金海晓｜宁波大学｜学者主页

2026

From structural evolution to an AI-driven future of 5-HT1F receptor agonists for migraine therapy.

Lu Lin, Jiale Wu, Ting-Ting Wang, Yahui Cao, Dashuai Zhang, Haixiao Jin, Shan He

European journal of medicinal chemistry

2023

Discovery of novel polysubstituted N -alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy

Ze Wang, Zhao Li, Bo Zhang, Bo Zhang, Jiahe Feng, Yule Wang, Bin Zhang, Bin Zhang, Haixiao Jin, Lijian Ding, Ning Wang, Shan He

Journal of Enzyme Inhibition and Medicinal Chemistry

DOI

2022

Design, synthesis, and structure – Activity relationship studies of novel tryptamine derivatives as 5‑HT1B receptor agonists

Liping Fang, Shan He, Peng Yin, Ning Wang, Bin Zhang, Haixiao Jin

Journal of Molecular Structure

DOI

2022

In silico, synthesis and anticancer evaluation of benzamide tryptamine derivatives as novel eEF2K inhibitors

Zedong Liu, Aili Jiang, Yaqi Wang, Pei Xu, Qiting Zhang, Yinda Wang, Shan He, Ning Wang, Haixiao Jin, Bin Zhang

Bioorganic & Medicinal Chemistry Letters

DOI

2021

Design and synthesis of novel tacrine-dipicolylamine dimers that are multiple-target-directed ligands with potential to treat Alzheimer’s disease

Panpan Zhang, Ze Wang, Chenye Mou, Jiamei Zou, Yanfei Xie, Zhiwen Liu, C. Benjamin Naman, Yuechun Mao, Jiaxin Wei, Xinghan Huang, Jiahui Dong, Mengxiang Yang, Ning Wang, Haixiao Jin, Fufeng Liu, Dongdong Lin, Hao Liu, Zhou Fei, Shan He, Bin Zhang, Wei Cui

Bioorganic Chemistry

DOI

2020

Synthesis and Anticancer Research of N ‐(2‐aminophenyl)benzamide Acridine Derivatives as Dual Topoisomerase I and Isoform‐Selective HDAC Inhibitors

Bin Zhang, Qiting Zhang, Zedong Liu, Ning Wang, Haixiao Jin, Feng Liu, Cunlong Zhang, Shan He

ChemistrySelect

DOI

2020

A Novel Methoxybenzyl 5-Nitroacridone Derivative Effectively Triggers G1 Cell Cycle Arrest in Chronic Myelogenous Leukemia K562 Cells by Inhibiting CDK4/6-Mediated Phosphorylation of Rb

Bin Zhang, Ting Zhang, Tian-Yi Zhang, Ning Wang, Shan He, Bin Wu, Haixiao Jin

International Journal of Molecular Sciences

DOI

2019

Efficient and Chemoselective Amidation of β ‐Carboline Carboxylic Acids

Miaoman Lin, Weida Liang, Jiale Ma, Ye Wu, Xiao Xiao, Jianxi Ying, Yinghua Yan, Lingling Zhao, Haixiao Jin, Hongze Liang, Wei Cui, Xiaojun Yan

ChemistrySelect

DOI

2019

Fascaplysin Derivatives Are Potent Multitarget Agents against Alzheimer’s Disease: in Vitro and in Vivo Evidence

Hanbo Pan, Hongda Qiu, Ke Zhang, Panpan Zhang, Weida Liang, Mengxiang Yang, Chenye Mou, Miaoman Lin, Ming He, Xiao Xiao, Difan Zhang, Haixing Wang, Fufeng Liu, Yongmei Li, Haixiao Jin, Xiaojun Yan, Hongze Liang, Wei Cui

ACS Chemical Neuroscience

DOI

2019

Design, synthesis and biological research of novel N-phenylbenzamide-4-methylamine acridine derivatives as potential topoisomerase I/II and apoptosis-inducing agents

Bin Zhang, Zhende Dou, Zheng Xin Xiong, Ning Wang, Shan He, Xiaojun Yan, Haixiao Jin

Bioorganic & Medicinal Chemistry Letters

DOI

2018

整合素αvβ3结构与激活及其肿瘤靶向药物的研究进展

戴明权，金海晓，严小军

《生物学杂志》

2018

Aerobic Oxidation of Methyl‐substituted β ‐Carbolines Catalyzed by N‐Hydroxyphthalimide and Metal Catalyst

Hongda Qiu, Weida Liang, Gongjun Zhang, Miaoman Lin, Wanmin Liu, Zhanghua Gao, Wen‐Ting Wei, Chunlan Tang, Haixiao Jin, Hongze Liang, Xiaojun Yan

ChemistrySelect

DOI

2017

整合蛋白与抑制剂设计

方剑，金海晓，朱鹏

《中国生物化学与分子生物学报》

2017

氨酰tRNA合成酶作用机制及其应用

葛俊驿，邱晓挺，金海晓

《中国生物化学与分子生物学报》

2015

Discovery and Structure-Based Optimization of 6-Bromotryptamine Derivatives as Potential 5-HT2A Receptor Antagonists

Lijian Ding, Shan He, Wei Wu, Haixiao Jin, Peng Zhu, Jinrong Zhang, Tingting Wang, Ye Yuan, Xiaojun Yan

Molecules

DOI

2015

Determining the Functions of HIV-1 Tat and a Second Magnesium Ion in the CDK9/Cyclin T1 Complex: A Molecular Dynamics Simulation Study

Haixiao Jin, Mei‐Lin Go, Peng Yin, Xiaoting Qiu, Peng Zhu, Xiaojun Yan

PLoS ONE

DOI

2014

5-甲基色胺衍生物的合成

朱海峰，陆海晶，余肖平，梁洪泽，金海晓，周雄

《宁波大学学报(理工版)》

2014

微囊藻毒素衍生物的化学酶法合成及活性评价

方剑，何魁芳，季赛，朱鹏，金海晓，严小军

《中国生物化学与分子生物学报》

2014

Functionalized tetrahydro-1H-pyrido[4,3-b]indoles: A novel chemotype with Sirtuin 2 inhibitory activity

Tianming Yang, Xiao Chen, Haixiao Jin, Gautam Sethi, Mei‐Lin Go

European Journal of Medicinal Chemistry

DOI

2014

Synthesis and Evaluation of Bisbenzylidenedioxotetrahydrothiopranones as Activators of Endoplasmic Reticulum (ER) Stress Signaling Pathways and Apoptotic Cell Death in Acute Promyelocytic Leukemic Cells

Kheng Lin Tan, Azhar Ali, Yuhong Du, Haian Fu, Haixiao Jin, Tan‐Min Chin, Matiullah Khan, Mei‐Lin Go

Journal of Medicinal Chemistry

DOI

2014

Acetylcholinesterase and Butyrylcholinesterase Inhibitory Properties of Functionalized Tetrahydroacridines and Related Analogs

Haixiao Jin

Medicinal Chemistry

DOI

2013

3D-QSAR and 3D-QSSR studies of thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as CDK4 inhibitors by CoMFA analysis

Bao-qin Cai, Haixiao Jin, Xiaojun Yan, Peng Zhu, Guixiang Hu

Acta Pharmacologica Sinica

DOI

2010

PKA酶及其抑制剂balanol的计算化学

金海晓，严小军，朱鹏

《化学进展》

2009

抑制剂BD2对PKA与PKCβⅡ的抑制选择性研究

金海晓，吴天星，严小军，蒋勇军，邹建卫

《化学学报》

2006

蛋白激酶A结构、功能及抑制剂的分子模拟研究

金海晓

《浙江大学》

2006

利用三维构效关系确定互变异构抑制剂的活性构象

许惠英，邹建卫，王艳花，张娜，金海晓

《浙江大学学报(理学版)》

2005

化合物膜水分配系数的QSPR研究和分子三维参数表征

胡桂香，邹建卫，曾敏，张兵，金海晓，俞庆森

《浙江大学学报(理学版)》

2004

药物水溶解度的QSAR研究和VolSurf参数

金海晓，胡桂香，吴天星，商志才，邹建卫，俞庆森

Chinese Journal of Structural Chemistry

金海晓

精选作品

期刊论文

From structural evolution to an AI-driven future of 5-HT1F receptor agonists for migraine therapy.

Discovery of novel polysubstituted N -alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy

Design, synthesis, and structure – Activity relationship studies of novel tryptamine derivatives as 5‑HT1B receptor agonists

In silico, synthesis and anticancer evaluation of benzamide tryptamine derivatives as novel eEF2K inhibitors

Design and synthesis of novel tacrine-dipicolylamine dimers that are multiple-target-directed ligands with potential to treat Alzheimer’s disease

Synthesis and Anticancer Research of N ‐(2‐aminophenyl)benzamide Acridine Derivatives as Dual Topoisomerase I and Isoform‐Selective HDAC Inhibitors

A Novel Methoxybenzyl 5-Nitroacridone Derivative Effectively Triggers G1 Cell Cycle Arrest in Chronic Myelogenous Leukemia K562 Cells by Inhibiting CDK4/6-Mediated Phosphorylation of Rb

Efficient and Chemoselective Amidation of β ‐Carboline Carboxylic Acids

Fascaplysin Derivatives Are Potent Multitarget Agents against Alzheimer’s Disease: in Vitro and in Vivo Evidence

Design, synthesis and biological research of novel N-phenylbenzamide-4-methylamine acridine derivatives as potential topoisomerase I/II and apoptosis-inducing agents

整合素αvβ3结构与激活及其肿瘤靶向药物的研究进展

Aerobic Oxidation of Methyl‐substituted β ‐Carbolines Catalyzed by N‐Hydroxyphthalimide and Metal Catalyst

整合蛋白与抑制剂设计

氨酰tRNA合成酶作用机制及其应用

Discovery and Structure-Based Optimization of 6-Bromotryptamine Derivatives as Potential 5-HT2A Receptor Antagonists

Determining the Functions of HIV-1 Tat and a Second Magnesium Ion in the CDK9/Cyclin T1 Complex: A Molecular Dynamics Simulation Study

5-甲基色胺衍生物的合成

微囊藻毒素衍生物的化学酶法合成及活性评价

Functionalized tetrahydro-1H-pyrido[4,3-b]indoles: A novel chemotype with Sirtuin 2 inhibitory activity

Synthesis and Evaluation of Bisbenzylidenedioxotetrahydrothiopranones as Activators of Endoplasmic Reticulum (ER) Stress Signaling Pathways and Apoptotic Cell Death in Acute Promyelocytic Leukemic Cells

Acetylcholinesterase and Butyrylcholinesterase Inhibitory Properties of Functionalized Tetrahydroacridines and Related Analogs

3D-QSAR and 3D-QSSR studies of thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as CDK4 inhibitors by CoMFA analysis

PKA酶及其抑制剂balanol的计算化学

抑制剂BD2对PKA与PKCβⅡ的抑制选择性研究

蛋白激酶A结构、功能及抑制剂的分子模拟研究

利用三维构效关系确定互变异构抑制剂的活性构象

化合物膜水分配系数的QSPR研究和分子三维参数表征

药物水溶解度的QSAR研究和VolSurf参数

研究方向