王鑫｜厦门大学｜学者主页

2026

阿尔茨海默病外周与中枢神经免疫交互机制及干预策略

张硕，郑秋阳，王鑫

《兰州大学学报(医学版)》

2025

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng

Advanced Science

DOI

2025

Peripheral and central neuroimmune mechanisms in Alzheimer’s disease pathogenesis

Shuo Zhang, Yue Gao, Yini Zhao, Timothy Y. Huang, Qiuyang Zheng, Xin Wang

Molecular Neurodegeneration

DOI

2025

The p75 neurotrophin receptor controls the skeletal stem cell niche through sensory innervation

Zuoxing Wu, Na Li, Zhengqiong Luo, Zihan Chen, Xuemei He, Fan Shi, Jie Han, Haitao Huang, Baohong Shi, Long Zhang, Yu Li, Junmin Shen, Seoyeon Bok, Jun Sun, Xing Niu, Ke Mo, Pengbin Yin, Lige Leng, Xin Wang, Jie Zhang, Lanfen Chen, Dawang Zhou, Weinan Cheng, Jianmin Huang, Matthew Blake Greenblatt, Ren Xu

Developmental Cell

DOI

2024

ZBTB21 suppresses CRE-mediated transcription to impair synaptic function in Down syndrome

Muzhen Qiao, Q Q Huang, Xin Wang, Jiahuai Han

Science Advances

DOI

2024

Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy

Qiuyang Zheng, Xin Wang

Protein & Cell

DOI

2024

The Role of Protein Quantity Control in Polyglutamine Spinocerebellar Ataxias

Hongfeng Zhang, Xin Wang

The Cerebellum

DOI

2024

Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity

Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Lihong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, Fang Huang, Hong Luo, Honghua Zheng, Xiao‐Fen Chen, Lige Leng, Yun-Wu Zhang, Xin Wang, Jie Zhang, Kai Xia Guo, Zhanxiang Wang, Hongsheng Zhang, Yingjun Zhao, Huaxi Xu

iScience

DOI

2023

β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice

Yini Zhao, Qiuyang Zheng, Yujuan Hong, Yue Gao, Jiaojiao Hu, Maoju Lang, Hongfeng Zhang, Ying Zhou, Hong Luo, Xian Zhang, Hao Sun, Xiao‐Xin Yan, Timothy Y. Huang, Yan‐Jiang Wang, Huaxi Xu, Cong Liu, Xin Wang

Nature Neuroscience

DOI

2023

β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function

Yue Gao, Yujuan Hong, Lihong Huang, Shuang Zheng, Haibin Zhang, Shihua Wang, Yi Yao, Yini Zhao, Lin Zhu, Qiang Xu, Xuhui Chai, Yuanyuan Zeng, Yuzhe Zeng, Liangkai Zheng, Yulin Zhou, Hong Luo, Xian Zhang, Hongfeng Zhang, Ying Zhou, Guo Fu, Hao Sun, Timothy Y. Huang, Qiuyang Zheng, Huaxi Xu, Xin Wang

Cell

DOI

2022

Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability

Haibin Zhang, Qiuyang Zheng, Tiantian Guo, Shijun Zhang, Shuang Zheng, Ruimin Wang, Qingfang Deng, Guowei Yang, Shuo Zhang, Linxin Tang, Qiuping Qi, Lin Zhu, Xiu-Fang Zhang, Hong Luo, Xian Zhang, Hao Sun, Yue Gao, Hongfeng Zhang, Ying Zhou, Aidong Han, Chen‐Song Zhang, Huaxi Xu, Xin Wang

Molecular Psychiatry

DOI

2022

Vulgarisin-type diterpenoids from self-heal ( Prunella vulgaris ) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway

Fengwei Ma, Qingfang Deng, Hua‐Yong Lou, Jinyu Li, Su Xu, Wenneng Wu, Qihua Wen, Lei Tang, Xin Wang, Weidong Pan

Food & Function

DOI

2021

DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome

Xiao-Yan Tang, Lei Xu, Jingshen Wang, Yuan Hong, Yuanyuan Wang, Qian Zhu, Da Wang, Xinyue Zhang, Chun-Yue Liu, Kai-Heng Fang, Xiao Han, Shihua Wang, Xin Wang, Min Xu, Anita Bhattacharyya, Xing Long Guo, Mingyan Lin, Yan Liu

Journal of Clinical Investigation

DOI

2021

SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate

Hongfeng Zhang, Yujuan Hong, Weijie Yang, Ruimin Wang, Ting Yao, Jian Wang, Ke Liu, Huilong Yuan, Chaoqun Xu, Yuanyuan Zhou, Guanxian Li, Lishan Zhang, Hong Luo, Xian Zhang, Dan Du, Hao Sun, Qiuyang Zheng, Yun‐wu Zhang, Yingjun Zhao, Ying Zhou, Huaxi Xu, Xin Wang

National Science Review

DOI

2021

Trisomy 21–induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25

Qiuyang Zheng, Guilin Li, Shihua Wang, Ying Zhou, Ke Liu, Yue Gao, Yulin Zhou, Liangkai Zheng, Lin Zhu, Qingfang Deng, Meiling Wu, Anjie Di, Lishan Zhang, Yingjun Zhao, Hongfeng Zhang, Hao Sun, Chen Dong, Huaxi Xu, Xin Wang

Science Advances

DOI

2020

RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation

Dongdong Zhao, Yunqiang Zhou, Yuanhui Huo, Jian Meng, Xiaoxia Xiao, Linkun Han, Xian Zhang, Hong Luo, Dan Can, Hao Sun, Timothy Y. Huang, Xin Wang, Jie Zhang, Farong Liu, Huaxi Xu, Yun‐wu Zhang

Cell Death and Differentiation

DOI

2020

Activation of FAK/Rac1/Cdc42‐GTPase signaling ameliorates impaired microglial migration response to Aβ 42 in triggering receptor expressed on myeloid cells 2 loss‐of‐function murine models

Zhouyi Rong, Baoying Cheng, Li Zhong, Xiaowen Ye, Xin Li, Lin Jia, Yanfang Li, Francis Shue, Na Wang, Yiyun Cheng, Xiaohua Huang, Chia‐Chen Liu, John Denis Fryer, Xin Wang, Yun‐wu Zhang, Honghua Zheng

The FASEB Journal

DOI

2019

The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

Fanwei Zeng, Xuehai Ma, Lin Zhu, Qiang Xu, Yuzhe Zeng, Yue Gao, Guilin Li, Tiantian Guo, Haibin Zhang, Xiaoyan Tang, Ziqiang Wang, Zesen Ye, Liangkai Zheng, Hongfeng Zhang, Qiuyang Zheng, Kunping Li, Jinfang Lu, Xueting Qi, Hong Luo, Xian Zhang, Zhanxiang Wang, Yulin Zhou, Yi Yao, Rongqin Ke, Ying Zhou, Yan Liu, Hao Sun, Timothy Y. Huang, Zhicheng Shao, Huaxi Xu, Xin Wang

PLoS Biology

DOI

2019

Novel KCNJ10 Compound Heterozygous Mutations Causing EAST/SeSAME-Like Syndrome Compromise Potassium Channel Function

Hongfeng Zhang, Lin Dan Zhu, Fengpeng Wang, Ruimin Wang, Yujuan Hong, Yangqin Chen, Bin Zhu, Yue Gao, Hong Luo, Xian Zhang, Hao Sun, Ying Zhou, Yi Yao, Xin Wang

Frontiers in Genetics

DOI

2019

A de novo SCN8A heterozygous mutation in a child with epileptic encephalopathy: a case report

Kao‐Min Lin, Geng Su, Feng‐Peng Wang, Xiaobin Zhang, Yuanqing Wang, Jun Ren, Xin Wang, Yi Yao, Ying Zhou

BMC Pediatrics

DOI

2018

Snx27 Deletion Promotes Recovery From Spinal Cord Injury by Neuroprotection and Reduces Macrophage/Microglia Proliferation

Yuzhe Zeng, Nawen Wang, Tiantian Guo, Qiuyang Zheng, Shuang Wang, Songsong Wu, Xi Li, Jin Chuan Wu, Zhida Chen, Huaxi Xu, Xin Wang, Bin Lin

Frontiers in Neurology

DOI

2018

The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases

Hongfeng Zhang, Timothy Y. Huang, Yujuan Hong, Weijie Yang, Xian Zhang, Hong Luo, Huaxi Xu, Xin Wang

Frontiers in Aging Neuroscience

DOI

2017

Intracellular trafficking of TREM2 is regulated by presenilin 1

Yingjun Zhao, Xiaoguang Li, Timothy Y. Huang, Lu-Lin Jiang, Zhenqiu Tan, Muxian Zhang, Irene Han-Juo Cheng, Xin Wang, Guojun Bu, Yun‐wu Zhang, Qi Wang, Huaxi Xu

Experimental & Molecular Medicine

DOI

2016

Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases

Qiuyang Zheng, Timothy Y. Huang, Lishan Zhang, Ying Zhou, Hong Luo, Huaxi Xu, Xin Wang

Frontiers in Aging Neuroscience

DOI

2016

SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis

Xin Wang, Ying Zhou, Jian Wang, I‐Chu Tseng, Timothy Y. Huang, Yingjun Zhao, Qiuyang Zheng, Yue Gao, Hong Luo, Xian Zhang, Guojun Bu, Wanjin Hong, Huaxi Xu

Journal of Neuroscience

DOI

2015

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

Yingjun Zhao, I‐Chu Tseng, Charles J. Heyser, Edward M. Rockenstein, Michael Mante, Anthony Adame, Qiuyang Zheng, Timothy Y. Huang, Xin Wang, Pharhad Eli Arslan, Paramita Chakrabarty, Chengbiao Wu, Guojun Bu, William Cary Mobley, Yun‐wu Zhang, Peter St George‐Hyslop, Eliezer Masliah, Paul Fraser, Huaxi Xu

Neuron

DOI

2014

Dysregulation of protein trafficking in neurodegeneration

Xin Wang, Timothy Y. Huang, Guojun Bu, Huaxi Xu

Molecular Neurodegeneration

DOI

王鑫

精选作品

期刊论文

阿尔茨海默病外周与中枢神经免疫交互机制及干预策略

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Peripheral and central neuroimmune mechanisms in Alzheimer’s disease pathogenesis

The p75 neurotrophin receptor controls the skeletal stem cell niche through sensory innervation

ZBTB21 suppresses CRE-mediated transcription to impair synaptic function in Down syndrome

Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy

The Role of Protein Quantity Control in Polyglutamine Spinocerebellar Ataxias

Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity

β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice

β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function

Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability

Vulgarisin-type diterpenoids from self-heal ( Prunella vulgaris ) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway

DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome

SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate

Trisomy 21–induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25

RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation

Activation of FAK/Rac1/Cdc42‐GTPase signaling ameliorates impaired microglial migration response to Aβ 42 in triggering receptor expressed on myeloid cells 2 loss‐of‐function murine models

The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

Novel KCNJ10 Compound Heterozygous Mutations Causing EAST/SeSAME-Like Syndrome Compromise Potassium Channel Function

A de novo SCN8A heterozygous mutation in a child with epileptic encephalopathy: a case report

Snx27 Deletion Promotes Recovery From Spinal Cord Injury by Neuroprotection and Reduces Macrophage/Microglia Proliferation

The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases

Intracellular trafficking of TREM2 is regulated by presenilin 1

Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases

SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

Dysregulation of protein trafficking in neurodegeneration

研究方向