刘磊｜清华大学｜学者主页

2026

FUNDC1-dependent mitophagy determines axon regeneration capacity

Wenlei Li, Yujiao Liu, Rui-Xuan Liu, Yuyuan Fan, Jinming Liu, Yingjie Guo, Zeping Hu, Lei Liu, Quan Chen, Bing Zhou

Autophagy

DOI

2025

“优等生”和“后进生”的选择：绩效反馈如何影响地方政府政策响应行为

刘磊，唐美琳

《公共管理评论》，Vol. 7, No. 4

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2024

理顺新时代财政体系的“央地关系”

刘磊

《清华金融评论》，No. 12

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2023

发挥财政政策空间，优化宏观杠杆率结构

刘磊

《清华金融评论》，No. 9

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2023

正确看待居民部门存贷差扩大现象

刘磊，王宇

《清华金融评论》，No. 3

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2023

地方政府债务管理的国际经验及政策建议

刘磊

《清华金融评论》，No. 10

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2023

Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis

Lei Liu, Yan-Jun Li, Guo Chen, Quan Chen

Journal of Biomedical Sciences

DOI

2023

Integration of FUNDC1-associated mitochondrial protein import and mitochondrial quality control contributes to TDP-43 degradation

Jinfa Ma, Lei Liu, Lu Song, Jianghong Liu, Lingyao Yang, Quan Chen, Jane Y. Wu, Li Zhu

Cell Death and Disease

DOI

2023

Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function

Lin-Bo Chen, Qianping Zhang, Yuan-Yuan Meng, Tian Zhao, Cheng-Long Mu, Chang-Ying Fu, Caijuan Deng, Jianyu Feng, Siling Du, Wei Liu, Guang-Feng Geng, K. Ma, Hong-Cheng Cheng, Qiang-Qiang Liu, Qian Luo, Jiao-Jiao Zhang, Zhanqiang Du, Lin Cao, Hui Wang, Yong Liu, Jianping Lin, Guo Chen, Lei Liu, S. Lam, Guang-Hou Shui, Yu-Shan Zhu, Quan Chen

EMBO Reports

DOI

2023

Publisher Correction: Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction

Yingjie Guo, Huan Zhang, Chen-Xi Yan, B. Shen, Yue Zhang, Xiangyang Guo, Sha Sun, Fan Yu, Jiayun Yan, Ronghe Liu, Qianping Zhang, Di Zhang, Haiyang Liu, Yang Liu, Yaoyao Zhang, Wenlei Li, Jiangyu Qin, H. Lv, Zhao-Xia Wang, Yun Yuan, Jie Yang, Y. Zhong, Song Gao, Bing Zhou, Lei Liu, Deling Kong, Xiao-Jiang Hao, Jun-Jie Hu, Quan Chen

Nature Chemical Biology

DOI

2023

Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction

Yingjie Guo, Huan Zhang, Chen-Xi Yan, B. Shen, Yue Zhang, Xiangyang Guo, Sha Sun, Fan Yu, Jiayun Yan, Ronghe Liu, Qianping Zhang, Di Zhang, Haiyang Liu, Yang Liu, Yaoyao Zhang, Wenlei Li, Jiangyu Qin, H. Lv, Zhao-Xia Wang, Yun Yuan, Jie Yang, Y. Zhong, Song Gao, Bing Zhou, Lei Liu, Deling Kong, Xiao-Jiang Hao, Jun-Jie Hu, Quan Chen

Nature Chemical Biology

DOI

2022

Mitophagy‐regulated mitochondrial health strongly protects the heart against cardiac dysfunction after acute myocardial infarction

Chunling Xu, Yangpo Cao, Ruxia Liu, Lei Liu, Wei-Lin Zhang, Xuan Fang, Shi Jia, Jingjing Ye, Yingying Liu, Lin Weng, Xue Qiao, Bo Li, Ming-Fei Zheng

Journal of Cellular and Molecular Medicine

DOI

2022

FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia

Ruxia Liu, Chunling Xu, Wei-Lin Zhang, Yangpo Cao, Jingjing Ye, Bo Li, Shi Jia, Lin Weng, Yingying Liu, Lei Liu, Ming-Fei Zheng

Cell Death and Disease

DOI

2022

BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy

Kun Liu, Qian Zhao, Hongyan Sun, Lei Liu, Chao-Qun Wang, Zheng Li, You-Qing Xu, Liang Wang, Lin Zhang, Hong-Hai Zhang, Quan Chen, Tong-Biao Zhao

Cell Death and Disease

DOI

2022

FUNDC1 Promotes Mitochondrial Translocation of TDP-43 and Modulates TDP-43 Induced Neurotoxicity

Jinfa Ma, Lei Liu, Lu Song, Jianghong Liu, Lingyao Yang, Quan Chen, Jane Y. Wu, Li Zhu

Social Science Research Network

DOI

2021

The Emerging Role of FUNDC1-Mediated Mitophagy in Cardiovascular Diseases

Lei Liu, Yimei Li, Quan Chen

Frontiers in Physiology

DOI

2021

Molecular regulation of mitochondrial autophagy and cellular fate

K. Ma, Hao Wu, Lei Liu, Yu-Shan Zhu, Quan Chen

DOI

2021

Mitophagy receptor FUNDC1 is regulated by PGC‐1α/NRF1 to fine tune mitochondrial homeostasis

Lei Liu, Yan-Jun Li, Jia-Ni Wang, Di Zhang, Hao Wu, Wenhui Li, Huifang Wei, Nan Ta, Yuyuan Fan, Yujiao Liu, Xiaohui Wang, Jun Wang, Xin Pan, Xudong Liao, Yu-Shan Zhu, Quan Chen

EMBO Reports

DOI

2020

Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy

Hao Wu, Huifang Wei, Di Zhang, S. A. Sehgal, De-Jiu Zhang, Xiaohui Wang, Yan Qin, Lei Liu, Quan Chen

Redox Biology

DOI

2020

Comparing the protective function of autophagy and mitophagy in myocardial infarction

Chunling Xu, Yangpo Cao, Ruxia Liu, Lei Liu, Wei-Lin Zhang, Jingjing Ye, Shi Jia, Xuan Fang, Li-Fang Zhao, Xue Qiao, Lin Weng, Yingying Liu, Bo Li, Ming-Fei Zheng

DOI

2020

Mitophagy and Its Contribution to Metabolic and Aging-Associated Disorders

Lei Liu, Xudong Liao, Hao Wu, Yan-Jun Li, Yu-Shan Zhu, Quan Chen

Antioxidants and Redox Signaling

DOI

2019

借鉴国际经验化解地方政府债务风险

刘磊

《清华金融评论》，No. 7

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2019

Mitochondria organize the cellular proteostatic response and promote cellular senescence

Yan-Jun Li, Lei Liu, Yu-Shan Zhu, Quan Chen

Cell Stress

DOI

2019

FUN14 Domain‐Containing 1–Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice

Wenhui Li, Yan-Jun Li, Sami Siraj, Haojie Jin, Yuyuan Fan, Xin-Rong Yang, Xiao-Wu Huang, Xiaohui Wang, Jun Wang, Lei Liu, Lei Du, Quan Chen

Hepatology

DOI

2019

Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome

Hao Wu, You Wang, Wenhui Li, Hui Chen, Lei Du, Dong Liu, Xiaohui Wang, Tao Xu, Lei Liu, Quan Chen

Autophagy

DOI

2019

Nix-mediated mitophagy regulates platelet activation and life span.

Wei-Lin Zhang, Qi Ma, Sami Siraj, P. Ney, Jun-Ling Liu, Xudong Liao, Yefeng Yuan, Wei Li, Lei Liu, Quan Chen

Blood Advances

DOI

2018

STING directly activates autophagy to tune the innate immune response

Dong Liu, Hao Wu, Chenguang Wang, Yan-Jun Li, Huabin Tian, Sami Siraj, S. A. Sehgal, Xiao-Hui Wang, Jun Wang, Yingli Shang, Zheng-Fan Jiang, Lei Liu, Quan Chen

Cell Death and Differentiation

DOI

2018

Mitophagy in Cardiomyocytes and in Platelets: A Major Mechanism of Cardioprotection Against Ischemia/Reperfusion Injury.

Wei-Lin Zhang, Chuyan Chen, Jun Wang, Lei Liu, Yubin He, Quan Chen

Physiology

DOI

2018

Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via AKT signaling pathway

Qi Ma, Chongzhuo Zhu, Wei-Lin Zhang, Nan Ta, Rong Zhang, Lei Liu, D. Feng, He-Ping Cheng, Jun-Ling Liu, Quan Chen

Cell Death and Differentiation

DOI

2018

Loss of SDHB reprograms energy metabolisms and inhibits high fat diet induced metabolic syndromes

Cheng-Long Mu, Biao Ma, Chuanmei Zhang, Guang-Feng Geng, Xin-Ling Zhang, Lin-Bo Chen, Meng Wang, Jie Li, Tian Zhao, Hong-Cheng Cheng, Qianping Zhang, K. Ma, Qian Luo, Rui Chang, Qiang-Qiang Liu, Hao Wu, Lei Liu, Xiaohui Wang, Jun Wang, Yong Zhang, Yungang Zhao, L. Wen, Quan Chen, Yu-Shan Zhu

bioRxiv

DOI

2018

A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity

Yan-Jun Li, Yanhong Xue, Xiao-Jun Xu, Guopeng Wang, Yiqun Liu, Hao Wu, Wenhui Li, Yueying Wang, Zi-Heng Chen, Wei-Lin Zhang, Yu-Shan Zhu, Wei Ji, Tao Xu, Lei Liu, Quan Chen

EMBO Journal

DOI

2018

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.

Ting-Ting Fu, Zhi-Sheng Xu, Lin Liu, Qiqi Guo, Hao Wu, Xi-Jun Liang, Danxia Zhou, Liwei Xiao, Lei Liu, Yong Liu, Min-Sheng Zhu, Quan Chen, Z. Gan

Cell Reports

DOI

2017

MARCH5-FUNDC1 axis fine-tunes hypoxia-induced mitophagy

Zi-Heng Chen, Sami Siraj, Lei Liu, Quan Chen

Autophagy

DOI

2017

Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine‐tune hypoxic mitophagy

Zi-Heng Chen, Lei Liu, Qi Cheng, Yan-Jun Li, Hao Wu, Wei-Lin Zhang, Yueying Wang, S. A. Sehgal, Sami Siraj, Xiaohui Wang, Jun Wang, Yu-Shan Zhu, Quan Chen

EMBO Reports

DOI

2016

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

Ming Chen, Zi-Heng Chen, Yueying Wang, Zheng Tan, Chongzhuo Zhu, Yan-Jun Li, Zhe Han, Lin-Bo Chen, Ruize Gao, Lei Liu, Quan Chen

Autophagy

DOI

2016

Mitophagy receptors sense stress signals and couple mitochondrial dynamic machinery for mitochondrial quality control.

Hao Wu, Huifang Wei, S. A. Sehgal, Lei Liu, Quan Chen

Free Radical Biology & Medicine

DOI

2016

Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

Wei-Lin Zhang, H. Ren, Chunling Xu, Chongzhuo Zhu, Hao Wu, Dong Liu, Jun Wang, Lei Liu, Wei Li, Qi Ma, Lei Du, Ming-Fei Zheng, Chuanmao Zhang, Jun-Ling Liu, Quan Chen

eLife

DOI

2016

Author response: Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

Wei-Lin Zhang, H. Ren, Chunling Xu, Chongzhuo Zhu, Hao Wu, Dong Liu, Jun Wang, Lei Liu, Wei Li, Qi Ma, Lei Du, Ming-Fei Zheng, Chuanmao Zhang, Jun-Ling Liu, Quan Chen

DOI

2015

执法吸纳政治：对城管执法的一个解释框架

刘磊

《政治学研究》，No. 6

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2015

谋利空间的形成：对城管违建执法困境的分析

刘磊，王会

《华中科技大学学报(社会科学版)》，Vol. 29, No. 4

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精选作品

期刊论文

FUNDC1-dependent mitophagy determines axon regeneration capacity

“优等生”和“后进生”的选择：绩效反馈如何影响地方政府政策响应行为

理顺新时代财政体系的“央地关系”

发挥财政政策空间，优化宏观杠杆率结构

正确看待居民部门存贷差扩大现象

地方政府债务管理的国际经验及政策建议

Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis

Integration of FUNDC1-associated mitochondrial protein import and mitochondrial quality control contributes to TDP-43 degradation

Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function

Publisher Correction: Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction

Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction

Mitophagy‐regulated mitochondrial health strongly protects the heart against cardiac dysfunction after acute myocardial infarction

FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia

BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy

FUNDC1 Promotes Mitochondrial Translocation of TDP-43 and Modulates TDP-43 Induced Neurotoxicity

The Emerging Role of FUNDC1-Mediated Mitophagy in Cardiovascular Diseases

Molecular regulation of mitochondrial autophagy and cellular fate

Mitophagy receptor FUNDC1 is regulated by PGC‐1α/NRF1 to fine tune mitochondrial homeostasis

Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy

Comparing the protective function of autophagy and mitophagy in myocardial infarction

Mitophagy and Its Contribution to Metabolic and Aging-Associated Disorders

借鉴国际经验化解地方政府债务风险

Mitochondria organize the cellular proteostatic response and promote cellular senescence

FUN14 Domain‐Containing 1–Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice

Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome

Nix-mediated mitophagy regulates platelet activation and life span.

STING directly activates autophagy to tune the innate immune response

Mitophagy in Cardiomyocytes and in Platelets: A Major Mechanism of Cardioprotection Against Ischemia/Reperfusion Injury.

Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via AKT signaling pathway

Loss of SDHB reprograms energy metabolisms and inhibits high fat diet induced metabolic syndromes

A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity.

MARCH5-FUNDC1 axis fine-tunes hypoxia-induced mitophagy

Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine‐tune hypoxic mitophagy

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

Mitophagy receptors sense stress signals and couple mitochondrial dynamic machinery for mitochondrial quality control.

Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

Author response: Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

执法吸纳政治：对城管执法的一个解释框架

谋利空间的形成：对城管违建执法困境的分析