陈卫民｜暨南大学｜学者主页

2026

Cyclic Diguanylate G-Quadruplex Inducer-Siderophore Hybrids as Bifunctional Antibiofilm Agents against Pseudomonas aeruginosa.

Ye-Si Huang, Jing Liu, Mei-Yan Huang, Yu-Jing Wang, Weimin Chen, Jing Lin

Journal of Medicinal Chemistry

DOI

2026

A review of antimicrobial peptides: Discovery, design strategies, and translational applications

Tong-Tong Chen, Bao‐Zhang Luo, Bing‐Hui Li, Chang-Ming Li, Tao Xie, Wei‐Min Chen, Jialiang Guo, Yuan‐Yuan Wang

European Journal of Medicinal Chemistry

DOI

2025

Discovery of Dual-Acting Biofilm Inhibitors against Pseudomonas aeruginosa by the Coupling of 3-Hydroxypyridin-4(1H)-ones with N-Phenylamide QS Inhibitors.

Hao-Zhong Long, Wei Tang, Mei-Yan Huang, Guo-Bin Yang, Xibing Hu, Ya-Ting Liu, Xiaoting Mo, Jing Lin, Weimin Chen, Jun Liu

Journal of Medicinal Chemistry

DOI

2025

Identification of ferredoxin PA1551 as an antibacterial synergistic target for biofilm inhibitors against Pseudomonas aeruginosa

Jun Liu, An-Min Ren, Zhi-Ying Miao, Tian Zhou, Chenhui Zhang, Yiqun Chang, Siyu Zhao, Xibing Hu, Xiao-Yi Zhang, Tian-Yuan Jia, Zhao Cai, Zheng-Qiu Li, Jing Lin, Liang Yang, Weimin Chen

npj Biofilms and Microbiomes

DOI

2025

Natural sideromycins and siderophore-conjugated natural products as inspiration for novel antimicrobial agents.

Zhi-Ying Miao, Jing Lin, Weimin Chen

European journal of medicinal chemistry

DOI

2025

Discovery of 3-hydroxypyridin-4(1H)-ones ester of ciprofloxacin as prodrug to combat biofilm-associated Pseudomonas aeruginosa.

Yuan-Yuan Wang, Bao-Zhang Luo, Chang-Ming Li, Jian-Long Liang, Zheng Liu, Weimin Chen, Jia-Liang Guo

European journal of medicinal chemistry

DOI

2024

Cyclic Diguanylate G-Quadruplex Inducer-Quorum Sensing Inhibitor Hybrids as Bifunctional Anti-biofilm and Anti-virulence Agents Against Pseudomonas aeruginosa.

Jie-Jia Liu, Jing Liu, Ye-Si Huang, Weimin Chen, Jing Lin

Journal of Medicinal Chemistry

DOI

2024

Hybrids of 3-Hydroxypyridin-4(1H)-ones and Long-Chain 4-Aminoquinolines as Potent Biofilm Inhibitors of Pseudomonas aeruginosa Potentiate Tobramycin and Polymyxin B Activity.

Zhi-Ying Miao, Xiao-Yi Zhang, Hao-Zhong Long, Jing Lin, Weimin Chen

Journal of Medicinal Chemistry

DOI

2024

Cajaninstilbene acid derivatives conjugated with siderophores of 3-hydroxypyridin-4(1H)-ones as novel antibacterial agents against Gram-negative bacteria based on the Trojan horse strategy.

Yong-jun Huang, Yi-Peng Zang, Lin-Jie Peng, Ming-Han Yang, Jing Lin, Weimin Chen

European journal of medicinal chemistry

DOI

2024

Exploring the Localization of Siderophore-Mediated Cargo Delivery in Gram-Negative Bacteria Using 3-Hydroxypyridin-4(1H)-one-Fluorescein Probes.

Yong-jun Huang, Ming-Han Yang, Ling-Yin Lin, Jun Liu, Yi-Peng Zang, Jing Lin, Weimin Chen

ACS Infectious Diseases

DOI

2023

3-Hydroxypyridin-4(1H)-one Derivatives as pqs Quorum Sensing Inhibitors Attenuate Virulence and Reduce Antibiotic Resistance in Pseudomonas aeruginosa.

Zhi-Ying Miao, Xiao-Yi Zhang, Ming-Han Yang, Yong-jun Huang, Jing Lin, Weimin Chen

Journal of Medicinal Chemistry

DOI

2023

Cyclic Diguanylate G-Quadruplex Inducer-Nitric Oxide Donor Conjugate as a Bifunctional Antibiofilm Agent and Antibacterial Synergist against Pseudomonas aeruginosa with a Hyperbiofilm Phenotype

Qianwen Lin, Jinqiang Lu, Ye-Si Huang, J.R. Liu, Wei‐Min Chen, Jing Lin

Journal of Medicinal Chemistry

DOI

2023

Design, synthesis and biological evaluation of novel 3-hydroxypyridin-4(1H)-ones based hybrids as Pseudomonas aeruginosa biofilm inhibitors

Jun Liu, Ying Meng, Ming-Han Yang, Xiaoyi Zhang, Jianfu Zhao, Pinghua Sun, Wei‐Min Chen

European Journal of Medicinal Chemistry

DOI

2023

3-Hydroxy-pyridin-4(1H)-ones as siderophores mediated delivery of isobavachalcone enhances antibacterial activity against pathogenic Pseudomonas aeruginosa

Yong-Jun Huang, Xiao-Lin Zhong, Yi-Peng Zang, Minghan Yang, Jing Lin, Wei‐Min Chen

European Journal of Medicinal Chemistry

DOI

2023

Design and Synthesis of 3-Hydroxy-pyridin-4(1 H )-ones–Ciprofloxacin Conjugates as Dual Antibacterial and Antibiofilm Agents against Pseudomonas aeruginosa

Yuan‐Yuan Wang, Xiaoyi Zhang, Xiao-Lin Zhong, Yong-Jun Huang, Jing Lin, Wei‐Min Chen

Journal of Medicinal Chemistry

DOI

2022

Design and synthesis of caffeic acid derivatives and evaluation of their inhibitory activity against Pseudomonas aeruginosa

Yun-feng Zeng, Ya-lun Su, Weiliang Liu, Hong-geng Chen, Shaogao Zeng, Haibo Zhou, Wei‐Min Chen, Junxia Zheng, Pinghua Sun

Medicinal Chemistry Research

DOI

2021

New Pqs Quorum Sensing System Inhibitor as an Antibacterial Synergist against Multidrug-Resistant Pseudomonas aeruginosa

Jun Liu, Jinsong Hou, Yiqun Chang, Lijun Peng, Xiaoyi Zhang, Zhi-Ying Miao, Pinghua Sun, Jing Lin, Wei‐Min Chen

Journal of Medicinal Chemistry

DOI

2021

Design and Synthesis of Novel c-di-GMP G-Quadruplex Inducers as Bacterial Biofilm Inhibitors

Teng-Fei Xuan, Ziqiang Wang, Jun Liu, Haitao Yu, Qianwen Lin, Wei‐Min Chen, Jing Lin

Journal of Medicinal Chemistry

DOI

2021

Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms

Jiahui Yu, Xiaofang Xu, Wen Sheng Hou, Ying Meng, Meiyan Huang, Jing Lin, Wei‐Min Chen

European Journal of Medicinal Chemistry

DOI

2020

Research Progress of Antibiotics Conjugated with Siderophores

Jun Liu, Jinsong Hou, Ying Meng, Zhi-Ying Miao, Jing Lin, Weimin Chen

Youji huaxue

DOI

2020

Novel 2-Substituted 3-Hydroxy-1,6-dimethylpyridin-4(1H)-ones as Dual-Acting Biofilm Inhibitors of Pseudomonas aeruginosa

Jun Liu, Jinsong Hou, Yibin Li, Zhi-Ying Miao, Pinghua Sun, Jing Lin, Wei‐Min Chen

Journal of Medicinal Chemistry

DOI

2020

Biological evaluation and chemoproteomics reveal potential antibacterial targets of a cajaninstilbene-acid analogue

Kuo Lu, Wen Sheng Hou, Xiaofang Xu, Qi Chen, Zhengqiu Li, Jing Lin, Wei‐Min Chen

European Journal of Medicinal Chemistry

DOI

2020

Induction of differentiation of the acute myeloid leukemia cell line (HL-60) by a securinine dimer

Wen Sheng Hou, Zhenya Wang, Jing Lin, Wei‐Min Chen

Cell Death Discovery

DOI

2020

Cajaninstilbene acid analogues as novel quorum sensing and biofilm inhibitors of Pseudomonas aeruginosa

Zhi-Xing Huang, Jiahui Yu, Xingjun Xu, Xiaofang Xu, Ting Zeng, Jing Lin, Wei‐Min Chen

Microbial Pathogenesis

DOI

2020

Fluorescent Detection of the Ubiquitous Bacterial Messenger 3′,5′ Cyclic Diguanylic Acid by Using a Small Aromatic Molecule

Teng-Fei Xuan, Jun Liu, Ziqiang Wang, Wei‐Min Chen, Jing Lin

Frontiers in Microbiology

DOI

2020

A fluorescence-based high-throughput screening method for determining the activity of diguanylate cyclases and c-di-GMP phosphodiesterases

Ziqiang Wang, Teng-Fei Xuan, Jun Liu, Wei‐Min Chen, Jing Lin

RSC Advances

DOI

2019

Novel virosecurinine bivalent mimetics as potent reversal agents against P-glycoprotein-mediated multidrug resistance

Wen Sheng Hou, Ying Meng, Xiaofang Xu, Zhi-Xing Huang, Jun Liu, Zhenya Wang, Jing Lin, Wei‐Min Chen

European Journal of Medicinal Chemistry

DOI

2019

Design, synthesis and evaluation of halogenated furanone derivatives as quorum sensing inhibitors in Pseudomonas aeruginosa

Yiqun Chang, Pengcheng Wang, Hong-Ming Ma, Siyu Chen, Yuhang Fu, Yuan-Yuan Liu, Xuan Wang, Guangchao Yu, Tao Huang, David E. Hibbs, Haibo Zhou, Wei‐Min Chen, Jing Lin, Chao Wang, Junxia Zheng, Pinghua Sun

European Journal of Pharmaceutical Sciences

DOI

2019

Novel 2, 8-bit derivatives of quinolines attenuate Pseudomonas aeruginosa virulence and biofilm formation

Man-Na Qiu, Fang Wang, Siyu Chen, Pengcheng Wang, Yuhang Fu, Yuanyuan Liu, Xuan Wang, Fan-Bei Wang, Chao Wang, Yang Hong-wen, Yang‐Chang Wu, Shiying Zhu, Haibo Zhou, Wei‐Min Chen, Jing Lin, Junxia Zheng, Pinghua Sun

Bioorganic & Medicinal Chemistry Letters

DOI

2019

Alopecuroides A–E, Matrine-Type Alkaloid Dimers from the Aerial Parts of Sophora alopecuroides

Chun‐Lin Fan, Yubo Zhang, Ye Chen, Pei Xie, Guo‐Cai Wang, Hai‐Yan Tian, Yao-Lan Li, Xiao‐Jun Huang, Xiao‐Qi Zhang, Zhi-Yong Li, Jun-Shan Liu, Wen‐Cai Ye, Wei‐Min Chen

Journal of Natural Products

DOI

2019

Novel benzyl phenyl sulfide derivatives as antibacterial agents against methicillin-resistant Staphylococcus aureus

Kuo Lu, Qi Chen, Xiaofang Xu, Ying Meng, Jing Lin, Wei‐Min Chen

The Journal of Antibiotics

DOI

2019

Design and synthesis of 2‐hydroxyl‐4‐methoxyl‐3‐(3‐methylbut‐2‐en‐1‐yl)‐6‐(4‐phenylbenzoylamino)benzoic acid derivatives as antibacterial agents based on cajaninstilbene acid scaffold hopping

Chang Zheng, Wen Sheng Hou, Jun Liu, Xiaofang Xu, Jing Lin, Pinghua Sun, Wei‐Min Chen

Drug Development Research

DOI

2019

A facile synthesis of cajaninstilbene acid and its derivatives

Qi Chen, Kuo Lu, Chang Zheng, Xiaofang Xu, Jing Lin, Wei‐Min Chen

Chinese Chemical Letters

DOI

2018

Design, synthesis and biological evaluation of 2-substituted 3-hydroxy-6-methyl-4H-pyran-4-one derivatives as Pseudomonas aeruginosa biofilm inhibitors

Yibin Li, Jun Liu, Zhi-Xing Huang, Jiahui Yu, Xiaofang Xu, Pinghua Sun, Jing Lin, Wei‐Min Chen

European Journal of Medicinal Chemistry

DOI

2018

Hybrids of arenobufagin and benzoisoselenazol reducing the cardiotoxicity of arenobufagin

Wen Sheng Hou, Zhi-Xing Huang, Hong‐Gui Xu, Jing Lin, Dongmei Zhang, Qun-Long Peng, Hui Lin, Yiqun Chang, Long-Hai Wang, Zhe Yao, Pinghua Sun, Wei‐Min Chen

Bioorganic & Medicinal Chemistry Letters

DOI

2018

Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System

Xingjun Xu, Ting Zeng, Zhi-Xing Huang, Xiaofang Xu, Jing Lin, Wei‐Min Chen

Journal of Natural Products

DOI

2018

A Bivalent Securinine Compound SN3-L6 Induces Neuronal Differentiation via Translational Upregulation of Neurogenic Transcription Factors

Yumei Liao, Xiaoji Zhuang, Xiaojie Huang, Yinghui Peng, Xuanyue Ma, Zhi-Xing Huang, Feng Liu, Junyu Xu, Ying Wang, Wei‐Min Chen, Wen‐Cai Ye, Lei Shi

Frontiers in Pharmacology

DOI

2018

Design, synthesis and biological evaluation of novel 5-hydroxy-2-methyl-4 H -pyran-4-one derivatives as antiglioma agents

Yibin Li, Wen Sheng Hou, Hui Lin, Pinghua Sun, Jing Lin, Wei‐Min Chen

MedChemComm

DOI

2017

“双链”融合创新教学模式在药物化学实验教学中的应用

林静，郭嘉亮，彭丽洁，陈卫民，丁克，孙平华

《药学教育》

2017

4-arylamidobenzyl substituted 5-bromomethylene-2(5 H )-furanones for chronic bacterial infection

Xingjun Xu, Fang Wang, Ting Zeng, Jing Lin, Jun Liu, Yiqun Chang, Pinghua Sun, Wei‐Min Chen

European Journal of Medicinal Chemistry

DOI

2017

Fibroblast Activation Protein α Activated Tripeptide Bufadienolide Antitumor Prodrug with Reduced Cardiotoxicity

Lijuan Deng, Long-Hai Wang, Cheng-Kang Peng, Yibin Li, Maohua Huang, Minfeng Chen, Xueping Lei, Ming Qi, Yun Cen, Wen‐Cai Ye, Dongmei Zhang, Wei‐Min Chen

Journal of Medicinal Chemistry

DOI

2017

Strigolactones: a plant phytohormone as novel anti-inflammatory agents

Junxia Zheng, Yushui Han, Jincai Wang, Hui Yang, Hao Kong, Kang-Jia Liu, Siyu Chen, Yirui Chen, Yiqun Chang, Wei‐Min Chen, Jialiang Guo, Pinghua Sun

MedChemComm

DOI

2017

Iodine‐Catalyzed Azidation/Cyclization Cascade Approach to 3a‐Azidofuroindolines and ‐pyrroloindolines under Mild Conditions

Jiajing Guo, Siyu Chen, Jingyuan Liu, Jialiang Guo, Wei‐Min Chen, Qian Cai, Peijun Liu, Pinghua Sun

European Journal of Organic Chemistry

DOI

2017

Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase

Xingjun Xu, Hye‐Sun Kim, Wei‐Min Chen, Xiang Ma, G.J. Correy, Martin G. Banwell, Colin J. Jackson, Anthony C. Willis, Paul D. Carr

European Journal of Organic Chemistry

DOI

2017

Novel bivalent securinine mimetics as topoisomerase I inhibitors

Wen Sheng Hou, Hui Lin, Zhenya Wang, Martin G. Banwell, Ting Zeng, Pinghua Sun, Jing Lin, Wei‐Min Chen

MedChemComm

DOI

2016

Novel 4-(4-substituted amidobenzyl)furan-2(5H)-one derivatives as topoisomerase I inhibitors

Cheng-Kang Peng, Ting Zeng, Xingjun Xu, Yiqun Chang, Wen Hou, Kuo Lu, Hui Lin, Pinghua Sun, Jing Lin, Wei‐Min Chen

European Journal of Medicinal Chemistry

DOI

2016

Novel securinine derivatives as topoisomerase I based antitumor agents

Wen Hou, Zhenya Wang, Cheng-Kang Peng, Jing Lin, Xin Liu, Yiqun Chang, Jun Hui Xu, Ren‐Wang Jiang, Hui Lin, Pinghua Sun, Wei‐Min Chen

European Journal of Medicinal Chemistry

DOI

2016

A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells

Nan Yao, Yingjie Li, Yuhe Lei, Nan Hu, Wei‐Min Chen, Zhe Yao, Miao Yu, Junshan Liu, Wen‐Cai Ye, Dongmei Zhang

Journal of Experimental & Clinical Cancer Research

DOI

2016

Design and Synthesis of Dimeric Securinine Analogues with Neuritogenic Activities

Genyun Tang, Xin Liu, Nan Ma, Xiaojie Huang, Zhen‐Long Wu, Wen Zhang, Ying Wang, Bing‐Xin Zhao, Zhenya Wang, Fanny C.F. Ip, Nancy Y. Ip, Wen‐Cai Ye, Lei Shi, Wei‐Min Chen

ACS Chemical Neuroscience

DOI

2016

3D-QSAR and docking studies on 1-hydroxypyridin-2-one compounds as mutant isocitrate dehydrogenase 1 inhibitors

Zhenya Wang, Yiqun Chang, Yushui Han, Kang-Jia Liu, Jinsong Hou, Chengli Dai, Yuanhao Zhai, Jialiang Guo, Pinghua Sun, Jing Lin, Wei‐Min Chen

Journal of Molecular Structure

DOI

2016

Design, Synthesis and Antibacterial Assay of Pinosylvin Acid Derivatives

Wen Hou, Pinghua Sun, Zhi-Zhong Geng, Hong‐Gui Xu, Jing Lin, Wei‐Min Chen

Journal of Pharmaceutical and Biomedical Sciences

2016

Anti-Inflammatory Effects of Cajaninstilbene Acid and Its Derivatives

Meiyan Huang, Jing Lin, Kuo Lu, Hong‐Gui Xu, Zhi-Zhong Geng, Pinghua Sun, Wei‐Min Chen

Journal of Agricultural and Food Chemistry

DOI

2016

Design, synthesis and anti-inflammatory effects of novel 9-O-substituted-berberine derivatives

Meiyan Huang, Jing Lin, Zhijian Huang, Hong‐Gui Xu, Juan Hong, Pinghua Sun, Jialiang Guo, Wei‐Min Chen

MedChemComm

DOI

2016

Correction: Design, synthesis and anti-inflammatory effects of novel 9-O-substituted-berberine derivatives electronic supplementary information

Meiyan Huang, Jing Lin, Zhijian Huang, Hong‐Gui Xu, Juan Hong, Pinghua Sun, Jialiang Guo, Wei‐Min Chen

MedChemComm

DOI

2015

提高实验课程中多媒体教学效果的实践与探索——以《药物化学实验》课程建设为例

孙平华，颜海波，郭嘉亮，林静，彭丽洁，陈卫民

《广东化工》

2015

Novel cajaninstilbene acid derivatives as antibacterial agents

Zhi-Zhong Geng, Jianjun Zhang, Jing Lin, Meiyan Huang, Lin‐Kun An, Hong-Bin Zhang, Pinghua Sun, Wen‐Cai Ye, Wei‐Min Chen

European Journal of Medicinal Chemistry

DOI

2015

ChemInform Abstract: Gold(I)‐Catalyzed Domino Cyclization for the Synthesis of Tricyclic Chromones.

Zhiqiang Li, Qingjiang Li, Guo‐Kai Liu, Wei‐Min Chen, Xiao‐Shui Peng, Henry Ν. C. Wong

ChemInform

DOI

2015

Arenobufagin intercalates with DNA leading to G2 cell cycle arrest via ATM/ATR pathway

Lijuan Deng, Qun-Long Peng, Long-Hai Wang, Jun Hui Xu, Junshan Liu, Yingjie Li, Zhenjian Zhuo, Liangliang Bai, Liping Hu, Wei‐Min Chen, Wen‐Cai Ye, Dongmei Zhang

Oncotarget

DOI

2015

Gold(I)-Catalyzed Domino Cyclization for the Synthesis of Tricyclic Chromones

Wei‐Min Chen, Henry Ν. C. Wong, Zhiqiang Li, Qingjiang Li, Guo‐Kai Liu, Xiao‐Shui Peng

Synlett

DOI

2015

Betulinic Acid and its Derivatives as Potential Antitumor Agents

Dongmei Zhang, Hong‐Gui Xu, Lei Wang, Ying‐Jie Li, Pinghua Sun, Xiao‐Ming Wu, Guangji Wang, Wei‐Min Chen, Wen‐Cai Ye

Medicinal Research Reviews

DOI

2015

Design and prediction of new anticoagulants as a selective Factor IXa inhibitor via three-dimensional quantitative structure-property relationships of amidinobenzothiophene derivatives

Pinghua Sun, Jia-Suo Gao, Xupeng Tong, Yiqun Chang, Yu-Xuan He, Yu-Dan Mei, Pei-Hong Tan, Jia-Liang Guo, Guochao Liao, Wei‐Min Chen, Shu‐Feng Zhou, Gaokeng Xiao

Drug Design Development and Therapy

DOI

2015

Novel Oxazolidinone Antibacterial Analogues with a Substituted Ligustrazine C‐ring Unit

Yan Chen, Zhixiong Ruan, Fang Wang, De‐Sheng Huangfu, Pinghua Sun, Jing Lin, Wei‐Min Chen

Chemical Biology & Drug Design

DOI

2014

3-羟基-5-甲氧基芪-2-羧酸衍生物的合成与抗炎活性

张建军，孙平华，陈艳，耿志忠，陈卫民

《中国医药工业杂志》

2014

4-烷基取代溴代呋喃酮合成及其对铜绿假单胞菌生物膜形成的抑制作用

徐星军，周群飞，林静，陈卫民

《中国抗生素杂志》

2014

Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain

Pinghua Sun, Ling-Xing Shan, Bao‐Qin Guo, Xinjun Xu, Zhi-Qiang Li, Jiazhi Sun, Shu-Feng Zhou, Wei‐Min Chen

Drug Design Development and Therapy

DOI

2014

Regioselective and stereoselective photodimerization of securinine-type and norsecurinine-type alkaloids

Yu-Quan Hu, Chen Li, Bing‐Xin Zhao, Jun-Yong Li, Xiao‐Jun Huang, Jing Lin, Ying Wang, Wen‐Cai Ye, Wei‐Min Chen

Tetrahedron

DOI

2014

B5H7, a Morpholine Derivative of 23-Hydroxybetulinic Acid, Reverses Doxorubicin Resistance in HepG2/ADM

Nan Yao, Dao-Lu Liu, Yingjie Li, Zhe‐Sheng Chen, Zhi Shi, Wei‐Min Chen, Zhe Yao, Dongmei Zhang, Wen‐Cai Ye

Journal of cancer research updates

DOI

2013

盐酸多奈哌齐的合成

单玲星，高加索，何宇轩，孙平华，陈卫民

《中国医药工业杂志》

2013

Morin Inhibits Sortase A and Subsequent Biofilm Formation in Streptococcus mutans

Ping-Hsiu Huang, Ping Hu, Su Zhou, Qian Li, Weimin Chen

Current Microbiology

DOI

2013

Curcumin Inhibits the Sortase A Activity of the Streptococcus mutans UA159

Ping Hu, Ping-Hsiu Huang, Weimin Chen

Applied Biochemistry and Biotechnology

DOI

2013

Design, synthesis and anti-inflammatory evaluation of novel 5-benzylidene-3,4-dihalo-furan-2-one derivatives

Fang Wang, Jun‐Rong Sun, Meiyan Huang, Huiying Wang, Pinghua Sun, Jing Lin, Wei‐Min Chen

European Journal of Medicinal Chemistry

DOI

2013

Discovery of Bufadienolides as a Novel Class of ClC-3 Chloride Channel Activators with Antitumor Activities

Jun-Shan Liu, Dongmei Zhang, Yuan Li, Wei‐Min Chen, Zhixiong Ruan, Lijuan Deng, Liwei Wang, Hai‐Yan Tian, Anita Yiu, Chunlin Fan, Hai Luo, Shanwen Liu, Ying Wang, Gaokeng Xiao, Lixin Chen, Wen‐Cai Ye

Journal of Medicinal Chemistry

DOI

2013

Flueggedine, a novel axisymmetric indolizidine alkaloid dimer from Flueggea virosa

Bing‐Xin Zhao, Ying Wang, Chen Li, Guo‐Cai Wang, Xiao‐Jun Huang, Chun‐Lin Fan, Qingming Li, Hua‐Jie Zhu, Wei‐Min Chen, Wen‐Cai Ye

Tetrahedron Letters

DOI

2013

Two pairs of new benzofuran enantiomers with unusual skeletons from Eupatorium chinense

Wen‐Jing Wang, Lei Wang, Xiao‐Jun Huang, Ren‐Wang Jiang, Xiaolin Yang, Dongmei Zhang, Wei‐Min Chen, Ben-Qin Tang, Ying Wang, Xiao‐Qi Zhang, Wen‐Cai Ye

Tetrahedron Letters

DOI

2013

Facile Synthesis of the Neuraminidase Inhibitor Peramivir

Fei Jia, Juan Hong, Pinghua Sun, Jianxin Chen, Wei‐Min Chen

Synthetic Communications

DOI

2012

铜绿假单胞菌群体感应信号分子类似物5-烷酸酯基-3,4-二氯-2(5H)-呋喃酮的合成及其生物膜抑制活性研究

杨晶晶，孙平华，陈卫民

《中国抗生素杂志》

2012

Molecular modeling studies on 3,4-dihydroquinazolines as trypanothione reductase inhibitors using 3D-QSAR and docking approaches

Zhixiong Ruan, De‐Sheng Huangfu, Pinghua Sun, Wei‐Min Chen

Medicinal Chemistry Research

DOI

2012

BBA, a Derivative of 23-Hydroxybetulinic Acid, Potently Reverses ABCB1-Mediated Drug Resistance in Vitro and in Vivo

Dongmei Zhang, Chang Shu, Jun-Jiang Chen, Kamlesh S. Sodani, Jiao Wang, Jaya Bhatnagar, Ping Lan, Zhixiong Ruan, Zhijie Xiao, Suresh V. Ambudkar, Wei‐Min Chen, Zhe‐Sheng Chen, Wen‐Cai Ye

Molecular Pharmaceutics

DOI

2012

Unexpected ring contraction and oxidation rearrangement reactions of securinine

Jun-Yong Li, Bing‐Xin Zhao, Wen Zhang, Chen Li, Xiao‐Jun Huang, Ying Wang, Pinghua Sun, Wen‐Cai Ye, Wei‐Min Chen

Tetrahedron

DOI

2011

帕拉米韦合成路线图解

贾飞，陈良柱，陈建新，孙平华，陈卫民

《中国医药工业杂志》

2011

利用Mitsunobu反应合成川芎嗪衍生物

王慧颖，孙平华，陈卫民

《合成化学》

2011

Synthesis and antiproliferative evaluation of 23-hydroxybetulinic acid derivatives

Ping Lan, Jiao Wang, Dongmei Zhang, Chang Shu, Huihui Cao, Pinghua Sun, Xiao-Ming Wu, Wen‐Cai Ye, Wei‐Min Chen

European Journal of Medicinal Chemistry

DOI

2011

ChemInform Abstract: Design, Synthesis and Antibacterial Activity of Novel Ketolides Bearing an Aryltetrazolyl‐Substituted Alkyl Side Chain.

Qiuling Song, Bao‐Qin Guo, Wen Zhang, Ping Lan, Pinghua Sun, Wei‐Min Chen

ChemInform

DOI

2011

Design, synthesis and antibacterial activity of novel ketolides bearing an aryltetrazolyl-substituted alkyl side chain

Qiuling Song, Bao‐Qin Guo, Wen Zhang, Ping Lan, Pinghua Sun, Wei‐Min Chen

The Journal of Antibiotics

DOI

2011

Flueggines A and B, Two New Dimeric Indolizidine Alkaloids fromFlueggea virosa

Bing‐Xin Zhao, Ying Wang, Dongmei Zhang, Ren‐Wang Jiang, Guo‐Cai Wang, Jun-Min Shi, Xiao‐Jun Huang, Wei‐Min Chen, Chun‐Tao Che, Wen‐Cai Ye

Organic Letters

DOI

2011

Molecular modeling studies on phosphonic acid-containing thiazole derivatives: design for fructose-1,6-bisphosphatase inhibitors

Ping Lan, Zhi-Wei Wu, Wan-Na Chen, Wan-Na Chen, Pinghua Sun, Wei‐Min Chen, Wei‐Min Chen

Journal of Molecular Modeling

DOI

2011

3D-QSAR and Docking Studies on Pyrrolopyrimidine Derivatives as LIM-Kinase 2 Inhibitors

Jun‐Rong Sun, Ping Lan, Pinghua Sun, Wei‐Min Chen

Letters in Drug Design & Discovery

DOI

2011

Synthesis of 4-(5-Quinolin-3-yl-tetrazol-2-yl)butylamine

Wei‐Min Chen

Hecheng huaxue

2011

Improvement of the synthesis technology of nolatrexed

Wei‐Min Chen

Chemical Reagents

2011

Synthesis of Tetramethylpyrazine Derivatives by Mitsunobu Reaction

Wei‐Min Chen

Hecheng huaxue

2010

白桦酸类化合物的结构修饰与生物活性研究进展

蓝平，张冬梅，陈卫民，叶文才

《药学学报》

DOI

2010

药物化学实验境内外学生分流教学改革的探索

郭嘉亮，孙平华，陈卫民

《基础医学教育》

2010

细菌生物膜抑制剂3,4-二氯呋喃-2(5H)-酮联合庆大霉素对铜绿假单胞菌的抑制作用

刘国勇，王泳珊，程超，陈卫民

《中国新药杂志》

2010

Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides

Lei Hu, Ping Lan, Qiuling Song, Zhijian Huang, Pinghua Sun, Chao Zhuo, Ying Wang, Shunian Xiao, Wei‐Min Chen

European Journal of Medicinal Chemistry

DOI

2010

Molecular modelling studies on d-annulated benzazepinones as VEGF-R2 kinase inhibitors using docking and 3D-QSAR

Ping Lan, Jun‐Rong Sun, Wan-Na Chen, Wan-Na Chen, Sun Ping-Hua, Wei‐Min Chen, Wei‐Min Chen

Journal of Enzyme Inhibition and Medicinal Chemistry

DOI

2010

Understanding the structure-activity relationship of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and docking

Ping Lan, Wan-Na Chen, Wan-Na Chen, Zhijian Huang, Pinghua Sun, Wei‐Min Chen, Wei‐Min Chen

Journal of Molecular Modeling

DOI

2010

3D-QSAR studies on betulinic acid and betulin derivatives as anti-HIV-1 agents using CoMFA and CoMSIA

Ping Lan, Wan-Na Chen, Wan-Na Chen, Pinghua Sun, Wei‐Min Chen, Wei‐Min Chen

Medicinal Chemistry Research

DOI

2010

3D-QSAR studies and molecular docking on [5-(4-amino-1H-benzoimidazol-2-yl)-furan-2-yl]-phosphonic acid derivatives as fructose-1,6-biphophatase inhibitors

Ping Lan, Mei-Qi Xie, Yue-Mei Yao, Wan-Na Chen, Wei‐Min Chen, Wei‐Min Chen, Wei‐Min Chen

Journal of Computer-Aided Molecular Design

DOI

2010

3D-QSAR and Molecular Docking Studies on Fused Pyrazoles as p38α Mitogen-Activated Protein Kinase Inhibitors

Ping Lan, Zhijian Huang, Jun‐Rong Sun, Wei‐Min Chen

International Journal of Molecular Sciences

DOI

2010

Synthesis of 4-(hydroxymethyl)-2(5H)-furanone and its effect on the biofilms of Pseudomonas Aeruginosa

Wei‐Min Chen

Chemical Reagents

2010

Bacteriostatic effect of bacterial biofilm inhibitor 3,4-dichlorofuran 2(5H)-one combined with gentamycin on Pseudomonas aeruginosa

Wei‐Min Chen

Zhongguo xin yao zazhi

2010

Synthesis of (Z)-5-(bromomethylene) furan-2(5H)-one

Guoyong Liu, Ye Chunqiang, Wang Yu-zhen, Wei‐Min Chen

Chemical Reagents

2009

盐酸坦洛新合成路线图解

孙平华，冯金，陈卫民，姚新生

《中国医药工业杂志》

2009

ChemInform Abstract: Synthesis and Antibacterial Activities of (9S)‐3‐O‐Descladinose‐6‐O‐methyl‐3‐oxo‐12‐ (Δ2‐pyrazolinyl) ‐12‐dehydroxy‐21‐demethyl‐9‐dihydroerythromycin A.

Yong‐Tao Wang, Lei Hu, Wei‐Min Chen, Ai‐Xi Hu, Qiuling Song, Dong Guan

ChemInform

DOI

2009

The Inhibitory Effects of Brominated 2(5H)-Furanones on the Biofilms of P.aeruginosa

Wei‐Min Chen

Life Science Research

2008

Pyridine‐4‐thiol and Amphoteric Analogs: Novel Protection of Aryl Bromides in Strong Alkali

Wei‐Min Chen, Chao Cheng, Bing‐Zhou Li, Tse‐Lok Ho, Zhao‐Shuo Cai, Yuqiang Wang, Pinghua Sun

Helvetica Chimica Acta

DOI

2007

药物化学课分流教学在侨校中的新探索

孙平华，易晖，杨兆琪，陈卫民

《基础医学教育》

2007

盐酸罗匹尼罗的合成

孙平华，陈卫民，李冰洲，杨兆琪，李茜

《中国医药工业杂志》

2007

3D-QSAR Analysis on Pyrrolopyridine Analogs as Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2) Inhibitors

Zhaoqi Yang, Pinghua Sun, Wei‐Min Chen

Letters in Drug Design & Discovery

DOI

2007

New Straightforward Synthesis of 2‐Amino‐6‐methyl‐5‐(pyridin‐4‐ylsulfanyl)‐3H‐quinazolin‐4‐one.

Wei‐Min Chen, Shanhe Wan

ChemInform

DOI

2007

Synthesis and antitumor activities of novel 2-substituted pyrimidinone-5-carboxylic acid benzylamides

Wei‐Min Chen, Feng Jin, Hongyi Tu

Frontiers of Chemistry in China

DOI

2007

New Straightforward Synthesis of2‐Amino‐6‐methyl‐5‐(pyridin‐4‐ylsulfanyl)‐3H‐quinazolin‐4‐one

Wei‐Min Chen, Shanhe Wan

Synthetic Communications

DOI

2006

Synthetic Studies on Erythromycin Derivatives: Reactivity of the C12-21 Alkene

Wei‐Min Chen

Molecules

DOI

2000

4-硝基吡啶N-氧化物制备方法的改进

朱秋华，陈卫民

《中国医药工业杂志》

1999

3,3’-(二硒双甲叉)双(5-羟基-6-甲基4-吡啶甲醇)的合成及抗肿瘤活性

陈卫民，曾陇梅，徐继红，吴曙光

《解放军药学学报》

1998

4-羟基咔唑的合成改进

陈卫民，徐继红

《中国医药工业杂志》

精选作品

期刊论文

Cyclic Diguanylate G-Quadruplex Inducer-Siderophore Hybrids as Bifunctional Antibiofilm Agents against Pseudomonas aeruginosa.

A review of antimicrobial peptides: Discovery, design strategies, and translational applications

Discovery of Dual-Acting Biofilm Inhibitors against Pseudomonas aeruginosa by the Coupling of 3-Hydroxypyridin-4(1H)-ones with N-Phenylamide QS Inhibitors.

Identification of ferredoxin PA1551 as an antibacterial synergistic target for biofilm inhibitors against Pseudomonas aeruginosa

Natural sideromycins and siderophore-conjugated natural products as inspiration for novel antimicrobial agents.

Discovery of 3-hydroxypyridin-4(1H)-ones ester of ciprofloxacin as prodrug to combat biofilm-associated Pseudomonas aeruginosa.

Cyclic Diguanylate G-Quadruplex Inducer-Quorum Sensing Inhibitor Hybrids as Bifunctional Anti-biofilm and Anti-virulence Agents Against Pseudomonas aeruginosa.

Hybrids of 3-Hydroxypyridin-4(1H)-ones and Long-Chain 4-Aminoquinolines as Potent Biofilm Inhibitors of Pseudomonas aeruginosa Potentiate Tobramycin and Polymyxin B Activity.

Cajaninstilbene acid derivatives conjugated with siderophores of 3-hydroxypyridin-4(1H)-ones as novel antibacterial agents against Gram-negative bacteria based on the Trojan horse strategy.

Exploring the Localization of Siderophore-Mediated Cargo Delivery in Gram-Negative Bacteria Using 3-Hydroxypyridin-4(1H)-one-Fluorescein Probes.

3-Hydroxypyridin-4(1H)-one Derivatives as pqs Quorum Sensing Inhibitors Attenuate Virulence and Reduce Antibiotic Resistance in Pseudomonas aeruginosa.

Cyclic Diguanylate G-Quadruplex Inducer-Nitric Oxide Donor Conjugate as a Bifunctional Antibiofilm Agent and Antibacterial Synergist against Pseudomonas aeruginosa with a Hyperbiofilm Phenotype

Design, synthesis and biological evaluation of novel 3-hydroxypyridin-4(1H)-ones based hybrids as Pseudomonas aeruginosa biofilm inhibitors

3-Hydroxy-pyridin-4(1H)-ones as siderophores mediated delivery of isobavachalcone enhances antibacterial activity against pathogenic Pseudomonas aeruginosa

Design and Synthesis of 3-Hydroxy-pyridin-4(1 H )-ones–Ciprofloxacin Conjugates as Dual Antibacterial and Antibiofilm Agents against Pseudomonas aeruginosa

Design and synthesis of caffeic acid derivatives and evaluation of their inhibitory activity against Pseudomonas aeruginosa

New Pqs Quorum Sensing System Inhibitor as an Antibacterial Synergist against Multidrug-Resistant Pseudomonas aeruginosa

Design and Synthesis of Novel c-di-GMP G-Quadruplex Inducers as Bacterial Biofilm Inhibitors

Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms

Research Progress of Antibiotics Conjugated with Siderophores

Novel 2-Substituted 3-Hydroxy-1,6-dimethylpyridin-4(1H)-ones as Dual-Acting Biofilm Inhibitors of Pseudomonas aeruginosa

Biological evaluation and chemoproteomics reveal potential antibacterial targets of a cajaninstilbene-acid analogue

Induction of differentiation of the acute myeloid leukemia cell line (HL-60) by a securinine dimer

Cajaninstilbene acid analogues as novel quorum sensing and biofilm inhibitors of Pseudomonas aeruginosa

Fluorescent Detection of the Ubiquitous Bacterial Messenger 3′,5′ Cyclic Diguanylic Acid by Using a Small Aromatic Molecule

A fluorescence-based high-throughput screening method for determining the activity of diguanylate cyclases and c-di-GMP phosphodiesterases

Novel virosecurinine bivalent mimetics as potent reversal agents against P-glycoprotein-mediated multidrug resistance

Design, synthesis and evaluation of halogenated furanone derivatives as quorum sensing inhibitors in Pseudomonas aeruginosa

Novel 2, 8-bit derivatives of quinolines attenuate Pseudomonas aeruginosa virulence and biofilm formation

Alopecuroides A–E, Matrine-Type Alkaloid Dimers from the Aerial Parts of Sophora alopecuroides

Novel benzyl phenyl sulfide derivatives as antibacterial agents against methicillin-resistant Staphylococcus aureus

Design and synthesis of 2‐hydroxyl‐4‐methoxyl‐3‐(3‐methylbut‐2‐en‐1‐yl)‐6‐(4‐phenylbenzoylamino)benzoic acid derivatives as antibacterial agents based on cajaninstilbene acid scaffold hopping

A facile synthesis of cajaninstilbene acid and its derivatives

Design, synthesis and biological evaluation of 2-substituted 3-hydroxy-6-methyl-4H-pyran-4-one derivatives as Pseudomonas aeruginosa biofilm inhibitors

Hybrids of arenobufagin and benzoisoselenazol reducing the cardiotoxicity of arenobufagin

Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System

A Bivalent Securinine Compound SN3-L6 Induces Neuronal Differentiation via Translational Upregulation of Neurogenic Transcription Factors

Design, synthesis and biological evaluation of novel 5-hydroxy-2-methyl-4 H -pyran-4-one derivatives as antiglioma agents

“双链”融合创新教学模式在药物化学实验教学中的应用

4-arylamidobenzyl substituted 5-bromomethylene-2(5 H )-furanones for chronic bacterial infection

Fibroblast Activation Protein α Activated Tripeptide Bufadienolide Antitumor Prodrug with Reduced Cardiotoxicity

Strigolactones: a plant phytohormone as novel anti-inflammatory agents

Iodine‐Catalyzed Azidation/Cyclization Cascade Approach to 3a‐Azidofuroindolines and ‐pyrroloindolines under Mild Conditions

Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase

Novel bivalent securinine mimetics as topoisomerase I inhibitors

Novel 4-(4-substituted amidobenzyl)furan-2(5H)-one derivatives as topoisomerase I inhibitors

Novel securinine derivatives as topoisomerase I based antitumor agents

A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells

Design and Synthesis of Dimeric Securinine Analogues with Neuritogenic Activities

3D-QSAR and docking studies on 1-hydroxypyridin-2-one compounds as mutant isocitrate dehydrogenase 1 inhibitors

Design, Synthesis and Antibacterial Assay of Pinosylvin Acid Derivatives

Anti-Inflammatory Effects of Cajaninstilbene Acid and Its Derivatives

Design, synthesis and anti-inflammatory effects of novel 9-O-substituted-berberine derivatives

Correction: Design, synthesis and anti-inflammatory effects of novel 9-O-substituted-berberine derivatives electronic supplementary information

提高实验课程中多媒体教学效果的实践与探索——以《药物化学实验》课程建设为例

Novel cajaninstilbene acid derivatives as antibacterial agents

ChemInform Abstract: Gold(I)‐Catalyzed Domino Cyclization for the Synthesis of Tricyclic Chromones.

Arenobufagin intercalates with DNA leading to G2 cell cycle arrest via ATM/ATR pathway

Gold(I)-Catalyzed Domino Cyclization for the Synthesis of Tricyclic Chromones

Betulinic Acid and its Derivatives as Potential Antitumor Agents

Design and prediction of new anticoagulants as a selective Factor IXa inhibitor via three-dimensional quantitative structure-property relationships of amidinobenzothiophene derivatives

Novel Oxazolidinone Antibacterial Analogues with a Substituted Ligustrazine C‐ring Unit

3-羟基-5-甲氧基芪-2-羧酸衍生物的合成与抗炎活性

4-烷基取代溴代呋喃酮合成及其对铜绿假单胞菌生物膜形成的抑制作用

Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain

Regioselective and stereoselective photodimerization of securinine-type and norsecurinine-type alkaloids

B5H7, a Morpholine Derivative of 23-Hydroxybetulinic Acid, Reverses Doxorubicin Resistance in HepG2/ADM

盐酸多奈哌齐的合成

Morin Inhibits Sortase A and Subsequent Biofilm Formation in Streptococcus mutans

Curcumin Inhibits the Sortase A Activity of the Streptococcus mutans UA159

Design, synthesis and anti-inflammatory evaluation of novel 5-benzylidene-3,4-dihalo-furan-2-one derivatives

Discovery of Bufadienolides as a Novel Class of ClC-3 Chloride Channel Activators with Antitumor Activities

Flueggedine, a novel axisymmetric indolizidine alkaloid dimer from Flueggea virosa

Two pairs of new benzofuran enantiomers with unusual skeletons from Eupatorium chinense

Facile Synthesis of the Neuraminidase Inhibitor Peramivir

铜绿假单胞菌群体感应信号分子类似物5-烷酸酯基-3,4-二氯-2(5H)-呋喃酮的合成及其生物膜抑制活性研究

Molecular modeling studies on 3,4-dihydroquinazolines as trypanothione reductase inhibitors using 3D-QSAR and docking approaches

BBA, a Derivative of 23-Hydroxybetulinic Acid, Potently Reverses ABCB1-Mediated Drug Resistance in Vitro and in Vivo