熊壮｜五邑大学｜学者主页

2026

Palladium-Catalyzed Cascade Reaction of Indoles with α,α-Difluoro-β,γ-Unsaturated Ketones: One-Step Access to 2-Fluorocarbazoles.

Chun-Ming Chen, Zhen-Li Luo, Mei Xie, Zhuang Xiong, Jin-Hui Hu, Hongwen Huang, Chun-Li Xia, Jia-Qiang Wu

Organic Letters

DOI

2026

Silver/Indium-Catalyzed Cyclization of O-Alkynylisocyanobenzenes with Nitriles for the Synthesis of Amide-Substituted Quinolines.

Jingjing Liu, Keying Gu, Zirou Mai, Shuang Luo, Jia-Qiang Wu, Zhuang Xiong

Journal of Organic Chemistry

DOI

2026

Palladium-catalyzed defluorinative coupling of indoles with α,α-difluoro-β,γ-unsaturated ketones: direct access to functionalized α-fluoroenones.

Chun-Ming Chen, Hui-Xuan Zhu, Zhen-Li Luo, Jin-Hui Hu, Zhuang Xiong, Fu-Yu Zhou, Jia-Qiang Wu

Organic and biomolecular chemistry

DOI

2026

One-pot sequential palladium-catalyzed defluorinative amination and Nazarov cyclization for the diastereoselective synthesis of α-fluorinated naphthocyclopentanones.

Zhen-Li Luo, Xiang-Ke Wang, Fang-Hai Tu, Qian-Yi Liang, Hui-Xuan Zhu, Zhuang Xiong, Jin-Hui Hu, Jia-Qiang Wu

Chemical Communications

DOI

2025

Palladium-Catalyzed [4+1] Cycloaddition of 3,3-Difluoropent-4-en-2-ones with Amines: A Modular Approach to 3-Fluoropyrroles.

Mei Xie, Zhen-Li Luo, Chun-Ming Chen, Zhuang Xiong, Jin-Hui Hu, Jia-Qiang Wu

Organic Letters

DOI

2025

Rh(III)-catalyzed C-H activation/β-F elimination/Michael addition: diastereoselective access to dihydroisoquinolinones featuring β-amino α-fluorocarbonyl motif.

Wei Lin, Zhen-Li Luo, Hui-Xuan Zhu, Jin-Hui Hu, Zhuang Xiong, Jia-Qiang Wu

Chemical Communications

DOI

2025

Design, synthesis and biological evaluation of cinnamoyl tethered betulinic acid derivatives as α-glucosidase inhibitors

Jiangyi Li, Jingjing Liu, Xuwen Li, Tiansong Wang, Yufei Zhang, Jinghua Liang, Jinghua Liang, Xuerou Zhang, Chen Li, Hongyan Sun, Lin Song, Dongdong Liang, Zhuang Xiong

Journal of Molecular Structure

DOI

2024

Rh(III)-Catalyzed, Redox-Neutral, C–H Multifluoroalkenylation of Benzamides

Wei Lin, Yifei Qu, Hui-Xuan Zhu, Mei Xie, Jin-Hui Hu, Zhuang Xiong, Wen-Hua Chen, Jun Xu, Jia-Qiang Wu

Synthesis

DOI

2024

One-pot sequential synthesis of unsymmetrical diarylmethanes using methylene chloride as a C1-synthon.

Xueli Cui, Chun-Ming Chen, Mei Xie, Taotao Zhao, Jian-Fen Yi, Wei-Qiang Sun, Zhuang Xiong, Jin-Hui Hu, Wing-Leung Wong, Jia-Qiang Wu

Organic and biomolecular chemistry

DOI

2024

Modular Synthesis of 1,2-Benzothiazines and 1,2-Benzothiazine 1-Imines via Palladium-Catalyzed C–H/C–C Activation Reactions

Yifan Ren, Lisha Mo, Yali Wang, Limin Yu, Minhai Yin, Zhuang Xiong, Fan Teng, Yimiao He

The Journal of Organic Chemistry

DOI

2024

Design, synthesis and biological evaluation of a 1,2,3-triazolyl-bearing betulinic acid derivatives as α-glucosidase inhibitors

Yufei Zhang, Jingjing Liu, Jiangyi Li, Jinping Sun, Bingwen Liang, Xiaofeng Min, Zhuang Xiong, Wen‐Hua Chen, Xuetao Xu

Journal of Molecular Structure

DOI

2024

Design, synthesis and biological evaluation of novel betulinic acid derivatives containing 1,2,4-triazole-derived schiff bases as α-glucosidase inhibitors

Yufei Zhang, Xiaoyan Yu, Jiangyi Li, Bingwen Liang, Jinping Sun, Xiaofeng Min, Zhuang Xiong, Wen‐Hua Chen, Xuetao Xu

Journal of Molecular Structure

DOI

2024

1,2,3-Triazole-based betulinic acid derivatives as α-glucosidase inhibitors: Synthesis and in vitro and in vivo biological evaluation

Yufei Zhang, Jiangyi Li, Xiaofeng Min, Bingwen Liang, Jinping Sun, Keyin Lin, Zhuang Xiong, Xuetao Xu, Wen‐Hua Chen

Journal of Molecular Structure

DOI

2023

Synthesis and biological evaluation of indole derivatives containing thiazolidine-2,4-dione as α-glucosidase inhibitors with antidiabetic activity

Chunmei Hu, Bingwen Liang, Jinping Sun, Jiangyi Li, Zhuang Xiong, Shao‐Hua Wang, Xuetao Xu

European Journal of Medicinal Chemistry

DOI

2023

Identification of 1,3,4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity

Di Xiao, Li Lu, Bingwen Liang, Zhuang Xiong, Xuetao Xu, Wen‐Hua Chen

European Journal of Medicinal Chemistry

DOI

2023

Bicyclic Amidine-Triggered Cyclization of o-Alkynylisocyanobenzenes: Synthesis of Lactam-Derived Quinolines

Zhuang Xiong, Chunmei Hu, Wenjian Zhu, Simin Wu, Dan Wang, Yang Liu, Jing Lin, Suqin Guo, Jia‐Qiang Wu, Xuetao Xu

The Journal of Organic Chemistry

DOI

2023

New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation

Yingying Zheng, Li Lu, Mengyue Li, DeHua Xu, LaiShun Zhang, Zhuang Xiong, Yubo Zhou, Jia Li, Xuetao Xu, Kun Zhang, Lei Xu

Bioorganic Chemistry

DOI

2023

Synthesis and biological evaluation of chromone-thiazolidine-2,4-dione derivatives as potential α-glucosidase inhibitors

Yingying Zheng, Mengyu Li, Simin Wu, Li Lü, Zhuang Xiong, Xuetao Xu, Kun Zhang, Yi Wen

Arabian Journal of Chemistry

DOI

2023

Development of glycyrrhetinic acid ligand-functionalized liposomes for targeting hepatocellular carcinoma: Synthesis, preparation, characterization, and evaluation

Yuan Lin, Yimin Zhang, Zhuang Xiong, Min Wu, Muling Zeng, Chuangnan Li, Fujin Liu, Yazhi Liao, Chunping Liu, Jing Chen

Arabian Journal of Chemistry

DOI

2023

New β-carboline derivatives as potential α-glucosidase inhibitor: Synthesis and biological activity evaluation

Jing Lin, Di Xiao, Li Lu, Bingwen Liang, Zhuang Xiong, Xuetao Xu

Journal of Molecular Structure

DOI

2023

Novel coumarin derivatives as potential tyrosinase inhibitors: Synthesis, binding analysis and biological evaluation

Li Lu, Xin Zhang, Yu Kang, Zhuang Xiong, Kun Zhang, Xuetao Xu, Li‐Ping Bai, Hongguang Li

Arabian Journal of Chemistry

DOI

2023

Synthesis and anti-α-glucosidase activity evaluation of betulinic acid derivatives

Xiao-Zheng Wu, Wenjian Zhu, Li Lu, Chunmei Hu, Yingying Zheng, Xin Zhang, Jing Lin, Jing-Ying Wu, Zhuang Xiong, Kun Zhang, Xuetao Xu

Arabian Journal of Chemistry

DOI

2023

Facile access to 2-hydroxy-2-substituted indole-3-ones via a copper-catalyzed oxidative cyclization of 2-arylethynylanilines

Weiqiang Sun, Xueli Cui, Jing Qu, Xiaojia Cai, Jinhui Hu, Zhuang Xiong, Suqin Guo, Jun Xu, Wen‐Hua Chen, Jia‐Qiang Wu

Chemical Communications

DOI

2022

Total synthesis of sinopyrine B

Jing Li, Liming Jiang, Fu Cheng, Yu-Jia Zhou, Dong-Sen Duan, Dao-Yong Zhu, Kun Zhang, Zhuang Xiong, Shao‐Hua Wang

Tetrahedron Letters

DOI

2022

Design, synthesis and evaluation of indole-based bisacylhydrazone derivatives as α-glucosidase inhibitors

Chunmei Hu, Yingying Zheng, Ai-Tian Lin, Xin Zhang, Xiao-Zheng Wu, Jing Lin, Xuetao Xu, Zhuang Xiong

Journal of Molecular Structure

DOI

2022

Responsive Fluorescent Coumarin–Cinnamic Acid Conjugates for α-Glucosidase Detection

Dong Luo, Xin Zhang, Xiaoying Li, Yi-Yu Zhen, Xingyi Zeng, Zhuang Xiong, Yinghui Zhang, Hongguang Li

Frontiers in Chemistry

DOI

2022

Synthesis and Evaluation of Coumarin-Chalcone Derivatives as α-Glucosidase Inhibitors

Chun‐Mei Hu, Yong-Xin Luo, Wenjing Wang, Jianping Li, Mengyue Li, Yufei Zhang, Di Xiao, Li Lu, Zhuang Xiong, Na Feng, Chen Li

Frontiers in Chemistry

DOI

2022

Synthesis and biological evaluation of coumarin derivatives containing oxime ester as α-glucosidase inhibitors

Xin Zhang, Yingying Zheng, Chunmei Hu, Xiao-Zheng Wu, Jing Lin, Zhuang Xiong, Kun Zhang, Xuetao Xu

Arabian Journal of Chemistry

DOI

2022

Synthesis and Biological Evaluation of 5-Fluoro-2-Oxindole Derivatives as Potential α-Glucosidase Inhibitors

Jing Lin, Qi-Ming Liang, Yuan-Na Ye, Di Xiao, Li Lu, Mengyue Li, Jianping Li, Yufei Zhang, Zhuang Xiong, Na Feng, Chen Li

Frontiers in Chemistry

DOI

2022

Synthesis and Biological Activity Evaluation of 2-Cyanopyrrole Derivatives as Potential Tyrosinase Inhibitors

Yaguang Hu, Zhu‐Peng Gao, Yingying Zheng, Chunmei Hu, Jing Lin, Xiao-Zheng Wu, Xin Zhang, Yongsheng Zhou, Zhuang Xiong, Dao-Yong Zhu

Frontiers in Chemistry

DOI

2022

Synthesis of Benzylidene Analogs of Oleanolic Acid as Potential α-Glucosidase and α-Amylase Inhibitors

Jun-Jie Ke, Jing Lin, Xin Zhang, Xiao-Zheng Wu, Yingying Zheng, Chunmei Hu, Yu Kang, Kun Zhang, Zhuang Xiong, Zhi-Qiang Ma

Frontiers in Chemistry

DOI

2021

In vitro and in silico studies of bis (indol-3-yl) methane derivatives as potential α-glucosidase and α-amylase inhibitors

Peng‐Fei Zheng, Zhuang Xiong, Cui-ying Liao, Xin Zhang, Mei Feng, Xiao-Zheng Wu, Jing‐Jer Lin, Lin-Sheng Lei, Youcheng Zhang, Shao‐Hua Wang, Xuetao Xu

Journal of Enzyme Inhibition and Medicinal Chemistry

DOI

2020

Palladium-catalysed dearomative aryl/cycloimidoylation of indoles

Jian Wang, Yuan Liu, Zhuang Xiong, Ling Zhong, Shumin Ding, Lianjie Li, Hai‐Xia Zhao, Chen Chen, Yongjia Shang

Chemical Communications

DOI

2019

Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C–H bond aminoimidoylation reaction from functionalized isocyanides

Zhuang Xiong, Panyuan Cai, Yingshuang Mei, Jian Wang

RSC Advances

DOI

熊壮

精选作品

期刊论文

Palladium-Catalyzed Cascade Reaction of Indoles with α,α-Difluoro-β,γ-Unsaturated Ketones: One-Step Access to 2-Fluorocarbazoles.

Silver/Indium-Catalyzed Cyclization of O-Alkynylisocyanobenzenes with Nitriles for the Synthesis of Amide-Substituted Quinolines.

Palladium-catalyzed defluorinative coupling of indoles with α,α-difluoro-β,γ-unsaturated ketones: direct access to functionalized α-fluoroenones.

One-pot sequential palladium-catalyzed defluorinative amination and Nazarov cyclization for the diastereoselective synthesis of α-fluorinated naphthocyclopentanones.

Palladium-Catalyzed [4+1] Cycloaddition of 3,3-Difluoropent-4-en-2-ones with Amines: A Modular Approach to 3-Fluoropyrroles.

Rh(III)-catalyzed C-H activation/β-F elimination/Michael addition: diastereoselective access to dihydroisoquinolinones featuring β-amino α-fluorocarbonyl motif.

Design, synthesis and biological evaluation of cinnamoyl tethered betulinic acid derivatives as α-glucosidase inhibitors

Rh(III)-Catalyzed, Redox-Neutral, C–H Multifluoroalkenylation of Benzamides

One-pot sequential synthesis of unsymmetrical diarylmethanes using methylene chloride as a C1-synthon.

Modular Synthesis of 1,2-Benzothiazines and 1,2-Benzothiazine 1-Imines via Palladium-Catalyzed C–H/C–C Activation Reactions

Design, synthesis and biological evaluation of a 1,2,3-triazolyl-bearing betulinic acid derivatives as α-glucosidase inhibitors

Design, synthesis and biological evaluation of novel betulinic acid derivatives containing 1,2,4-triazole-derived schiff bases as α-glucosidase inhibitors

1,2,3-Triazole-based betulinic acid derivatives as α-glucosidase inhibitors: Synthesis and in vitro and in vivo biological evaluation

Synthesis and biological evaluation of indole derivatives containing thiazolidine-2,4-dione as α-glucosidase inhibitors with antidiabetic activity

Identification of 1,3,4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity

Bicyclic Amidine-Triggered Cyclization of o-Alkynylisocyanobenzenes: Synthesis of Lactam-Derived Quinolines

New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation

Synthesis and biological evaluation of chromone-thiazolidine-2,4-dione derivatives as potential α-glucosidase inhibitors

Development of glycyrrhetinic acid ligand-functionalized liposomes for targeting hepatocellular carcinoma: Synthesis, preparation, characterization, and evaluation

New β-carboline derivatives as potential α-glucosidase inhibitor: Synthesis and biological activity evaluation

Novel coumarin derivatives as potential tyrosinase inhibitors: Synthesis, binding analysis and biological evaluation

Synthesis and anti-α-glucosidase activity evaluation of betulinic acid derivatives

Facile access to 2-hydroxy-2-substituted indole-3-ones via a copper-catalyzed oxidative cyclization of 2-arylethynylanilines

Total synthesis of sinopyrine B

Design, synthesis and evaluation of indole-based bisacylhydrazone derivatives as α-glucosidase inhibitors

Responsive Fluorescent Coumarin–Cinnamic Acid Conjugates for α-Glucosidase Detection

Synthesis and Evaluation of Coumarin-Chalcone Derivatives as α-Glucosidase Inhibitors

Synthesis and biological evaluation of coumarin derivatives containing oxime ester as α-glucosidase inhibitors

Synthesis and Biological Evaluation of 5-Fluoro-2-Oxindole Derivatives as Potential α-Glucosidase Inhibitors

Synthesis and Biological Activity Evaluation of 2-Cyanopyrrole Derivatives as Potential Tyrosinase Inhibitors

Synthesis of Benzylidene Analogs of Oleanolic Acid as Potential α-Glucosidase and α-Amylase Inhibitors

In vitro and in silico studies of bis (indol-3-yl) methane derivatives as potential α-glucosidase and α-amylase inhibitors

Palladium-catalysed dearomative aryl/cycloimidoylation of indoles

Access to 1-amino-3,4-dihydroisoquinolines via palladium-catalyzed C–H bond aminoimidoylation reaction from functionalized isocyanides

研究方向