周凌云｜皖南医学院｜学者主页

2026

双价人乳头瘤病毒疫苗中3-(N-吗啉基)丙磺酸残留量高效液相色谱检测方法的建立及验证

顾永吉，周凌云，王永宝

《中国生物制品学杂志》

DOI

2026

基于雨课堂的分析化学实验课程线上线下混合教学模式探索与实践

陈云艳，胡琦艳，周凌云，孙玉，王绍臻

《济宁医学院学报》

2026

A Rare Nonsense Mutation in the ABCB4 Gene Associated with Progressive Familial Intrahepatic Cholestasis Type 3: A Case Report

Bin Cai, Duoduo Lv, Xue-Feng Luo, Lingyun Zhou

Journal of Clinical Medicine

DOI

2026

Impact of Air Pollution on Metabolic Dysfunction-Associated Fatty Liver Disease

Duoduo Lv, He-Yue Tang, Lingyun Zhou

International Journal of Molecular Sciences

DOI

2026

Epigenetic Alterations in Hepatocellular Carcinoma: Mechanisms and Biomarkers for Precision Therapy

B. Cai, Duoduo Lv, Qiang Qiu, Wen-Ju Xiong, He-Yue Tang, Yi-Xiao Bai, Si-Cheng Zhou, Yi-Guo Hu, Rifaat Safadi, Cheng-Di Wang, Lingyun Zhou

Cancers

DOI

2025

“药物合成反应”课程教学模式探究

侯少华，汤琳，孙玉，周凌云，邵太丽

《现代盐化工》

DOI

2025

Recent progress in developing ATR inhibitors as anticancer agents

Shaohua Hou, Yu Sun, Lingyun Zhou, Lin Tang, Ruobing Tang, Fangfang Li, Xiaoyu He, Yanwen Cao, Guodong Wang, Sihui Nian, Peng Wei Zhu

Biochemical Pharmacology

DOI

2025

Protocol for quantifying hepatitis B virus transcript abundance and genomic segment distribution from single-cell RNA-seq

Li-Na Liu, Liyu Chen, Lingyun Zhou

STAR Protocols

DOI

2025

Halting hepatocellular carcinoma: Identifying intercellular crosstalk in HBV-driven disease.

Lingyun Zhou, Chang-hai Liu, Duoduo Lv, Klarke M. Sample, Á. Rojas, Yu-Gu Zhang, Huan-Di Qiu, Lin-Gao He, Li Zheng, Liyu Chen, B. Cai, Yi-Guo Hu, M. Romero-Gómez

Cell Reports

DOI

2024

Safety assessment of Brexpiprazole: Real-world adverse event analysis from the FAERS database

Ying Jiang, Lingyun Zhou, Yuan Shen, Qin Zhou, Yingying Ji, Haohao Zhu

Journal Of Affective Disorders，Vol. 3460

DOI

2024

药物不良事件因果关系评估方法及实施步骤讨论

房虹，贾硕鹏，王海学，裴小静，刘敏，于安琪，周凌云，石方芳，卢淑杰，王书航，俞悦，崔丹丹，唐玉，李宁，温泽淮

《中国临床药理学杂志》

2024

An anti-inflammatory active ingredients in Poriae cutis: Screening based on network pharmacology.

Runze Jin, Zitong Zhao, Qing Zhang, Yizhou Sun, Wei Wang, Daiyin Peng, Sihui Nian, Lingyun Zhou

PubMed

DOI

2023

口服钙通道阻滞剂类药品临床综合评价专家共识(湖南)

周凌云，邓晟，徐萍，李昕，颜滢，欧阳林旗，刘湘，何鸽飞，陈艳平，史志华，王安发，黄宇，王立新，何益锋，张继红，郭艳，左笑丛

《中国医院药学杂志》

2023

Liver cancer stem cell dissemination and metastasis: uncovering the role of NRCAM in hepatocellular carcinoma

Lingyun Zhou, Lin-Gao He, Chang-Hai Liu, Huan-Di Qiu, Li Zheng, Klarke M. Sample, Qin-Fang Wu, Jiaxin Li, Kunlin Xie, J. Ampuero, Zhihui Li, Duoduo Lv, Miao Liu, M. Romero-Gómez, Yi-Guo Hu, Hong Tang

Journal of experimental & clinical cancer research : CR

DOI

2023

Circular RNAs in non-alcoholic fatty liver disease: Functions and clinical significance

Qing-Min Zeng, Chang-Hai Liu, J. Ampuero, Dongbo Wu, Wei Jiang, Lingyun Zhou, Hong Li, Lang Bai, M. Romero-Gómez, Hong Tang

RNA Biology

DOI

2023

CircRNA-PI4KB Induces Hepatic Lipid Deposition in Non-Alcoholic Fatty Liver Disease by Transporting miRNA-122 to Extra-Hepatocytes

Chang-Hai Liu, Wei Jiang, Qingmin Zeng, Dongbo Wu, Hong Li, Lingyun Zhou, L. Bai, Hong Tang

International Journal of Molecular Sciences

DOI

2022

后疫情时代“药物化学”课程思政实施路径探索

孙玉，汤琳，周凌云，邵太丽

《广东化工》

2022

案例教学结合客观结构化临床考试在临床药学专业本科课程教学中的应用

周凌云，汤志耀，陈林华，左笑丛

《中国临床药学杂志》

2022

4种低分子肝素预防骨科大手术静脉血栓栓塞症的网状Meta分析及药物经济学评价

朴慧玲，谷旭瑞，周凌云，周光亮，蒋安琪，谢悦良，左笑丛

《中国临床药学杂志》

2022

医学院校药物化学课程标准建设

邵太丽，陈靠山，孙玉，周凌云，汤琳，昌盛

《吉林医药学院学报》

2022

不同处置方式对菊芋多糖分子量及活性的影响

何曙光，袁平川，周凌云，汤琳，汪瑞，陈靠山

《皖南医学院学报》

2021

Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment

Duoduo Lv, Lingyun Zhou, Hong Tang

Experimental and Molecular Medicine

DOI

2021

Simple non‐invasive scoring systems and histological scores in predicting mortality in patients with non‐alcoholic fatty liver disease: A systematic review and meta‐analysis

Chang-Hai Liu, J. Ampuero, M. Pavlides, V. Wong, Jian-Gao Fan, L. Bai, Hong Li, Dongbo Wu, Lingyun Zhou, Ling-Yao Du, Tian-Kuo Yang, Wei Jiang, Ying Shi, Antonio Gil-Gómez, Wen-Ting Zhang, Jiakun Liang, M. Romero-Gómez, Hong Tang

Journal of Gastroenterology and Hepatology

DOI

2021

Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B Patients

Da-Feng Liu, Lingyun Zhou, Xin-Yi Zhang, Yi-Lan Zeng, L. Bai, Dongbo Wu, Hong Tang

International Journal of Endocrinology

DOI

2021

Significantly decreased islet β cell function and increased fasting plasma glucose in patients with chronic hepatitis B: a cross-sectional study

Da-Feng Liu, Lingyun Zhou, Xin-Yi Zhang, Yi-Lan Zeng, L. Bai, Dongbo Wu, Hong Tang

DOI

2021

Emerging Regulatory Mechanisms Involved in Liver Cancer Stem Cell Properties in Hepatocellular Carcinoma

Duoduo Lv, Liyu Chen, Ling-Yao Du, Lingyun Zhou, Hong Tang

Frontiers in Cell and Developmental Biology

DOI

2020

专业课课程思政在《药物化学》教学中的探索与实践

孙玉，周凌云，汤琳，邵太丽

《贵阳学院学报(自然科学版)》

DOI

2020

Present and Future Therapies for Chronic Hepatitis B.

Ya-Chao Tao, Dongbo Wu, Lingyun Zhou, En-Qiang Chen, Chang-Hai Liu, Xiaoqiong Tang, Wei Jiang, N. Han, Hong Li, Hong Tang

Advances in Experimental Medicine and Biology

DOI

2020

Association between Hepatitis B Virus Infection and Metabolic Syndrome in Southwest China: A Cross-sectional Study

Li-Bo Yan, J. Liao, N. Han, Lingyun Zhou, Xue-Er Wang, You-Juan Wang, Hong Tang

Scientific Reports

DOI

2019

网络平台应用于“药物化学”课程的探索

周凌云，孙玉，邵太丽，汤琳，陈靠山

《普洱学院学报》

2019

波生坦片致肝损伤1例

潘忙忙，刘晓琰，左笑丛，周凌云，顾智淳

《中国药物警戒》

DOI

2019

Decompensated islet beta cell function in patients with chronic hepatitis B: a retrospective case-control study

Da-Feng Liu, Lingyun Zhou, Xin-Yi Zhang, Yi-Lan Zeng, L. Bai, Dongbo Wu, Hong Tang

DOI

2019

Exosomal Interferon‐Induced Transmembrane Protein 2 Transmitted to Dendritic Cells Inhibits Interferon Alpha Pathway Activation and Blocks Anti–Hepatitis B Virus Efficacy of Exogenous Interferon Alpha

Ying Shi, Ling-Yao Du, Duoduo Lv, Hong Li, J. Shang, Jia-Jie Lu, Lingyun Zhou, L. Bai, Hong Tang

Hepatology

DOI

2019

HBcAg distribution predicts virologic response to PEG-IFNα therapy in HBeAg-positive CHB with minimally elevated ALT

Lingyun Zhou, Xin-Yi Zhang, Jian-rong Cai, Li-Bo Yan, Duoduo Lv, Xiaoqiong Tang, Da-Feng Liu, Hong Tang

Future Virology

DOI

2019

Exosome-mediated communication in the tumor microenvironment contributes to hepatocellular carcinoma development and progression

Qin Wu, Lingyun Zhou, Duoduo Lv, Xia Zhu, Hong Tang

Journal of Hematology & Oncology

DOI

2017

Establishment of an alcoholic fatty liver disease model in mice

Peizhu Tan, Huan Liang, Junhui Nie, Yan Diao, Qi He, Baoyu Hou, Tingting Zhao, Hui Huang, Yanze Li, Xu Gao, Lingyun Zhou, Ying Liu

American Journal Of Drug And Alcohol Abuse，Vol. 430, No. 1

DOI

2017

Serum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B

En-Qiang Chen, Shu Feng, Menglan Wang, ling-Bo liang, Lingyun Zhou, Ling-Yao Du, Li-Bo Yan, Chuan-min Tao, Hong Tang

Scientific Reports

DOI

2017

Diagnostic value of PIVKA-II in detecting hepatocellular carcinoma

Xiaoqiong Tang, Hong Li, Li-Bo Yan, Lingyun Zhou, En-Qiang Chen, Miao Liu, Dong-Mei Zhang, Hong Tang

DOI

2017

Plasma Apolipoprotein A-V Predicts Long-term Survival in Chronic Hepatitis B Patients with Acute-on-Chronic Liver Failure

En-Qiang Chen, Menglan Wang, Dong-Mei Zhang, Ying Shi, Dongbo Wu, Li-Bo Yan, Ling-Yao Du, Lingyun Zhou, Hong Tang

Scientific Reports

DOI

2016

氨氯地平对重组人细胞色素P450 3A5酶代谢他克莫司影响的体外研究

汪江林，陈清洁，关晓凤，黄利华，周凌云，左笑丛

《中国临床药理学杂志》

2016

《药物化学》实验教学模式改革初探

周凌云，邵太丽，孙玉，汤琳，陈靠山

《广州化工》

2016

《药物化学》精品课程建设实践与体会

周凌云，邵太丽，孙玉，汤琳，陈靠山

《广州化工》

2016

Biological characteristics comparison of HBV rtA181T mutants with truncated or substituted HBsAg expression in vitro and in vivo model systems

Lingyun Zhou, En-Qiang Chen, Menglan Wang, Lan-Lan Chen, Cui-ping Liu, Fan Zeng, Hong Tang

Scientific Reports

DOI

2015

药物专题讨论教学法在《药物化学》教学中的实践与探索

孙玉，汤琳，周凌云，邵太丽

《广州化工》

2015

Early warning and clinical outcome prediction of acute-on-chronic hepatitis B liver failure.

En-Qiang Chen, Fan Zeng, Lingyun Zhou, Hong Tang

World Journal of Gastroenterology

DOI

2014

钙调神经磷酸酶/NFATc信号通路介导他克莫司诱导移植后糖尿病的研究进展

汪江林，左笑丛，杨梦，周凌云

《中国临床药理学与治疗学》

2012

医学院校药学类专业《药物化学》精品课程的建设与实施

邵太丽，周凌云，孙玉，汤林，吴少云，陈靠山

《北方药学》

2012

药物化学教学中多种教学法的综合应用

孙玉，邵太丽，周凌云，汤琳，陈靠山

《今日药学》

2010

《药物化学》理论教学中增加自主专题讲座的探索

周凌云

《中国民族民间医药》

精选作品

期刊论文

双价人乳头瘤病毒疫苗中3-(N-吗啉基)丙磺酸残留量高效液相色谱检测方法的建立及验证

基于雨课堂的分析化学实验课程线上线下混合教学模式探索与实践

A Rare Nonsense Mutation in the ABCB4 Gene Associated with Progressive Familial Intrahepatic Cholestasis Type 3: A Case Report

Impact of Air Pollution on Metabolic Dysfunction-Associated Fatty Liver Disease

Epigenetic Alterations in Hepatocellular Carcinoma: Mechanisms and Biomarkers for Precision Therapy

“药物合成反应”课程教学模式探究

Recent progress in developing ATR inhibitors as anticancer agents

Protocol for quantifying hepatitis B virus transcript abundance and genomic segment distribution from single-cell RNA-seq

Halting hepatocellular carcinoma: Identifying intercellular crosstalk in HBV-driven disease.

Safety assessment of Brexpiprazole: Real-world adverse event analysis from the FAERS database

药物不良事件因果关系评估方法及实施步骤讨论

An anti-inflammatory active ingredients in Poriae cutis: Screening based on network pharmacology.

口服钙通道阻滞剂类药品临床综合评价专家共识(湖南)

Liver cancer stem cell dissemination and metastasis: uncovering the role of NRCAM in hepatocellular carcinoma

Circular RNAs in non-alcoholic fatty liver disease: Functions and clinical significance

CircRNA-PI4KB Induces Hepatic Lipid Deposition in Non-Alcoholic Fatty Liver Disease by Transporting miRNA-122 to Extra-Hepatocytes

后疫情时代“药物化学”课程思政实施路径探索

案例教学结合客观结构化临床考试在临床药学专业本科课程教学中的应用

4种低分子肝素预防骨科大手术静脉血栓栓塞症的网状Meta分析及药物经济学评价

医学院校药物化学课程标准建设

不同处置方式对菊芋多糖分子量及活性的影响

Hepatocyte nuclear factor 4α and cancer-related cell signaling pathways: a promising insight into cancer treatment

Simple non‐invasive scoring systems and histological scores in predicting mortality in patients with non‐alcoholic fatty liver disease: A systematic review and meta‐analysis

Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B Patients

Significantly decreased islet β cell function and increased fasting plasma glucose in patients with chronic hepatitis B: a cross-sectional study

Emerging Regulatory Mechanisms Involved in Liver Cancer Stem Cell Properties in Hepatocellular Carcinoma

专业课课程思政在《药物化学》教学中的探索与实践

Present and Future Therapies for Chronic Hepatitis B.

Association between Hepatitis B Virus Infection and Metabolic Syndrome in Southwest China: A Cross-sectional Study

网络平台应用于“药物化学”课程的探索

波生坦片致肝损伤1例

Decompensated islet beta cell function in patients with chronic hepatitis B: a retrospective case-control study

Exosomal Interferon‐Induced Transmembrane Protein 2 Transmitted to Dendritic Cells Inhibits Interferon Alpha Pathway Activation and Blocks Anti–Hepatitis B Virus Efficacy of Exogenous Interferon Alpha

HBcAg distribution predicts virologic response to PEG-IFNα therapy in HBeAg-positive CHB with minimally elevated ALT

Exosome-mediated communication in the tumor microenvironment contributes to hepatocellular carcinoma development and progression

Establishment of an alcoholic fatty liver disease model in mice

Serum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B

Diagnostic value of PIVKA-II in detecting hepatocellular carcinoma

Plasma Apolipoprotein A-V Predicts Long-term Survival in Chronic Hepatitis B Patients with Acute-on-Chronic Liver Failure

氨氯地平对重组人细胞色素P450 3A5酶代谢他克莫司影响的体外研究

《药物化学》实验教学模式改革初探

《药物化学》精品课程建设实践与体会

Biological characteristics comparison of HBV rtA181T mutants with truncated or substituted HBsAg expression in vitro and in vivo model systems

药物专题讨论教学法在《药物化学》教学中的实践与探索

Early warning and clinical outcome prediction of acute-on-chronic hepatitis B liver failure.

钙调神经磷酸酶/NFATc信号通路介导他克莫司诱导移植后糖尿病的研究进展

医学院校药学类专业《药物化学》精品课程的建设与实施

药物化学教学中多种教学法的综合应用

《药物化学》理论教学中增加自主专题讲座的探索

会议论文

中国人群中造影前造影剂肾病预测模型的建立

长期服用氯氮平及利培酮治疗对精神分裂症患者血浆瘦素、ghrelin、chemerin、FGF21水平及胰岛素抵抗的影响(英文)

非典型抗精神病药对精神分裂症患者糖脂代谢和体重的影响