bioinformatics

DOI

2022

A chemical CRISPR off switch efficiently controls gene editing

Xingyu Liu, Wei Xiong, Qian-Qian Qi, Huimin Ji, Yutong Zhang, Huajun Lei, Jian Liu, Ping Yin, Tian Tian, Xiang Zhou

Cell Reports Physical Science

DOI

2022

Inert Pepper aptamer-mediated endogenous mRNA recognition and imaging in living cells

Qi Wang, Feng Xiao, Haomiao Su, Hui Liu, Jinglei Xu, Heng Yuan Tang, Shanshan Qin, Zhentian Fang, Ziang Lu, Jian Wu, Xiaocheng Weng, Xiang Zhou

Nucleic Acids Research

DOI

2022

Hydrogen Peroxide‐triggered Chemical Strategy for Controlling CRISPR systems

Huimin Ji, Wei Xiong, Kaisong Zhang, Tian Tian, Xiang Zhou

Chemistry - An Asian Journal

DOI

2022

Rational guide RNA engineering for small-molecule control of CRISPR/Cas9 and gene editing

Xingyu Liu, Wei Xiong, Qianqian Qi, Yutong Zhang, Huimin Ji, Shuangyu Cui, Jing An, Xiaoming Sun, Hao Yin, Tian Tian, Xiang Zhou

Nucleic Acids Research

DOI

2022

6-Iodopurine as a Versatile Building Block for RNA Purine Architecture Modifications

Yalun Xie, Zhentian Fang, Wei Yang, Zhiyong He, Kun Chen, Panpan Heng, Baoshan Wang, Xiang Zhou

Bioconjugate Chemistry

DOI

2022

Supramolecular CRISPR-OFF switches with host–guest chemistry

Wei Xiong, Xingyu Liu, Qianqian Qi, Huimin Ji, Fengbo Liu, Cheng Zhong, Simin Liu, Tian Tian, Xiang Zhou

Nucleic Acids Research

DOI

2022

Live-cell RNA imaging using the CRISPR-dCas13 system with modified sgRNAs appended with fluorescent RNA aptamers

Heng Yuan Tang, Junran Peng, Shuang Peng, Qi Wang, Xin Quan Jiang, Xiaocheng Xue, Yanxin Tao, Limin Xiang, Quanjiang Ji, Song‐Mei Liu, Xiaocheng Weng, Xiang Zhou

Chemical Science

DOI

2022

Transcriptome-wide profiling of N 6 -methyladenosine via a selective chemical labeling method

Yalun Xie, Shaoqing Han, Qiming Li, Zhentian Fang, Wei Yang, Qi Wei, Yafen Wang, Yu Zhou, Xiaocheng Weng, Xiang Zhou

Chemical Science

DOI

2022

Labeling and sequencing nucleic acid modifications using bio-orthogonal tools

Hui Liu, Yafen Wang, Xiang Zhou

RSC Chemical Biology

DOI

2022

Norbornene-tetrazine ligation chemistry for controlling RNA-guided CRISPR systems

Qianqian Qi, Yutong Zhang, Wei Xiong, Xingyu Liu, Shuangyu Cui, Xiaofang Ye, Kaisong Zhang, Tian Tian, Xiang Zhou

Chemical Science

DOI

2022

Oxime formation coordination-directed detection of genome-wide thymine oxides with nanogram-scale sample input

Feng Xiao, Qi Wang, Kaiyuan Zhang, Chaoxing Liu, Guangrong Zou, Xiang Zhou

Chemical Science

DOI

2021

亚硫酸钠介导的s4U转化检测转录组新生RNA中m6A

危琦，韩少卿，陈玉琪，周翔

《化学学报》

2021

DNA步行器调控的纳米粒子超晶格

郭宜君，魏冰，周翔，姚东宝，梁好均

《化学学报》

2021

5-Formyluracil targeted biochemical reactions with proteins inhibit DNA replication, induce mutations and interference gene expression in living cells

Guangrong Zou, Kaiyuan Zhang, Wei Yang, Chaoxing Liu, Zhentian Fang, Xiang Zhou

Chinese Chemical Letters

DOI

2021

Chemical labelling for m6A detection: opportunities and challenges

Yafen Wang, Wei Yang, Xiang Zhou

Fundamental Research

DOI

2021

Single-Base Resolution Mapping Reveals Distinct 5-Formylcytidine in Saccharomyces cerevisiae mRNAs

Yafen Wang, Zonggui Chen, Xiong Zhang, Xiaocheng Weng, Jikai Deng, Wei Yang, Fan Wu, Shaoqing Han, Chao Xia, Yu Zhou, Yu Zheng Chen, Xiang Zhou

ACS Chemical Biology

DOI

2021

Visually Intracellular Detection of Telomerase Activity Based on DNA Strand Displacement Reaction and Gold Nanoparticle Labeling

Yajun Zhang, Yan Shen, Zhaoxin Chen, Xin Quan Jiang, S. T. Rao, Zhuoran Jiang, Shanshan Qin, Xiang Zhou, Yuhao Du

Chinese Journal of Chemistry

DOI

2021

G-Quadruplexes in Neurobiology and Virology: Functional Roles and Potential Therapeutic Approaches

Jinglei Xu, Haiyan Huang, Xiang Zhou

JACS Au

DOI

2021

Enzymatic deamination of the epigenetic nucleosideN6-methyladenosine regulates gene expression

Zhuoran Jiang, Chao Wang, Zixin Wu, Kun Chen, Wei Yang, Hexiang Deng, Heng Song, Xiang Zhou

Nucleic Acids Research

DOI

2021

Sequencing 5-Formyluracil in Genomic DNA at Single-Base Resolution

Wei Yang, Shaoqing Han, Xiong Zhang, Yafen Wang, Guangrong Zou, Chaoxing Liu, Muxin Xu, Xiang Zhou

Analytical Chemistry

DOI

2021

A longitudinal sampling study of transcriptomic and epigenetic profiles in patients with thrombocytopenia syndrome

Yafen Wang, Shaoqing Han, Ruoxi Ran, Anling Li, Huanyu Liu, Mingjun Liu, Yongwei Duan, Xiong Zhang, Zhigang Zhao, Shihui Song, Xiaocheng Weng, Song‐Mei Liu, Xiang Zhou

Nature Communications

DOI

2021

Copper (II) synergistic AS1411 conjunction with chemical decaging reactions for selective fluorescence imaging and prodrug activation in living systems

Kun Chen, Guangrong Zou, Wei Xiong, Zhiyong He, Yan Shen, Shanshan Qin, Qi Wang, Hengjiang Cong, Chun‐Jiang Wang, Xiang Zhou

Sensors and Actuators B Chemical

DOI

2021

Cover Feature: N3‐Kethoxal‐Based Bioorthogonal Intracellular RNA Labeling (ChemBioChem 9/2021)

Jinguo Huang, Ruiqi Zhao, Jing Mo, Fang Wang, Xiaocheng Weng, Xiang Zhou

ChemBioChem

DOI

2021

Base-Resolution Analysis of Deoxyuridine at the Genome Scale Based on the Artificial Incorporation Modified Nucleobase

Yafen Wang, Xiong Zhang, Shaoqing Han, Wei Yang, Zonggui Chen, Fan Wu, Jizhou Liu, Xiaocheng Weng, Xiang Zhou

ACS Central Science

DOI

2021

Photoactive G-Quadruplex Ligand Identifies Multiple G-Quadruplex-Related Proteins with Extensive Sequence Tolerance in the Cellular Environment

Haomiao Su, Jinglei Xu, Yuqi Chen, Qi Wang, Ziang Lu, Yage Chen, Kun Chen, Shaoqing Han, Zhentian Fang, Ping Wang, Bi‐Feng Yuan, Xiang Zhou

Journal of the American Chemical Society

DOI

2021

N3‐Kethoxal‐Based Bioorthogonal Intracellular RNA Labeling

Jinguo Huang, Ruiqi Zhao, Jing Mo, Fang Wang, Xiaocheng Weng, Xiang Zhou

ChemBioChem

DOI

2021

Direct decarboxylation of ten-eleven translocation-produced 5-carboxylcytosine in mammalian genomes forms a new mechanism for active DNA demethylation

Feng Yang, Juanjuan Chen, Neng‐Bin Xie, Jiang-Hui Ding, Xue‐Jiao You, Wan-Bing Tao, Xiaoxue Zhang, Chengqi Yi, Xiang Zhou, Bi‐Feng Yuan, Yu‐Qi Feng

Chemical Science

DOI

2021

Chemical methods and advanced sequencing technologies for deciphering mRNA modifications

Yafen Wang, Xiong Zhang, Hui Liu, Xiang Zhou

Chemical Society Reviews

DOI

2021

Bisulfite-free and quantitative detection of 5-formylcytosine in DNA through qPCR

Jizhou Liu, Wei Yang, Xiong Zhang, Yafen Wang, Xiang Zhou

Chemical Communications

DOI

2021

One-pot fluorescent assay for sensitive detection of APOBEC3A activity

Bingyao Wang, Xiong Zhang, Yafen Wang, Kun Chen, Fang Wang, Xiaocheng Weng, Xiang Zhou

RSC Chemical Biology

DOI

2021

A far-red emissive two-photon fluorescent probe for quantification of uracil in genomic DNA

Bingyao Wang, Yi Chen, Xiong Zhang, Zhuoran Jiang, Yafen Wang, Kun Chen, Fang Wang, Xiaocheng Weng, Xiang Zhou

Chemical Communications

DOI

2021

Correction: Small-molecule-based human genome G4 profiling reveals potential gene regulation activity

Weiwu Zeng, Fan Wu, Chaoxing Liu, Yan Yang, Bingyao Wang, Yushu Yuan, Jiaqi Wang, Yuqi Chen, Boshi Fu, Zhiguo Wu, Xiang Zhou

Chemical Communications

DOI

2020

Enantioselective Diels–Alder reactions with left-handed G-quadruplex DNA-based catalysts

Kun Chen, Zhiyong He, Wei Xiong, Chun‐Jiang Wang, Xiang Zhou

Chinese Chemical Letters

DOI

2020

Cascaded DNA circuits-programmed self-assembly of spherical nucleic acids for high signal amplification

Xiang Li, Dongbao Yao, Junxiang Zhou, Xiang Zhou, Xianbao Sun, Bing Wei, Chengxu Li, Bin Zheng, Haojun Liang

Science China Chemistry

2020

NEase-based amplification for detection of miRNA, multiple miRNAs and circRNA

Yajun Zhang, Qiuyang Zhang, Xiaocheng Weng, Yuhao Du, Xiang Zhou

Analytica Chimica Acta

DOI

2020

Cover Feature: 4‐Thiouridine‐Enhanced Peroxidase‐Generated Biotinylation of RNA (ChemBioChem 1/2021)

Jinguo Huang, Ruiqi Zhao, Shanshan Qin, Shixi Yang, Wei Li, Jing Mo, Fang Wang, Yuhao Du, Xiaocheng Weng, Xiang Zhou

ChemBioChem

DOI

2020

4‐Thiouridine‐Enhanced Peroxidase‐Generated Biotinylation of RNA

Jinguo Huang, Ruiqi Zhao, Shanshan Qin, Shixi Yang, Wei Li, Jing Mo, Fang Wang, Yuhao Du, Xiaocheng Weng, Xiang Zhou

ChemBioChem

DOI

2020

Selective Chemical Labeling and Sequencing of 5-Carboxylcytosine in DNA at Single-Base Resolution

Yalun Xie, Yafen Wang, Zhiyong He, Wei Yang, Boshi Fu, Guangrong Zou, Xiong Zhang, Jinguo Huang, Xiang Zhou

Analytical Chemistry

DOI

2020

TRADES: Targeted RNA Demethylation by SunTag System

Jing Mo, Zonggui Chen, Shanshan Qin, Shu Li, Chuangang Liu, Lu Zhang, Ruoxi Ran, Ying Kong, Fang Wang, Song‐Mei Liu, Yu Zhou, Xiao‐Lian Zhang, Xiaocheng Weng, Xiang Zhou

Advanced Science

DOI

2020

Transformation of 5-Carboxylcytosine to Cytosine Through C–C Bond Cleavage in Human Cells Constitutes a Novel Pathway for DNA Demethylation

Feng Yang, Neng‐Bin Xie, Wan-Bing Tao, Jiang-Hui Ding, Xue‐Jiao You, Cheng-Jie Ma, Xiaoxue Zhang, Chengqi Yi, Xiang Zhou, Bi‐Feng Yuan, Yu‐Qi Feng

CCS Chemistry

DOI

2020

The Manipulation of RNA‐Guided Nucleic Acid Cleavage with Ninhydrin Chemistry

Shaoru Wang, Haiyan Huang, Jian Liu, Lai Wei, Ling‐Yu Wu, Wei Xiong, Ping Yin, Tian Tian, Xiang Zhou

Advanced Science

DOI

2020

Metabolic Labeling and Imaging of Cellular RNA via Bioorthogonal Cyclopropene−Tetrazine Ligation

Zhiyong He, Shuang Peng, Qi Wei, Shaokang Jia, Shan Guo, Kun Chen, Xiang Zhou

CCS Chemistry

DOI

2020

Biochemical Insights into the Role of Guanosine Oxidation on RNA G-Quadruplex

Haiyan Huang, Shaoru Wang, Ling‐Yu Wu, Yutong Zhang, Yanyan Song, Lai Wei, Tian Tian, Xiang Zhou

CCS Chemistry

DOI

2020

Light-Driven Activation of RNA-Guided Nucleic Acid Cleavage

Shaoru Wang, Lai Wei, Jiaqi Wang, Huimin Ji, Wei Xiong, Jian Liu, Ping Yin, Tian Tian, Xiang Zhou

ACS Chemical Biology

DOI

2020

A m6A Sensing Method by Its Impact on the Stability of RNA Double Helix

Shixi Yang, Fan Wu, Shuang Peng, Fang Wang, Yi Chen, Yushu Yuan, Xiaocheng Weng, Xiang Zhou

Chemistry & Biodiversity

DOI

2020

Acrylonitrile‐Mediated Nascent RNA Sequencing for Transcriptome‐Wide Profiling of Cellular RNA Dynamics

Yuqi Chen, Fan Wu, Zonggui Chen, Zhiyong He, Qi Wei, Weiwu Zeng, Kun Chen, Feng Xiao, Yushu Yuan, Xiaocheng Weng, Yu Zhou, Xiang Zhou

Advanced Science

DOI

2020

Multiplexed microRNA Detection Using Metal–Organic Framework for Signal Output

Shuang Peng, Min Liu, Binglin Bie, Yajun Zhang, Heng Yuan Tang, Yuqing Sun, Xiang Zhou

ACS Applied Bio Materials

DOI

2020

Efficient Separation of Nucleic Acids with Different Secondary Structures by Metal–Organic Frameworks

Shuang Peng, Binglin Bie, Hongnan Jia, Heng Yuan Tang, Xiong Zhang, Yuqing Sun, Qi Wei, Fan Wu, Yushu Yuan, Hexiang Deng, Xiang Zhou

Journal of the American Chemical Society

DOI

2020

Regulable DNA–Protein Interactions in Vitro and Vivo at Epigenetic DNA Marks

Guangrong Zou, Chaoxing Liu, Weiwu Zeng, Wei Yang, Kaiyuan Zhang, Yalun Xie, Cong Chen, Xiang Zhou

CCS Chemistry

DOI

2020

Keth-seq for transcriptome-wide RNA structure mapping

Xiaocheng Weng, Jing Gong, Yi Chen, Tong Wu, Fang Wang, Shixi Yang, Yushu Yuan, Guan‐Zheng Luo, Kai Chen, Lulu Hu, Honghui Ma, Pingluan Wang, Qiangfeng Cliff Zhang, Xiang Zhou, Chuan He

Nature Chemical Biology

DOI

2020

Conditional control of RNA-guided nucleic acid cleavage and gene editing

Shaoru Wang, Ling‐Yu Wu, Haiyan Huang, Wei Xiong, Jian Liu, Lai Wei, Ping Yin, Tian Tian, Xiang Zhou

Nature Communications

DOI

2019

基于G-四联体比色生物传感器检测肉制品中羊源性成分

王心一，刘榜，谌阳，许文涛，周翔

《生物技术进展》

DOI

2019

Systematic investigation of bioorthogonal cellular DNA metabolic labeling in a photo-controlled manner

Shaokang Jia, Shixi Yang, Huimin Ji, Shuang Peng, Kun Chen, Zhiyong He, Xiang Zhou

Chinese Chemical Letters

DOI

2019

The roles of microRNAs in epigenetic regulation

Qian Yao, Yuqi Chen, Xiang Zhou

Current Opinion in Chemical Biology

DOI

2019

Photocaged probes for spatiotemporal imaging

Guangrong Zou, Chaoxing Liu, Zhentian Fang, Shaokang Jia, Wei Yang, Xiong Zhang, Mingkai Chen, Tian Tian, Xiaocheng Weng, Xiang Zhou

Sensors and Actuators B Chemical

DOI

2019

Detection and Application of 5-Formylcytosine and 5-Formyluracil in DNA

Yafen Wang, Xiong Zhang, Guangrong Zou, Shuang Peng, Chaoxing Liu, Xiang Zhou

Accounts of Chemical Research

DOI

2019

N 1-Methyladenosine detection with CRISPR-Cas13a/C2c2

Yi Chen, Shixi Yang, Shuang Peng, Wei Li, Fan Wu, Qian Yao, Fang Wang, Xiaocheng Weng, Xiang Zhou

Chemical Science

DOI

2019

Biotinylation and isolation of an RNA G-quadruplex based on its peroxidase-mimicking activity

Wei Li, Weiwu Zeng, Yi Chen, Fang Wang, Fan Wu, Xiaocheng Weng, Xiang Zhou

The Analyst

DOI

2019

The construction of DNAzyme-based logic gates for amplified microRNA detection and cancer recognition

Ling‐Yu Wu, Min Pan, Yuqi Chen, Haiyan Huang, Xiaoe Zhang, Fuan Wang, Xiang Zhou

The Analyst

DOI

2019

Small-molecule-based human genome G4 profiling reveals potential gene regulation activity

Weiwu Zeng, Fan Wu, Chaoxing Liu, Yan Yang, Bingyao Wang, Yushu Yuan, Jiaqi Wang, Yuqi Chen, Boshi Fu, Zhiguo Wu, Xiang Zhou

Chemical Communications

DOI

2019

Direct detection of circRNA in real samples using reverse transcription-rolling circle amplification

Yaqian Liu, Xiong Zhang, Min Liu, Fa Xu, Qiuyang Zhang, Yajun Zhang, Xiaocheng Weng, Song‐Mei Liu, Yuhao Du, Xiang Zhou

Analytica Chimica Acta

DOI

2019

High-efficiency and integrable DNA arithmetic and logic system based on strand displacement synthesis

Haomiao Su, Jinglei Xu, Qi Wang, Fuan Wang, Xiang Zhou

Nature Communications

DOI

2019

A sensitive and radiolabeling-free method for pseudouridine detection

Wei Li, Fang Wang, Yi Chen, Xiaocheng Weng, Xiang Zhou

Analytical Biochemistry

DOI

2019

Efficient Self‐Assembled DNA Nanoparticles through Rolling Circle Amplification for siRNA Delivery in vitro

Qian Yao, Yuqi Chen, Fan Wu, Fan Wu, Chaoxing Liu, Tingting Hong, Wei Li, Yi Chen, Xiang Zhou

Chinese Journal of Chemistry

DOI

2019

Specific stabilization of DNA G-quadruplex structures with a chemically modified complementary probe

Min Liu, Yaqian Liu, Fan Wu, Yuhao Du, Xiang Zhou

Bioorganic & Medicinal Chemistry

DOI

2019

DNAzyme‐Loaded Metal–Organic Frameworks (MOFs) for Self‐Sufficient Gene Therapy

Huimin Wang, Yuqi Chen, Hong Wang, Xiaoqing Liu, Xiang Zhou, Fuan Wang

Angewandte Chemie

DOI

2018

Ligation-Based qPCR-Amplification Assay for Radiolabel-Free Detection of ATP and NAD+ with High Selectivity and Sensitivity

Xiong Zhang, Yafen Wang, Xiang Zhou

Analytical Chemistry

DOI

2018

Amplified MicroRNA Detection and Intracellular Imaging Based on an Autonomous and Catalytic Assembly of DNAzyme

Lei Yang, Qiong Di Wu, Yuqi Chen, Xiaoqing Liu, Fuan Wang, Xiang Zhou

ACS Sensors

DOI

2018

Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication

Wen‐Xiu Bian, Yan Xie, Xiaoning Wang, Guohua Xu, Boshi Fu, Shu Li, Gang Long, Xiang Zhou, Xiao‐Lian Zhang

Nucleic Acids Research

DOI

2018

Selective Labeling Aldehydes in DNA

Chaoxing Liu, Xiaomeng Luo, Yuqi Chen, Fan Wu, Wei Yang, Yafen Wang, Xiong Zhang, Guangrong Zou, Xiang Zhou

Analytical Chemistry

DOI

2018

Highly Selective 5-Formyluracil Labeling and Genome-wide Mapping Using (2-Benzimidazolyl)Acetonitrile Probe

Yafen Wang, Chaoxing Liu, Fan Wu, Xiong Zhang, Sheng Liu, Zonggui Chen, Weiwu Zeng, Wei Yang, Xiao‐Lian Zhang, Yu Zhou, Xiaocheng Weng, Zhiguo Wu, Xiang Zhou

iScience

DOI

2018

Supramolecular Coordination-Directed Reversible Regulation of Protein Activities at Epigenetic DNA Marks

Shaoru Wang, Jiaqi Wang, Boshi Fu, Kun Chen, Wei Xiong, Lai Wei, Guangyan Qing, Tian Tian, Xiang Zhou

Journal of the American Chemical Society

DOI

2018

Bisulfite-free, single base-resolution analysis of 5-hydroxymethylcytosine in genomic DNA by chemical-mediated mismatch

Yafen Wang, Xiong Zhang, Fan Wu, Zonggui Chen, Xiang Zhou

Chemical Science

DOI

2018

Ligation-promoted hyperbranched rolling circle amplification enables ultrasensitive detection of microRNA in clinical specimens

Xiaoe Zhang, Yinong Liu, Yiwen Yang, Junjie Huang, Haitao Wang, Zirui Zhu, Xi Wang, Pei Ma, Xin Ming Zhou, Xin Zhou, Shaoru Wang, Xiang Zhou, Xiang Zhou

Sensors and Actuators B Chemical

DOI

2018

Luminescence Sensing for Qualitative and Quantitative Detection of 5-Methylcytosine

Yushu Yuan, Tingting Hong, Yi Chen, Yafen Wang, Xueping Qiu, Fang Zheng, Xiaocheng Weng, Xiang Zhou

Analytical Chemistry

DOI

2018

An Ultrasensitive Diagnostic Biochip Based on Biomimetic Periodic Nanostructure-Assisted Rolling Circle Amplification

Qian Yao, Yingqian Wang, Jie Wang, Shaomin Chen, Haoyang Liu, Zhuoran Jiang, Xiaoe Zhang, Song‐Mei Liu, Quan Yuan, Xiang Zhou

ACS Nano

DOI

2018

5‐Formyluracil as a Multifunctional Building Block in Biosensor Designs

Chaoxing Liu, Guangrong Zou, Shuang Peng, Yafen Wang, Wei Yang, Fan Wu, Zhuoran Jiang, Xiong Zhang, Xiang Zhou

Angewandte Chemie

DOI

2018

The Cucurbit[7]Uril‐Based Supramolecular Chemistry for Reversible B/Z‐DNA Transition

Shaoru Wang, Jiaqi Wang, Guohua Xu, Lai Wei, Boshi Fu, Ling‐Yu Wu, Yanyan Song, Xiran Yang, Conggang Li, Si‐Min Liu, Xiang Zhou

Advanced Science

DOI

2018

Existence of Diverse Modifications in Small‐RNA Species Composed of 16–28 Nucleotides

Meng‐Dan Lan, Jun Xiong, Xue‐Jiao You, Xiaocheng Weng, Xiang Zhou, Bi‐Feng Yuan, Yu‐Qi Feng

Chemistry - A European Journal

DOI

2018

Precise Antibody-Independent m6A Identification via 4SedTTP-Involved and FTO-Assisted Strategy at Single-Nucleotide Resolution

Tingting Hong, Yushu Yuan, Zonggui Chen, Kun Xi, Tianlu Wang, Yalun Xie, Zhiyong He, Haomiao Su, Yu Zhou, Zhi-Jie Tan, Xiaocheng Weng, Xiang Zhou

Journal of the American Chemical Society

DOI

2018

Construction of an enzyme-free concatenated DNA circuit for signal amplification and intracellular imaging

Huimin Wang, Chunxiao Li, Xiaoqing Liu, Xiang Zhou, Fuan Wang

Chemical Science

DOI

2018

Naphthalimide derivatives as multifunctional molecules for detecting 5-formylpyrimidine by both PAGE analysis and dot-blot assays

Yafen Wang, Chaoxing Liu, Wei Yang, Guangrong Zou, Xiong Zhang, Fan Wu, Shuyi Yu, Xiaomeng Luo, Xiang Zhou

Chemical Communications

DOI

2018

Gene specific-loci quantitative and single-base resolution analysis of 5-formylcytosine by compound-mediated polymerase chain reaction

Yafen Wang, Chaoxing Liu, Xiong Zhang, Wei Yang, Fan Wu, Guangrong Zou, Xiaocheng Weng, Xiang Zhou

Chemical Science

DOI

2018

5-Formyluracil as a cornerstone for aluminum detection in vitro and in vivo : a more natural and sustainable strategy

Guangrong Zou, Chaoxing Liu, Chen Cong, Zhentian Fang, Wei Yang, Xiaomeng Luo, Shaokang Jia, Fan Wu, Xiang Zhou

Chemical Communications

DOI

2018

A novel nucleic acid aptamer tag: a rapid fluorescence strategy using a self-constructing G-quadruplex from AGG trinucleotide repeats

Boshi Fu, Yoojin Park, Ki Tae Kim, Kun Chen, Guangrong Zou, Qi Wei, Shuang Peng, Yuqi Chen, Byeang Hyean Kim, Xiang Zhou

Chemical Communications

DOI

2018

G-Quadruplex: A Regulator of Gene Expression and Its Chemical Targeting

Tian Tian, Yuqi Chen, Shaoru Wang, Xiang Zhou

Chem

DOI

2017

锌配体化合物选择性诱导、稳定、荧光检测G-四联体

王雅芬，张雄，刘朝兴，周翔

《化学学报》

2017

An aptamer-based ligation-triggered rolling circle amplification strategy for ATP detection and imaging in situ

Fan Wu, Wenting Liu, Shixi Yang, Qian Yao, Yi Chen, Xiaocheng Weng, Xiang Zhou

Journal of Photochemistry and Photobiology A Chemistry

DOI

2017

Programmable DNA-responsive microchip for the capture and release of circulating tumor cells by nucleic acid hybridization

Shan Guo, Haiyan Huang, Xujing Deng, Yuqi Chen, Zhuoran Jiang, Min Xie, Song‐Mei Liu, Wei‐Hua Huang, Xiang Zhou

Nano Research

DOI

2017

Cucurbit[7]uril-Driven Host–Guest Chemistry for Reversible Intervention of 5-Formylcytosine-Targeted Biochemical Reactions

Shaoru Wang, Yanyan Song, Lai Wei, Chaoxing Liu, Boshi Fu, Jiaqi Wang, Xiran Yang, Yi-Nong Liu, Simin Liu, Tian Tian, Xiang Zhou

Journal of the American Chemical Society

DOI

2017

Reversible photoregulation of DNA B-Z transition by a photochromic nucleoside

Yinong Liu, Cheng Zhong, Zhiyong He, S. T. Rao, Haomiao Su, Fan Wu, Boshi Fu, Jinjun Wu, Yanyan Song, Yuhao Du, Xiang Zhou

Sensors and Actuators B Chemical

DOI

2017

Application of Ammonium Persulfate for Selective Oxidation of Guanines for Nucleic Acid Sequencing

Yafen Wang, Chaoxing Liu, Tingting Hong, Fan Wu, Shuyi Yu, Zhiyong He, Wuxiang Mao, Xiang Zhou

Molecules

DOI

2017

5‐Formylcytosine and 5‐Carboxylcytosine Significantly Reduce the Catalytic Activity of Hhal DNA Methyltransferase

Tingting Hong, Fan Wu, Boshi Fu, Yushu Yuan, Jinglei Xu, Tianlu Wang, Xiang Zhou

Chinese Journal of Chemistry

DOI

2017

A highly efficient fluorescence-based switch-on detection method of 5-formyluracil in DNA

Chaoxing Liu, Yuqi Chen, Yafen Wang, Fan Wu, Xiong Zhang, Wei Yang, Jiaqi Wang, Yi Chen, Zhiyong He, Guangrong Zou, Shaoru Wang, Xiang Zhou

Nano Research

DOI

2017

Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host–guest interactions

Tian Tian, Yanyan Song, Lai Wei, Jiaqi Wang, Boshi Fu, Zhiyong He, Xiran Yang, Fan Wu, Guohua Xu, Simin Liu, Conggang Li, Shaoru Wang, Xiang Zhou

Nucleic Acids Research

DOI

2017

Epigenetic modification of nucleic acids: from basic studies to medical applications

Yuqi Chen, Tingting Hong, Shaoru Wang, Jing Mo, Tian Tian, Xiang Zhou

Chemical Society Reviews

DOI

2017

Fluorogenic labeling and single-base resolution analysis of 5-formylcytosine in DNA

Chaoxing Liu, Yafen Wang, Wei Yang, Fan Wu, Weiwu Zeng, Zonggui Chen, Jinguo Huang, Guangrong Zou, Xiong Zhang, Shaoru Wang, Xiaocheng Weng, Zhiguo Wu, Yu Zhou, Xiang Zhou

Chemical Science

DOI

2017

Enrichment and fluorogenic labelling of 5-formyluracil in DNA

Chaoxing Liu, Yafen Wang, Xiong Zhang, Fan Wu, Wei Yang, Guangrong Zou, Qian Yao, Jiaqi Wang, Yuqi Chen, Shaoru Wang, Xiang Zhou

Chemical Science

DOI

2017

The m 6 A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide

Shaoru Wang, Yanyan Song, Yafen Wang, Xin Li, Boshi Fu, Yinong Liu, Jiaqi Wang, Lai Wei, Tian Tian, Xiang Zhou

Chemical Science

DOI

2016

RNA表观遗传修饰及其纳米检测探针研究进展

田沺，周翔

《中国科学:化学》

2016

Simultaneous and Sensitive Detection of Multisite 5-Methylcytosine Including Non-CpG Sites at Single-5mC-Resolution

Shuang Rao, Yuqi Chen, Tingting Hong, Zhiyong He, Shan Guo, Han Lai, Ge Guo, Yuhao Du, Xiang Zhou

Analytical Chemistry

DOI

2016

Chemical Targeting of a G-Quadruplex RNA in the Ebola Virus L Gene

Shaoru Wang, Qiu‐Yan Zhang, Jiaqi Wang, Xing‐Yi Ge, Yanyan Song, Yafen Wang, Xiaodan Li, Boshi Fu, Guohua Xu, Bo Shu, Peng Gong, Bo Zhang, Tian Tian, Xiang Zhou

Cell chemical biology

DOI

2016

pH-controlled DNAzymes: Rational design and their applications in DNA-machinery devices

Yuqi Chen, Yanyan Song, Zhiyong He, Zijing Wang, Wenting Liu, Fuan Wang, Xiao‐Lian Zhang, Xiang Zhou

Nano Research

DOI

2016

Selective detection of N6-methyladenine in DNA via metal ion-mediated replication and rolling circle amplification

Tingting Hong, Yushu Yuan, Tianlu Wang, Jingwei Ma, Qian Yao, Xiaoluan Hua, Yu Xia, Xiang Zhou

Chemical Science

DOI

2016

Visualization of G-quadruplexes in gel and in live cells by a near-infrared fluorescent probe

Fan Wu, Chaoxing Liu, Yuqi Chen, Shixi Yang, Jiahui Xu, Rong Huang, Xiang Wang, Manjia Li, Wenting Liu, Wuxiang Mao, Xiang Zhou

Sensors and Actuators B Chemical

DOI

2016

A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti–hepatitis C target

Shaoru Wang, Yuan‐Qin Min, Jia-Qi Wang, Chaoxing Liu, Boshi Fu, Fan Wu, Ling‐Yu Wu, Zhixian Qiao, Yanyan Song, Guo-Hua Xu, Zhiguo Wu, Gai Huang, Nanfang Peng, Rong Huang, Wuxiang Mao, Shuang Peng, Yuqi Chen, Ying Zhu, Tian Tian, Xiao‐Lian Zhang, Xiang Zhou

Science Advances

DOI

2016

Highly Selective Detection of 5-Methylcytosine in Genomic DNA Based on Asymmetric PCR and Specific DNA Damaging Reagents

Yafen Wang, Chaoxing Liu, Tianlu Wang, Tingting Hong, Haomiao Su, Shuyi Yu, Hongwei Song, Song-Mei Liu, Xin Hua Zhou, Xin Zhou, Wuxiang Mao, Xiang Zhou, Xiang Zhou

Analytical Chemistry

DOI

2016

Small-Molecule-Triggered and Light-Controlled Reversible Regulation of Enzymatic Activity

Tian Tian, Yanyan Song, Jiaqi Wang, Boshi Fu, Zhiyong He, Xianqun Xu, Anling Li, Xin Hua Zhou, Xin Zhou, Shaoru Wang, Xiang Zhou, Xiang Zhou

Journal of the American Chemical Society

DOI

2016

Right-handed and left-handed G-quadruplexes have the same DNA sequence: distinct conformations induced by an organic small molecule and potassium

Boshi Fu, Jinguo Huang, Yuqi Chen, Yafen Wang, Tianrui Xue, Guohua Xu, Shaoru Wang, Xiang Zhou

Chemical Communications

DOI

2016

A rapidly photo-activatable light-up fluorescent nucleoside and its application in DNA base variation sensing

Zhiyong He, Yuqi Chen, Yafen Wang, Jiaqi Wang, Jing Mo, Boshi Fu, Zijing Wang, Yuhao Du, Xiang Zhou

Chemical Communications

DOI

2016

Detecting 5-methylcytosine using an enzyme-free DNA strand exchange reaction without pretreatment under physiological conditions

Xu Chen, Jinjun Wu, Wenting Liu, Tingting Hong, Tianlu Wang, Xiaoe Zhang, Boshi Fu, Fan Wu, Zhiguo Wu, Xiang Zhou

Chemical Communications

DOI

2015

基于核酸的疾病诊断技术新进展

彭双，李娓，田沺，周翔

《世界复合医学(中英文)》

2015

N 6 -Methyladenine hinders RNA- and DNA-directed DNA synthesis: application in human rRNA methylation analysis of clinical specimens

Shaoru Wang, Jiaqi Wang, Xiaoe Zhang, Boshi Fu, Yanyan Song, Pei Ma, Kai Gu, Xin Hua Zhou, Xin Zhou, Xiao‐Lian Zhang, Tian Tian, Xiang Zhou, Xiang Zhou

Chemical Science

DOI

2015

Enantioselective Diels–Alder reactions using a G-triplex DNA-based catalyst

Xiaowei Xu, Wuxiang Mao, Feng Lin, Jianlin Hu, Zhiyong He, Xiaocheng Weng, Chun‐Jiang Wang, Xiang Zhou

Catalysis Communications

DOI

2015

Single-Molecule Manipulation of the Duplex Formation and Dissociation at the G-Quadruplex/i-Motif Site in the DNA Nanostructure

Masayuki Endo, Xiwen Xing, Xiang Zhou, Tomoko Emura, Kumi Hidaka, Bodin Tuesuwan, Hiroshi Sugiyama

ACS Nano

DOI

2015

Editorial (Thematic Issue: Biological Function of G-Quadruplex Nucleic Acids and Potential Application in Medicinal Chemistry)

Zhi‐Shu Huang, Xiang Zhou, Z. Tan

Current Topics in Medicinal Chemistry

DOI

2015

ChemInform Abstract: A Review: MicroRNA Detection Methods

Tian Tian, Jiaqi Wang, Xiang Zhou

ChemInform

DOI

2015

DNA methyltransferase activity detection based on fluorescent silver nanocluster hairpin-shaped DNA probe with 5’-C-rich/G-rich-3’ tails

Wenting Liu, Han Lai, Rong Huang, Chuntao Zhao, Yimo Wang, Xiaocheng Weng, Xiang Zhou

Biosensors and Bioelectronics

DOI

2015

A DNA logic gate based on strand displacement reaction and rolling circle amplification, responding to multiple low-abundance DNA fragment input signals, and its application in detecting miRNAs

Yuqi Chen, Yanyan Song, Fan Wu, Wenting Liu, Boshi Fu, Bingkun Feng, Xiang Zhou

Chemical Communications

DOI

2015

Novel insights into a major DNA oxidative lesion: its effects on Z-DNA stabilization

Jiaqi Wang, Shaoru Wang, Cheng Zhong, Tian Tian, Xiang Zhou

Organic & Biomolecular Chemistry

DOI

2015

N 6 -Hydroperoxymethyladenosine: a new intermediate of chemical oxidation of N 6 -methyladenosine mediated by bicarbonate-activated hydrogen peroxide

Jinjun Wu, Heng Xiao, Tianlu Wang, Tingting Hong, Boshi Fu, Dongsheng Bai, Zhiyong He, Shuang Peng, Xiwen Xing, Jianlin Hu, Pu Guo, Xiang Zhou

Chemical Science

DOI

2015

A highly sensitive fluorescence assay for methyltransferase activity by exonuclease-aided signal amplification

Feng Tang, Xiwen Xing, Jie-Mei Chu, Quan Yuan, Xiang Zhou, Yu‐Qi Feng, Bi‐Feng Yuan

The Analyst

DOI

2014

A review: microRNA detection methods

Tian Tian, Jiaqi Wang, Xiang Zhou

Organic & Biomolecular Chemistry

DOI

2014

Specific recognition of guanines in non-duplex regions of nucleic acids with potassium tungstate and hydrogen peroxide

Wuxiang Mao, Xiaowei Xu, Huan He, Rong Huang, Xi Chen, Heng Xiao, Zhenduo Yu, Yi Liu, Xiang Zhou

Nucleic Acids Research

DOI

2014

Regulation of DNA strand displacement using a G-quadruplex-mediated toehold

Shuo Feng, Fan Wu, Jiahui Xu, Yuqi Chen, Xiang Zhou

RSC Advances

DOI

2014

Sensitive Detection of DNA Methyltransferase Activity Based on Exonuclease-Mediated Target Recycling

Xiwen Xing, Feng Tang, Jun Wu, Jie-Mei Chu, Yu‐Qi Feng, Xiang Zhou, Bi‐Feng Yuan

Analytical Chemistry

DOI

2014

Formation of DNA:RNA Hybrid G‐Quadruplexes of Two G‐Quartet Layers in Transcription: Expansion of the Prevalence and Diversity of G‐Quadruplexes in Genomes

Shan Xiao, Jiayu Zhang, Jun Wu, Renyi Wu, Ye Xia, Ke‐wei Zheng, Yu‐hua Hao, Xiang Zhou, Zheng Tan

Angewandte Chemie

DOI

2014

ChemInform Abstract: Chemical Labeling of 5‐Iodo‐2′‐deoxyuridine with 4‐Ethynyl‐N‐ethyl‐1,8‐naphthalimide Using Copper‐Free Sonogashira Cross‐Coupling in Aqueous Medium.

Libo Yuan, Zhengan Zhang, Xiaowei Xu, Xiang Zhou

ChemInform

DOI

2014

Corrigendum to “Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling” [Bioorg. Med. Chem. Lett. 24 (2014) 294–297]

Jianlin Hu, Yuqi Chen, Xiaowei Xu, Fan Wu, Xiwen Xing, Zhenghao Xu, Jiahui Xu, Xiaocheng Weng, Xiang Zhou

Bioorganic & Medicinal Chemistry Letters

DOI

2014

A novel aggregation-induced emission fluorescent probe for nucleic acid detection and its applications in cell imaging

Xiaowei Xu, Shengyong Yan, Yimin Zhou, Rong Huang, Yuqi Chen, Jiaqi Wang, Xiaocheng Weng, Xiang Zhou

Bioorganic & Medicinal Chemistry Letters

DOI

2014

ChemInform Abstract: One‐Step to Get 5‐Azidomethyl‐2′‐deoxyuridine from 5‐Hydroxymethyl‐2′‐deoxyuridine and Detection of It Through Click Reaction.

Xiaowei Xu, Shengyong Yan, Jianlin Hu, Pu Guo, Lai Wei, Xiaocheng Weng, Xiang Zhou

ChemInform

DOI

2014

Novel Amplex Red Oxidases Based on Noncanonical DNA Structures: Property Studies and Applications in MicroRNA Detection

Shaoru Wang, Boshi Fu, Jiaqi Wang, Yuelin Long, Xiaoe Zhang, Shuang Peng, Pu Guo, Tian Tian, Xiang Zhou

Analytical Chemistry

DOI

2014

Symmetric cyanovinyl-pyridinium triphenylamine: a novel fluorescent switch-on probe for an antiparallel G-quadruplex

Hai Lai, Yijie Xiao, Shengyong Yan, Fang-Fang Tian, Cheng Zhong, Yi Liu, Xiaocheng Weng, Xiang Zhou

The Analyst

DOI

2014

Nonlinear optical dye TSQ1 as an efficiently selective fluorescent probe for G-quadruplex DNA

Yuqi Chen, Shengyong Yan, Libo Yuan, Yimin Zhou, Yanyan Song, Heng Xiao, Xiaocheng Weng, Xiang Zhou

Organic Chemistry Frontiers

DOI

2014

Qualitative and quantitative detection of methylation at CpG sites using the fluorescein-dGTP incorporated asymmetric PCR assay strategy

Tingting Hong, Tianlu Wang, Zhiyong He, Jingwei Ma, Heng Xiao, Jinguo Huang, Wuxiang Mao, Xiang Zhou

Chemical Communications

DOI

2013

The G-triplex DNA could function as a new variety of DNA peroxidase

Shaoru Wang, Boshi Fu, Shuang Peng, Xiaoe Zhang, Tian Tian, Xiang Zhou

Chemical Communications

DOI

2013

Synthesis and spectroscopic properties of fluorescent 5-benzimidazolyl-2′-deoxyuridines 5-fdU probes obtained from o-phenylenediamine derivatives

Pu Guo, Xiaowei Xu, Xiaoyu Qiu, Yimin Zhou, Shengyong Yan, Changcheng Wang, Chunjiang Lu, Wen Ma, Xiaocheng Weng, Xian‐Zheng Zhang, Xiang Zhou

Organic & Biomolecular Chemistry

DOI

2013

Fluoride as an inducible DNA cross-linking agent for new antitumor prodrug

Jun Wu, Rong Huang, Tianlu Wang, Xi Zhao, Wanyi Zhang, Xiaocheng Weng, Tian Tian, Xiang Zhou

Organic & Biomolecular Chemistry

DOI

2013

A convenient method for selective detection of 5-hydroxymethylcytosine and 5-formylcytosine sites in DNA sequences

Wuxiang Mao, Jianlin Hu, Tingting Hong, Xiwen Xing, Sen Wang, Xi Chen, Xiang Zhou

Organic & Biomolecular Chemistry

DOI

2013

5-Methyldeoxycytidine enhances the substrate activity of DNA polymerase

Tian Tian, Shuang Peng, Heng Xiao, Yuelin Long, Boshi Fu, Xiaoe Zhang, Shan Guo, Shaoru Wang, Xiang Zhou, Xiang Zhou, Song‐Mei Liu, Xin Zhou, Xin Zhou

Chemical Communications

DOI

2013

Graphene oxide-based fluorescent detection of DNA and enzymes using Hoechst 33258 and its use for dual-output fluorescent logic gates

Wenting Liu, Ling‐Yu Wu, Shengyong Yan, Rong Huang, Xiaocheng Weng, Xiang Zhou

Analytical Methods

DOI

2013

A selective turn-on fluorescence strategy for the detection of 5-hydroxymethyl-2′-deoxycytidine

Shengyong Yan, Xiaowei Xu, Pu Guo, Jianlin Hu, Changcheng Wang, Rong Huang, Xiaocheng Weng, Yuhao Du, Xiang Zhou

RSC Advances

DOI

2013

Systematic investigation of DNAs with modified cytosines under hot alkali treatment

Tian Tian, Xiaoe Zhang, Boshi Fu, Yuelin Long, Shuang Peng, Shaoru Wang, Xiang Zhou, Xin Zhou, Xin Zhou, Xin Zhou

Chemical Communications

DOI

2013

Systematic Investigations of Different Cytosine Modifications on CpG Dinucleotide Sequences: The Effects on the B-Z Transition

Shaoru Wang, Yuelin Long, Jiaqi Wang, Yushu Ge, Pu Guo, Yi Liu, Tian Tian, Xiang Zhou

Journal of the American Chemical Society

DOI

2013

DNA nanomachines as evolved molecular Beacons for in vitro and in vivo detection

Shuo Feng, Ye Shang, Fan Wu, Fei Ding, Bin Li, Jiahui Xu, Liang Xu, Xiang Zhou

Talanta

DOI

2013

Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine in DNA by selective chemical labeling

Jianlin Hu, Yuqi Chen, Xiaowei Xu, Fan Wu, Xiwen Xing, Zhenghao Xu, Jiahui Xu, Xiaocheng Weng, Xiang Zhou

Bioorganic & Medicinal Chemistry Letters

DOI

2013

Chemical Labeling of 5-Iodo-2′-deoxyuridine with 4-Ethynyl-N-ethyl-1,8-naphthalimide Using Copper-Free Sonogashira Cross-Coupling in Aqueous Medium

Libo Yuan, Zhengan Zhang, Xiaowei Xu, Xiang Zhou

Synthetic Communications

DOI

2013

An L-DNA G-Quadruplex: Application for Peroxidase DNAzyme

Libo Yuan, Tian Tian, Yuqi Chen, Zhengan Zhang, Xiang Zhou

Nucleosides Nucleotides & Nucleic Acids

DOI

2013

A novel combined bisulfite UDG assay for selective 5-methylcytosine detection

Rong Huang, Jiaqi Wang, Wuxiang Mao, Boshi Fu, Xiwen Xing, Ge Guo, Xiang Zhou

Talanta

DOI

2013

Mutagenic and Cytotoxic Properties of Oxidation Products of 5-Methylcytosine Revealed by Next-Generation Sequencing

Xiwen Xing, Yu‐Li Liu, Mario Vargas, Yinsheng Wang, Yu‐Qi Feng, Xiang Zhou, Bi‐Feng Yuan

PLoS ONE

DOI

2013

One-step to get 5-azidomethyl-2′-deoxyuridine from 5-hydroxymethyl-2′-deoxyuridine and detection of it through click reaction

Xiaowei Xu, Shengyong Yan, Jianlin Hu, Pu Guo, Lai Wei, Xiaocheng Weng, Xiang Zhou

Tetrahedron

DOI

2013

Fluorescent Strategy Based on Cationic Conjugated Polymer Fluorescence Resonance Energy Transfer for the Quantification of 5-(Hydroxymethyl)cytosine in Genomic DNA

Tingting Hong, Tianlu Wang, Pu Guo, Xiwen Xing, Fei Ding, Yuqi Chen, Jinjun Wu, Jingwei Ma, Fan Wu, Xiang Zhou

Analytical Chemistry

DOI

2013

Targeting Non-B-Form DNA in Living Cells

Yuhao Du, Xiang Zhou

The Chemical Record

DOI

2013

ChemInform Abstract: Synthesis and Spectroscopic Properties of Fluorescent 5‐Benzimidazolyl‐2′‐deoxyuridines 5‐fdU Probes Obtained from o‐Phenylenediamine Derivatives.

Xiang Zhou, et al. et al.

ChemInform

DOI

2013

Selective Detection of 5-Formyl-2′-deoxycytidine in DNA Using a Fluorogenic Hydroxylamine Reagent

Pu Guo, Shengyong Yan, Jianlin Hu, Xiwen Xing, Changcheng Wang, Xiaowei Xu, Xiaoyu Qiu, Wen Ma, Chunjiang Lu, Xiaocheng Weng, Xiang Zhou

Organic Letters

DOI

2013

Hydrophilic Material for the Selective Enrichment of 5-Hydroxymethylcytosine and Its Liquid Chromatography–Tandem Mass Spectrometry Detection

Yang Tang, Jie-Mei Chu, Wei Huang, Jun Xiong, Xiwen Xing, Xiang Zhou, Yu‐Qi Feng, Bi‐Feng Yuan

Analytical Chemistry

DOI

2013

Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy

Libo Yuan, Tian Tian, Yuqi Chen, Shengyong Yan, Xiwen Xing, Zhengan Zhang, Qianqian Zhai, Liang Xu, Shaoru Wang, Xiaocheng Weng, Bi‐Feng Yuan, Yuqi Feng, Xiang Zhou

Scientific Reports

DOI

2013

Selective Chemical Labelling of 5‐Formylcytosine in DNA by Fluorescent Dyes

Jianlin Hu, Xiwen Xing, Xiaowei Xu, Fan Wu, Pu Guo, Shengyong Yan, Zhenghao Xu, Jiahui Xu, Xiaocheng Weng, Xiang Zhou

Chemistry - A European Journal

DOI

2013

Equilibrious Strand Exchange Promoted by DNA Conformational Switching

Zhiguo Wu, Xiao Xie, Puzhen Li, Jiayi Zhao, Lili Huang, Xiang Zhou

Scientific Reports

DOI

2013

Application of N-Halogeno-N-sodiobenzenesulfonamide Reagents to the Selective Detection of 5-Methylcytosine in DNA Sequences

Tianlu Wang, Tingting Hong, Tun Tang, Qianqian Zhai, Xiwen Xing, Wuxiang Mao, Xiaolong Zheng, Liang Xu, Jinjun Wu, Xiaocheng Weng, Shaoru Wang, Tian Tian, Bi‐Feng Yuan, Bing Huang, Lin Zhuang, Xiang Zhou

Journal of the American Chemical Society

DOI

2013

Highly sensitive detection of telomerase based on a DNAzyme strategy

Tian Tian, Shuang Peng, Heng Xiao, Xiaoe Zhang, Shan Guo, Shaoru Wang, Xiang Zhou, Xiang Zhou, Song‐Mei Liu, Xin Hua Zhou, Xin Hua Zhou

Chemical Communications

DOI

2012

基于小分子的核酸结构探针最新研究进展

田沺，肖珩，翁小成，王少儒，周翔

《中国科学:化学》

2012

Sensitive and Convenient Detection of microRNAs Based on Cascade Amplification by Catalytic DNAzymes

Tian Tian, Heng Xiao, Zhengan Zhang, Yuelin Long, Shuang Peng, Shaoru Wang, Xiang Zhou, Xiang Zhou, Song‐Mei Liu, Xin Hua Zhou, Xin Hua Zhou

Chemistry - A European Journal

DOI

2012

Preparation of a Hyper‐cross‐linked Polymer Monolithic Column and Its Application to the Sensitive Determination of Genomic DNA Methylation

Mingluan Chen, Yuli Liu, Xiwen Xing, Xiang Zhou, Yu‐Qi Feng, Bi‐Feng Yuan

Chemistry - A European Journal

DOI

2012

Simultaneously sensitive detection of multiple miRNAs based on a strand displacement amplification

Tian Tian, Heng Xiao, Xiao‐Lian Zhang, Shuang Peng, Xiaoe Zhang, Shan Guo, Shaoru Wang, Song‐Mei Liu, Xin Ming Zhou, Xin Ming Zhou, Craig Meyers, Xiang Zhou, Xiang Zhou

Chemical Communications

DOI

2012

Selective recognition of G–G mismatch using the double functional probe with electrochemical activeferrocenyl

Hanping He, Jingping Xia, Gang Chang, Xiaoqian Peng, Zhaowen Lou, Kazuhiko Nakatani, Xiang Zhou, Shengfu Wang

Biosensors and Bioelectronics

DOI

2012

Selective cleavage of DNA at guanosine bases which locate in DNA non-duplex portions within duplexes by ruthenium(II) complexes

Lin Liu, Qianqian Zhai, Tingting Hong, Yushu Ge, Peng Hu, Xiaocheng Weng, Yi Liu, Xiang Zhou

Inorganica Chimica Acta

DOI

2012

Visual Detection ofrpoBMutations in Rifampin-Resistant Mycobacterium tuberculosis Strains by Use of an Asymmetrically Split Peroxidase DNAzyme

Ming‐Gang Deng, Shuo Feng, Fengling Luo, Shaoru Wang, Xiaoming Sun, Xiang Zhou, Xiao‐Lian Zhang

Journal of Clinical Microbiology

DOI

2012

Structural polymorphism of human telomere G-quadruplex induced by a pyridyl carboxamide molecule

Liang Xu, Zhouxin Xu, Ye Shang, Shuo Feng, Xiang Zhou

Bioorganic & Medicinal Chemistry Letters

DOI

2012

Advancements in Z-DNA: Development of Inducers and Stabilizers for B to Z Transition

Ling Yang, S. Wang, T. Tian, Xiang Zhou

Current Medicinal Chemistry

DOI

2012

Sensitive analysis of DNA methyltransferase based on a hairpin-shaped DNAzyme

Tian Tian, Heng Xiao, Yuelin Long, Xiaoe Zhang, Shaoru Wang, Xiang Zhou, Xiang Zhou, Song‐Mei Liu, Xin Hua Zhou, Xin Hua Zhou

Chemical Communications

DOI

2012

Ag+ and cysteine detection by Ag+–guanine interaction based on graphene oxide and G-quadruplex DNA

Lin Liu, Wenting Liu, Tingting Hong, Xiaocheng Weng, Qianqian Zhai, Xiang Zhou

Analytical Methods

DOI

2012

Studies of the Activity of Peroxidase‐Like DNAzyme by Modifying 3′‐ or 5′‐End of Aptamers

Ming Zhang, Haiqun Li, Ming‐Gang Deng, Xiaocheng Weng, Heng Ma, Shuo Feng, Yangyang Zhou, Xiang Zhou

Chemistry & Biodiversity

DOI

2011

Promoting the formation of tetramolecular G-quadruplexes under freezing condition

Qianqian Zhai, Ming‐Gang Deng, Liang Xu, Xiao‐Lian Zhang, Xiang Zhou

Bioorganic & Medicinal Chemistry Letters

DOI

2011

A pyridyl carboxamide molecule selectively stabilizes DNA G-quadruplex and regulates duplex–quadruplex competition

Liang Xu, Weixin Wu, Jie Ding, Shuo Feng, Xiwen Xing, Ming‐Gang Deng, Xiang Zhou

RSC Advances

DOI

2011

Formation of Sequence‐Independent Z‐DNA Induced by a Ruthenium Complex at Low Salt Concentrations

Zhiguo Wu, Tian Tian, Junping Yu, Xiaocheng Weng, Yi Liu, Xiang Zhou

Angewandte Chemie

DOI

2011

Site‐Specific Recognition of Guanosine by Manganese(III) Corroles in DNA Non‐Duplex Regions through Active Oxygen Transfer

Qianqian Zhai, Liang Xu, Yushu Ge, Tian Tian, Wendi Wu, Shengyong Yan, Yangyang Zhou, Ming‐Gang Deng, Yi Liu, Xiang Zhou

Chemistry - A European Journal

DOI

2011

Dissecting the Strand Folding Orientation and Formation of G-Quadruplexes in Single- and Double-Stranded Nucleic Acids by Ligand-Induced Photocleavage Footprinting

Ke‐wei Zheng, Dan Zhang, Lixia Zhang, Yu‐hua Hao, Xiang Zhou, Zheng Tan

Journal of the American Chemical Society

DOI

2011

Designing label-free DNA sequences to achieve controllable turn-off/on fluorescence response for Hg2+ detection

Zece Zhu, Liang Xu, Xiang Zhou, Jingui Qin, Chuluo Yang

Chemical Communications

DOI

2011

Human telomeric G-quadruplexes undergo dynamic conversion in a molecular crowding environment

Liang Xu, Shuo Feng, Xiang Zhou

Chemical Communications

DOI

2011

Label-free aptamer-based sensors for l-argininamide by using nucleic acid minor groove binding dyes

Zece Zhu, Chuluo Yang, Xiang Zhou, Jingui Qin

Chemical Communications

DOI

2011

Light-driven conformational regulation of human telomeric G-quadruplex DNA in physiological conditions

Xiwen Xing, Xiao-Ling Wang, Liang Xu, Yang Tai, Luyang Dai, Xiaolong Zheng, Wuxiang Mao, Xiaowei Xu, Xiang Zhou

Organic & Biomolecular Chemistry

DOI

2011

Review: Advances in methodology of DNA methylation assay

Tian Tian, Shaoru Wang, Jianguo Wu, Xiang Zhou

Science China Chemistry

DOI

2010

A novel cationic triazatetrabenzcorrole: selective detection of mercury( ii ) by nucleic acid-induced aggregation

Yangyang Zhou, Ming‐Gang Deng, Yuanyuan Du, Shengyong Yan, Rong Huang, Xiaocheng Weng, Chuluo Yang, Xiao‐Lian Zhang, Xiang Zhou

The Analyst

DOI

2010

Quadruplex-Duplex Motifs as New Topoisomerase I Inhibitors

Shuai Li, Ming‐Gang Deng, Dan Zhang, Yangyang Zhou, Xiang Zhou

Nucleosides Nucleotides & Nucleic Acids

DOI

2010

Aptamer-based turn-on fluorescent four-branched quaternary ammonium pyrazine probe for selective thrombin detection

Shengyong Yan, Rong Huang, Yangyang Zhou, Ming Zhang, Ming‐Gang Deng, Xiaolin Wang, Xiaocheng Weng, Xiang Zhou

Chemical Communications

DOI

2010

Highly Selective Suppression of Melanoma Cells by Inducible DNA Cross-Linking Agents: Bis(catechol) Derivatives

Minghui Bai, Jing Huang, Xiaolong Zheng, Zhibin Song, Miru Tang, Wuxiang Mao, Libo Yuan, Jun Wu, Xiaocheng Weng, Xiang Zhou

Journal of the American Chemical Society

DOI

2010

Conformational Switching of G‐Quadruplex DNA by Photoregulation

Xiaolin Wang, Jing Huang, Yangyang Zhou, Shengyong Yan, Xiaocheng Weng, Xiaojun Wu, Ming‐Gang Deng, Xiang Zhou

Angewandte Chemie

DOI

2009

Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition

Yuhao Du, Dan Zhang, Wei Chen, Ming Zhang, Yangyang Zhou, Xiang Zhou

Bioorganic & Medicinal Chemistry

DOI

2009

Pyridyl‐Substituted Corrole Isomers: Synthesis and their Regulation to G‐quadruplex Structures

Heng Ma, Ming Zhang, Dan Zhang, Rong Huang, Yang Zhao, Hao Yang, Yijing Liu, Xiaocheng Weng, Yangyang Zhou, Ming‐Gang Deng, Liang Xu, Xiang Zhou

Chemistry - An Asian Journal

DOI

2009

Synthesis and Anti‐HIV Activity of [ddN]‐[ddN] Dimers and Benzimidazole Nucleoside Dimers

Guorui Li, Jun Liu, Qin Pan, Zhi‐Bin Song, Fengling Luo, Shaoru Wang, Xiao‐Lian Zhang, Xiang Zhou

Chemistry & Biodiversity

DOI

2009

Molecular modeling study of binding site selectivity of TQMP to G-quadruplex DNA

Aixiao Li, François Maurel, Florent Barbault, Michel Delamar, Baoshan Wang, Xiang Zhou, Wang Ping

European Journal of Medicinal Chemistry

DOI

2009

High fluorescence selectivity and visual detection ofG-quadruplex structures by a novel dinuclear ruthenium complex

Liang Xu, Dan Zhang, Jing Huang, Ming‐Gang Deng, Ming Zhang, Xiang Zhou

Chemical Communications

DOI

2009

Oligonucleotide-selenide conjugate: Synthesis and its inducible sequence-specific alkylation of DNA

Yuhao Du, Xiaocheng Weng, Jing Huang, Dan Zhang, Heng Ma, Dong Chen, Xiang Zhou, Jean‐François Constant

Bioorganic & Medicinal Chemistry

DOI

2009

Visual observation of G-quadruplex DNA with the label-free fluorescent probe silole with aggregation-induced emission

Jing Huang, Ming Wang, Yangyang Zhou, Xiaocheng Weng, Liang Shuai, Xiang Zhou, Deqing Zhang

Bioorganic & Medicinal Chemistry

DOI

2009

Some cationic porphyrins: synthesis, stabilization of G-quadruplexes, and down-regulation ofc-mycin Hep G2 cells

Shao R. Wang, Dan Zhang, Feng L. Luo, Lin Liu, Xiao C. Weng, Jing Huang, Guo R. Li, Xiao L. Zhang, Xiang Zhou

Journal of Porphyrins and Phthalocyanines

DOI

2009

The Sensitive and Selective Optical Detection of Mercury(II) Ions by Using a Phosphorothioate DNAzyme Strategy

Dan Zhang, Ming‐Gang Deng, Liang Xu, Yangyang Zhou, Jing Yuwen, Xiang Zhou

Chemistry - A European Journal

DOI

2009

Sensitive and Visual Detection of Adenosine by a Rationally Designed FokI‐Based Biosensing Strategy

Ming Zhang, Jing Huang, Ming‐Gang Deng, Xiaocheng Weng, Heng Ma, Xiang Zhou

Chemistry - An Asian Journal

DOI

2009

Cationic Ester Porphyrins Cause High Levels of Phototoxicity in Tumor Cells and Induction of Apoptosis in HeLa Cells

Lin Wu, Yang Li, Jing Huang, Lixia Zhang, Xiaocheng Weng, Xiao‐Lian Zhang, Chao Shen, Xiang Zhou, Congyi Zheng

Chemistry & Biodiversity

DOI

2009

Cationic Porphyrins and Analogues as New DNA Topoisomerase I and II Inhibitors

Shuai Li, Shaoru Wang, Lixia Zhang, Boqiao Fu, Xiang Zhou

Chemistry & Biodiversity

DOI

2009

Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomereG-quadruplex

Jing Huang, Guorui Li, Zhiguo Wu, Zhibin Song, Yangyang Zhou, Liang Shuai, Xiaocheng Weng, Xiang Zhou, Guang‐Fu Yang

Chemical Communications

DOI

2008

Highly Effective Colorimetric and Visual Detection of Nucleic Acids Using an Asymmetrically Split Peroxidase DNAzyme

Ming‐Gang Deng, Dan Zhang, Yangyang Zhou, Xiang Zhou

Journal of the American Chemical Society

DOI

2008

Cationic Metal–Corrole Complexes: Design, Synthesis, and Properties of Guanine‐Quadruplex Stabilizers

Boqiao Fu, Dan Zhang, Xiaocheng Weng, Ming Zhang, Heng Ma, Yuzhi Ma, Xiang Zhou

Chemistry - A European Journal

DOI

2008

Octa-Substituted Anionic Porphyrins: Topoisomerase I Inhibition and Tumor Cell Apoptosis Induction

Baoping Zhai, Shuai Li, Li Yang, Xiaocheng Weng, Lin Wu, Shaoru Wang, Tian Tian, Xiaojun Wu, Xiang Zhou, Congyi Zheng

Bioconjugate Chemistry

DOI

2008

Synthesis and Oxidation‐Induced DNA Cross‐Linking Capabilities of Bis(catechol) Quaternary Ammonium Derivatives

Zhibin Song, Xiaocheng Weng, Liwei Weng, Jing Huang, Xiaolin Wang, Minghui Bai, Yangyang Zhou, Guang‐Fu Yang, Xiang Zhou

Chemistry - A European Journal

DOI

2008

Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand

Guorui Li, Jing Huang, Ming Zhang, Yangyang Zhou, Dan Zhang, Zhiguo Wu, Shaoru Wang, Xiaocheng Weng, Xiang Zhou, Guang‐Fu Yang

Chemical Communications

DOI

2008

Synthesis and DNA‐Recognition and ‐Cleavage Properties of Multiply Charged Porphyrin Esters

Lin Wu, Peng Hu, Ying Xiao, Ming Zhang, Lixia Zhang, Xiaocheng Weng, Xiaojun Wu, Xiang Zhou, Xiao‐Ping Cao

Chemistry & Biodiversity

DOI

2007

Synthesis and evaluation of cationic phthalocyanine derivatives as potential inhibitors of telomerase

Lixia Zhang, Jing Huang, Lige Ren, Minghui Bai, Lin Wu, Baoping Zhai, Xiang Zhou

Bioorganic & Medicinal Chemistry

DOI

2007

Synthesis and Biological Studies of Inducible DNA Cross‐Linking Agents

Xiaocheng Weng, Lige Ren, Liwei Weng, Jing Huang, Shugao Zhu, Xiang Zhou, Linhong Weng

Angewandte Chemie

DOI

2007

Specific Recognition of Loop DNA by Dicationic Porphyrins

Xiaocheng Weng, Jing Huang, Song Wu, Lige Ren, Liwei Weng, Shugao Zhu, Xiang Zhou

Chemistry & Biodiversity

DOI

2007

Quaternary Ammonium Zinc Phthalocyanine: Inhibiting Telomerase by Stabilizing G quadruplexes and Inducing G‐Quadruplex Structure Transition and Formation

Lige Ren, Anming Zhang, Jing Huang, Ping Wang, Xiaocheng Weng, Lixia Zhang, Feng Liang, Zheng Tan, Xiang Zhou

ChemBioChem

DOI

2007

A Water‐Soluble, Octacationic Zinc Phthalocyanine as Molecular Probe for Nucleic Acid Secondary Structure

An‐Ming Zhang, Jing Huang, Xiaocheng Weng, Jin‐Xi Li, Lige Ren, Zhi‐Bin Song, Xiaoqin Xiong, Xiang Zhou, Xiao‐Ping Cao, Yan Zhou

Chemistry & Biodiversity

DOI

2007

Cationic corrole derivatives: a new family of G-quadruplex inducing and stabilizing ligands

Boqiao Fu, Jing Huang, Lige Ren, Xiaocheng Weng, Yangyang Zhou, Yuhao Du, Xiaojun Wu, Xiang Zhou, Guang‐Fu Yang

Chemical Communications

DOI

2006

A Phenol Quaternary Ammonium Porphyrin as a Potent Telomerase Inhibitor by Selective Interaction with Quadruplex DNA

Ping Wang, Lige Ren, Hanping He, Feng Liang, Xiang Zhou, Zheng Tan

ChemBioChem

DOI

2006

Synthesis of some multi-β-substituted cationic porphyrins and studies on their interaction with DNA

Bo Chen, Song Wu, Aixiao Li, Feng Liang, Xiang Zhou, Xiao‐Ping Cao, Zhike He

Tetrahedron

DOI

2006

DNA hydrolysis promoted by 1,7-dimethyl-1,4,7,10-tetraazacyclododecane

Shuhui Wan, Feng Liang, Xiaoqin Xiong, Yang Li, Xiaojun Wu, Ping Wang, Xiang Zhou, Chengtai Wu

Bioorganic & Medicinal Chemistry Letters

DOI

2006

Phenol quaternary ammonium derivatives: charge and linker effect on their DNA photo-inducible cross-linking abilities

Yang Song, Tian Tian, Ping Wang, Hanping He, Wulue Liu, Xiang Zhou, Xiao‐Ping Cao, Xiao‐Lian Zhang, Xin Hua Zhou

Organic & Biomolecular Chemistry

DOI

2005

Dicationic pyridium porphyrins appending different peripheral substituents: Synthesis and studies for their interactions with DNA

Song Wu, Zheng Li, Lige Ren, Bo Chen, Feng Liang, Xiang Zhou, Tao Jia, Xiao‐Ping Cao

Bioorganic & Medicinal Chemistry

DOI

2005

Biological studies of photoinducible phenol quaternary ammonium derivatives

Yang Song, Ping Wang, Juanjuan Wu, Xiang Zhou, Xiao‐Lian Zhang, Linhong Weng, Xiao‐Ping Cao, Feng Liang

Bioorganic & Medicinal Chemistry Letters

DOI

2005

Combination of porphyrins and DNA-alkylation agents: Synthesis and tumor cell apoptosis induction

Hanping He, Yan Ni Zhou, Feng Liang, Dongqing Li, Juanjuan Wu, Yang Li, Xiang Zhou, Xiao‐Lian Zhang, Xiao‐Ping Cao

Bioorganic & Medicinal Chemistry

DOI

2005

Assembling zwitterionic, water-soluble porphyrin and its biological studies

Zhihang Chen, Bo Chen, Zhe-Xue Lu, Dai‐Wen Pang, Yang Song, MA Hong-juan, Xiang Zhou, Xiao‐Lian Zhang, Xiaojun Wu, Yuhao Du

Wuhan University Journal of Natural Sciences

DOI

2004

Peripheral Substituents of Di(pyridiumyl)porphyrins Affected on Their Interactions with DNA.

Song Wu, Ping Q. Wang, Tian Tian, Lin Wu, Hanping He, Xiang Zhou, Xiao‐Lian Zhang, Xiao‐Ping Cao

ChemInform

DOI

2004

Porphyrin?DNA cross-linking agent hybrids: chemical synthesis and biological studies

Hanping He, Tian Tian, Ping Wang, Lin Wu, Jingjing Xu, Xiang Zhou, Xiao‐Lian Zhang, Xiao‐Ping Cao, Xiaojun Wu

Bioorganic & Medicinal Chemistry Letters

DOI

2004

Peripheral substituents of di(pyridiumyl)porphyrins affected on their interactions with DNA

Song Wu, Ping Wang, Tian Tian, Lin Wu, Hanping He, Xiang Zhou, Xiao‐Lian Zhang, Xiao‐Ping Cao

Bioorganic & Medicinal Chemistry Letters

DOI

2003

Synthesis of β-substituted cationic porphyrins and their interactions with DNA

Bo Chen, Wen Qin, Ping Wang, Tian Tian, MA Hong-juan, Xiao‐Ping Cao, Xiaojun Wu, Xiang Zhou, Xiao‐Lian Zhang, Fang Liu, Fang Zheng, Xia Li

Bioorganic & Medicinal Chemistry Letters

DOI

2003

Corrigendum to “Synthesis and antibacterial study of 10, 15, 20-Triphenyl-5-{4-hydroxy-3-(tri-methylammonium)methyl} phenylporphyrin as models for combination of porphyrin and alkylating agent” [Bioorg. Med. Chem. Lett. 13 (2003) 1097]†

Jianye Zhang, Xiaojun Wu, Xiao‐Ping Cao, Fan Yang, Jiangfeng Wang, Xiang Zhou, Xiao‐Lian Zhang

Bioorganic & Medicinal Chemistry Letters

DOI

2003

Synthesis and antibacterial study of 10, 15, 20-triphenyl-5-{4-hydroxy-3-(trimethylammonium)methyl}phenylporphyrin as models for combination of porphyrin and alkylating agent

Jiangye Zhang, Xiaojun Wu, Xiao‐Ping Cao, Fan Yang, Jiangfeng Wang, Xiang Zhou, Xiao‐Lian Zhang

Bioorganic & Medicinal Chemistry Letters

DOI

2003

A Potent, Water-Soluble and Photoinducible DNA Cross-Linking Agent

Ping Wang, Renpeng Liu, Xiaojun Wu, MA Hong-juan, Xiao‐Ping Cao, Ping Zhou, Jiangye Zhang, Xiaocheng Weng, Xiao‐Lian Zhang, Jun Qi, Xiang Zhou, Linhong Weng

Journal of the American Chemical Society

DOI

精选作品

期刊论文

核酸修饰驱动的分子医学:现状、挑战与机遇

Targeted detection method for locus-specific m 6 A modifications in low-abundance transcripts based on chemical conversion

Photocatalytic Proximity Labeling Maps RNA and Protein Subcellular Landscapes

Metal–Organic Framework as a Bioorthogonal Catalyst for Gene Editing

Development of the First YTHDC1 Degrader with Improved Antileukemia Activity

Simultaneous single-base resolution profiling of 5mC and 5hmC using BRIGHT-seq

Harnessing a single molecule for dual bioorthogonal regulation of RNA function and m6A methylation

Chemical-Assisted Ligation-qPCR for Locus-Specific Detection of RNA N 4 -Acetylcytidine and 5-Formylcytidine

Advantages and Challenges of G-Quadruplexes in Regulating Alternative Splicing

Dynamic Control of RNA Structure and Function through Bioorthogonal Staudinger Chemistry

Nanobody-Tethered Transposition for Dual Profiling of Histone Modification and DNA Methylation

A catalyst-free bioorthogonal reaction for malononitrile addition to azodicarboxylates

Mechanistic Insights into the Borane-Mediated Conversion of 5-Carboxylcytosine to Dihydrouracil in DNA Enable an Efficient Labeling Method Using Alkoxyamines

Whole-genome methylation profiling of extracellular vesicle DNA in gastric cancer identifies intercellular communication features

Author Correction: In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes

In situ proximity labeling of proteins associated with circRNA and RNA G-quadruplexes

Single-cell imaging of N 4-acetylcytidine-modified RNA using fluorine metabolic labeling mediated proximity ligation assay

Developments of the mDZ-RhoBAST Probe for Super-Resolution Imaging of FTO Demethylation in Live Cells

Unveiling the clinical significance of RNA pseudouridine in colorectal cancer

Innovative Chemical Strategies for Advanced CRISPR Modulation

Selict-seq profiles genome-wide off-target effects in adenosine base editing

Enhanced or reversible RNA N6-methyladenosine editing by red/far-red light induction

Customized Controllable Pyrophosphate Nanosensor Based on Lanthanide Metal–Organic Frameworks for Accurate and Sensitive Detection of Nucleic Acids

NSUN2-mediated HCV RNA m5C Methylation Facilitates Viral RNA Stability and Replication

Strategic base modifications refine RNA function and reduce CRISPR–Cas9 off-targets

Unraveling the Cleavage Reaction of Hydroxylamines with Cyclopropenones Considering Biocompatibility

Reducing CRISPR-Cas9 off-target effects by optically controlled chemical modifications of guide RNA

Unveiling a Potent Small Molecule Disruptor for RNA G-Quadruplexes Tougher Than DNA G-Quadruplex Disruption

Rapid degradation of DHX36 revealing its transcriptional role by interacting with G‐quadruplex

Programmable Lanthanide Metal–Organic Framework for Ultra-Efficient Nucleic Acids Extraction and Interaction Analysis

HCV 5-Methylcytosine Enhances Viral RNA Replication through Interaction with m5C Reader YBX1

A bisulfite-assisted and ligation-based qPCR amplification technology for locus-specific pseudouridine detection at base resolution

Developing nucleoside tailoring strategies against SARS-CoV-2 via ribonuclease targeting chimera

Identification of G-quadruplex-interacting proteins in living cells using an artificial G4-targeting biotin ligase

Regulating CRISPR /Cas9 Using Streptavidin‐Biotin Interactions†

Cellular Metabolic Labeling of Nucleic Acids and Its Applications

Recent advances in design strategies of aptamer‐based liquid biopsy

Locus-specific detection of pseudouridine with CRISPR-Cas13a

Steric hindrance of N 6 -methyl in m 6 A and its application for specific loci detection

Exonuclease-assisted enrichment and base resolution analysis of pseudouridine in single-stranded RNA

核酸修饰与编辑的化学生物学前沿专辑

Circulating nucleic acids as liquid biopsies for disease prediction, screening and diagnosis

Preface: special issue celebrating the 130th anniversary of Wuhan University

中国蛋白质、核酸与糖类等的合成、修饰、功能与调控领域发展现状和未来挑战

Method for the extraction of circulating nucleic acids based on MOF reveals cell-free RNA signatures in liver cancer

Antibody-Free Fluorine-Assisted Metabolic Sequencing of RNA N 4‑Acetylcytidine

Detection, Clinical Application, and Manipulation of RNA Modifications

Nanoporous Crystalline Materials for the Recognition and Applications of Nucleic Acids

G-quadruplex in hepatitis B virus pregenomic RNA promotes its translation

Disease Diagnosis Based on Nucleic Acid Modifications

Isonitrile-Tetrazine Click-and-Release Chemistry for Controlling RNA-Guided Nucleic Acid Cleavage

Transcriptome-wide profiling of A-to-I RNA editing by Slic-seq

Mesoporous Metal–Organic Frameworks for Catalytic RNA Deprotection and Activation

Extremely Large 3D Cages in Metal–Organic Frameworks for Nucleic Acid Extraction

Utilizing Epigenetic Modification as a Reactive Handle To Regulate RNA Function and CRISPR-Based Gene Regulation

The Transcriptome-Wide Mapping of 2-Methylthio-N6-isopentenyladenosine at Single-Base Resolution

A CRISPR-Cas and Tat Peptide with Fluorescent RNA Aptamer System for Signal Amplification in RNA Imaging

NSUN2-mediated m 5 C methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections

Chemical Control of CRISPR Gene Editing via Conditional Diacylation Crosslinking of Guide RNAs

Engineered aptamers for molecular imaging

Transcriptome-wide identification of single-stranded RNA binding proteins

N6‐methyladenine profiling of low‐input multiplex clinical samples on transcriptome reveals RNA modifications implicated in type 2 diabetes and acute myocardial infarction

The development of an iridium(III) complex functionalized G-quadruplex probe for the stability of G-quadruplex and lifetime image in cytoplasm

Construction of an Autocatalytic Hybridization Assembly Circuit for Amplified In Vivo MicroRNA Imaging

Recent Advances in Exosomal miRNA Biosensing for Liquid Biopsy

G-quadruplex-guided RNA engineering to modulate CRISPR-based genomic regulation

Determination of 5‐Formyluracil via Oxime‐Based Nucleotide‐Metal Coordination

N 6 -Methyladenosine and Its Implications in Viruses

A chemical CRISPR off switch efficiently controls gene editing

Inert Pepper aptamer-mediated endogenous mRNA recognition and imaging in living cells

Hydrogen Peroxide‐triggered Chemical Strategy for Controlling CRISPR systems

Rational guide RNA engineering for small-molecule control of CRISPR/Cas9 and gene editing

6-Iodopurine as a Versatile Building Block for RNA Purine Architecture Modifications

Supramolecular CRISPR-OFF switches with host–guest chemistry

Live-cell RNA imaging using the CRISPR-dCas13 system with modified sgRNAs appended with fluorescent RNA aptamers

Transcriptome-wide profiling of N 6 -methyladenosine via a selective chemical labeling method

Labeling and sequencing nucleic acid modifications using bio-orthogonal tools

Norbornene-tetrazine ligation chemistry for controlling RNA-guided CRISPR systems