周可成｜安徽医科大学｜学者主页

2026

LAPTM4B Confers Resistance to EGFR-TKIs by Suppressing the Proteasomal Degradation of ATP1A1 in Non-small Cell Lung Cancer

Dan Liu, Minxia Liu, Dongjin Lv, Yuxiang Li, Hongjuan Guo, Bingxiao Lu, Hao Leng, Ruyu Yan, Hongtao Yu, Tomas Blom, Kecheng Zhou

International Journal on Biological Sciences

DOI

2026

TRPS1 inhibits cervical cancer progression by suppressing ORC6-mediated tumor stemness.

Juan He, Ruyu Yan, Yi-Tong Du, Hui-Ling Yang, Yichen Feng, Mingjin Tian, Zejun Wu, Lei Li, Lan Xiang, Duo-Xiang Sun, Xianghua Li, Kecheng Zhou, Ya-Li Zhuang

Tissue & Cell

DOI

2025

The impact of exposure to scientific research and inclusive mentoring style on medical undergraduates' perceptions of critical thinking, communication, and passion

Kecheng Zhou, Chunhua Cao, Xiao Liu, Mengqi Sun, Zhihan Wu, Weiqin Zheng, Cheng Peng

Medical Education Online，Vol. 30, No. 10

DOI

2025

MiR-3202–DTL signaling axis impedes NSCLC malignancy via regulating the ubiquitination-proteasome degradation of p21

Hongjuan Guo, Qi Tang, Yu-Jie Zhao, Jianghao Cheng, Jun-Jie Wang, Dan Liu, Ruyu Yan, Dongjin Lv, Bingxiao Lu, Ming-Song Wu, Hongtao Yu, Hao Leng, Bo Liu, Minxia Liu, Kecheng Zhou

Molecular and Cellular Biochemistry

DOI

2025

LAPTM5 Confers the Resistance to Venetoclax via Promoting the Autophagosome‐Lysosome Fusion in Multiple Myeloma

Yuxiang Li, Jing Bai, Dan Liu, Jinxia Hao, Ruyu Yan, Hongjuan Guo, Yu-Zhi Huang, Hongtao Yu, Hao Leng, Kecheng Zhou, Minxia Liu

Journal of Cellular and Molecular Medicine

DOI

2025

ARPC1A Promotes NSCLC Malignancy via Stimulating the Drug Resistance and Cell Migration

Hongjuan Guo, Dan Liu, Ruyu Yan, Tianjing Zhang, Kecheng Zhou, Minxia Liu

Biocell (Mendoza)

DOI

2024

Crosstalk between GBP2 and M2 macrophage promotes the ccRCC progression

Wei Zheng, Shujiang Ye, Bin Liu, Dan Liu, Ruyu Yan, Hongjuan Guo, Hongtao Yu, Xudong Hu, Huaiming Zhao, Kecheng Zhou, Guangyuan Li

Cancer Science

DOI

2024

Pan‐Cancer Analysis Reveals PRIM2 as a Potential Biomarker for Diagnosis, Prognosis, and Immunomodulatory

Xi Zhang, Yuanyue Zhang, Leheng Liu, Zheng Gong, Kecheng Zhou

International Journal of Genomics

DOI

2024

LAPTM4B counteracts ferroptosis via suppressing the ubiquitin-proteasome degradation of SLC7A11 in non-small cell lung cancer

Ruyu Yan, Dan Liu, Hongjuan Guo, Minxia Liu, Dongjin Lv, B. Björkblom, Ming-Song Wu, Hongtao Yu, Hao Leng, Bingxiao Lu, Yuxiang Li, Miao-Miao Gao, Tomas Blom, Kecheng Zhou

Cell Death and Disease

DOI

2023

VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma

Shuo Yang, P. Zhou, Lelei Zhang, Xiangpeng Xie, Yuanyi Zhang, Kai-Da Bo, Jing Xue, Wei Zhang, Faxue Liao, Peng-Fei Xu, Yong Hu, Ruyu Yan, Dan Liu, Jun Chang, Kecheng Zhou

Cancer Biology & Therapy

DOI

2023

Editorial: Functional screening for cancer drug discovery: from experimental approaches to data integration

Kecheng Zhou, Wenyu Wang, Jing Tang

Frontiers in Genetics

DOI

2023

miR-137–LAPTM4B regulates cytoskeleton organization and cancer metastasis via the RhoA-LIMK-Cofilin pathway in osteosarcoma

Ruyu Yan, Dan Liu, Junjie Wang, Minxia Liu, Hong-Juan Guo, J. Bai, Shuo Yang, Jun Chang, Zhihong Yao, Zuo-Zhang Yang, T. Blom, Kecheng Zhou

Oncogenesis

DOI

2022

LAPTM4B‐35 promotes cancer cell migration via stimulating integrin beta1 recycling and focal adhesion dynamics

Minxia Liu, Ruyu Yan, Junjie Wang, Zhihong Yao, Xinyu Fan, Kecheng Zhou

Cancer Science

DOI

2022

CRISPR accelerates the cancer drug discovery

Ruyu Yan, Junjie Wang, Minxia Liu, Kecheng Zhou

Biocell (Mendoza)

DOI

2020

Lysosome Associated Protein Transmembrane 4B (LAPTM4B)-24 is the predominant protein isoform in human tissues and undergoes rapid, nutrient-regulated turnover.

Kecheng Zhou, A. Dichlberger, E. Ikonen, T. Blom

American Journal of Pathology

DOI

2020

LAPTM4B controls the sphingolipid and ether lipid signature of small extracellular vesicles.

A. Dichlberger, Kecheng Zhou, N. Bäck, T. Nyholm, Anders P. E. Backman, P. Mattjus, E. Ikonen, T. Blom

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

DOI

2018

A Ceramide-Regulated Element in the Late Endosomal Protein LAPTM4B Controls Amino Acid Transporter Interaction

Kecheng Zhou, A. Dichlberger, Hector Martinez-Seara, T. Nyholm, Shiqian Li, Young Ah Kim, I. Vattulainen, E. Ikonen, T. Blom

ACS Central Science

DOI

2017

New Insight into microRNA Functions in Cancer: Oncogene–microRNA–Tumor Suppressor Gene Network

Kecheng Zhou, Minxia Liu, Yi Cao

Frontiers in Molecular Biosciences

DOI

2016

MicroRNA-944 Affects Cell Growth by Targeting EPHA7 in Non-Small Cell Lung Cancer

Minxia Liu, Kecheng Zhou, Yi Cao

International Journal of Molecular Sciences

DOI

2015

The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR–155–Rb1 pathway

Minxia Liu, Kecheng Zhou, Yun-Chao Huang, Yi Cao

Journal of experimental & clinical cancer research : CR

DOI

2015

Trafficking and Functions of Bioactive Sphingolipids: Lessons from Cells and Model Membranes

Kecheng Zhou, T. Blom

Lipid Insights

DOI

2015

Additional file 4: of The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR–155–Rb1 pathway

Minxia Liu, Kecheng Zhou, Yun-Chao Huang, Yi Cao

DOI

2014

MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer

Minxia Liu, Kecheng Zhou, Yi Cao

Molecular Cancer

DOI

周可成

精选作品

期刊论文

LAPTM4B Confers Resistance to EGFR-TKIs by Suppressing the Proteasomal Degradation of ATP1A1 in Non-small Cell Lung Cancer

TRPS1 inhibits cervical cancer progression by suppressing ORC6-mediated tumor stemness.

The impact of exposure to scientific research and inclusive mentoring style on medical undergraduates' perceptions of critical thinking, communication, and passion

MiR-3202–DTL signaling axis impedes NSCLC malignancy via regulating the ubiquitination-proteasome degradation of p21

LAPTM5 Confers the Resistance to Venetoclax via Promoting the Autophagosome‐Lysosome Fusion in Multiple Myeloma

ARPC1A Promotes NSCLC Malignancy via Stimulating the Drug Resistance and Cell Migration

Crosstalk between GBP2 and M2 macrophage promotes the ccRCC progression

Pan‐Cancer Analysis Reveals PRIM2 as a Potential Biomarker for Diagnosis, Prognosis, and Immunomodulatory

LAPTM4B counteracts ferroptosis via suppressing the ubiquitin-proteasome degradation of SLC7A11 in non-small cell lung cancer

VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma

Editorial: Functional screening for cancer drug discovery: from experimental approaches to data integration

miR-137–LAPTM4B regulates cytoskeleton organization and cancer metastasis via the RhoA-LIMK-Cofilin pathway in osteosarcoma

LAPTM4B‐35 promotes cancer cell migration via stimulating integrin beta1 recycling and focal adhesion dynamics

CRISPR accelerates the cancer drug discovery

Lysosome Associated Protein Transmembrane 4B (LAPTM4B)-24 is the predominant protein isoform in human tissues and undergoes rapid, nutrient-regulated turnover.

LAPTM4B controls the sphingolipid and ether lipid signature of small extracellular vesicles.

A Ceramide-Regulated Element in the Late Endosomal Protein LAPTM4B Controls Amino Acid Transporter Interaction

New Insight into microRNA Functions in Cancer: Oncogene–microRNA–Tumor Suppressor Gene Network

MicroRNA-944 Affects Cell Growth by Targeting EPHA7 in Non-Small Cell Lung Cancer

The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR–155–Rb1 pathway

Trafficking and Functions of Bioactive Sphingolipids: Lessons from Cells and Model Membranes

Additional file 4: of The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR–155–Rb1 pathway

MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer

会议论文

新的肺癌相关基因MCRS1病理生理功能研究

新的肺癌相关基因RacGAP1和MCRS1的病理生理功能及机制