李英霞｜复旦大学｜学者主页

2026

Targeting Transcriptional Coactivators p300/CBP: Small-Molecule Inhibitors or Bifunctional Proximity-Inducing Modalities?

Zonglong Chen, Xun Huang, Yingxia Li

Journal of Medicinal Chemistry

2026

Rapid Identification of a Potent, Selective, and Orally Active p300/CBP Bromodomain Inhibitor Bearing an Imidazo[1,2- a ]pyridine Scaffold via a Highly Efficient Four-Step Synthesis

Zonglong Chen, Ying Zhang, Z Y Li, Hui Shen, Hao Wang, Hong Yang, Cheng zhang, Hu J, Yujie Wang, Qiongyu Shi, Yan Zhang, Jian Ding, Yanfen Fang, Yong Xu, X Y Huang, Yingxia Li

Journal of Medicinal Chemistry

DOI

2026

Discovery of CZL-149: A Novel, Highly Potent, and Orally Bioavailable Dual Inhibitor Targeting BET and p300/CBP Bromodomains with Strong Antitumor Efficacy

Zonglong Chen, Qiongyu Shi, Yan Zhang, Hanqi Wang, Zihan Li, Ying Zhang, Cheng zhang, Yujie Wang, Hui Shen, Jian Ding, Xun Huang, Yanfen Fang, Yong Xu, Hong Yang, Yingxia Li

Journal of Medicinal Chemistry

DOI

2026

Discovery of Novel Small-Molecule Toll-like Receptor 2 Agonists via a Scaffold Hopping Strategy

Yueyue Zhu, Longhai Wang, Yuqi Chen, Yujie Wang, Zonglong Chen, Yingxia Li, Wei Zhang

ACS Medicinal Chemistry Letters

DOI

2025

Discovery of Potent and Selective FABP4/5 Inhibitors with an Isoquinolone Scaffold as Potential Therapeutics for Inflammation-Related Diseases

Yulong He, Shunyi Li, Yuqi Chen, Yiyang Xu, Yujie Wang, Zonglong Chen, Heyao Wang, Yingxia Li

Journal of Medicinal Chemistry

DOI

2025

Discovery of Novel Class of METTL3 Inhibitors with a Pyridin-2(1 H )-one Moiety

Weihang Zhang, Yuting Huang, Hong Yang, Haiyan Wang, Xinsheng Lei, Jinxi Xiang, Yujie Wang, Yingxia Li, Xun Huang, Yu Sun

ACS Medicinal Chemistry Letters

DOI

2025

Pretargeted Mitochondrial Delivery of Organoarsenicals for Cancer Immunotherapy

Run Wang, Yuyang Tian, Xiaoxia Lü, Leyi Fang, Yinxing Miao, Daqing Fang, Yingxia Li, Hong Shu Liu, Deju Ye

Journal of the American Chemical Society

DOI

2025

Discovery of Novel MTA-Cooperative PRMT5 Inhibitors with a 2,3-Dihydro-1H-imidazo[1,2-b]pyrazole Scaffold

Yuxin Yang, Zonglong Chen, Yujie Wang, Xun Huang, Chun Hu, Hong Jun Yang, Yingxia Li

ACS Medicinal Chemistry Letters

DOI

2024

"One pot" synthesis of quinazolinone-[2,3]-fused polycyclic scaffolds in a three-step reaction sequence.

Yuanmung Zhang, Lingxuan Zhu, Yi Lu, Xinsheng Lei, Yingxia Li

Organic and biomolecular chemistry

DOI

2024

Discovery of CZL-046 with an (S)-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple Myeloma

Zonglong Chen, Hong Yang, Yan Zhang, Xiaodong Lyu, Qiongyu Shi, Cheng Zhang, Xingcan Wang, Zekun Wang, Ying Zhang, Yue Wen Deng, Yujie Wang, Yuting Huang, Yong Xu, Xun Huang, Yingxia Li

Journal of Medicinal Chemistry

DOI

2024

Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma

Qi Chang, Jiayi Li, Yue Wen Deng, Ruilin Zhou, Bingwei Wang, Yujie Wang, Mingming Zhang, Xun Huang, Yingxia Li

Journal of Medicinal Chemistry

DOI

2024

Formyl phloroglucinol meroterpenoids from the leaves of Eucalyptus globulus subsp. maidenii and their ATP-citrate lyase inhibitory activities

Zhu Hu, Yi-Nan Liu, Mei-Hua Yu, Ai‐Jun Hou, Jing-Ya Li, Yingxia Li, Chun Lei

Fitoterapia

DOI

2024

Development of ketalized unsaturated saccharides as multifunctional cysteine-targeting covalent warheads

Sanfeng Dong, Hui Yu Huang, Jintian Li, Xiaomei Li, Samuel J. Bunu, Yun Yang, Yong Zhang, Qi Jia, Zhijian Xu, Yingxia Li, Hu Zhou, Bo Li, Weiliang Zhu

Communications Chemistry

DOI

2023

作为FABP4/5抑制剂喹啉类化合物的设计合成与生物活性研究（英文）

高建飞，李瞬依，何玉龙，李英霞，王贺瑶，黄二芳，胡春

《有机化学》

2023

Biomimetic Total Synthesis of Clavicipitic Acid: A DDQ-Mediated Intramolecular Cross-Dehydrogenative Coupling Approach.

Kuei-Wei Chiu, Yu-Hsun Tseng, Yingxia Li, Rong‐Jie Chein

Organic Letters

DOI

2023

Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation

Yulong He, Shunyi Li, Shunyi Li, Yueyue Zhu, Yujie Wang, Yujie Wang, Yuqi Chen, Deqiang Zhang, Heyao Wang, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2023

Discovery of Small-Molecule Autophagy Inhibitors by Disrupting the Protein–Protein Interactions Involving Autophagy-Related 5

Honggang Xiang, Ruiqi Liu, Xiangying Zhang, Ran An, Mi Zhou, Chang‐Heng Tan, Qing Li, Minyi Su, Chun Guo, Lu Zhou, Yingxia Li, Renxiao Wang

Journal of Medicinal Chemistry

DOI

2023

Synthesis, evaluation and molecular dynamics study of human toll-like receptor 2/6 specific monoacyl lipopeptides as candidate immunostimulants

Yueyue Zhu, Bo Liu, Zonglong Chen, Xianyang Wang, Yujie Wang, Yujie Wang, Yujie Wang, Wenhong Zhang, Wenhong Zhang, Sen Wang, Mingming Zhang, Yingxia Li

Bioorganic Chemistry

DOI

2023

Design, Synthesis and Biological Evaluation of FABP4/5 Inhibitors Based on Quinoline Scaffold

Jianfei Gao, Shunyi Li, Yulong He, Yingxia Li, Heyao Wang, Er-Fang Huang, Chun Hu

Chinese Journal of Organic Chemistry

DOI

2022

Identification and immunological evaluation of novel TLR2 agonists through structural optimization of Diprovocim

Xianyang Wang, Yujie Wang, Yueyue Zhu, Xinsheng Lei, Mingming Zhang, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2022

Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti-proliferative activity in multiple cancer cells

Zonglong Chen, Jiayi Li, Hong Yang, Yulong He, Qiongyu Shi, Qi Chang, Ruiqi Liu, Xun Huang, Yingxia Li

Bioorganic & Medicinal Chemistry

DOI

2022

Discovery of 4′-O-methylscutellarein as a potent SARS-CoV-2 main protease inhibitor

Qianqian Wu, Shiqiang Yan, Yujie Wang, Maotian Li, Yibei Xiao, Yingxia Li

Biochemical and Biophysical Research Communications

DOI

2022

Recent Studies on the Pharmacological Activities and Structural Modifications of Compound-K

Mingming Zhang, Yingxia Li, Yujie Wang

Mini-Reviews in Medicinal Chemistry

DOI

2022

Design, synthesis and biological evaluation of (R)-5-methylpyrrolidin-2-ones as p300 bromodomain inhibitors with Anti-Tumor activities in multiple tumor lines

Ruiqi Liu, Hong Jun Yang, Zonglong Chen, Kaixin Zhou, Qiongyu Shi, Jiayi Li, Yuting Huang, Xun Huang, Yingxia Li

Bioorganic Chemistry

DOI

2021

Synthesis of the analogs of plocabulin and their preliminary structure-activity relationship study.

Leiming Wang, Xin Li, H. Cui, Xin-Sheng Lei, Hong-Chun Liu, Quan-Rui Wang, Yingxia Li

Bioorganic & Medicinal Chemistry Letters

DOI

2021

Copper-catalyzed cross-coupling of amino acid-derived amides with (Z)-vinyl iodides: Unexpected solvent effect and preparation of plocabulin

Leiming Wang, Xin-Sheng Lei, Quan-Rui Wang, Yingxia Li

DOI

2021

Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus

Yulong He, Meng-Ting Chen, Ting Wang, Ming-Ming Zhang, Yingxia Li, Heyao Wang, Ning Ding

European Journal of Medicinal Chemistry

DOI

2021

Synthesis and biological evaluation of novel cabazitaxel analogues

Sumei Ren, Minmin Zhang, Yujie Wang, Jia Guo, Junfei Wang, Yingxia Li, Ning Ding

Bioorganic & Medicinal Chemistry

DOI

2021

Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors

Dingding Gao, Nan Jin, Yixian Fu, Yueyue Zhu, Yujie Wang, Ting Wang, Yuehong Chen, Mingming Zhang, Qiang Xiao, Min Huang, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2021

Combined treatment with FABP4 inhibitor ameliorates rosiglitazone‐induced liver steatosis in obese diabetic db/db mice

Mengting Chen, Jun‐Shang Huang, Dingding Gao, Yingxia Li, Heyao Wang

Basic & Clinical Pharmacology & Toxicology

DOI

2020

靶向Toll样受体2激动剂的研究进展

杜鑫明，张鸣鸣，王玉杰，李英霞

《中国药物化学杂志》

DOI

2020

海洋来源的微管蛋白聚集抑制剂tubulysins的研究进展

熊樱，李英霞

《中国海洋药物》

DOI

2020

Recent Advances in the Development of CBP/p300 Bromodomain Inhibitors

Ying Xiong, Mingming Zhang, Yingxia Li

Current Medicinal Chemistry

DOI

2020

Total synthesis of leontopodioside A

Shiqiang Yan, Yueyue Zhu, Yujie Wang, Qiang Xiao, Ning Ding, Yingxia Li

Tetrahedron Letters

DOI

2020

Semi-synthesis of a series natural flavonoids and flavonoid glycosides from scutellarin

Shiqiang Yan, Mingxian Xie, Yujie Wang, Qiang Xiao, Ning Ding, Yingxia Li

Tetrahedron

DOI

2020

Palladium‐Catalysed C(sp3)−H Glycosylation for the Synthesis of C‐Alkyl Glycoamino Acids

Yichu Liu, Yibing Wang, Wenhao Dai, Wei Huang, Yingxia Li, Hong Shu Liu

Angewandte Chemie

DOI

2020

Investigation of the remote acyl group participation in glycosylation from conformational perspectives by using trichloroacetimidate as the acetyl surrogate

Ke Cheng XU, Qingmin Man, Yang Zhang, Jia Guo, Yichu Liu, Zunyun Fu, Yueyue Zhu, Yingxia Li, Mingyue Zheng, Ning Ding

Organic Chemistry Frontiers

DOI

2019

Corrigendum to “Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors” [Eur. J. Med. Chem. 180 (2019) 171e190]

Ruiqi Liu, Zhuqing Zhang, Hong Yang, Kaixin Zhou, Meiyu Geng, Weicheng Zhou, Mingming Zhang, Xun Huang, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2019

Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives

Zhenkang Wang, Chunhua Ma, Yujie Wang, Qiang Xiao, Cheng‐Hui Xu, Yingxia Li

Bioorganic & Medicinal Chemistry Letters

DOI

2019

Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor

Yulong He, Huixia Dou, Dingding Gao, Ting Wang, Mingming Zhang, Heyao Wang, Yingxia Li

Bioorganic & Medicinal Chemistry

DOI

2019

Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors

Ruiqi Liu, Zhuqing Zhang, Zhuqing Zhang, Hong Yang, Kaixin Zhou, Weicheng Zhou, Meiyu Geng, Weicheng Zhou, Mingming Zhang, Xun Huang, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2019

Identification and immunological evaluation of novel TLR2 agonists through structure optimization of Pam3CSK4

Xinming Du, Jiawen Qian, Yujie Wang, Mingming Zhang, Yiwei Chu, Yingxia Li

Bioorganic & Medicinal Chemistry

DOI

2019

Corrigendum to “From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4” [Ejmech 154 (2018) 44–59]

Dingding Gao, Huixia Dou, Haixia Su, Mingming Zhang, Ting Wang, Qiu-Feng Liu, Haiyan Cai, Hai-Peng Ding, Zhuo Yang, Weiliang Zhu, Yechun Xu, Heyao Wang, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2019

Research on the Semi-synthesis of Pectolinarin from Scutellarin

Shiqiang Yan, Mingxian Xie, Yujie Wang, Yingxia Li

Chinese Journal of Organic Chemistry

DOI

2019

Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes

Huixia Dou, Ting Wang, Haixia Su, Dingding Gao, Yechun Xu, Yingxia Li, Heyao Wang

Endocrine

DOI

2019

A novel assay for measuring recombinant human lysophosphatidylcholine acyltransferase 3 activity

Xinming Du, Jiachun Hu, Qing Zhang, Qi Liu, Xinxin Xiang, Jibin Dong, Bin Lou, Shuhua He, Xiang Gu, Yu Cao, Yingxia Li, Tingbo Ding

FEBS Open Bio

DOI

2018

Synthesis and biological evaluation of novel 1-substituted 3-(3-phenoxyprop-1-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors

Nan Zheng, Qun Hao, Kuaile Lin, Jing Pan, Yingxia Li, Weicheng Zhou

Bioorganic & Medicinal Chemistry Letters

DOI

2018

Synthesis and biological evaluation of Ginsenoside Compound K analogues as a novel class of anti-asthmatic agents

Sumei Ren, Ruiqi Liu, Yujie Wang, Ning Ding, Yingxia Li

Bioorganic & Medicinal Chemistry Letters

DOI

2018

Synthesis and biological evaluation of novel larotaxel analogues

Sumei Ren, Yujie Wang, Junfei Wang, Dingding Gao, Minmin Zhang, Ning Ding, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2018

From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4

Dingding Gao, Huixia Dou, Haixia Su, Mingming Zhang, Ting Wang, Qiu-Feng Liu, Haiyan Cai, Hai-Peng Ding, Zhuo Yang, Weiliang Zhu, Yechun Xu, Heyao Wang, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2018

Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation

Yan Qi, Yuzhe Chen, Baiyou Tang, Qiang Xiao, Rong Qu, Linjiang Tong, Jian Liu, Jian Ding, Yi Chen, Ning Ding, Wenfu Tan, Hua Xie, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2018

Design, synthesis and biological evaluation of novel 3-substituted pyrazolopyrimidine derivatives as potent Bruton’s tyrosine kinase (BTK) inhibitors

Nan Zheng, Jing Pan, Qun Hao, Yingxia Li, Weicheng Zhou

Bioorganic & Medicinal Chemistry

DOI

2018

Glycosylation of a Ketone with an O-Glycosyl Trichloroacetimidate Provides an Enol Glycoside

Xianglai Liu, Sumei Ren, Qi Gao, Chun Hu, Yingxia Li, Ning Ding

Organic Letters

DOI

2018

Concise total synthesis of acylated phenolic glycosides vitexnegheteroin A and ovatoside D

Shiqiang Yan, Sumei Ren, Ning Ding, Yingxia Li

Carbohydrate Research

DOI

2017

Optimization of 1H-indazol-3-amine derivatives as potent fibroblast growth factor receptor inhibitors

Jing Cui, Peng Xia, Dingding Gao, Yang Dai, Jing Ai, Yingxia Li

Bioorganic & Medicinal Chemistry Letters

DOI

2017

Identification and preliminary structure–activity relationships of 1-Indanone derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors

Dingding Gao, Yingxia Li

Bioorganic & Medicinal Chemistry

DOI

2017

Rapid access to 6″-functionalized α-galactosyl ceramides by using 2-naphthylmethyl ether as the permanent protecting group

Yichu Liu, Xiaoyan Xu, Qi Gao, Shiqiang Yan, Yingxia Li, Ning Ding

Bioorganic & Medicinal Chemistry Letters

DOI

2017

In Vivo Fate of Biomimetic Mixed Micelles as Nanocarriers for Bioavailability Enhancement of Lipid–Drug Conjugates

Yuhua Ma, Haisheng He, Wufa Fan, Yingxia Li, Wei Zhang, Weili Zhao, Jianping Qi, Yi Lü, Xiaochun Dong, Wei Wu

ACS Biomaterials Science & Engineering

DOI

2017

Corrigendum to “Synthesis and biological evaluation of oxoapratoxin E and its C30 epimer” [Tetrahedron Lett 58 (33) (2017) 3333–3336]

Ping Wu, Hao Xu, Zhi Li, Yang Zhou, Yingxia Li, Wei Zhang

Tetrahedron Letters

DOI

2017

In vivo fate of lipid-silybin conjugate nanoparticles: Implications on enhanced oral bioavailability

Yuhua Ma, Haisheng He, Fei Xia, Yingxia Li, Yan Lu, Yan Lu, Daofeng Chen, Jianping Qi, Yi Lü, Yi Lü, Wei Zhang, Wei Wu

Nanomedicine Nanotechnology Biology and Medicine

DOI

2017

Synthesis and biological evaluation of oxoapratoxin E and its C30 epimer

Ping Wu, Hao Xu, Zhi Li, Yang Zhou, Yingxia Li, Wei Zhang

Tetrahedron Letters

DOI

2017

Synthesis of oligo-fructopyranoside with difructopyranosyl N-phenyltrifluoroacetimidate donor

Hongliang Zhang, Hengtao Wang, Qiulong Xu, Rui Min Lu, Yunhua Cao, Zhefeng Wang, Pingping Tang, Feng Wu Lin, Yingxia Li

Carbohydrate Research

DOI

2017

Evidence of robust participation by an equatorial 4-O group in glycosylation on a 2-azido-2-deoxy-glucopyranosyl donor

Dongming Yao, Yichu Liu, Shiqiang Yan, Yingxia Li, Chun Hu, Ning Ding

Chemical Communications

DOI

2016

信号转导及转录激活因子3(STAT3)信号通路小分子抑制剂的设计、合成及其生物活性研究

高顶顶，包可婷，张鸣鸣，李英霞

《有机化学》

2016

Design, synthesis and biological evaluation of c-Met kinase inhibitors bearing 2-oxo-1,2-dihydroquinoline scaffold

Hong Cui, Peng Xia, Jian Liu, Chunhua Ma, Yinchun Ji, Wei Zhang, Meiyu Geng, Yingxia Li

Bioorganic & Medicinal Chemistry Letters

DOI

2016

Novel Azetidine-Containing TZT-1027 Analogues as Antitumor Agents

Yan Qi, Yujie Wang, Wei Zhang, Yingxia Li

Marine Drugs

DOI

2016

Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors

Qiang Xiao, Rong Qu, Dingding Gao, Yan Qi, Linjiang Tong, Wei Zhang, Jian Ding, Hua Xie, Yingxia Li

Bioorganic & Medicinal Chemistry

DOI

2016

Design, synthesis and biological evaluation of benzyloxyphenyl-methylaminophenol derivatives as STAT3 signaling pathway inhibitors

Dingding Gao, Qiang Xiao, Mingming Zhang, Yingxia Li

Bioorganic & Medicinal Chemistry

DOI

2016

Total Synthesis and Biological Evaluation of Apratoxin E and Its C30 Epimer: Configurational Reassignment of the Natural Product

Ping Wu, Weijing Cai, Qi-Yin Chen, Senhan Xu, Ruwen Yin, Yingxia Li, Wei Yan Zhang, Hendrik Luesch

Organic Letters

DOI

2016

Synthesis, conformational analysis and biological evaluation of the lactam analogue of the cyclodepsipeptide apratoxin A

Ruwen Yin, Wei Zhang, Guoyun Liu, Ping Wu, Choiwan Lau, Yingxia Li

Tetrahedron

DOI

2016

Design, Synthesis and Biological Evaluation of Small-Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway

Dingding Gao, Keting Bao, Mingming Zhang, Yingxia Li

Chinese Journal of Organic Chemistry

DOI

2016

Facile Synthesis of (S)-4-Amino-5-mercaptopentanoic Acid

Ping Wu, Chunhua Ma, Senhan Xu, Yingxia Li, Yanjun Zhai, Wei Zhang

Chinese Journal of Organic Chemistry

DOI

2015

Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation

Chunhua Ma, Jiangying Cao, Xuewu Liang, Yongxue Huang, Ping Wu, Yingxia Li, Wenfang Xu, Yingjie Zhang

European Journal of Medicinal Chemistry

DOI

2015

Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors

Jian Liu, Wuyan Chen, Yechun Xu, Sumei Ren, Wei Zhang, Yingxia Li

Bioorganic & Medicinal Chemistry

DOI

2015

Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold

Jian Liu, Peng Xia, Yang Dai, Wei Zhang, Sumei Ren, Jing Ai, Meiyu Geng, Yingxia Li

Organic & Biomolecular Chemistry

DOI

2015

Synthesis and biological evaluation of novel dioxa-bicycle C-aryl glucosides as SGLT2 inhibitors

Yan Qi, Ning Ding, Yingxia Li

Carbohydrate Research

DOI

2015

Total Synthesis of Two Diastereomers of Megastigmane Glycoside Lauroside B

Xiaozhe Fu, Mingming Zhang, Qi Gao, Feng‐Ling Yang, Yingxia Li, Ning Ding

Journal of Carbohydrate Chemistry

DOI

2014

Novel fatty acid binding protein 4 (FABP4) inhibitors: Virtual screening, synthesis and crystal structure determination

Haiyan Cai, Qiufeng Liu, Dingding Gao, Ting Wang, Tiantian Chen, Guirui Yan, Kaixian Chen, Yechun Xu, Heyao Wang, Yingxia Li, Weiliang Zhu

European Journal of Medicinal Chemistry

DOI

2014

Design, Synthesis and Biological Evaluation of Tasiamide Analogues as Tumor Inhibitors

Wei Zhang, Tiantian Sun, Zhenhua Ma, Yingxia Li

Marine Drugs

DOI

2014

Discovery of novel type II c-Met inhibitors based on BMS-777607

Wei Zhang, Jing Ai, Da‐Kuo Shi, Peng Xia, Yinchun Ji, Jian Liu, Meiyu Geng, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2014

ChemInform Abstract: Heck‐Type Cross‐Coupling Between Halo‐exo‐Glycals and endo‐Glycals: A Practical Way to Achieve C‐Glycosidic Disaccharides.

Yongfeng Tao, Ning Ding, Sumei Ren, Yingxia Li

ChemInform

DOI

2014

Discovery of Novel c-Met Inhibitors Bearing a 3-Carboxyl Piperidin-2-one Scaffold

Wei Zhang, Jing Ai, Da‐Kuo Shi, Peng Xia, Yinchun Ji, Jian Liu, Meiyu Geng, Yingxia Li

Molecules

DOI

2014

Research Progress of Apratoxin A：A Marine Cyclicdepsipeptide with Significant Anti-cancer Activity

Wei Yan Zhang, Guoyun Liu, Ruwen Yin, Yingxia Li

Chinese Journal of Organic Chemistry

DOI

2013

脂肪酸结合蛋白4小分子抑制剂研究进展

刘璐，张鸣鸣，李英霞，孟艳秋

《中国药物化学杂志》

2013

Discovery of novel inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening

Mingming Zhang, Weiliang Zhu, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2013

Small Molecule Inhibitors of Human Adipocyte Fatty Acid Binding Protein (FABP4)

Mingming Zhang, Weiliang Zhu, Yingxia Li

Medicinal Chemistry

DOI

2013

Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives

Qingchao Liu, Hong‐Chun Liu, Lei Zhang, Tiantian Guo, Peng Wang, Meiyu Geng, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2013

Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors

Qingchao Liu, Tiantian Guo, Lei Justan Zhang, Yue Yu, Peng Wang, Ju-Fang Yang, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2013

Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening

Mingming Zhang, Weiliang Zhu, Ning Ding, Wei Zhang, Yingxia Li

Bioorganic & Medicinal Chemistry Letters

DOI

2013

ChemInform Abstract: Ultrasound‐Assisted Selective Deprotection of Terminal Acetonides Catalyzed by Silica‐Supported Boron Trifluoride.

Junlong Xiong, Shiqiang Yan, Ning Ding, Wei Zhang, Yingxia Li

ChemInform

DOI

2013

Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice

Haiyan Cai, Ting Wang, Jian-chun Zhao, Peng Gang Sun, Guirui Yan, Hai-Peng Ding, Yingxia Li, Heyao Wang, Weiliang Zhu, Kaixian Chen

Acta Pharmacologica Sinica

DOI

2013

Heck-type cross-coupling between halo-exo-glycals and endo-glycals: a practical way to achieve C-glycosidic disaccharides

Yongfeng Tao, Ning Ding, Sumei Ren, Yingxia Li

Tetrahedron Letters

DOI

2013

Synthesis of the Pentasaccharide Moiety of Thornasterside A

Junlong Xiong, Zhichao Lu, Ning Ding, Sumei Ren, Yingxia Li

European Journal of Organic Chemistry

DOI

2013

ChemInform Abstract: A Facile and Efficient Method for the One‐Pot Synthesis of Per‐O‐Acetylated Thioglycosides from Unprotected Sugars.

Shiqiang Yan, Ning Ding, Wei Zhang, Peng Wang, Yingxia Li, Ming Li

ChemInform

DOI

2013

Ultrasound-Assisted Selective Deprotection of Terminal Acetonides Catalyzed by Silica-Supported Boron Trifluoride

Junlong Xiong, Shiqiang Yan, Ning Ding, Wei Zhang, Yingxia Li

Journal of Carbohydrate Chemistry

DOI

2013

Synthesis of analogues of linckoside B, a new neuritogenic steroid glycoside

Qingchao Liu, Yue Yu, Peng Wang, Yingxia Li

New Journal of Chemistry

DOI

2012

抗多药耐药紫杉烷类抗肿瘤药物研究进展

于跃，王军飞，王长云，李英霞

《中国现代应用药学》

2012

Cyanobacterial Peptides as a Prototype for the Design of Potent β-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases

Yanxia Liu, Wei Yan Zhang, Li Li, Lilibeth A. Salvador, Tiantian Chen, Wuyan Chen, Kevin M. Felsenstein, Thomas B. Ladd, Ashleigh R. Price, Todd Eliot Golde, Jianhua He, Yechun Xu, Yingxia Li, Hendrik Luesch

Journal of Medicinal Chemistry

DOI

2012

Total synthesis of grassystatin A, a probe for cathepsin E function

Siming Yang, Wei Zhang, Ning Ding, Jeannette Lo, Yanxia Liu, Michael J Clare-Salzler, Hendrik Luesch, Yingxia Li

Bioorganic & Medicinal Chemistry

DOI

2012

Structure–activity relationships of saponin derivatives: A series of entry inhibitors for highly pathogenic H5N1 influenza virus

Ning Ding, Qing Chen, Wei Zhang, Sumei Ren, Ying Guo, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2012

Synthesis and Biological Evaluation of Analogs of Methyl Ursolate 3-O-β-Chacotrioside as H5N1 Viral Entry Inhibitors

Sumei Ren, Qing Chen, Ning Ding, Wei Zhang, Yingxia Li, Ying Guo

Journal of Carbohydrate Chemistry

DOI

2012

A Facile and Efficient Method for the One-Pot Synthesis of Per-O-acetylated Thioglycosides from Unprotected Sugars

Shiqiang Yan, Ning Ding, Wei Zhang, Peng Wang, Yingxia Li, Ming Li

Journal of Carbohydrate Chemistry

DOI

2012

ChemInform Abstract: Synthesis and Biological Evaluation of Antifungal Activities of Novel 1,2‐trans Glycosphingolipids.

Ning Ding, Wei Zhang, Guokai Lv, Yingxia Li

ChemInform

DOI

2012

An efficient and recyclable catalyst for the cleavage of tert-butyldiphenylsilyl ethers

Shiqiang Yan, Ning Ding, Wei Zhang, Peng Wang, Yingxia Li, Ming Li

Carbohydrate Research

DOI

2012

ChemInform Abstract: Synthesis of 1,6‐Anhydro Sugars Catalyzed by Silica Supported Perchloric Acid.

Yuexing Chun, Shiqiang Yan, Xiangpeng Li, Ning Ding, Wei Zhang, Peng Wang, Ming Li, Yingxia Li

ChemInform

DOI

2012

Bromodimethylsulfonium Bromide Catalyzed Synthesis of Methyl 2‐Dexoy‐4,6‐O‐benzylidene Galactopyranoside from Galactal and the Rapid Route to 2,3‐ and 2,6‐Dideoxygalactopyranoses

Ning Ding, Yuexing Chun, Wei Zhang, Yingxia Li

Chinese Journal of Chemistry

DOI

2012

Stereoselective synthesis of fully protected (2S,4S,6S)‐2‐amino‐6‐hydroxy‐4‐methyl‐8‐oxodecanoic acid (AHMOD)

Wei Zhang, Xiangpeng Li, Ning Ding, Yingxia Li

Journal of Peptide Science

DOI

2012

Progress in the Chemical Synthesis of 2-Deoxy-glycosides

Zhongzhen Li, Ning Ding, Wei Zhang, Peng Wang, Ming Li, Yingxia Li

Chinese Journal of Organic Chemistry

DOI

2012

Antimicrobial mechanism of novel oligorhamnoside derivatives of dirhamnoside derivative compound 7 and cleistrioside-5 against Gram-positive cocci

Yingxia Li

The Chinese Journal of Clinical Pharmacology

2012

Antibacterial activity and mechanism of new acetylated ligorhamnosides

Yingxia Li

The Chinese Journal of Clinical Pharmacology

2011

Design, synthesis and biological evaluation of novel glycosylated diphyllin derivatives as topoisomerase II inhibitors

Da‐Kuo Shi, Wei Zhang, Ning Ding, Ming Li, Yingxia Li

European Journal of Medicinal Chemistry

DOI

2011

Synthesis, cytotoxic activities and cell cycle arrest profiles of naphtho[2,1-α]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dione glycosides

Ning Ding, Xiaoguang Du, Wei Zhang, Zhichao Lu, Yingxia Li

Bioorganic & Medicinal Chemistry Letters

DOI

2011

Effects of an Indolocarbazole-Derived CDK4 Inhibitor on Breast Cancer Cells

Yuan Sun, Yingxia Li, Haijun Wu, Si-hung Wu, Yanru Wang, Dianzhong Luo, Dezhong Joshua Liao

Journal of Cancer

DOI

2011

Synthesis of RingA‐Modified Baicalein Derivatives

Junfei Wang, Ning Ding, Wei Zhang, Peng Wang, Yingxia Li

Helvetica Chimica Acta

DOI

2011

ChemInform Abstract: Synthesis, Cytotoxic Activities and Cell Cycle Profiles of Naphtho[2,1‐α]pyrrolo[3,4‐c]carbazole‐5,7(6H,12H)‐dione Glycosides.

Ning Ding, Xiaoguang Du, Wei Zhang, Zhichao Lu, Yingxia Li

ChemInform

DOI

2011

Synthesis and Biological Evaluation of Antifungal Activities of Novel 1,2‐trans Glycosphingolipids

Ning Ding, Wei Zhang, Guokai Lv, Yingxia Li

Archiv der Pharmazie

DOI

2011

Synthesis of 1,6-anhydro sugars catalyzed by silica supported perchloric acid

Yuexing Chun, Shiqiang Yan, Xiangpeng Li, Ning Ding, Wei Zhang, Peng Wang, Ming Li, Yingxia Li

Tetrahedron Letters

DOI

2011

Differentiating the 2,3-diols of glucopyranosides by 4,6-O-benzylidene-protected-1,2-d-glucopyranosylorthoesters strategy

Guangfa Wang, Zhichao Lu, Ning Ding, Wei Zhang, Peng George Wang, Yingxia Li

Carbohydrate Research

DOI

2011

Synthesis and antibacterial evaluation of a series of oligorhamnoside derivatives

Ning Ding, Zaihong Zhang, Wei Yan Zhang, Yuexing Chun, Peng Wang, Huimin Qi, Shan Wang, Yingxia Li

Carbohydrate Research

DOI

2011

ChemInform Abstract: Facile Synthesis of Four Natural Triterpene Saponins with Important Antitumor Activity.

Tiantian Guo, Qingchao Liu, Lei Zhang, Peng Wang, Yingxia Li

ChemInform

DOI

2011

An improved synthesis of (2 S , 4 S )‐ and (2 S , 4 R )‐2‐amino‐4‐methyldecanoic acids: assignment of the stereochemistry of culicinins

Wei Zhang, Ning Ding, Yingxia Li

Journal of Peptide Science

DOI

2011

A convenient synthesis of the core trisaccharide of the N-glycans

Zhichao Lu, Ning Ding, Wei Zhang, Peng Wang, Yingxia Li

Tetrahedron Letters

DOI

2011

Synthesis and biological evaluation of analogues of the marine cyclic depsipeptide obyanamide

Wei Zhang, Ning Ding, Yingxia Li

Journal of Peptide Science

DOI

2011

Facile Synthesis of Four Natural Triterpene Saponins with Important Antitumor Activity

Tiantian Guo, Qingchao Liu, Lei Zhang, Peng Wang, Yingxia Li

Synthetic Communications

DOI

2011

Cyclin D1 inhibits whereas c-Myc enhances the cytotoxicity of cisplatin in mouse pancreatic cancer cells via regulation of several members of the NF-κB and Bcl-2 families

Yingxia Li, Ayman I. Elkady, Yuan Sun, Dezhong Joshua Liao

Journal of Carcinogenesis

DOI

2010

紫杉醇类前药的研究进展

王军飞，张伟，丁宁，李英霞

《中国药物化学杂志》

2010

Synthesis and biological evaluation of cytotoxic activity of novel anthracene l-rhamnopyranosides

Gaopeng Song, Hong‐Chun Liu, Wei Zhang, Meiyu Geng, Yingxia Li

Bioorganic & Medicinal Chemistry

DOI

2010

ChemInform Abstract: Convenient Synthesis of D‐Talose from D‐Galactose.

Hualing Xiao, Guangfa Wang, Peng Wang, Yingxia Li

ChemInform

DOI

2010

ChemInform Abstract: Improved Enantioselective Synthesis of Protected (3S,4S)‐4‐Amino‐3,5‐dihydroxypentanoic Acid (ADPA).

Duo Mei, Wei Zhang, Yingxia Li

ChemInform

DOI

2010

Total synthesis and stereochemical reassignment of tasiamide B

Tiantian Sun, Wei Zhang, Chengli Zong, Peng Wang, Yingxia Li

Journal of Peptide Science

DOI

2010

Convenient synthesis of sulfated oligofucosides

Chengli Zong, Zhongzhen Li, Tiantian Sun, Peng Wang, Ning Ding, Yingxia Li

Carbohydrate Research

DOI

2010

Improved Enantioselective Synthesis of Protected (3S,4S)-4-Amino-3,5-dihydroxypentanoic Acid (ADPA)

Duo Mei, Wei Zhang, Yingxia Li

Synthetic Communications

DOI

2010

Total synthesis of caminoside B, a novel antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia

Zaihong Zhang, Chengli Zong, Gaopeng Song, Guokai Lv, Yuexing Chun, Peng Wang, Ning Ding, Yingxia Li

Carbohydrate Research

DOI

2010

Synthesis and cytotoxic activity of the N-acetylglucosamine-bearing triterpenoid saponins

Peng Wang, Jun Wang, Tiantian Guo, Yingxia Li

Carbohydrate Research

DOI

2010

Progress on the prodrugs of paclitaxel

Yingxia Li

Zhongguo yaowu huaxue zazhi

2010

Synthesis of Per-acetyl Ganglioside GM_3 Trisaccharide 4-Methoxyphenoside

Li Xiangpeng, Peng Wang, Yingxia Li

Hecheng huaxue

2009

Efficient Synthesis of Flaccidoside II, a Bioactive Component of Chinese Folk Medicine Di Wu

Qingchao Liu, Lei Zhang, Xiangpeng Li, Tiantian Guo, Peng Wang, Yingxia Li

Journal of Carbohydrate Chemistry

DOI

2003

甘油糖脂生物活性研究进展

李春霞，李英霞，管华诗

《中国海洋药物》

2001

N-吡啶乙酰基-β-D-葡萄糖胺的合成

李英霞，宋妮，褚世栋，管华诗

《中国海洋药物》

2001

基于Internet的海洋药物虚拟研究

褚世栋，李英霞，耿美玉，宋妮，管华诗

《中国海洋药物》

2001

几丁糖酯抗动脉粥样硬化作用研究

丁华，祝清芬，徐鲁源，吴葆杰，李英霞，吕志华

《中国海洋药物》

2001

海洋硫酸多糖911抗氧化性及其作用机理的初步探讨——911的抗氧化与抗艾滋病的关系

李静，耿美玉，梁平方，李英霞，管华诗

《中国海洋药物》

2001

一种新型水溶性甲壳胺衍生物的制备及结构确证

李英霞，宋妮，褚世栋，张晓宁，管华诗

《中国海洋药物》

2001

N-烷基,O-羧甲基甲壳胺衍生物的制备及结构分析

宋妮，李英霞，褚世栋，李春霞，张晓宁，管华诗

《中国海洋药物》

2001

甲壳质衍生物916体外抗氧化作用的研究

胡金凤，耿美玉，于广利，李英霞，徐家敏

《中国海洋药物》

2000

海洋硫酸多糖911抗艾滋病毒作用及其机理研究——体内对猴免疫缺陷病毒(SIV)增殖的影响

辛现良，丁华，耿美玉，梁平方，李英霞，管华诗

《中国海洋药物》

2000

羧甲基壳聚糖碱式铝盐的制备

李英霞，褚世栋，宋妮，张晓宁，管华诗

《中国海洋药物》

精选作品

期刊论文

Targeting Transcriptional Coactivators p300/CBP: Small-Molecule Inhibitors or Bifunctional Proximity-Inducing Modalities?

Rapid Identification of a Potent, Selective, and Orally Active p300/CBP Bromodomain Inhibitor Bearing an Imidazo[1,2- a ]pyridine Scaffold via a Highly Efficient Four-Step Synthesis

Discovery of CZL-149: A Novel, Highly Potent, and Orally Bioavailable Dual Inhibitor Targeting BET and p300/CBP Bromodomains with Strong Antitumor Efficacy

Discovery of Novel Small-Molecule Toll-like Receptor 2 Agonists via a Scaffold Hopping Strategy

Discovery of Potent and Selective FABP4/5 Inhibitors with an Isoquinolone Scaffold as Potential Therapeutics for Inflammation-Related Diseases

Discovery of Novel Class of METTL3 Inhibitors with a Pyridin-2(1 H )-one Moiety

Pretargeted Mitochondrial Delivery of Organoarsenicals for Cancer Immunotherapy

Discovery of Novel MTA-Cooperative PRMT5 Inhibitors with a 2,3-Dihydro-1H-imidazo[1,2-b]pyrazole Scaffold

"One pot" synthesis of quinazolinone-[2,3]-fused polycyclic scaffolds in a three-step reaction sequence.

Discovery of CZL-046 with an (S)-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple Myeloma

Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma

Formyl phloroglucinol meroterpenoids from the leaves of Eucalyptus globulus subsp. maidenii and their ATP-citrate lyase inhibitory activities

Development of ketalized unsaturated saccharides as multifunctional cysteine-targeting covalent warheads

作为FABP4/5抑制剂喹啉类化合物的设计合成与生物活性研究（英文）

Biomimetic Total Synthesis of Clavicipitic Acid: A DDQ-Mediated Intramolecular Cross-Dehydrogenative Coupling Approach.

Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation

Discovery of Small-Molecule Autophagy Inhibitors by Disrupting the Protein–Protein Interactions Involving Autophagy-Related 5

Synthesis, evaluation and molecular dynamics study of human toll-like receptor 2/6 specific monoacyl lipopeptides as candidate immunostimulants

Design, Synthesis and Biological Evaluation of FABP4/5 Inhibitors Based on Quinoline Scaffold

Identification and immunological evaluation of novel TLR2 agonists through structural optimization of Diprovocim

Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti-proliferative activity in multiple cancer cells

Discovery of 4′-O-methylscutellarein as a potent SARS-CoV-2 main protease inhibitor

Recent Studies on the Pharmacological Activities and Structural Modifications of Compound-K

Design, synthesis and biological evaluation of (R)-5-methylpyrrolidin-2-ones as p300 bromodomain inhibitors with Anti-Tumor activities in multiple tumor lines

Synthesis of the analogs of plocabulin and their preliminary structure-activity relationship study.

Copper-catalyzed cross-coupling of amino acid-derived amides with (Z)-vinyl iodides: Unexpected solvent effect and preparation of plocabulin

Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus

Synthesis and biological evaluation of novel cabazitaxel analogues

Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors

Combined treatment with FABP4 inhibitor ameliorates rosiglitazone‐induced liver steatosis in obese diabetic db/db mice

靶向Toll样受体2激动剂的研究进展

海洋来源的微管蛋白聚集抑制剂tubulysins的研究进展

Recent Advances in the Development of CBP/p300 Bromodomain Inhibitors

Total synthesis of leontopodioside A

Semi-synthesis of a series natural flavonoids and flavonoid glycosides from scutellarin

Palladium‐Catalysed C(sp3)−H Glycosylation for the Synthesis of C‐Alkyl Glycoamino Acids

Investigation of the remote acyl group participation in glycosylation from conformational perspectives by using trichloroacetimidate as the acetyl surrogate

Corrigendum to “Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors” [Eur. J. Med. Chem. 180 (2019) 171e190]

Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives

Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor

Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors

Identification and immunological evaluation of novel TLR2 agonists through structure optimization of Pam3CSK4

Corrigendum to “From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4” [Ejmech 154 (2018) 44–59]

Research on the Semi-synthesis of Pectolinarin from Scutellarin

Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes

A novel assay for measuring recombinant human lysophosphatidylcholine acyltransferase 3 activity

Synthesis and biological evaluation of novel 1-substituted 3-(3-phenoxyprop-1-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors

Synthesis and biological evaluation of Ginsenoside Compound K analogues as a novel class of anti-asthmatic agents

Synthesis and biological evaluation of novel larotaxel analogues

From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4

Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation

Design, synthesis and biological evaluation of novel 3-substituted pyrazolopyrimidine derivatives as potent Bruton’s tyrosine kinase (BTK) inhibitors

Glycosylation of a Ketone with an O-Glycosyl Trichloroacetimidate Provides an Enol Glycoside

Concise total synthesis of acylated phenolic glycosides vitexnegheteroin A and ovatoside D

Optimization of 1H-indazol-3-amine derivatives as potent fibroblast growth factor receptor inhibitors

Identification and preliminary structure–activity relationships of 1-Indanone derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors

Rapid access to 6″-functionalized α-galactosyl ceramides by using 2-naphthylmethyl ether as the permanent protecting group

In Vivo Fate of Biomimetic Mixed Micelles as Nanocarriers for Bioavailability Enhancement of Lipid–Drug Conjugates

Corrigendum to “Synthesis and biological evaluation of oxoapratoxin E and its C30 epimer” [Tetrahedron Lett 58 (33) (2017) 3333–3336]

In vivo fate of lipid-silybin conjugate nanoparticles: Implications on enhanced oral bioavailability

Synthesis and biological evaluation of oxoapratoxin E and its C30 epimer

Synthesis of oligo-fructopyranoside with difructopyranosyl N-phenyltrifluoroacetimidate donor

Evidence of robust participation by an equatorial 4-O group in glycosylation on a 2-azido-2-deoxy-glucopyranosyl donor

信号转导及转录激活因子3(STAT3)信号通路小分子抑制剂的设计、合成及其生物活性研究

Design, synthesis and biological evaluation of c-Met kinase inhibitors bearing 2-oxo-1,2-dihydroquinoline scaffold

Novel Azetidine-Containing TZT-1027 Analogues as Antitumor Agents

Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors

Design, synthesis and biological evaluation of benzyloxyphenyl-methylaminophenol derivatives as STAT3 signaling pathway inhibitors

Total Synthesis and Biological Evaluation of Apratoxin E and Its C30 Epimer: Configurational Reassignment of the Natural Product

Synthesis, conformational analysis and biological evaluation of the lactam analogue of the cyclodepsipeptide apratoxin A

Design, Synthesis and Biological Evaluation of Small-Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway

Facile Synthesis of (S)-4-Amino-5-mercaptopentanoic Acid

Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, synthesis and activity evaluation

Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors

Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold

Synthesis and biological evaluation of novel dioxa-bicycle C-aryl glucosides as SGLT2 inhibitors

Total Synthesis of Two Diastereomers of Megastigmane Glycoside Lauroside B

Novel fatty acid binding protein 4 (FABP4) inhibitors: Virtual screening, synthesis and crystal structure determination