艾永兴｜吉林大学｜学者主页

2026

Neuroprotective Mechanisms of Paeoniflorin in Parkinson’s Models: Involvement of BDNF-Dependent PI3K/Akt and ERK/CREB Pathways

Chang Jin, Yue Zhang, Bing Li, Zhifeng Cheng, Meizhu Zheng, Kai Song, Yongxing Ai

Current Issues in Molecular Biology

DOI

2026

Astilbin Protects Against Ischemic Stroke by Regulating ERK1/2/CREB/p90RSK Signaling and Ferroptosis-Related SLC7A11/ACSL4/GPX4 Axis: Insights from Network Pharmacology, Multi-Omics, and Molecular Dynamics

Chang Jin, Yue Zhang, Li B, Zhifeng Cheng, Meizhu Zheng, Weihua Dong, Kai Song, Yongxing Ai

International Journal of Molecular Sciences

DOI

2026

Gallic acid antagonizes deoxynivalenol toxicity by inhibiting DON-induced ferroptosis

Haorong Wang, Jiacui Xu, Jinghan Feng, Yifan Zhang, Zixian Zhao, Yan Lv, Chuanqi Wang, Jing Zhang, Yongxing Ai

npj Science of Food

DOI

2025

Multi-Pathway Mechanisms of Engeletin in Ischemic Stroke: A Comprehensive Study Based on Network Pharmacology, Machine Learning, and Immune Infiltration Analysis

Huiming Xue, Yuchen Wen, Jiahui Yang, Yue Zhang, Chang Hyun Jin, Bing Li, Yongxing Ai, Meizhu Zheng, Boge Wen, Kai Song

International Journal of Molecular Sciences

DOI

2025

Tandem Mass Tags Quantitative Proteomics Reveal the Mechanism by Which Paeoniflorin Regulates the PI3K/AKT and BDNF/CREB Signaling Pathways to Inhibit Parkinson’s Disease

Zhen Feng, Chang Hyun Jin, Yue Zhang, Huiming Xue, Yongxing Ai, Jing Wang, Meizhu Zheng, Dongfang Shi

International Journal of Molecular Sciences

DOI

2025

Soy Isoflavones Protects Against Stroke by Inhibiting Keap1/NQO1/Nrf2/HO-1 Signaling Pathway: Network Pharmacology Analysis Combined with the Experimental Validation

Huiming Xue, Zhen Feng, Chang Hyun Jin, Yue Zhang, Yongxing Ai, Jing Wang, Meizhu Zheng, Dongfang Shi

Pharmaceuticals

DOI

2025

Network Pharmacology Analysis and Experimental Validation of Tectoridin in the Treatment of Ischemic Stroke by Inhibiting Apoptosis and Regulating Inflammation

Tingting Lu, Zhen Feng, Hui Yi Xue, Chang Hyun Jin, Yue Zhang, Yongxing Ai, Meizhu Zheng, Dongfang Shi, Kai Song

International Journal of Molecular Sciences

DOI

2024

Uncovering the profile of ubiquitination motif in catalytic proteins using sequence contextual features

Yifan Zhang, Yongxing Ai, Qingsong Fan, Baihang Chen, Jing Zhang, Yan Yun Lv, Yu Qiu Song, Huanmin Zhang, Ziang Guo, Jiacui Xu

Animals and zoonoses.

DOI

2024

Epigenetic Factor MicroRNAs Likely Mediate Vaccine Protection Efficacy against Lymphomas in Response to Tumor Virus Infection in Chickens through Target Gene Involved Signaling Pathways

Lei Zhang, Qingmei Xie, Shuang Chang, Yongxing Ai, Kunzhe Dong, Huanmin Zhang

Veterinary Sciences

DOI

2023

金葡素SEC2改构蛋白2M-118对小鼠的致呕吐、致热毒性和免疫原性作用

潘梦，王义山，宋颖，李洪义，周锦，艾永兴，宋宇

《海南热带海洋学院学报》

2023

Small RNA deep sequencing revealed microRNAs’ involvement in modulating cellular senescence and immortalization state

Chen Zhu, Lei Zhang, Mohammad Heidari, Shuhong Sun, Shuang Chang, Qingmei Xie, Yongxing Ai, Kunzhe Dong, Huanmin Zhang

Poultry Science

DOI

2022

去泛素化酶UL36的抑制剂LDN57444抑制马立克氏病病毒的增殖

王文婧，范青松，刘宇航，王婷，邓国辉，谢知航，王梦涵，吕岩，许家翠，艾永兴

《中国兽医学报》

2022

A comprehensive analysis of avian lymphoid leukosis-like lymphoma transcriptomes including identification of LncRNAs and the expression profiles

Kunzhe Dong, Mohammad Heidari, Jody K. Mays, Shuang Chang, Qingmei Xie, Lei Zhang, Yongxing Ai, Huanmin Zhang

PLoS ONE

DOI

2021

去泛素化酶抑制剂b-AP15抑制马立克氏病病毒的复制

于翀，王文婧，谢知航，周正轩，王婷，范青松，王梦涵，吕岩，许家翠，艾永兴

《中国兽医学报》

2021

Viral deubiquitinases and innate antiviral immune response in livestock and poultry

Zhengxuan ZHOU, Jiacui Xu, Zhanjun Li, Yan LV, Shanli Wu, Huanmin Zhang, Yu Song, Yongxing Ai

Journal of Veterinary Medical Science

DOI

2021

Genomic Changes and Genetic Divergence of Vibrio alginolyticus Under Phage Infection Stress Revealed by Whole-Genome Sequencing and Resequencing

Wenjie Zhou, Yingying Li, Zhuobo Li, Bo Ma, Xiaojin Jiang, Chaoqun Hu, Yongxing Ai, Peng Luo

Frontiers in Microbiology

DOI

2020

UL36 Encoded by Marek’s Disease Virus Exhibits Linkage-Specific Deubiquitinase Activity

Junyan Lin, Yongxing Ai, Hongda Zhou, Yan Li Lv, Menghan Wang, Jiacui Xu, Cong Yu, Huanmin Zhang, Mengyun Wang

International Journal of Molecular Sciences

DOI

2019

基于核酸i-motif结构的pH响应荧光传感器

吕岩，贾美琪，周会鹏，廖冬丽，艾永兴，于聪

《分析科学学报》

DOI

2019

Four Cysteine Residues Contribute to Homodimerization of Chicken Interleukin-2

Chen Deng, Hailiang Tan, Hongda Zhou, Mengyun Wang, Yan Lü, Jiacui Xu, Huanmin Zhang, Limei Han, Yongxing Ai

International Journal of Molecular Sciences

DOI

2019

Marek’s Disease Virus Regulates the Ubiquitylome of Chicken CD4+ T Cells to Promote Tumorigenesis

Xiaolu Zhou, Shanli Wu, Hongda Zhou, Mengyun Wang, Menghan Wang, Yan Lü, Zhongyi Cheng, Jiacui Xu, Yongxing Ai

International Journal of Molecular Sciences

DOI

2018

An Eimeria acervulina OTU protease exhibits linkage-specific deubiquitinase activity

Pu Wang, Pengtao Gong, Weirong Wang, Jianhua Li, Yongxing Ai, Xichen Zhang

Parasitology Research

DOI

2018

An OTU deubiquitinating enzyme in Eimeria tenella interacts with Eimeria tenella virus RDRP

Pu Wang, Jianhua Li, Pengtao Gong, Weirong Wang, Yongxing Ai, Xichen Zhang

Parasites & Vectors

DOI

2017

马立克氏病毒UL36蛋白的表达及其去泛素化酶活性分析

王梦云，周宏达，韦美甜，吕岩，吴山力，艾永兴

《畜牧与兽医》

2017

shRNA介导chTERT基因沉默抑制MDCC-MSB1细胞增殖

邹亚学，杜利强，孙莹，潘风光，郑梅竹，艾永兴，张玉静，刘朋朋，赵丽，安翠萍，卢鹤真，姚传玉

《中国兽医学报》

2017

马立克氏病毒被膜蛋白VP16(UL48)的表达及多克隆抗体的制备

宋敬敬，邓晨，吴山力，郑海南，于佩峰，王梦云，周小露，张玉静，艾永兴

《中国兽医学报》

2017

Characterization of the deubiquitination activity and substrate specificity of the chicken ubiquitin-specific protease 1/USP associated factor 1 complex

Hainan Zheng, Mengyun Wang, Chengcheng Zhao, Shanli Wu, Peifeng Yu, Yan Lü, Tiedong Wang, Yongxing Ai

PLoS ONE

DOI

2016

鸡马立克氏病毒UL36USP的pTYB1表达载体的构建及表达分析

金雯，王梦云，余致君，郑海南，邓晨，艾永兴

《吉林农业大学学报》

2015

应用Intein融合的鸡IL-2蛋白制备多克隆抗体

邓晨，于佩峰，张鑫，王梦云，吕岩，艾永兴

《吉林农业大学学报》

2015

Intein融合表达鸡IL-2蛋白的多克隆抗体制备

邓晨，郑海南，于佩峰，张鑫，吴山力，王梦云，吕岩，艾永兴

《中国兽医学报》

2015

鸡chUSP1 His594Ala突变使其去泛素化酶活性丧失

赵程程，邓晨，于佩峰，王梦云，吴山力，吕岩，艾永兴

《中国兽医学报》

2015

鸡SUMO1的HIS/GST双融合纯化标签载体的构建及表达分析

于佩峰，郑海南，邓晨，张鑫，吴山力，王梦云，吕岩，艾永兴

《中国兽医学报》

2014

马立克病毒UL36USP蛋白的表达及其抗体制备

郑海南，邓晨，王梦云，金雯，吴山力，吕岩，于子阳，艾永兴

《中国兽医学报》

2013

鸡去泛素化相关因子1基因原核表达载体的构建及表达

赵程程，郑海南，吴山力，郑梅竹，杨德才，张玉静，艾永兴

《中国兽医学报》

2013

红松松子壳多糖对Hela细胞增殖的影响

李明谦，张鹏，张大伟，官员，马强，房希碧，于浩，郝林琳，艾永兴，刘松财

《中国兽医学报》

2013

Complete genome sequence of Escherichia coli O157:H7 lytic phage JL1

Fengguang Pan, Han Wu, Jinhua Liu, Yongxing Ai, Xian-Mei Meng, Rizeng Meng, Qing-Feng Meng

Archives of Virology

DOI

2012

鸡UAF1基因的克隆及原核表达

赵程程，郑海南，吴山力，吴涵，艾永兴

《畜牧与兽医》

2011

Allicin Reduces the Production of α-Toxin by Staphylococcus aureus

Bingfeng Leng, Jiazhang Qiu, Xiaohan Dai, Jing Dong, Jianfeng Wang, Mingjing Luo, Hong-En Li, Xiaodi Niu, Yu Zhang, Yongxing Ai, Xuming Deng

Molecules

DOI

2011

Effect of Copper on Levels of Collagen and Alkaline Phosphatase Activity from Chondrocytes in Newborn Piglets In Vitro

Xue Yuan, Jianguo Wang, Xiaoyan Zhu, Zhigang Zhang, Yongxing Ai, Guoquan Sun, Zhe Wang, Guowen Liu

Biological Trace Element Research

DOI

2011

Cloning and characterization of telomerase reverse transcriptase gene in Trichinella spiralis

Yanan Cai, Yongxing Ai, Quan Zhao, Jianhua Li, Guilian Yang, Pengtao Gong, Qiuyue Wang, Honglie Hou, Guocai Zhang, Lingdan Li, Ju Yang, He Li, Jun Zheng, Shuhong Li, Xichen Zhang

Parasitology Research

DOI

2010

HRE增强hTERT启动子-tk/GCV基因系统对缺氧环境肿瘤细胞的杀伤作用

胡薇，艾永兴，郑梅竹，张玉静

《吉林大学学报(医学版)》

2009

鸡端粒酶RNA基因的克隆

郑梅竹，时东方，潘风光，艾永兴，王秋悦，刘春明

《基因组学与应用生物学》

2009

p15在杆状病毒-昆虫细胞表达系统中的表达

艾永兴，肖昌，郝军元，胡薇，潘风光，郑梅竹，张玉静

《中国兽医学报》

2008

鸡p15INK4B蛋白单克隆抗体的制备与鉴定

艾永兴，郝军元，肖昌，邹亚学，郑梅竹，张玉静

《吉林农业大学学报》

2008

hTERT核心启动子调控HSV-TK自杀基因系统诱导肿瘤细胞的凋亡

胡薇，郝军元，张惠英，艾永兴

《中国生物制品学杂志》

2008

MDV中meq基因对CEF细胞chTERT,chTR表达影响的研究

潘风光，艾永兴，卢士英，孟宪梅，张俊辉，周玉

《河北师范大学学报(自然科学版)》

2008

鸡p15因子抑制MDCC-MSB1细胞的增殖及端粒酶活性

艾永兴，邹亚学，潘风光，郝军元，张玉静

《中国兽医学报》

2008

小干扰RNA(siRNA)对马立克氏病淋巴瘤细胞chTERT基因表达的抑制

邹亚学，孙莹，潘风光，郑梅竹，艾永兴，张玉静

《中国兽医学报》

2007

凋亡素原核表达及纯化

郝军元，胡薇，张英波，艾永兴，张玉静

《吉林农业大学学报》

2007

马立克病病毒中meq基因对CEF细胞chTERT mRNA转录水平的影响

潘风光，郑梅竹，周玉，卢士英，罗翔丹，艾永兴

《中国生物制品学杂志》

2007

潜伏期马立克氏病病鸡血清型病毒L-meq、meq基因的比较及遗传分析

潘风光，郑梅竹，邹亚学，孙莹，艾永兴，崔文璟，罗翔丹，张玉静

《中国兽医学报》

2006

人血管内皮生长因子和端粒酶催化亚基复合调控序列的构建及转录活性的研究

胡薇，郝军元，艾永兴，张英波，张玉静

《吉林农业大学学报》

2006

鸡p15INK4B基因的克隆表达及纯化

艾永兴，张玉静，胡薇，郝军元，邹亚学，张英波

《吉林农业大学学报》

2004

地衣芽孢杆菌α-耐高温淀粉酶基因的克隆及在大肠杆菌中的表达

潘风光，宋德群，任洪林，艾永兴，柳增善

《沈阳农业大学学报》

2002

二甲苯胺噻嗪对大鼠血浆、下丘脑和垂体中β-内啡肽含量的影响

艾永兴，李东郊，闫章年

《中国兽医学报》

1999

二甲苯胺噻嗪对大鼠镇痛和麻醉的ED50及时效的测定

艾永兴，李东郊，田慧英，闫章年

《畜牧兽医杂志》

精选作品

期刊论文

Neuroprotective Mechanisms of Paeoniflorin in Parkinson’s Models: Involvement of BDNF-Dependent PI3K/Akt and ERK/CREB Pathways

Astilbin Protects Against Ischemic Stroke by Regulating ERK1/2/CREB/p90RSK Signaling and Ferroptosis-Related SLC7A11/ACSL4/GPX4 Axis: Insights from Network Pharmacology, Multi-Omics, and Molecular Dynamics

Gallic acid antagonizes deoxynivalenol toxicity by inhibiting DON-induced ferroptosis

Multi-Pathway Mechanisms of Engeletin in Ischemic Stroke: A Comprehensive Study Based on Network Pharmacology, Machine Learning, and Immune Infiltration Analysis

Tandem Mass Tags Quantitative Proteomics Reveal the Mechanism by Which Paeoniflorin Regulates the PI3K/AKT and BDNF/CREB Signaling Pathways to Inhibit Parkinson’s Disease

Soy Isoflavones Protects Against Stroke by Inhibiting Keap1/NQO1/Nrf2/HO-1 Signaling Pathway: Network Pharmacology Analysis Combined with the Experimental Validation

Network Pharmacology Analysis and Experimental Validation of Tectoridin in the Treatment of Ischemic Stroke by Inhibiting Apoptosis and Regulating Inflammation

Uncovering the profile of ubiquitination motif in catalytic proteins using sequence contextual features

Epigenetic Factor MicroRNAs Likely Mediate Vaccine Protection Efficacy against Lymphomas in Response to Tumor Virus Infection in Chickens through Target Gene Involved Signaling Pathways

金葡素SEC2改构蛋白2M-118对小鼠的致呕吐、致热毒性和免疫原性作用

Small RNA deep sequencing revealed microRNAs’ involvement in modulating cellular senescence and immortalization state

去泛素化酶UL36的抑制剂LDN57444抑制马立克氏病病毒的增殖

A comprehensive analysis of avian lymphoid leukosis-like lymphoma transcriptomes including identification of LncRNAs and the expression profiles

去泛素化酶抑制剂b-AP15抑制马立克氏病病毒的复制

Viral deubiquitinases and innate antiviral immune response in livestock and poultry

Genomic Changes and Genetic Divergence of Vibrio alginolyticus Under Phage Infection Stress Revealed by Whole-Genome Sequencing and Resequencing

UL36 Encoded by Marek’s Disease Virus Exhibits Linkage-Specific Deubiquitinase Activity

基于核酸i-motif结构的pH响应荧光传感器

Four Cysteine Residues Contribute to Homodimerization of Chicken Interleukin-2

Marek’s Disease Virus Regulates the Ubiquitylome of Chicken CD4+ T Cells to Promote Tumorigenesis

An Eimeria acervulina OTU protease exhibits linkage-specific deubiquitinase activity

An OTU deubiquitinating enzyme in Eimeria tenella interacts with Eimeria tenella virus RDRP

马立克氏病毒UL36蛋白的表达及其去泛素化酶活性分析

shRNA介导chTERT基因沉默抑制MDCC-MSB1细胞增殖

马立克氏病毒被膜蛋白VP16(UL48)的表达及多克隆抗体的制备

Characterization of the deubiquitination activity and substrate specificity of the chicken ubiquitin-specific protease 1/USP associated factor 1 complex

鸡马立克氏病毒UL36USP的pTYB1表达载体的构建及表达分析

应用Intein融合的鸡IL-2蛋白制备多克隆抗体

Intein融合表达鸡IL-2蛋白的多克隆抗体制备

鸡chUSP1 His594Ala突变使其去泛素化酶活性丧失

鸡SUMO1的HIS/GST双融合纯化标签载体的构建及表达分析

马立克病毒UL36USP蛋白的表达及其抗体制备

鸡去泛素化相关因子1基因原核表达载体的构建及表达

红松松子壳多糖对Hela细胞增殖的影响

Complete genome sequence of Escherichia coli O157:H7 lytic phage JL1

鸡UAF1基因的克隆及原核表达

Allicin Reduces the Production of α-Toxin by Staphylococcus aureus

Effect of Copper on Levels of Collagen and Alkaline Phosphatase Activity from Chondrocytes in Newborn Piglets In Vitro

Cloning and characterization of telomerase reverse transcriptase gene in Trichinella spiralis

HRE增强hTERT启动子-tk/GCV基因系统对缺氧环境肿瘤细胞的杀伤作用

鸡端粒酶RNA基因的克隆

p15在杆状病毒-昆虫细胞表达系统中的表达

鸡p15INK4B蛋白单克隆抗体的制备与鉴定

hTERT核心启动子调控HSV-TK自杀基因系统诱导肿瘤细胞的凋亡

MDV中meq基因对CEF细胞chTERT,chTR表达影响的研究

鸡p15因子抑制MDCC-MSB1细胞的增殖及端粒酶活性

小干扰RNA(siRNA)对马立克氏病淋巴瘤细胞chTERT基因表达的抑制

凋亡素原核表达及纯化

马立克病病毒中meq基因对CEF细胞chTERT mRNA转录水平的影响

潜伏期马立克氏病病鸡血清型病毒L-meq、meq基因的比较及遗传分析

人血管内皮生长因子和端粒酶催化亚基复合调控序列的构建及转录活性的研究

鸡p15INK4B基因的克隆表达及纯化

地衣芽孢杆菌α-耐高温淀粉酶基因的克隆及在大肠杆菌中的表达

二甲苯胺噻嗪对大鼠血浆、下丘脑和垂体中β-内啡肽含量的影响

二甲苯胺噻嗪对大鼠镇痛和麻醉的ED50及时效的测定

会议论文

MDV编码的UL36基因在MDCC-MSB1细胞中表达情况的鉴定

鸡SUMO1-IL2融合蛋白的表达纯化

病毒编码的泛素化酶与去泛素化酶的研究进展

MDV被膜蛋白UL36的去泛素化活性研究

UAF1与去泛素化酶USP家族相互作用的研究进展

以组蛋白为核心的基因转染

鸡USP1基因的克隆及原核表达