张书衍｜沈阳大学｜学者主页

2026

TALEN和CRISPR/Cas9编辑NF-κB基因构建稳转细胞系

许益，张书衍，刘忆洁，黄琪珈，张靖宇，刘周莉，王晓微，肖延铭

《高校化学工程学报》

2025

响应面法优化米卡芬净母环前体发酵培养基

张书衍，蔡思杰，刘周莉，王晓微

《化学与生物工程》

2023

基于特异性引物高效构建TALE文库

蔡思杰，张书衍，王晓微，郭显阳，詹硕

《高校化学工程学报》

2023

DNA scaffold assisted ectoine production in Escherichia coli

Ziwei Liu, Yu Fang, Hedan Li, Shuyan Zhang, Ying Li, Dan-na Huang, Yang Wang, Xin Eric Wang

Systems Microbiology and Biomanufacturing

DOI

2023

Metabolic engineering for improving ectoine production in Escherichia coli

Ying Li, Shuyan Zhang, Hedan Li, Dan-na Huang, Ziwei Liu, Dengke Gong, Yang Wang, Zhen Wang, Xin Eric Wang

Systems Microbiology and Biomanufacturing

DOI

2021

Metabolic Detoxification of 2-Oxobutyrate by Remodeling Escherichia coli Acetate Bypass

Yu Fang, Shuyan Zhang, Jianli Wang, Liang-Hong Yin, Hai-Ling Zhang, Zhen Wang, Jie Song, Xiaoqing Hu, Xiao-Yuan Wang

Metabolites

DOI

2021

Metabolic engineering of Escherichia coli for efficient ectoine production

Shuyan Zhang, Yu Fang, Lifei Zhu, Hedan Li, Zhen Wang, Ying Li, Xin Eric Wang

DOI

2021

Improving l-threonine production in Escherichia coli by elimination of transporters ProP and ProVWX

Shuai Wang, Yu Fang, Zhen Wang, Shuyan Zhang, Liangjia Wang, Yong Guo, Xiao-Yuan Wang

Microbial Cell Factories

DOI

2020

高效快速基因靶向调控及编辑技术系统研究

张书衍

《东南大学》

2020

Metabolic engineering of Corynebacterium glutamicum WM001 to improve l‐isoleucine production

Yan-Chao Zhang, Yadi Liu, Shuyan Zhang, Wen-Jian Ma, Jianli Wang, Liang-Hong Yin, Xiao-Yuan Wang

Biotechnology and applied biochemistry

DOI

2020

Rebalancing microbial carbon distribution for L-threonine maximization using a thermal switch system.

Yu Fang, Jianli Wang, Wen-Jian Ma, Jun Yang, Hai-Ling Zhang, Lei Zhao, Shan-Shan Chen, Shuyan Zhang, Xiaoqing Hu, Ye Li, Xiao-Yuan Wang

Metabolic Engineering

DOI

2019

pH selectively regulates citric acid and lipid production in Yarrowia lipolytica W29 during nitrogen-limited growth on glucose.

Shuyan Zhang, S. Jagtap, Anshu Deewan, C. V. Rao

Journal of Biotechnology

DOI

2019

Developing an l‐threonine‐producing strain from wild‐type Escherichia coli by modifying the glucose uptake, glyoxylate shunt, and l‐threonine biosynthetic pathway

Lifei Zhu, Yu Fang, Zhi-Xiang Ding, Shuyan Zhang, Xiao-Yuan Wang

Biotechnology and applied biochemistry

DOI

2016

Engineering Rhodosporidium toruloides for increased lipid production

Shuyan Zhang, Jeffrey M. Skerker, Charles D. Rutter, M. Maurer, A. Arkin, Christopher V. Rao

Biotechnology and Bioengineering

DOI

2016

Metabolic engineering of the oleaginous yeast Rhodosporidium toruloides IFO0880 for lipid overproduction during high-density fermentation

Shuyan Zhang, Masakazu Ito, Jeffrey M. Skerker, A. Arkin, C. V. Rao

Applied Microbiology and Biotechnology

DOI

2016

Genetic engineering oleaginous yeasts for improved lipid production

Shuyan Zhang

2015

Engineering Yarrowia lipolytica for production of medium-chain fatty acids

Charles D. Rutter, Shuyan Zhang, C. V. Rao

Applied Microbiology and Biotechnology

DOI

2015

Development and physiological characterization of cellobiose‐consuming Yarrowia lipolytica

S. Lane, Shuyan Zhang, Na Wei, Christopher V. Rao, Yong-Su Jin

Biotechnology and Bioengineering

DOI

2014

一株产新型水溶性抗真菌化合物的海洋芽胞杆菌发酵动力学的研究

王涛，张书衍，吴绵斌，陈正杰，林建平，杨立荣

《高校化学工程学报》

2012

Quantitative analysis of translational coupling in Escherichia coli

Shuyan Zhang

2011

新型抗真菌抗生素发酵工艺和分离纯化的研究

张书衍

《浙江工业大学》

2011

新型抗真菌代谢产物发酵条件的响应面优化

陈正杰，朱婉萍，张书衍，吴绵斌，贺娟，陈华，孟强

《浙江大学学报(工学版)》

2010

新型抗真菌抗生素发酵工艺及动力学研究

贺娟，陈正杰，吴恩国，刘文辉，张书衍，孟强，吴绵斌

《化学工程》

张书衍

精选作品

期刊论文

TALEN和CRISPR/Cas9编辑NF-κB基因构建稳转细胞系

响应面法优化米卡芬净母环前体发酵培养基

基于特异性引物高效构建TALE文库

DNA scaffold assisted ectoine production in Escherichia coli

Metabolic engineering for improving ectoine production in Escherichia coli

Metabolic Detoxification of 2-Oxobutyrate by Remodeling Escherichia coli Acetate Bypass

Metabolic engineering of Escherichia coli for efficient ectoine production

Improving l-threonine production in Escherichia coli by elimination of transporters ProP and ProVWX

高效快速基因靶向调控及编辑技术系统研究

Metabolic engineering of Corynebacterium glutamicum WM001 to improve l‐isoleucine production

Rebalancing microbial carbon distribution for L-threonine maximization using a thermal switch system.

pH selectively regulates citric acid and lipid production in Yarrowia lipolytica W29 during nitrogen-limited growth on glucose.

Developing an l‐threonine‐producing strain from wild‐type Escherichia coli by modifying the glucose uptake, glyoxylate shunt, and l‐threonine biosynthetic pathway

Engineering Rhodosporidium toruloides for increased lipid production

Metabolic engineering of the oleaginous yeast Rhodosporidium toruloides IFO0880 for lipid overproduction during high-density fermentation

Genetic engineering oleaginous yeasts for improved lipid production

Engineering Yarrowia lipolytica for production of medium-chain fatty acids

Development and physiological characterization of cellobiose‐consuming Yarrowia lipolytica

一株产新型水溶性抗真菌化合物的海洋芽胞杆菌发酵动力学的研究

Quantitative analysis of translational coupling in Escherichia coli

新型抗真菌抗生素发酵工艺和分离纯化的研究

新型抗真菌代谢产物发酵条件的响应面优化

新型抗真菌抗生素发酵工艺及动力学研究

研究方向