陆五元｜复旦大学｜学者主页

2026

Enteric α-defensins contribute to intestinal mucosal immunity against SARS-CoV-2 infection

Yilin Yang, 杨倩曦, Xin Huang, Chongbing Liao, Zhenguo Chen, Wuyuan Lu

Mucosal Immunology

2026

Pyridinyl ring defines a noncanonical P1-S1 axis that revamps inhibitor design against coronaviral main proteases

Gan Luo, Baisen Zhong, Gang Wang, Lu Zheng, Chongbing Liao, Jie Rao, Man Luo, Junjie Zhang, Jue Zhang, Xihui Gao, Wuyuan Lu

Cell Reports Physical Science

DOI

2026

Human enteric defensin 5 protects intestinal barrier integrity via cell state–dependent P2Y11–FAK–Rac1 signaling

Mengyao Guo, Yaqian Zhang, LIU Yaxin, Chenyi Mao, Xu Xin, Yang Shen, Ruifen Zhang, Qingxia Wang, Wuyuan Lu, Kai Ye, Dan Xu

Mucosal Immunology

DOI

2026

Next-generation inhibitors of SARS-CoV-2 Mpro overcome the deficiencies of Paxlovid

Gan Luo, Gang Wang, Chongbing Liao, Baisen Zhong, Lianfeng Fan, Jue Zhang, Jie Rao, Junjie Zhang, Ziqiao Wang, Man Luo, Yan YAN, Lu Lu, Wei Xu, Fan Wu, Xihui Gao, Wuyuan Lu

Nature Communications

DOI

2026

Breaking disulfide bonds in a weakly bactericidal α-defensin unleashes a potent antimicrobial peptide with an altered conformation

Gan Luo, Mingzhu Zhao, Qingxia Wang, Yang Zhou, Dan Yao, Jue Zhang, Gang Wang, Junjie Zhang, Chongbing Liao, Wuyuan Lu

PLoS Pathogens

DOI

2025

Human neutrophil α-defensin HNP1 interacts with bacterial cell wall components to promote biofilm formation by Staphylococcus aureus

Chongbing Liao, Dan Yao, Zeyu Sun, Bryan Ericksen, Bei Jiang, Yang Zhou, Mingzhu Zhao, Xiaomei Hu, Dan Xu, Yang Wu, Wuyuan Lu

Biofilm

DOI

2025

Human neutrophil α-defensin HNP1 interacts with bacterial OmpA to promote Acinetobacter baumannii biofilm formation

Chongbing Liao, Qihui Liu, Gan Luo, Yinyue Luo, Dan Yao, Qingxia Wang, Jue Zhang, Yang Wu, Jialin Jin, Dan Xu, Wuyuan Lu

Nature Communications

DOI

2025

Systematic All-Hydrocarbon Stapling Analysis for Cecropin A Generates a Potent and Stable Antimicrobial Peptide

Yejiao Shi, Gan Luo, Borui Zhen, Zhinan Liu, Sumeng Chen, Zhe Wang, Wuyuan Lu, Honggang Hu, Xiang Li

Journal of Medicinal Chemistry

DOI

2025

Shigella infection is facilitated by interaction of human enteric α-defensin 5 with colonic epithelial receptor P2Y11

Dan Xu, Mengyao Guo, Xin Xu, Gan Luo, Yaxin Liu, Stephen J. Bush, Chengyao Wang, Tun Xu, Wenxin Zeng, Chongbing Liao, Qingxia Wang, Wei Zhao, Wenying Zhao, Yuezhuangnan Liu, Shanshan Li, Shuangshuang Zhao, Yaming Jiu, Nathalie Sauvonnet, Wuyuan Lu, Philippe Jean Sansonetti, Kai Ye

Nature Microbiology

DOI

2022

Configuration-Specific Antibody for Bacterial Heptosylation: An Antiadhesion Therapeutic Strategy

Xiang Li, Chongbing Liao, Yue Xu, Qiuhe Lu, Si Chen, Li Su, Yan Zou, Feng Shao, Wuyuan Lu, Weidong Zhang, Honggang Hu

Journal of the American Chemical Society

DOI

2022

Mouse α-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt

Qingxia Wang, Yilin Yang, Gan Luo, Yang Zhou, William David Tolbert, Marzena Pazgier, Chongbing Liao, Wuyuan Lu

Infection and Immunity

DOI

2022

Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance

Chongbing Liao, Xin Huang, Qingxia Wang, Dan Yao, Wuyuan Lu

Frontiers in Cellular and Infection Microbiology

DOI

2022

Human defensin-inspired discovery of peptidomimetic antibiotics

Gan Luo, Jue Zhang, Hanbin Wang, Yaqi Sun, Baoli Cheng, Zhipeng Xu, Yan Zhang, Hui Li, Wuyuan Lu, Elizabeta Nemeth, Tomas Ganz, Xiangming Fang

Proceedings of the National Academy of Sciences

DOI

2021

Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression

Xiang Li, Neelakshi Gohain, Si Chen, Yinghua Li, Xiaoyuan Zhao, Bo Li, William David Tolbert, Wangxiao He, Marzena Pazgier, Honggang Hu, Wuyuan Lu

Acta Pharmaceutica Sinica B

DOI

2021

Defensins: The natural peptide antibiotic

Xihui Gao, Junqiang Ding, Chongbing Liao, Jinliang Xu, Xiaoxiao Liu, Wuyuan Lu

Advanced Drug Delivery Reviews

DOI

2021

Inhibition of SARS-CoV-2 Infection by Human Defensin HNP1 and Retrocyclin RC-101

Elena Kudryashova, Ashley Zani, Géraldine Vilmen, Amit Sharma, Wuyuan Lu, Jacob S. Yount, Dmitri S. Kudryashov

Journal of Molecular Biology

DOI

2021

Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry

Chuan Xu, Annie Wang, Mariana Marin, William J. Honnen, Santhamani Ramasamy, Edith Martin Porter, Selvakumar Subbian, Abraham Pinter, Gregory B. Melikyan, Wuyuan Lu, Theresa Li-Yun Chang

Viruses

DOI

2021

Nanodefensin-encased hydrogel with dual bactericidal and pro-regenerative functions for advanced wound therapy

Gan Luo, Yaqi Sun, Jue Zhang, Zhipeng Xu, Wuyuan Lu, Hanbin Wang, Yan Zhang, Hui Li, Zhengwei Mao, Shixin Ye, Baoli Cheng, Xiangming Fang

Theranostics

DOI

2011

镜像配基筛选:克服“酶屏障”的多肽、寡核苷酸药物研发技术

李翀，沈洁，陆伟跃，陆五元

《中国科学:化学》

2010

Functional interaction of human neutrophil peptide‐1 with the cell wall precursor lipid II

Erik de Leeuw, Changqing Li, Pengyun Zeng, Chong Li, Marlies Diepeveen-de Bruin, Weiyue Lu, Wei-Yue Lu, Eefjan J. Breukink, Wuyuan Lu, Wuyuan Lu

FEBS Letters

DOI

2007

Impact of Pro Segments on the Folding and Function of Human Neutrophil α-Defensins

Zhibin Wu, Xiangqun Li, Bryan Ericksen, Erik de Leeuw, Guozhang Zou, Pengyun Zeng, Cao Xie, Chong Li, Jacek T. Lubkowski, Weiyue Lu, Wuyuan Lu, Wuyuan Lu, Wuyuan Lu

Journal of Molecular Biology

DOI

2005

Effects of the terminal charges in human neutrophil α-defensin 2 on its bactericidal and membrane activity

Cao Xie, Pengyun Zeng, Bryan Ericksen, Zhibin Wu, Weiyue Lu, Wuyuan Lu

Peptides

DOI

2005

Reconstruction of the Conserved β-Bulge in Mammalian Defensins Using d-Amino Acids

Cao Xie, Adam Prahl, Bryan Ericksen, Zhibin Wu, Pengyun Zeng, Xiangqun Li, Weiyue Lu, Weiyue Lu, Jacek T. Lubkowski, Wuyuan Lu, Wuyuan Lu

Journal of Biological Chemistry

DOI

陆五元

精选作品

期刊论文

Enteric α-defensins contribute to intestinal mucosal immunity against SARS-CoV-2 infection

Pyridinyl ring defines a noncanonical P1-S1 axis that revamps inhibitor design against coronaviral main proteases

Human enteric defensin 5 protects intestinal barrier integrity via cell state–dependent P2Y11–FAK–Rac1 signaling

Next-generation inhibitors of SARS-CoV-2 Mpro overcome the deficiencies of Paxlovid

Breaking disulfide bonds in a weakly bactericidal α-defensin unleashes a potent antimicrobial peptide with an altered conformation

Human neutrophil α-defensin HNP1 interacts with bacterial cell wall components to promote biofilm formation by Staphylococcus aureus

Human neutrophil α-defensin HNP1 interacts with bacterial OmpA to promote Acinetobacter baumannii biofilm formation

Systematic All-Hydrocarbon Stapling Analysis for Cecropin A Generates a Potent and Stable Antimicrobial Peptide

Shigella infection is facilitated by interaction of human enteric α-defensin 5 with colonic epithelial receptor P2Y11

Configuration-Specific Antibody for Bacterial Heptosylation: An Antiadhesion Therapeutic Strategy

Mouse α-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt

Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance

Human defensin-inspired discovery of peptidomimetic antibiotics

Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression

Defensins: The natural peptide antibiotic

Inhibition of SARS-CoV-2 Infection by Human Defensin HNP1 and Retrocyclin RC-101

Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry

Nanodefensin-encased hydrogel with dual bactericidal and pro-regenerative functions for advanced wound therapy

镜像配基筛选:克服“酶屏障”的多肽、寡核苷酸药物研发技术

Functional interaction of human neutrophil peptide‐1 with the cell wall precursor lipid II

Impact of Pro Segments on the Folding and Function of Human Neutrophil α-Defensins

Effects of the terminal charges in human neutrophil α-defensin 2 on its bactericidal and membrane activity

Reconstruction of the Conserved β-Bulge in Mammalian Defensins Using d-Amino Acids

会议论文

A Polymeric Micelle Carrying Stapled Peptide Targets Tumors,Activates p53 and Sensitizes Glioblastoma to Temozolomide

D-peptide Drug Discovery for Anticancer Therapy

预印本

Monkeypox virus M2 rewires nucleocytoplasmic transport to coordinate host translation suppression and immune evasion

A Neutrophil Defensin–VDAC1 Axis Drives Steatotic Liver Disease