百晓学者学者目录

任士芳

副教授、教授、讲师，复旦大学

精选作品

期刊论文

2026

基于IgG衰老相关糖链绝对定量的生物年龄预测研究——来自糖组学与转录组学的见解（英文）

Huijuan Zhao, Jiteng Fan, Jing Han, Wenjun Qin, Jichen Sha, Weilong Zhang, Yong Gu, Xiaonan Ma, Jianxin Gu, Shifang Ren

Engineering

2026

Plasma IgG glycan dynamics predict adverse reactions in allergen immunotherapy

Ran Zhao, Na Dong, Zhikang Yu, Yue Xie, Weilong Zhang, Qin Wang, Lang Yuan, Yongyu Tang, Shifang Ren, Xiaoyan Dong

Clinical Proteomics

DOI

2025

Absolute Quantification of Aging-Associated Glycans in IgG for Biological Age Prediction: Insights from Glycomics and Transcriptomics

Huijuan Zhao, Jiteng Fan, Jing Han, Wenjun Qin, Jichen Sha, Weilong Zhang, Yong Gu, Xiaonan Ma, Jianxin Gu, Shifang Ren

Engineering

DOI

2025

Glycosylation of anti-dsDNA IgG correlates with organ involvement in treatment-naïve patients with systemic lupus erythematosus

Zhuochao Zhou, Yuhong Liu, Xiao-Tong Gu, Hao-Wen Zhang, Panan Zhang, Yue Sun, Hong-Lei Liu, Xiao-Bing Cheng, Yu-Tong Su, Hui Shi, Qiong-Yi Hu, Huihui Chi, Jian-Fen Meng, Jin-Chao Jia, Ting-Ting Liu, Meng-Yan Wang, Cui Lu, Yunping Cai, Yijun You, De-Hao Zhu, Shifang Ren, Jia-Lin Teng, Jing-Yi Wu, Cheng-De Yang, Jun-Na Ye

Lupus Science and Medicine

DOI

2025

High-throughput glycosylation screening method for biologics development using MALDI-TOF-MS

Wei-Long Zhang, Liqi Xie, Huijuan Zhao, Xiaonan Ma, Shifang Ren

Communications Chemistry

DOI

2024

Glycosylation in aging and neurodegenerative diseases

Wei-Long Zhang, Tian Chen, Huijuan Zhao, Shifang Ren

Acta Biochimica et Biophysica Sinica

DOI

2023

Development of an impedance-based biosensor for determination of IgG galactosylation levels.

Ahmed A. Khorshed, Oleksandr Savchenko, Jing Liu, Shou-Te C. T. Lian, Jie Zeng, Shifang Ren, Jianxin Gu, Naresh Jha, Zhong Yang, Jiu-Cun Wang, Li Jin, Jie Chen

Biosensors & bioelectronics

DOI

2023

Generalized low levels of serum N‐glycans associate with better health status

Jiteng Fan, Jichen Sha, Shuwai Chang, Huijuan Zhao, Xiaoyun Niu, Yong Gu, Jianxin Gu, Shifang Ren

Aging Cell

DOI

2023

α2,3-Sialylation with Fucosylation Associated with More Severe Anti-MDA5 Positive Dermatomyositis Induced by Rapidly Progressive Interstitial Lung Disease

Rongrong Zhang, Li Guo, Jichen Sha, Shuwai Chang, Jiangfeng Zhao, Kaiwen Wang, Jiucun Wang, Jianxin Gu, Jing Liu, Shifang Ren

Phenomics

DOI

2022

Serum IgG N‐glycans enable early detection and early relapse prediction of colorectal cancer

Yong Gu, Bensong Duan, Jichen Sha, Rongrong Zhang, Jiteng Fan, Xiaoyan Xu, Huijuan Zhao, Xiaoyun Niu, Zhi Geng, Jianxin Gu, Ben Huang, Shifang Ren

International Journal of Cancer

DOI

2022

B-cell-specific ablation of β-1,4-galactosyltransferase 1 prevents aging-related IgG glycans changes and improves aging phenotype in mice

Jichen Sha, Jiteng Fan, Rongrong Zhang, Yong Gu, Xiaoyan Xu, Shifang Ren, Jianxin Gu

Journal of Proteomics

DOI

2022

The B-Cell-Specific Ablation of B4GALT1 Reduces Cancer Formation and Reverses the Changes in Serum IgG Glycans during the Induction of Mouse Hepatocellular Carcinoma

Jichen Sha, Rongrong Zhang, Jiteng Fan, Yong Gu, Yiqing Pan, Jing Han, Xiaoyan Xu, Shifang Ren, Jianxin Gu

Cancers

DOI

2022

Fucosylation of anti-dsDNA IgG1 correlates with disease activity of treatment-naïve systemic lupus erythematosus patients

Jing Han, Zhuochao Zhou, Rongrong Zhang, Yijun You, Zizhen Guo, Jinyan Huang, Fan Wang, Yue Sun, Honglei Liu, Xiaobing Cheng, Yutong Su, Hui Shi, Qiongyi Hu, Jialin Teng, Chengde Yang, Shifang Ren, Junna Ye

EBioMedicine

DOI

2021

Characteristics of purified anti-β2GPI IgG N-glycosylation associate with thrombotic, obstetric and catastrophic antiphospholipid syndrome

Tingting Liu, Jing Han, Rongrong Zhang, Zihan Tang, Gang Yi, Wen Gong, Liyan Wan, Qiongyi Hu, Jialin Teng, Honglei Liu, Xiaobing Cheng, Junna Ye, Yutong Su, Yue Sun, Yi Shi, Jianxin Gu, Shifang Ren, Chengde Yang, Hui Shi

Lara D. Veeken

DOI

2021

CA125-Tn ELISA assay improves specificity of pre-operative diagnosis of ovarian cancer among patients with elevated serum CA125 levels

Yisheng Wang, Shifang Ren, Wei Jiang, Jiaqi Lu, Xiaoyan Zhang, Xiaoping Li, Rui Cao, Congjian Xu

Annals of Translational Medicine

DOI

2021

Screening and diagnosis of colorectal cancer and advanced adenoma by Bionic Glycome method and machine learning.

Yiqing Pan, Lei Zhang, Rongrong Zhang, Jing Han, Wenjun Qin, Yong Gu, Jichen Sha, Xiaoyan Xu, Yi Feng, Zhipeng Ren, Jiawen Dai, Ben Huang, Shifang Ren, Jianxin Gu

PubMed

2020

Quantitation of sex-specific serum N-glycome changes in expression level during mouse aging based on Bionic Glycome method

Jing Han, Yiqing Pan, Wenjun Qin, Yong Gu, Xiaoyan Xu, Ran Zhao, Jichen Sha, Rongrong Zhang, Jianxin Gu, Shifang Ren

Experimental Gerontology

DOI

2020

A nomogram based on glycomic biomarkers in serum and clinicopathological characteristics for evaluating the risk of peritoneal metastasis in gastric cancer

Junjie Zhao, Ruihuan Qin, Hao Chen, Yupeng Yang, Wenjun Qin, Jing Han, Xuefei Wang, Shifang Ren, Yihong Sun, Jianxin Gu

Clinical Proteomics

DOI

2020

Profiling of IgG N-glycome during mouse aging: Fucosylated diantennary glycans containing one Neu5Gc-linked LacNAc are associated with age

Jing Han, Yiqing Pan, Yong Gu, Xiaoyan Xu, Ran Zhao, Jichen Sha, Rongrong Zhang, Jianxin Gu, Shifang Ren

Journal of Proteomics

DOI

2020

Correction to: The IgG galactosylation ratio is higher in spondyloarthritis patients and associated with the MRI score

Jing Liu, Qi Zhu, Jing Han, Hui Zhang, Yuan Li, Yanyun Ma, Hengdong Ji, Dongyi He, Jianxin Gu, Xiaodong Zhou, John D. Reveille, Jin Li, Hejian Zou, Shifang Ren, Jiucun Wang

Clinical Rheumatology

DOI

2020

Dynamic alterations in serum IgG N-glycan profiles in the development of colitis-associated colon Cancer in mouse model

Yong Gu, Jing Han, Xin Liu, Yiqing Pan, Xiaoyan Xu, Jichen Sha, Shifang Ren, Jianxin Gu

Biochimica et Biophysica Acta (BBA) - General Subjects

DOI

2020

Relative Quantitation of Subclass-Specific Murine IgG Fc N -Glycoforms by Multiple Reaction Monitoring

Jing Han, Qingmei Liu, Xiaoyan Xu, Wenjun Qin, Yiqing Pan, Ruihuan Qin, Ran Zhao, Yong Gu, Jianxin Gu, Shifang Ren

ACS Omega

DOI

2020

Use of the serum glycan state to predict ovarian cancer patients' clinical response to chemotherapy treatment

Ran Zhao, Guiling Lin, Yisheng Wang, Wenjun Qin, Tong Gao, Jing Han, Ruihuan Qin, Yiqing Pan, Jie Sun, Changhao Ren, Shifang Ren, Congjian Xu

Journal of Proteomics

DOI

2020

Quantitative analysis of serum-based IgG agalactosylation for tuberculosis auxiliary diagnosis

Peng Liu, Shifang Ren, Yan Xie, Chuangang Liu, Wenjun Qin, Yuanyuan Zhou, Mingxia Zhang, Qianting Yang, Xinchun Chen, Ting Liu, Qili Yao, Zhen Xiao, Jianxin Gu, Xiao‐Lian Zhang

Glycobiology

DOI

2020

The IgG galactosylation ratio is higher in spondyloarthritis patients and associated with the MRI score

Jing Liu, Qi Zhu, Jing Han, Hui Zhang, Yuan Li, Yanyun Ma, Hengdong Ji, Dongyi He, Jianxin Gu, Xiaodong Zhou, John D. Reveille, Jin Li, Hejian Zou, Shifang Ren, Jiucun Wang

Clinical Rheumatology

DOI

2020

Dynamic analysis of N-glycomic and transcriptomic changes in the development of ovarian cancer cell line A2780 to its three cisplatin-resistant variants

Guiling Lin, Ran Zhao, Yisheng Wang, Jing Han, Yong Gu, Yiqing Pan, Changhao Ren, Shifang Ren, Congjian Xu

Annals of Translational Medicine

DOI

2020

Prediction of neoadjuvant chemotherapeutic efficacy in patients with locally advanced gastric cancer by serum IgG glycomics profiling

Ruihuan Qin, Yupeng Yang, Hao Chen, Wenjun Qin, Jing Han, Yong Gu, Yiqing Pan, Xi Cheng, Junjie Zhao, Xuefei Wang, Shifang Ren, Yihong Sun, Jianxin Gu

Clinical Proteomics

DOI

2019

Immunoglobulin G galactosylation levels are decreased in systemic sclerosis patients and differ according to disease subclassification

Q Liu, J Lin, Jing Han, Y Zhang, Jiahong Lu, Wenzhen Tu, Yinhuan Zhao, Gang Guo, Haiyan Chu, Weilin Pu, Jiayang Liu, Yanyun Ma, Xiao Chen, R Zhang, Jianxin Gu, Hejian Zou, Jin Li, Wenyu Wu, Shifang Ren, J Wang

Scandinavian Journal of Rheumatology

DOI

2019

Providing Bionic Glycome as internal standards by glycan reducing and isotope labeling for reliable and simple quantitation of N-glycome based on MALDI- MS

Wenjun Qin, Zejian Zhang, Ruihuan Qin, Jing Han, Ran Zhao, Yong Gu, Yiqing Pan, Jianxin Gu, Shifang Ren

Analytica Chimica Acta

DOI

2019

IgG Galactosylation status combined with MYOM2-rs2294066 precisely predicts anti-TNF response in ankylosing spondylitis

Jing Liu, Qi Zhu, Jing Han, Hui Zhang, Yuan Li, Yanyun Ma, Dongyi He, Jianxin Gu, Xiaodong Zhou, John D. Reveille, Jin Li, Hejian Zou, Shifang Ren, Jiucun Wang

Molecular Medicine

DOI

2019

Response to immune complex vaccine in chronic hepatitis B patients is associated with lower baseline level of serum IgG galactosylation

Jing Han, Guozhong Gong, Jianhua Lei, Wenjun Qin, Ruihuan Qin, Xuanyi Wang, Jianxin Gu, Shifang Ren, Yu‐Mei Wen

Medicine

DOI

2019

Diagnostic Significance of Serum IgG Galactosylation in CA19-9-Negative Pancreatic Carcinoma Patients

Ailing Zhong, Ruihuan Qin, Wenjun Qin, Jing Han, Yong Gu, Lei Zhou, Hongqin Zhang, Shifang Ren, Renquan Lu, Lin Guo, Jianxin Gu

Frontiers in Oncology

DOI

2019

The Value of Serum Immunoglobulin G Glycome in the Preoperative Discrimination of Peritoneal Metastasis from Advanced Gastric Cancer

Ruihuan Qin, Yupeng Yang, Wenjun Qin, Jing Han, Hao Chen, Junjie Zhao, Ran Zhao, Can Li, Yong Gu, Yiqing Pan, Xuefei Wang, Shifang Ren, Yihong Sun, Jianxin Gu

Journal of Cancer

DOI

2018

O-GlcNAcylation of RACK1 promotes hepatocellular carcinogenesis

Fangfang Duan, Hao Wu, Dongwei Jia, Weicheng Wu, Shifang Ren, Lan Wang, Shushu Song, Xinying Guo, Fenglin Liu, Yuanyuan Ruan, Jianxin Gu

Journal of Hepatology

DOI

2018

Alteration of Serum IgG Galactosylation as a Potential Biomarker for Diagnosis of Neuroblastoma

Wenjun Qin, Hao Pei, Ruihuan Qin, Ran Zhao, Jing Han, Zejian Zhang, Kuiran Dong, Shifang Ren, Jianxin Gu

Journal of Cancer

DOI

2017

Discovery of Non-invasive Glycan Biomarkers for Detection and Surveillance of Gastric Cancer

Ruihuan Qin, Junjie Zhao, Wenjun Qin, Zejian Zhang, Ran Zhao, Jing Han, Yupeng Yang, Lixiao Li, Xuefei Wang, Shifang Ren, Yihong Sun, Jianxin Gu

Journal of Cancer

DOI

2016

Integrated glycomic analysis of ovarian cancer side population cells

Ran Zhao, Xiaoxia Liu, Yisheng Wang, Xiaoxiang Jie, Ruihuan Qin, Wenjun Qin, Mengyu Zhang, Haiyan Tai, Caiting Yang, Lili Li, Peike Peng, Miaomiao Shao, Xingwang Zhang, Hao Wu, Yuanyuan Ruan, Congjian Xu, Shifang Ren, Jianxin Gu

Clinical Proteomics

DOI

2016

Distribution of IgG galactosylation as a promising biomarker for cancer screening in multiple cancer types

Shifang Ren, Zejian Zhang, Congjian Xu, Lin Guo, Renquan Lu, Yihong Sun, Jianming Guo, Ruihuan Qin, Wenjun Qin, Jianxin Gu

Cell Research

DOI

2015

Mutation of N-linked glycosylation at Asn548 in CD133 decreases its ability to promote hepatoma cell growth

Ying Liu, Shifang Ren, Liqi Xie, Chunhong Cui, Yang Xing, Chanjuan Liu, Benjin Cao, Fan Yang, Yinan Li, Xiaoning Chen, Yuanyan Wei, Haojie Lu, Jianhai Jiang

Oncotarget

DOI

2014

Elucidation of differences in N-glycosylation between different molecular weight forms of recombinant CLEC-2 by LC MALDI tandem MS

Lei Zhou, Yifan Qian, Xingwang Zhang, Yuanyuan Ruan, Shifang Ren, Jianxin Gu

Carbohydrate Research

DOI

2014

Sample preparation for mass spectrometric analysis of human serum N-glycans using hydrophilic interaction chromatography-based solid phase extraction

Liwei Cao, Ye Zhang, Linlin Chen, Aijin Shen, Xingwang Zhang, Shifang Ren, Jianxin Gu, Long Yu, Xinmiao Liang

The Analyst

DOI

2014

Discovery of Specific Metastasis-Related N-Glycan Alterations in Epithelial Ovarian Cancer Based on Quantitative Glycomics

Xingwang Zhang, Yisheng Wang, Yifan Qian, Xin Wu, Zejian Zhang, Xijun Liu, Ran Zhao, Lei Zhou, Yuanyuan Ruan, Jiejie Xu, Haiou Liu, Shifang Ren, Congjian Xu, Jianxin Gu

PLoS ONE

DOI

2013

Quantitative Analysis of Serum IgG Galactosylation Assists Differential Diagnosis of Ovarian Cancer

Yifan Qian, Yisheng Wang, Xingwang Zhang, Lei Zhou, Zejian Zhang, Jiejie Xu, Yuanyuan Ruan, Shifang Ren, Congjian Xu, Jianxin Gu

Journal of Proteome Research

DOI

2012

Surface-associated GroEL facilitates the adhesion of Escherichia coli to macrophages through lectin-like oxidized low-density lipoprotein receptor-1

Haiyan Zhu, Chiayu Lee, Dongmei Zhang, Weicheng Wu, Lan Wang, Xiaoyun Fang, Xiaolin Xu, Dongli Song, Jianhui Xie, Shifang Ren, Jianxin Gu

Microbes and Infection

DOI

2012

Structural and functional conservation of CLEC-2 with the species-specific regulation of transcript expression in evolution

Lan Wang, Shifang Ren, Haiyan Zhu, Dongmei Zhang, Yuqing Hao, Yuanyuan Ruan, Lei Zhou, Chiayu Lee, Lin Qiu, Xiaojing Yun, Jianhui Xie

Glycoconjugate Journal

DOI

2012

The production of soluble C-type lectin-like receptor 2 is a regulated process

Min Fei, Lei Zhou, Jianhui Xie, Yuanyuan Ruan, Jiejie Xu, Songbin He, Hongjie Shen, Yumin Hu, Shifang Ren, Changgeng Ruan

Glycoconjugate Journal

DOI

2012

Site-specific N-glycosylation identification of recombinant human lectin-like oxidized low density lipoprotein receptor-1 (LOX-1)

Yifan Qian, Xingwang Zhang, Lei Zhou, Xiaojing Yun, Jianhui Xie, Jiejie Xu, Yuanyuan Ruan, Shifang Ren

Glycoconjugate Journal

DOI

会议论文

2018

Cancer associated alteration of Human Serum IgG galactosylation and its potential as a pan-cancer diagnosis biomarker

Shifang Ren, Zejian Zhang, Wenjun Qin, Ruihuan Qin, Jin Han, Jianxin Gu

《中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议》

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