卓林胜｜南华大学｜学者主页

期刊论文

2026

Discovery of Potent o-Aminobenzoamide-Based NAMPT Inhibitors for Targeting NAPRT-Deficient Gastric Cancer.

Heng Yang, Zhi-Yi Li, Huiqian Peng, Lixian Shen, Zhen Li, Lejing Zhu, Rifan Ding, Yiting Shi, Yuting Liu, Miao Zhang, Linsheng Zhuo, Meiling Yang, Zhen Wang, Weifan Jiang

Journal of Medicinal Chemistry

DOI

2026

O-aminobenzamide: An increasingly popular privileged scaffold in drug discovery

Linsheng Zhuo, Hao Xiong, Xi Zhang, Goeun Kim, Yan Peng, Hongyun Zou, Hoyeon Jang, Jun Li, Zhen Wang, Jong Seung Kim

Coordination chemistry reviews

DOI

2026

Discovery of a novel 10-hydroxy-12-methyl-substituted evodiamine derivative with anti-hepatocellular carcinoma activity through multi-pathway modulation involving suppression of PKA/AKT signaling cascades and moderate Topo I inhibition.

Yan Peng, Zi-Xuan Li, Hanxuan Mo, Xinyu Deng, Xin-Jue Ping, Le-Le Zhou, Chao-Feng Feng, Keting Wu, Yongxia Xiong, Lin Long, Hui-Hong Wang, Linsheng Zhuo, Zhen Wang, Xuelin Li

European journal of medicinal chemistry

DOI

2025

Novel Carbamate-Based o-aminobenzamide Derivatives as Potent Antigastric Carcinoma Agents via Disrupting NAD+ Salvage Synthesis.

Siyi Zhang, Zhen Li, Bo Li, Zhi-Yi Li, Huiqian Peng, Lixian Shen, Lejing Zhu, Tong Mo, Jialiang Peng, Linsheng Zhuo, Zhen Wang, Weifan Jiang

Journal of Medicinal Chemistry

DOI

2025

N(14)-phenyl-substituted evodiamine derivatives for the treatment of superficial fungal infections by inhibiting xanthine dehydrogenase.

Ying Peng, Yan Peng, Jiachen Li, Yu Zhang, Xi Zhang, Kang Liu, Peng Chen, Weifan Jiang, Linsheng Zhuo, Xue Peng, Jun-Bo Wu, Heng Yang, Li Tan, Jinjin Chen, Linyi Liu, Zhen Wang

Bioorganic chemistry (Print)

DOI

2024

Novel N-phenyl-2-(aniline) benzamide hydrochloride salt development for colon cancer therapy

Yan Peng, Ying Peng, Wei Zhang, Siyi Zhang, Huiqian Peng, Zhen Li, Bo Li, Linyi Liu, Linsheng Zhuo, Zhen Wang, Jun-Bo Wu, Weifan Jiang

Frontiers in Pharmacology

DOI

2024

Identification of a novel 10-hydroxyevodiamine prodrug as a potent topoisomerase inhibitor with improved aqueous solubility for treatment of hepatocellular carcinoma.

Xiuzhen Wei, Xi Zhang, Yan Peng, Jun-Bo Wu, Hanxuan Mo, Zhigang An, Xinyu Deng, Ying Peng, Linyi Liu, Weifan Jiang, Jinjin Chen, Zecheng Hu, Zhen Wang, Linsheng Zhuo

European journal of medicinal chemistry

DOI

2024

Discovery of 7-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridine derivatives as potent inhibitors of rearranged during transfection (RET) and RET solvent-front mutants for overcoming selpercatinib resistance.

Jun-Bo Wu, Hanxuan Mo, Zhigang An, Zishu Tang, Xinyu Deng, Hui-Fang Zhou, Yi Gong, Chenggong Zheng, Linsheng Zhuo, Shu-Guang Tan

European journal of medicinal chemistry

DOI

2024

Discovery of novel small molecules targeting the USP21/JAK2/STAT3 axis for the treatment of triple-negative breast cancer.

Lin Long, Jiachi Xu, Xiaowen Qi, Pen Yan, Chengkun Wang, Weifan Jiang, Xue Peng, Zecheng Hu, Wenjun Yi, Liming Xie, Xiaoyong Lei, Zhen Wang, Linsheng Zhuo

European journal of medicinal chemistry

DOI

2024

Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future

Junfang Li, Xiaodong Wang, Honghua Zhang, Xiao-ling Hu, Xue Peng, Weifan Jiang, Linsheng Zhuo, Yan Peng, Guo-Li Zeng, Zhen Wang

Medicinal research reviews (Print)

DOI

2014

Synthesis,Crystal Structure and Biological Activity of 8-((4-((2,3-diaminopyridin-4-yl)oxy)-3-fluorophenyl)-amino)-2-(4-fluorophenyl)-3-methyl-2,7-naphthyridin-1(2H)-one

卓林胜，董欢，黄伟，赵兴俄，佘能芳

Chinese Journal of Structural Chemistry

会议论文

2019

克服多重耐药的新一代TRK抑制剂的分子设计及其抗肿瘤活性

卓林胜，徐红闯，王明书，黄伟，杨光富

《第十一届全国化学生物学学术会议论文摘要（第一卷）》

DOI

卓林胜

精选作品

期刊论文

Discovery of Potent o-Aminobenzoamide-Based NAMPT Inhibitors for Targeting NAPRT-Deficient Gastric Cancer.

O-aminobenzamide: An increasingly popular privileged scaffold in drug discovery

Discovery of a novel 10-hydroxy-12-methyl-substituted evodiamine derivative with anti-hepatocellular carcinoma activity through multi-pathway modulation involving suppression of PKA/AKT signaling cascades and moderate Topo I inhibition.

Novel Carbamate-Based o-aminobenzamide Derivatives as Potent Antigastric Carcinoma Agents via Disrupting NAD+ Salvage Synthesis.

N(14)-phenyl-substituted evodiamine derivatives for the treatment of superficial fungal infections by inhibiting xanthine dehydrogenase.

Novel N-phenyl-2-(aniline) benzamide hydrochloride salt development for colon cancer therapy

Identification of a novel 10-hydroxyevodiamine prodrug as a potent topoisomerase inhibitor with improved aqueous solubility for treatment of hepatocellular carcinoma.

Discovery of 7-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridine derivatives as potent inhibitors of rearranged during transfection (RET) and RET solvent-front mutants for overcoming selpercatinib resistance.

Discovery of novel small molecules targeting the USP21/JAK2/STAT3 axis for the treatment of triple-negative breast cancer.

Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future

Synthesis,Crystal Structure and Biological Activity of 8-((4-((2,3-diaminopyridin-4-yl)oxy)-3-fluorophenyl)-amino)-2-(4-fluorophenyl)-3-methyl-2,7-naphthyridin-1(2H)-one

会议论文

克服多重耐药的新一代TRK抑制剂的分子设计及其抗肿瘤活性

研究方向