董志强｜华中农业大学｜学者主页

2026

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Mi Yang, Zhiqiang Dong

Advanced Science

DOI

2026

Lamprey 3D single-cell transcriptomics reveals ancestral and specialized features of the vertebrate brain

Haixu Wu, Duoyuan Chen, Jun Li, Tao Zhou, Zhenkun Zhuang, Zhiwei Niu, Zeyu Du, Yongjie Chen, Shunqin Chuan, Chunyan Xu, Xun Liao, Xiaoyu Meng, Jiali Lu, Wenxue Cui, Youning Lin, Fubaoqian Huang, Kuo Liao, Liu Yan, Tao Yang, Jing Chen, H Wang, Zhiqiang Dong, Longqi Liu, Xiaodong Fang, Xun Xu, Qingwei Li, Yue Pang, Shiping Liu, Bing Su

Science

DOI

2026

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Zi Wang, Wendai Bao, Ke Shui, Jun Qin, J Y Chen, M Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong

Advanced Science

DOI

2026

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiefeng Wang, Weiwei Tao

Advanced Science

DOI

2026

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Lan Li, Muyang Li, Lei Sun, Yanrong Yang, Yongwei Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, J L Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Mengchao Zhang

Advanced Science

DOI

2026

USP10 promotes glioma stem cell maintenance and glioblastoma growth by antagonizing DTX3L-mediated SATB2 ubiquitination

Mengyue Guo, Wenlong Luo, Peng Ling, Hong Lei, Lihua Li, Chao Duan, Zhen Xue, Min Zhang, Xiaoyan Zhang, Wendai Bao, Wenchao Zhou, Jianghong Man, Suojun Zhang, Kai Shu, Jun Qin, Xiuxing Wang, Zhiqiang Dong, Weiwei Tao

Nature Communications

DOI

2026

Riluzole preserves brain endothelial integrity in ischemic stroke via SLC7A11-dependent GPX4 and HIF-1α/VEGFA signaling

Haipeng Wang, Ying Feng, Wei Jiang, Han Wang, Ruolin Zhang, Guangqiang Li, Chao Duan, Yuneng Zhou, Wendai Bao, Ke Shui, Min Zhang, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong

Cellular Signalling

DOI

2025

Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer’s disease

Aodi He, Yue Wang, Yuhang Shen, Zhiqiang Dong, Lingli Luo, Xiangyu Ge, Xinlu Liu, Yue Mao, Tongmei Zhang, Xinyan Li, Hao Ran Li, Wei Jing, Ling‐Qiang Zhu, Qifa Zhang, Youming Lu

Nature Aging

DOI

2025

PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate

Xiang Zhao, Vincent Mouilleau, Yiqi Wang, Ahmet Can Solak, Jason Q. Garcia, Xinye Chen, Xiaoyu Shi, Christopher J. Wilkinson, Löıc A. Royer, Zhiqiang Dong, Su Guo

Nature Communications

DOI

2025

Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR

Aixin Yu, Yiqi Wang, Chao Duan, Jun Qin, Miaomiao Liao, Haiyan Zhu, Junrong Lei, Jun Liu, Zehao Yang, Yu Li, Hui Gui, Jinxin Xin, Weiwei Tao, Wendai Bao, Zhiqiang Dong

Communications Biology

DOI

2025

Monitoring of single-nucleus chromatin landscape of ischemic stroke in mouse cerebral cortex across time

Ruolin Zhang, Sicheng Guo, Jie Zhou, Xiumei Lin, Ying Wang, Yiqi Wang, Muyang Li, Kaichen Zhao, Wendai Bao, Ke Shui, Chuanyu Liu, Chang Liu, Chang Liu, Chang Liu, Zhiqiang Dong

Scientific Data

DOI

2024

Protocol to profile snATAC-seq datasets and motif enrichment analysis during zebrafish early embryogenesis

Jie Zhou, Xueqian Yang, Xiumei Lin, Kaichen Zhao, Xue Wang, Zhiqiang Dong, Chuanyu Liu, Chang Xin Liu

STAR Protocols

DOI

2024

Zinc sulfide nanoparticles serve as gas slow-release bioreactors for H2S therapy of ischemic stroke

Guangqiang Li, Ruolin Zhang, Keyu Chen, Jiawen Dong, Jiawen Dong, Zhihao Yang, Hangyu Chen, Hui Wang, Hui Wang, Huali Lei, Wendai Bao, Min Zhang, Zhidong Xiao, Liang Cheng, Zhiqiang Dong

Biomaterials

DOI

2024

Stanniocalcin-1 promotes temozolomide resistance of glioblastoma through regulation of MGMT

Chao Duan, Bincan He, Yiqi Wang, Wanying Liu, Wendai Bao, Yu Li, Jinxin Xin, Hui Gui, Junrong Lei, Zehao Yang, Jun Liu, Weiwei Tao, Jun Qin, Jie Luo, Zhiqiang Dong

Scientific Reports

DOI

2024

Editorial: The immune microenvironment landscape in cerebrovascular diseases

Zhiqiang Dong

Frontiers in Immunology

DOI

2024

Retraction Note: Integration of clinical and spatial data to explore lipid metabolism-related genes for predicting prognosis and immune microenvironment in gliomas

Zhangyi Yu, Yuneng Zhou, Yongxue Li, Zhiqiang Dong

Functional & Integrative Genomics

DOI

2024

Large language models assisted multi-effect variants mining on cerebral cavernous malformation familial whole genome sequencing

Yiqi Wang, Jinmei Zuo, Chao Duan, Hao Peng, Jia Huang, Liang Zhao, Li Zhang, Zhiqiang Dong

Computational and Structural Biotechnology Journal

DOI

2024

Identification of PANoptosis-related predictors for prognosis and tumor microenvironment by multiomics analysis in glioma

Fengzeng Sun, Miaomiao Liao, Zi Tao, Ruiqi Hu, Jun Qin, Weiwei Tao, Wentong Liu, Yiqi Wang, Guoliang Pi, Junrong Lei, Wendai Bao, Zhiqiang Dong

Journal of Cancer

DOI

2024

Deciphering the Cell-Specific Transcript Heterogeneity and Alternative Splicing during the Early Embryonic Development of Zebrafish

Xiu-Mei Lin, Xue Wang, Chang Liu, Chuan Liu, Tao Zeng, Ziqi Yuan, Meidi Hu, Rong Xiang, Kaichen Zhao, Jie Zhou, Shichen Yang, Yang Wang, Kaifeng Meng, Hui Wang, Guang-Liang He, Ruiyang Zhao, Jiaheng Liu, Yun Huang, Jingfang Pan, Jia-Lu Wang, Jun-Yi Chen, Fei Guo, Yu-Liang Dong, Xun Xu, Da-Ji Luo, Ying Gu, Long-Qi Liu, Zhiqiang Dong, Liang Chen

bioRxiv

DOI

2023

Single-nucleus chromatin landscapes during zebrafish early embryogenesis

Xiumei Lin, Xueqian Yang, Chuan Chen, Wen Ma, Yiqi Wang, Xuerong Li, Kaichen Zhao, Qiuting Deng, Weimin Feng, Yuting Ma, Hui Wang, Lveming Zhu, Sunil Kumar Sahu, Fengzhen Chen, Xiuqing Zhang, Zhiqiang Dong, Chuanyu Liu, Longqi Liu, Chang Xin Liu

Scientific Data

DOI

2023

NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice

Ruolin Zhang, Weibing Mao, Lumeng Niu, Wendai Bao, Yiqi Wang, Ying Wang, Yasha Zhu, Zhihao Yang, Jincao Chen, Jiawen Dong, Meng Cai, Zilong Yuan, Haikun Song, Guangqiang Li, Min Zhang, Nanxiang Xiong, Jun Wei, Zhiqiang Dong

eLife

DOI

2023

Author response: NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice

DOI

2023

RETRACTED ARTICLE: Integration of clinical and spatial data to explore lipid metabolism-related genes for predicting prognosis and immune microenvironment in gliomas

Zhangyi Yu, Yuneng Zhou, Yongxue Li, Zhiqiang Dong

Functional & Integrative Genomics

DOI

2022

Novel INHAT repressor drives glioblastoma growth by promoting ribosomal DNA transcription in glioma stem cells

Weiwei Tao, Hong Lei, Wenlong Luo, Zhi Huang, Peng Ling, Mengyue Guo, Lihao Wan, Kui Zhai, Qian Huang, Qiulian Wu, Shutong Xu, Liang Zeng, Xiuxing Wang, Zhiqiang Dong, Jeremy N. Rich, Shideng Bao

Neuro-Oncology

DOI

2022

Novel Brain-Stiffness-Mimicking Matrix Gel Enables Comprehensive Invasion Analysis of 3D Cultured GBM Cells

Shuowen Wang, Yiqi Wang, Jin Xiong, Wendai Bao, Yaqi Li, Jun Qin, Guangchao Han, Sheng Hong Hu, Junrong Lei, Zehao Yang, Yu Qian, Shuang Dong, Zhiqiang Dong

Frontiers in Molecular Biosciences

DOI

2022

Mammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia

Lei Sun, Yang He, Dong He, Jian Chen, Zhiqiang Dong, Shaoxiang Luo, Huiting Liang, Yu Cao, Bingcheng Cai, Min Zhang

Cell Death and Disease

DOI

2022

Spatiotemporal mapping of gene expression landscapes and developmental trajectories during zebrafish embryogenesis

Chang Xin Liu, Rui Li, Young Li, Xiumei Lin, Kaichen Zhao, Qun Liu, Shuowen Wang, Xueqian Yang, Xuyang Shi, Yuting Ma, Chenyu Pei, Hui Wang, Wendai Bao, Junhou Hui, Tao Yang, Zhicheng Xu, Tingting Lai, Michael A. Berberoglu, Sunil Kumar Sahu, Miguel Angel Esteban, Kailong Ma, Guangyi Fan, Yuxiang Li, Shiping Liu, Ao Chen, Xun Xu, Zhiqiang Dong, Longqi Liu

Developmental Cell

DOI

2022

Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs

Carlos Sánchez-Priego, Ruiqi Hu, Linda L. Boshans, Matthew A. Lalli, Justyna A. Janas, Sarah Williams, Zhiqiang Dong, Nan Yang

Cell Reports

DOI

2020

RBM38 in cancer: role and mechanism

Cheng Zou, Ying Wan, Lingjing He, Jin Hai Zheng, Mei Jun Yang, Junfeng Shi, Min Zhang, Zhiqiang Dong, Dingxiao Zhang

Cellular and Molecular Life Sciences

DOI

2020

Complexity of Detecting CRISPR/Cas9-Mediated Homologous Recombination in Zebrafish

Y. Pi, K. Z. He, W. Q. Zhang, Zhiqiang Dong, Fuguo Jiang, Keji Jiang, Su Guo

Molecular Biology

DOI

2019

Designing a Green Fluorogenic Protease Reporter by Flipping a Beta Strand of GFP for Imaging Apoptosis in Animals

Qiang Zhang, Antonino Schepis, Hai Huang, Junjiao Yang, Wen Ma, Joaquim Torra, Shaoqing Zhang, Lina Yang, Haifan Wu, Santi Nonell, Zhiqiang Dong, Thomas B. Kornberg, Shaun R. Coughlin, Xiaokun Shu

Journal of the American Chemical Society

DOI

2019

Expression of RNA-binding protein Rbfox1l demarcates a restricted population of dorsal telencephalic neurons within the adult zebrafish brain

Fengjun Ma, Zhiqiang Dong, Michael A. Berberoglu

Gene Expression Patterns

DOI

2018

Dissecting Molecular and Circuit Mechanisms for Inhibition and Delayed Response of ASI Neurons during Nociceptive Stimulus

Min Yi Guo, Ming-Hai Ge, Michael A. Berberoglu, Jie H. S. Zhou, Long Ma, Juan Yang, Qiyan Dong, Yanni Feng, Zheng‐Xing Wu, Zhiqiang Dong

Cell Reports

DOI

2018

Csy4-based vector system enables conditional chimeric gene editing in zebrafish without interrupting embryogenesis

Jingjing Wang, Fei Fei, Michael A. Berberoglu, Shaoyang Sun, Lei Wang, Zhiqiang Dong, Xu Wang

Journal of Molecular Cell Biology

DOI

2016

Rational Design of a GFP-Based Fluorogenic Caspase Reporter for Imaging Apoptosis In Vivo

Tsz‐Leung To, Antonino Schepis, Rubén Ruiz‐González, Qiang Zhang, Dan Yu, Zhiqiang Dong, Shaun R. Coughlin, Xiaokun Shu

Cell chemical biology

DOI

2015

Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo

Dan Yu, Zhiqiang Dong, William Clay Gustafson, Rubén Ruiz‐González, Luca Signor, Fanny Marzocca, Franck Borel, Matthew P. Klassen, Kalpana Makhijani, Antoine Royant, Yuh Nung Jan, William A. Weiss, Su Guo, Xiaokun Shu

Protein Science

DOI

精选作品

期刊论文

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Lamprey 3D single-cell transcriptomics reveals ancestral and specialized features of the vertebrate brain

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

USP10 promotes glioma stem cell maintenance and glioblastoma growth by antagonizing DTX3L-mediated SATB2 ubiquitination

Riluzole preserves brain endothelial integrity in ischemic stroke via SLC7A11-dependent GPX4 and HIF-1α/VEGFA signaling

Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer’s disease

PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate

Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR

Monitoring of single-nucleus chromatin landscape of ischemic stroke in mouse cerebral cortex across time

Protocol to profile snATAC-seq datasets and motif enrichment analysis during zebrafish early embryogenesis

Zinc sulfide nanoparticles serve as gas slow-release bioreactors for H2S therapy of ischemic stroke

Stanniocalcin-1 promotes temozolomide resistance of glioblastoma through regulation of MGMT

Editorial: The immune microenvironment landscape in cerebrovascular diseases

Retraction Note: Integration of clinical and spatial data to explore lipid metabolism-related genes for predicting prognosis and immune microenvironment in gliomas

Large language models assisted multi-effect variants mining on cerebral cavernous malformation familial whole genome sequencing

Identification of PANoptosis-related predictors for prognosis and tumor microenvironment by multiomics analysis in glioma

Deciphering the Cell-Specific Transcript Heterogeneity and Alternative Splicing during the Early Embryonic Development of Zebrafish

Single-nucleus chromatin landscapes during zebrafish early embryogenesis

NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice

Author response: NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice

RETRACTED ARTICLE: Integration of clinical and spatial data to explore lipid metabolism-related genes for predicting prognosis and immune microenvironment in gliomas

Novel INHAT repressor drives glioblastoma growth by promoting ribosomal DNA transcription in glioma stem cells

Novel Brain-Stiffness-Mimicking Matrix Gel Enables Comprehensive Invasion Analysis of 3D Cultured GBM Cells

Mammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia

Spatiotemporal mapping of gene expression landscapes and developmental trajectories during zebrafish embryogenesis

Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs

RBM38 in cancer: role and mechanism

Complexity of Detecting CRISPR/Cas9-Mediated Homologous Recombination in Zebrafish

Designing a Green Fluorogenic Protease Reporter by Flipping a Beta Strand of GFP for Imaging Apoptosis in Animals

Expression of RNA-binding protein Rbfox1l demarcates a restricted population of dorsal telencephalic neurons within the adult zebrafish brain

Dissecting Molecular and Circuit Mechanisms for Inhibition and Delayed Response of ASI Neurons during Nociceptive Stimulus

Csy4-based vector system enables conditional chimeric gene editing in zebrafish without interrupting embryogenesis

Rational Design of a GFP-Based Fluorogenic Caspase Reporter for Imaging Apoptosis In Vivo

Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo

预印本

Mammalian-unique eIF4E2 maintains GSK3β proline kinase activity to resist senescence against hypoxia

研究方向