涂小林｜重庆医科大学｜学者主页

2026

Wnt-activated osteocyte-driven 3D-bioprinted scaffolds orchestrate bone remodeling, angiogenesis, and innervation to accelerate critical bone defect repair

Ying Liu, J Huang, Shan Li, Xiaolin Tu

Regenerative Biomaterials

DOI

2026

LF3 exerts anti-osteosarcoma effects through Wnt signaling inhibition-coupled ferroptosis induction via HO-1/ACSL4 axis

Mengfan Yang, Pei Liu, Hongjun Zhang, Xun Tang, Xiang Hong, Yujiao Liu, Meichao Deng, Xiaolin Tu, Gaohai Shao

Frontiers in Oncology

DOI

2026

Engineering a Wnt-activated osteomimetic microenvironment with iPSC-derived MSCs for synergistic bone regeneration, angiogenesis, and neurogenesis.

Qiqi Bu, Hao Bai, Minjie Ruan, Lu Gao, Liuqing Wang, Mao Nie, Mingming Zhao, Xiaolin Tu, Chengzhu Zhao

Biomaterials

DOI

2026

Engineered Dll4-overexpressing osteocyte-derived exosomes enhanced bone regeneration by regulating osteogenesis and angiogenesis

Yujie Yan, Pengtao Wang, Xi Tang, Yuhang Wang, Meng-Ting Xiao, Zhen-Bao Liu, Xiaolin Tu, Xian Li

Theranostics

DOI

2025

Inhibition of ferroptosis rescues BMP osteogenic differentiation impaired by iron overload in the osteoporotic microenvironment

Xun Tang, Mengfan Yang, Yujiao Liu, Hongjun Zhang, Xiang Hong, Meichao Deng, Pei Liu, Qing Sun, Xiaolin Tu, Gaohai Shao

Cellular Signalling

DOI

2025

BMP9 attenuates microgravity-related disuse osteoporosis by modulating TGFβ and BMP signaling

Haoyang Zhao, Mengfan Yang, Yujiao Liu, Xiaolin Tu, Gaohai Shao

npj Microgravity

DOI

2025

3D bioprinted osteocytes expressing Wnt7b protect osteoblast differentiation from microgravity

Jinling Zhang, Pengtao Wang, Xiaoling Chen, Saima Khan, Haiping Ouyang, Yangxi Liu, Boeyeo He, Xian Li, Xing Liu, Xiaolin Tu

International Journal of Bioprinting

DOI

2025

Osteocytes Produces RANKL Via Wnt-TGFβ Signaling Axis for Osteoclastogenesis

Yu-Jiao Liu, Lizhou Zhao, Mo-Lin Li, Weimin Gong, Xiaofang Wang, Yu Cheng, Ying Zhang, Pengtao Wang, Yi-Sheng Luo, Yining Zhang, Yufei Shao, M. Taketo, Teresita M. Bellido, Gao-Hai Shao, Xing Liu, Xiaolin Tu

International Journal on Biological Sciences

DOI

2025

The potential key genes within focal adhesion that regulate mesenchymal stem cells osteogenesis or adipogenesis in microgravity related disuse osteoporosis: an integrated analysis

Haoyang Zhao, Xiaolin Tu

Frontiers in Endocrinology

DOI

2024

Establishing stable and highly osteogenic hiPSC-derived MSCs for 3D-printed bone graft through microenvironment modulation by CHIR99021-treated osteocytes

Qiuling Guo, Jingjing Chen, Qiqi Bu, Jinling Zhang, M.Q. Ruan, Xiaoyu Chen, Mingming Zhao, Xiaolin Tu, Chengzhu Zhao

Materials Today Bio

DOI

2024

The Osteocyte with SB216763-Activated Canonical Wnt Signaling Constructs a Multifunctional 4D Intelligent Osteogenic Module

Jinling Zhang, Ying Zhang, Jiafeng Chen, Weimin Gong, Xiaolin Tu

Biomolecules

DOI

2024

Osteocytic PGE2 receptors EP2/4 signaling create a physiological osteogenic microenvironment in polycaprolactone 3D module

Jingjing Chen, Qiuling Guo, Jinling Zhang, Ying Zhang, Yangxi Liu, Pengtao Wang, Chengzhu Zhao, L.F. Bonewald, Xiaolin Tu

International Journal of Bioprinting

DOI

2023

MLO-Y4来源外泌体对破骨细胞调控机制的研究

赵丽洲，勾蓉，王晨，涂小林

《中国骨质疏松杂志》

2023

PPP3R1 Promotes MSCs Senescence by Inducing Plasma Membrane Depolarization and Increasing Ca2+ Influx

Molin Li, Weimin Gong, Jie Chen, Yining Zhang, Yufei Ma, Xiaolin Tu

International Journal of Molecular Sciences

DOI

2023

Sustained release of a highly specific GSK3β inhibitor SB216763 in the PCL scaffold creates an osteogenic niche for osteogenesis, anti-adipogenesis, and potential angiogenesis

Weimin Gong, Molin Li, Lizhou Zhao, Pengtao Wang, Xiaofang Wang, Bo Wang, Xing Liu, Xiaolin Tu

Frontiers in Bioengineering and Biotechnology

DOI

2023

CHIR99021-Treated Osteocytes with Wnt Activation in 3D-Printed Module Form an Osteogenic Microenvironment for Enhanced Osteogenesis and Vasculogenesis

Yisheng Luo, Yangxi Liu, Bo Wang, Xiaolin Tu

International Journal of Molecular Sciences

DOI

2022

激活骨髓基质细胞Notch信号体外促进小鼠成骨作用

刘忻钰，罗岑，涂小林

《细胞与分子免疫学杂志》

2022

Activating Wnt/β-Catenin Signaling in Osteocytes Promotes Osteogenic Differentiation of BMSCs through BMP-7

Yining Zhang, Yixin Zhao, Zhengsong Xie, Molin Li, Yujiao Liu, Xiaolin Tu

International Journal of Molecular Sciences

DOI

2022

A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis

Xiaofang Wang, Yufei Ma, Jie Chen, Yujiao Liu, Guangliang Liu, Pengtao Wang, Bo Wang, Makoto Mark Taketo, Teresita Bellido, Xiaolin Tu

Bioactive Materials

DOI

2022

Functionalized 3D-Printed ST2/Gelatin Methacryloyl/Polcaprolactone Scaffolds for Enhancing Bone Regeneration with Vascularization

Guangliang Liu, Jie Chen, Xiaofang Wang, Yujiao Liu, Yufei Ma, Xiaolin Tu

International Journal of Molecular Sciences

DOI

2022

A Highly Selective GSK-3β Inhibitor CHIR99021 Promotes Osteogenesis by Activating Canonical and Autophagy-Mediated Wnt Signaling

Bo Wang, Saima Dawood Khan, Pengtao Wang, Xiaofang Wang, Yangxi Liu, Jingjing Chen, Xiaolin Tu

Frontiers in Endocrinology

DOI

2022

Canonical Wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation

Cen Luo, Wenjuan Xu, Xun Tang, Xinyu Liu, Yu Cheng, Yixun Wu, Zhengsong Xie, Xiaohong Wu, Xin He, Qian Wang, Yao Xiao, Xueting Qiu, Zhurong Tang, Gaohai Shao, Xiaolin Tu

Free Radical Biology and Medicine

DOI

2022

3D printing of osteocytic Dll4 integrated with PCL for cell fate determination towards osteoblasts in vitro

Pengtao Wang, Xiaofang Wang, Bo Wang, Xian Li, Zhengsong Xie, Jie Chen, Tasuku Honjo, Xiaolin Tu

Bio-Design and Manufacturing

DOI

2022

The Osteocyte Stimulated by Wnt Agonist SKL2001 Is a Safe Osteogenic Niche Improving Bioactivities in a Polycaprolactone and Cell Integrated 3D Module

Yangxi Liu, Xiaojie Ruan, Jun Li, Bo Wang, Jie Chen, Xiaofang Wang, Pengtao Wang, Xiaolin Tu

Cells

DOI

2022

Modified enzymatic collagen digestion-mediated isolation of osteocytes

Wenjuan Xu, Guangming Dai, Yifei Lyu, Yining Zhang, Xiaolin Tu

Biocell (Mendoza)

DOI

2022

The Notch pathway regulates the bone gain induced by PTH anabolic signaling

J. Delgado-Calle, K. McAndrews, Gerald J. Wu, Ashley L Orr, Adam J. Ferrari, Xiaolin Tu, Venkat Srinivasan, G. David Roodman, F. Ebetino, R. K. Boeckman, T. Bellido

The FASEB Journal

DOI

2022

Wnt3a-induced ST2 decellularized matrix ornamented PCL scaffold for bone tissue engineering

Xiaofang Wang, Xiaolin Tu, Yufei Ma, Jie Chen, Yangzhou Song, Guangliang Liu

Biocell (Mendoza)

DOI

2022

[Activation of Notch signaling in bone marrow stromal cells promotes osteogenesis in mice in vitro].

Xin-Yu Liu, C. Luo, Xiaolin Tu

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

2021

激活BMP信号的骨细胞对骨髓基质细胞成骨及成脂分化的作用研究

赵怡心，曾继涛，涂小林，刘宏

《中国骨质疏松杂志》

2021

铁过载对Wnt信号诱导的ST2细胞成骨分化的作用及机制

罗岑，武异洵，刘忻钰，涂小林

《中国细胞生物学学报》

2021

Notch信号介导骨细胞过表达BMP4促进骨髓基质细胞成骨分化

谢正松，赵怡心，吕子灵，刘宏，涂小林

《陆军军医大学学报》

DOI

2020

全反式维甲酸与VEGF联合应用诱导小鼠胚胎成纤维细胞定向成骨分化

冯玮，涂小林

《中国修复重建外科杂志》

2020

过表达Notch配体Delta-like基因的MLO-Y4骨细胞株的建立及其对骨髓基质细胞成骨分化的作用

冯玮，谢正松，罗岑，涂小林

《陆军军医大学学报》

DOI

2020

TGF-βⅡ型受体小分子抑制剂ITD-1对骨髓基质细胞成骨分化和血管形成的作用

曾继涛，涂小林，刘宏

《陆军军医大学学报》

DOI

2020

体外激活骨细胞Notch信号对骨髓基质细胞成骨分化的影响

谢映春，涂小林

《陆军军医大学学报》

DOI

2020

In vivo evaluation of porous nanohydroxyapatite/polyamide 66 struts in a goat cervical fusion model

Xi Liang, Feilong Li, Xuan Gong, Junchao Li, Shijie Yin, Qi Li, Ziming Liu, Zenghui Zhao, Xiaolin Tu, Wei Chun Huang, Ning Hu

Scientific Reports

DOI

2020

[All-trans retinoic acid and vascular endothelial growth factor induced the directional osteogenic differentiation of mouse embryonic fibroblasts].

Wei Feng, Xiaolin Tu

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

DOI

2019

骨再生修复中的骨形态发生蛋白信号通路:精准调节与治疗靶点

刘俊银，冯玮，谢映春，李豫皖，曾继涛，刘子铭，涂小林

《中国组织工程研究》

2019

Smad4促进成骨分化的机制研究

刘俊银，冯玮，涂小林

《中国骨质疏松杂志》

2019

FSHβ在BMP9诱导间充质干细胞成骨分化中的作用研究

成亚琳，曾继涛，黄敏，刘俊银，涂小林，刘宏

《中国骨质疏松杂志》

2019

Differentiation of Neural Crest Stem Cells in Response to Matrix Stiffness and TGF-β1 in Vascular Regeneration

Xian Li, Rong Xu, Xiaolin Tu, Randall Raphael R. Janairo, George Kwong, Dong Wang, Yiqian Zhu, Song Li

Stem Cells and Development

DOI

2019

Outcome after a new porous tantalum rod implantation for treatment of early-stage femoral head osteonecrosis

Wei Huang, Xuan Gong, Steve Sandiford, Xiaoqiang He, Feilong Li, Yuwan Li, Ziming Liu, Leilei Qin, Jianye Yang, Sizheng Zhu, Jiawei Wang, Xiaolin Tu, Lei Ye, Ning Hu

Annals of Translational Medicine

DOI

2018

骨细胞Wnt/β-Catenin通过Notch信号促进BMSCs成骨分化

任磊，代光明，林枭，张东力，田冕，贺尧，许文娟，涂小林，黄伟

《中国骨质疏松杂志》

2017

下调骨细胞TGF-β/Smad4信号可抑制小鼠BMSCs成骨及破骨分化

代光明，任磊，陈虹，刘文，陈宇，何小强，刘伟，涂小林，黄伟

《基础医学与临床》

2016

In vitro and in vivo biocompatibility and osteogenesis of graphene-reinforced nanohydroxyapatite polyamide66 ternary biocomposite as orthopedic implant material

Shiyang Zhang, Qiming Yang, Weikang Zhao, Bo Qiao, Hongwang Cui, Jianjun Fan, Hong Li, Xiaolin Tu, Dianming Jiang

International Journal of Nanomedicine

DOI

2016

Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor

J. Delgado-Calle, Xiaolin Tu, Rafael Pacheco-Costa, K. McAndrews, Rachel Edwards, G. Pellegrini, K. Kuhlenschmidt, Naomie Olivos, A. Robling, M. Peacock, L. I. Plotkin, T. Bellido

Journal of Bone and Mineral Research

DOI

2015

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

Xiaolin Tu, J. Delgado-Calle, K. Condon, M. Maycas, Huajia Zhang, N. Carlesso, M. Taketo, D. Burr, L. Plotkin, T. Bellido

Proceedings of the National Academy of Sciences of the United States of America

DOI

2015

Osteocyte-Mediated Parathyroid Hormone (PTH) Signaling Regulates Hematopoietic Stem Cells Under Physiologic and Continuous PTH Exposure

Benjamin J. Frisch, Alexandra N. Goodman, R. Staversky, Olga Bromberg, Xiaolin Tu, T. Bellido, L. Calvi

DOI

2015

BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse

Joohyun Lim, Xiaolin Tu, Kyunghee Choi, H. Akiyama, Y. Mishina, Fanxin Long

Developmental Biology

DOI

2014

WNT7B Promotes Bone Formation in part through mTORC1

Jianquan Chen, Xiaolin Tu, E. Esen, K. Joeng, Congxing Lin, J. Arbeit, M. Rüegg, M. Hall, Liang Ma, Fanxin Long

PLoS Genetics

DOI

2014

Prevention of Glucocorticoid Induced-Apoptosis of Osteoblasts and Osteocytes by Protecting against Endoplasmic Reticulum (ER) Stress in vitro and in vivo in Female Mice

A. Sato, Xiaolin Tu, K. McAndrews, L. Plotkin, T. Bellido

Bone

DOI

2014

Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes.

A. N. Ben-awadh, J. Delgado-Calle, Xiaolin Tu, K. Kuhlenschmidt, M. Allen, L. Plotkin, T. Bellido

Endocrinology

DOI

2014

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB dependent manner

Lin Wang, Huajia Zhang, Sonia Rodriguez, Li-Yun Cao, Jonathan M. Parish, Christen L. Mumaw, Amy L. Zollman, Gosia Kamocka, Jian Mu, D. Chen, E. Srour, B. Chitteti, H. Hogenesch, Xiaolin Tu, T. Bellido, S. Boswell, T. Manshouri, S. Verstovsek, M. Yoder, R. Kapur, A. Cardoso, N. Carlesso

Cell Stem Cell

DOI

2012

Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1

Xiaolin Tu, Jianquan Chen, Joohyun Lim, Courtney M. Karner, Seung-Yon Lee, J. Heisig, Cornelia Wiese, K. Surendran, Raphael Kopan, M. Gessler, Fanxin Long

PLoS Genetics

DOI

2011

Indian Hedgehog Requires Additional Effectors besides Runx2 to Induce Osteoblast Differentiation

Xiaolin Tu, K. Joeng, Fanxin Long

Developmental Biology

DOI

2011

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

Xiaolin Tu, Y. Rhee, K. Condon, Nicoletta Bivi, M. Allen, D. Dwyer, M. Stolina, C. Turner, A. Robling, L. Plotkin, T. Bellido

Bone

DOI

2009

Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model.

Yunglin D. Ma, Changwon Park, Hai-Bo Zhao, K. Oduro, Xiaolin Tu, Fanxin Long, P. Allen, S. Teitelbaum, Kyunghee Choi

Blood

DOI

2008

Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice.

S. Ramanadham, K. Yarasheski, Matthew J. Silva, M. Wohltmann, D. Novack, B. Christiansen, Xiaolin Tu, Sheng Zhang, Xiao-Yong Lei, J. Turk

American Journal of Pathology

DOI

2008

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

Matthew J. Hilton, Xiaolin Tu, Ximei Wu, Shuting Bai, Hai-Bo Zhao, Tatsuya Kobayashi, H. Kronenberg, S. Teitelbaum, F. Ross, Raphael Kopan, Fanxin Long

Nature Medicine

DOI

2008

Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.

Ximei Wu, Xiaolin Tu, K. Joeng, Matthew J. Hilton, David A. Williams, Fanxin Long

Cell

DOI

2007

Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage.

Matthew J. Hilton, Xiaolin Tu, Fanxin Long

Developmental Biology

DOI

2007

Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation.

Xiaolin Tu, K. Joeng, K. Nakayama, Keiko Nakayama, J. Rajagopal, Thomas J. Carroll, A. McMahon, Fanxin Long

Developmental Cell

DOI

2005

Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development

Matthew J. Hilton, Xiaolin Tu, Julie Cook, Hong-Liang Hu, Fanxin Long

Development

DOI

2004

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

Hong-Liang Hu, Matthew J. Hilton, Xiaolin Tu, Kai Yu, D. Ornitz, Fanxin Long

Development

DOI

impor-miR‑125a‑3p targetedly regulates GIT1 expression to inhibit osteoblastic proliferation and differentiation

Xiaolin Tu, Yang Gu, Guoshun Ren

精选作品

期刊论文

Wnt-activated osteocyte-driven 3D-bioprinted scaffolds orchestrate bone remodeling, angiogenesis, and innervation to accelerate critical bone defect repair

LF3 exerts anti-osteosarcoma effects through Wnt signaling inhibition-coupled ferroptosis induction via HO-1/ACSL4 axis

Engineering a Wnt-activated osteomimetic microenvironment with iPSC-derived MSCs for synergistic bone regeneration, angiogenesis, and neurogenesis.

Engineered Dll4-overexpressing osteocyte-derived exosomes enhanced bone regeneration by regulating osteogenesis and angiogenesis

Inhibition of ferroptosis rescues BMP osteogenic differentiation impaired by iron overload in the osteoporotic microenvironment

BMP9 attenuates microgravity-related disuse osteoporosis by modulating TGFβ and BMP signaling

3D bioprinted osteocytes expressing Wnt7b protect osteoblast differentiation from microgravity

Osteocytes Produces RANKL Via Wnt-TGFβ Signaling Axis for Osteoclastogenesis

The potential key genes within focal adhesion that regulate mesenchymal stem cells osteogenesis or adipogenesis in microgravity related disuse osteoporosis: an integrated analysis

Establishing stable and highly osteogenic hiPSC-derived MSCs for 3D-printed bone graft through microenvironment modulation by CHIR99021-treated osteocytes

The Osteocyte with SB216763-Activated Canonical Wnt Signaling Constructs a Multifunctional 4D Intelligent Osteogenic Module

Osteocytic PGE2 receptors EP2/4 signaling create a physiological osteogenic microenvironment in polycaprolactone 3D module

MLO-Y4来源外泌体对破骨细胞调控机制的研究

PPP3R1 Promotes MSCs Senescence by Inducing Plasma Membrane Depolarization and Increasing Ca2+ Influx

Sustained release of a highly specific GSK3β inhibitor SB216763 in the PCL scaffold creates an osteogenic niche for osteogenesis, anti-adipogenesis, and potential angiogenesis

CHIR99021-Treated Osteocytes with Wnt Activation in 3D-Printed Module Form an Osteogenic Microenvironment for Enhanced Osteogenesis and Vasculogenesis

激活骨髓基质细胞Notch信号体外促进小鼠成骨作用

Activating Wnt/β-Catenin Signaling in Osteocytes Promotes Osteogenic Differentiation of BMSCs through BMP-7

A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis

Functionalized 3D-Printed ST2/Gelatin Methacryloyl/Polcaprolactone Scaffolds for Enhancing Bone Regeneration with Vascularization

A Highly Selective GSK-3β Inhibitor CHIR99021 Promotes Osteogenesis by Activating Canonical and Autophagy-Mediated Wnt Signaling

Canonical Wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation

3D printing of osteocytic Dll4 integrated with PCL for cell fate determination towards osteoblasts in vitro

The Osteocyte Stimulated by Wnt Agonist SKL2001 Is a Safe Osteogenic Niche Improving Bioactivities in a Polycaprolactone and Cell Integrated 3D Module

Modified enzymatic collagen digestion-mediated isolation of osteocytes

The Notch pathway regulates the bone gain induced by PTH anabolic signaling

Wnt3a-induced ST2 decellularized matrix ornamented PCL scaffold for bone tissue engineering

[Activation of Notch signaling in bone marrow stromal cells promotes osteogenesis in mice in vitro].

激活BMP信号的骨细胞对骨髓基质细胞成骨及成脂分化的作用研究

铁过载对Wnt信号诱导的ST2细胞成骨分化的作用及机制

Notch信号介导骨细胞过表达BMP4促进骨髓基质细胞成骨分化

全反式维甲酸与VEGF联合应用诱导小鼠胚胎成纤维细胞定向成骨分化

过表达Notch配体Delta-like基因的MLO-Y4骨细胞株的建立及其对骨髓基质细胞成骨分化的作用

TGF-βⅡ型受体小分子抑制剂ITD-1对骨髓基质细胞成骨分化和血管形成的作用

体外激活骨细胞Notch信号对骨髓基质细胞成骨分化的影响

In vivo evaluation of porous nanohydroxyapatite/polyamide 66 struts in a goat cervical fusion model

[All-trans retinoic acid and vascular endothelial growth factor induced the directional osteogenic differentiation of mouse embryonic fibroblasts].

骨再生修复中的骨形态发生蛋白信号通路:精准调节与治疗靶点

Smad4促进成骨分化的机制研究

FSHβ在BMP9诱导间充质干细胞成骨分化中的作用研究

Differentiation of Neural Crest Stem Cells in Response to Matrix Stiffness and TGF-β1 in Vascular Regeneration

Outcome after a new porous tantalum rod implantation for treatment of early-stage femoral head osteonecrosis

骨细胞Wnt/β-Catenin通过Notch信号促进BMSCs成骨分化

下调骨细胞TGF-β/Smad4信号可抑制小鼠BMSCs成骨及破骨分化

In vitro and in vivo biocompatibility and osteogenesis of graphene-reinforced nanohydroxyapatite polyamide66 ternary biocomposite as orthopedic implant material

Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

Osteocyte-Mediated Parathyroid Hormone (PTH) Signaling Regulates Hematopoietic Stem Cells Under Physiologic and Continuous PTH Exposure

BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse

WNT7B Promotes Bone Formation in part through mTORC1

Prevention of Glucocorticoid Induced-Apoptosis of Osteoblasts and Osteocytes by Protecting against Endoplasmic Reticulum (ER) Stress in vitro and in vivo in Female Mice

Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes.

Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB dependent manner

Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1

Indian Hedgehog Requires Additional Effectors besides Runx2 to Induce Osteoblast Differentiation

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model.

Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice.

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.

Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage.

Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation.

Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

impor-miR‑125a‑3p targetedly regulates GIT1 expression to inhibit osteoblastic proliferation and differentiation

预印本

Aloe-emodin Antagonizes Cisplatin-induced Ferroptosis and Osteogenic Suppression in Bone Marrow Stromal Cells by Targeting the Hippo-YAP1 Pathway

研究方向