赵小阳｜南方医科大学｜学者主页

2023

A fast chemical reprogramming system promotes cell identity transition through a diapause-like state

Xi Chen, Yun-Kun Lu, Le-Yun Wang, Xiao-Jie Ma, Jia-Qi Pu, Lianyu Lin, Qiang Deng, Yu-Han Li, Wei-Yun Wang, Yan Jin, Zhensheng Hu, Zi-Yu Zhou, Guo Chen, Li-Ling Jiang, Hao Wang, Xiaoyang Zhao, Xiang-Wei He, Jun-Fen Fu, H. Russ, Wei Li, Sai-Yong Zhu

Nature Cell Biology

DOI

2023

Lovastatin promotes the self-renewal of murine and primate spermatogonial stem cells

Chao-Hui Li, Zhaokai Yao, Linzi Ma, Xiuling Song, Wen Wang, Cong Wan, Shao-Fang Ren, Ding-Yao Chen, Yi Zheng, Yong-Tong Zhu, Gang Chang, Shi-Hao Wu, Kai Miao, Fang Luo, Xiaoyang Zhao

Stem Cell Reports

DOI

2022

The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting

Yuhan Chen, Jiansen Lu, Yanwen Xu, Yaping Huang, Da-Zhuang Wang, Pei-Yun Liang, Shao-Fang Ren, Xuesong Hu, Ye-Wen Qin, Wei Ke, R. Jauch, A. Hutchins, Mei Wang, Fu-Chou Tang, Xiaoyang Zhao

Protein & Cell

DOI

2022

Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models

Ke Song, Xinyan Yang, G. An, Xinyu Xia, Jiexiang Zhao, Xiaoheng Xu, Cong Wan, Tianyuan Liu, Y. Zheng, Shao-Fang Ren, Mei Wang, Gang Chang, Shane J.F. Cronin, J. Penninger, Tao Jing, Xianghong Ou, Shuan Rao, Zhaoting Liu, Xiaoyang Zhao

Nature Communications

DOI

2022

Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like state

Yang Yang, Liyang Shi, Xiu-Ling Fu, Gang Ma, Zhong-Zhou Yang, Yu-Hao Li, Yi-Bin Zhou, Lihua Yuan, Ye Xia, Xiufang Zhong, Ping Yin, Li Sun, Wu-Wen Zhang, I. A. Babarinde, Yong-Jun Wang, Xiaoyang Zhao, A. Hutchins, Guo-Qing Tong

PLoS Biology

DOI

2021

Human embryos arrest in a quiescent-like state characterized by metabolic and zygotic genome activation problems

Yang Yang, Liyang Shi, Xiu-Ling Fu, Gang Ma, Zhong-Zhou Yang, Yu-Hao Li, Yi-Bin Zhou, Lihua Yuan, Ye Xia, Xiufang Zhong, Ping Yin, Li Sun, Wu-Wen Zhang, I. A. Babarinde, Yongjun Wang, Xiaoyang Zhao, A. Hutchins, Guo-Qing Tong

bioRxiv

DOI

2021

The histone demethylase KDM2B regulates human primordial germ cell-like cells specification

Wei-Yan Yuan, Zhaokai Yao, Veeramohan Veerapandian, Xinyan Yang, Xiaoman Wang, Ding-Yao Chen, Linzi Ma, Chao-Hui Li, Yi Zheng, Fang Luo, Xiaoyang Zhao

International Journal on Biological Sciences

DOI

2021

Deciphering the autophagy regulatory network via single-cell transcriptome analysis reveals a requirement for autophagy homeostasis in spermatogenesis

Mei Wang, Yanwen Xu, Yun-Cong Zhang, Yuhan Chen, Gang Chang, G. An, Xinyan Yang, Caihong Zheng, Jiexiang Zhao, Zhaoting Liu, Da-Zhuang Wang, Kai Miao, Shuan Rao, Meng Dai, Dong Wang, Xiaoyang Zhao

Theranostics

DOI

2021

The chromatin accessibility landscape reveals distinct transcriptional regulation in the induction of human primordial germ cell-like cells from pluripotent stem cells

Xiaoman Wang, Veeramohan Veerapandian, Xinyan Yang, Ke Song, Xiaoheng Xu, Manman Cui, Wei-Yan Yuan, Yaping Huang, Xinyu Xia, Zhaokai Yao, Cong Wan, Fang Luo, Xiuling Song, Xiao-Ru Wang, Yi Zheng, A. Hutchins, R. Jauch, Meiyan Liang, Chenhong Wang, Zhaoting Liu, Gang Chang, Xiaoyang Zhao

Stem Cell Reports

DOI

2021

Cell-fate transition and determination analysis of mouse male germ cells throughout development

Jiexiang Zhao, P. Lu, Cong Wan, Yaping Huang, Manman Cui, Xinyan Yang, Yuqiong Hu, Yi Zheng, Ji Dong, Mei Wang, Shu Zhang, Zhaoting Liu, Shuhui Bian, Xiaoman Wang, Rui Wang, Shao-Fang Ren, Da-Zhuang Wang, Zhaokai Yao, Gang Chang, Fu-Chou Tang, Xiaoyang Zhao

Nature Communications

DOI

2021

Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2S production

Wei-Yun Wang, Shao-Fang Ren, Yun-Kun Lu, Xi Chen, Juan-Juan Qu, Xiao-Jie Ma, Qiang Deng, Zhensheng Hu, Yan Jin, Zi-Yu Zhou, Wenyan Ge, Yi-Bing Zhu, Nannan Yang, Qin H Li, Jia-Qi Pu, Guo Chen, Cunqi Ye, Hao Wang, Xiaoyang Zhao, Zhiqiang Liu, Sai-Yong Zhu

EMBO Journal

DOI

2020

精原干细胞的自我更新及分化调控的研究现状与展望

罗芳，李朝晖，赵小阳

《发育医学电子杂志》

2019

Novel insights into mammalian spermatogenesis:From mouse to human

汪妹，常港，赵小阳

Science Foundation in China

DOI

2019

比较两种转录激活系统对生殖相关基因的表达调控

卢佳豪，黄亚萍，罗芳，肖亚梅，赵小阳

《生命科学研究》

DOI

2019

Generation of Stable Induced Pluripotent Stem-like Cells from Adult Zebra Fish Fibroblasts

Li Peng, Yonghua Zhou, Wen-Ting Xu, Minggui Jiang, Huajin Li, Mindi Long, Wenbin Liu, Jin-Hui Liu, Xiaoyang Zhao, Ya-Mei Xiao

International Journal on Biological Sciences

DOI

2019

Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale

Xiaoman Wang, Ting-Ting Liao, Cong Wan, Xiaoyu Yang, Jiexiang Zhao, Rui Fu, Zhaokai Yao, Yaping Huang, Yujia Shi, Gang Chang, Yi Zheng, Fang Luo, Zhaoting Liu, Yu Wang, X. Mao, Xiaoyang Zhao

PeerJ

DOI

2018

Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis.

Mei Wang, Xi-Xi Liu, Gang Chang, Yidong Chen, G. An, Li-Ying Yan, Shuai Gao, Yanwen Xu, Yueli Cui, Ji Dong, Yu-Han Chen, Xiao-Ying Fan, Yuqiong Hu, Ke Song, Xiaohui Zhu, Yun Gao, Zhaokai Yao, Shuhui Bian, Yu Hou, Jiahao Lu, Rui Wang, Yong Fan, Y. Lian, Wenhao Tang, Ya-Peng Wang, Jian-Qiao Liu, Lianming Zhao, Lu-Yong Wang, Zhaoting Liu, Ren-Pei Yuan, Yujia Shi, Boqiang Hu, Xiulian Ren, Fu-Chou Tang, Xiaoyang Zhao, J. Qiao

Cell Stem Cell

DOI

2017

胚胎干细胞体外减数分裂获得功能配子

Quan Zhou, Mei Wang, Yan Yuan, Xuepeng Wang, Rui Fu, Haifeng Wan, Mingming Xie, Mingxi Liu, Xuejiang Guo, Ying Zheng, Guihai Feng, Qinghua Shi, 赵小阳, 沙家豪, 周琪

《科学新闻》

2017

Mitochondrial complex I deficiency leads to the retardation of early embryonic development in Ndufs4 knockout mice

Mei Wang, Yaping Huang, Han Wu, Ke Song, Cong Wan, A. Chi, Yamei Xiao, Xiaoyang Zhao

PeerJ

DOI

2016

Helq对干细胞多能性影响的研究

万聪，黄亚萍，汪妹，肖亚梅，赵小阳

《中国实验动物学报》

2016

Autotetraploid cell Line induced by SP600125 from crucian carp and its developmental potentiality

Yonghua Zhou, Mei Wang, Minggui Jiang, Liang-Yue Peng, Cong Wan, Jin-Hui Liu, Wenbin Liu, Rurong Zhao, Xiaoyang Zhao, Wei Hu, Shaojun Liu, Ya-Mei Xiao

Scientific Reports

DOI

2013

单倍体胚胎干细胞——哺乳动物基因功能研究的新工具

帅领，李伟，赵小阳，周琪

《中国细胞生物学学报》

2012

体细胞重编程研究进展及前景展望

蒋明贵，汪妹，肖亚梅，赵小阳

《生物物理学报》

2012

Research Advances and Forecast Prospect of Somatic Reprogramming

Minggui Jiang, Mei Wang, Yamei Xiao, Xiaoyang Zhao

DOI

赵小阳

精选作品

期刊论文

A fast chemical reprogramming system promotes cell identity transition through a diapause-like state

Lovastatin promotes the self-renewal of murine and primate spermatogonial stem cells

The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting

Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models

Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like state

Human embryos arrest in a quiescent-like state characterized by metabolic and zygotic genome activation problems

The histone demethylase KDM2B regulates human primordial germ cell-like cells specification

Deciphering the autophagy regulatory network via single-cell transcriptome analysis reveals a requirement for autophagy homeostasis in spermatogenesis

The chromatin accessibility landscape reveals distinct transcriptional regulation in the induction of human primordial germ cell-like cells from pluripotent stem cells

Cell-fate transition and determination analysis of mouse male germ cells throughout development

Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2S production

精原干细胞的自我更新及分化调控的研究现状与展望

Novel insights into mammalian spermatogenesis:From mouse to human

比较两种转录激活系统对生殖相关基因的表达调控

Generation of Stable Induced Pluripotent Stem-like Cells from Adult Zebra Fish Fibroblasts

Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale

Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis.

胚胎干细胞体外减数分裂获得功能配子

Mitochondrial complex I deficiency leads to the retardation of early embryonic development in Ndufs4 knockout mice

Helq对干细胞多能性影响的研究

Autotetraploid cell Line induced by SP600125 from crucian carp and its developmental potentiality

单倍体胚胎干细胞——哺乳动物基因功能研究的新工具

体细胞重编程研究进展及前景展望

Research Advances and Forecast Prospect of Somatic Reprogramming

会议论文

男性不育机制研究与治疗探索