雷云龙｜重庆医科大学｜学者主页

2026

Ru3: a novel ruthenium-based compound overcomes cisplatin resistance in non-small cell lung cancer via the E2F2-IGFBP3-GPX4 pathway

Yiting Lu, Shiming Wu, Ying Jiang, Meishu Wang, Xinyu Liao, Jian Zhang, Junqi Xiang, Hua Yang, Min Yu, Min Jiang, Chen Fu, Yunlong Lei

APOPTOSIS

DOI

2025

Construction of a Prognostic Model for Cervical Cancer Related to lncRNA Based on Differential Co-expression Network and Functional Study of Key Gene EGFR-AS1

Kailong Du, Qian Chen, Hui Fan, Yunlong Lei, Jian Zhang

Journal of Cancer

DOI

2025

PARP inhibitor BMN673 triggers PARylation-mediated ATF4-GDF15 pathway to drive autophagy and ferroptosis in ataxia telangiectasia mutated gene-deficient colorectal cancer cells

Junqi Xiang, Jie Xu, Hui Fan, Qian Chen, Yiting Lu, Xinyan Wan, Ying Jiang, Xia Zhang, Chun‐Dong Zhang, Qingyuan Liu, Degang Ding, Yunlong Lei

Molecular Biomedicine

DOI

2025

ETV4 interacts with LOXL2 to induce epigenetic activation of NID1 during colorectal cancer progression

Tinghui Jiang, Xin Liu, Hao Liu, Kailong Du, Sen Wang, Hui Fan, Ying E. Zhang, Lin Cui, Hewei Zhang, Chun‐Dong Zhang, Yong Xia Zhu, Zhongyu Liu, Youquan Bu, Yunlong Lei

International Journal of Biological Sciences

DOI

2025

ROS confer resistance to 3TC in p53 mutant colorectal cancer by promoting autophagy and ER stress

Yiting Lu, Ying Jiang, Xinyu Liao, Junqi Xiang, Xiao Hui Xu, Yidan Han, Lin Cui, Jian Zhang, Yue Li, Xia Zhang, Yunlong Lei, Longhao Li

European Journal of Pharmacology

DOI

2024

Epigenetic remodeling under oxidative stress: Mechanisms driving tumor metastasis

Peilan Peng, Siyuan Qin, Lei Li, Zhijun He, Bowen Li, Edouard Collins Nice, Li Zhou, Yunlong Lei

MedComm – Oncology

DOI

2024

Erratum to “Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma” [J Hepatol 70 (1) 2019 66–77]

Yan Chen, Hai‐Ning Chen, Kui Wang, Lu Zhang, Zhao Huang, Jiayang Liu, Zhe Zhang, Maochao Luo, Yunlong Lei, Yong Peng, Zong‐Guang Zhou, Yuquan Wei, Canhua Huang

Journal of Hepatology

DOI

2024

CRLF1 bridges AKT and mTORC2 through SIN1 to inhibit pyroptosis and enhance chemo-resistance in ovarian cancer

Cong Xiang, Li Chen, Shilei Zhu, Yue Chen, Haodong Huang, Chunmao Yang, Yugang Chi, Yanzhou Wang, Yunlong Lei, Xiongwei Cai

Cell Death and Disease

DOI

2024

Reuterin promotes pyroptosis in hepatocellular cancer cells through mtDNA-mediated STING activation and caspase 8 expression

Lin Cui, Xiao Hui Xu, Hui Fan, Xinyan Wan, Qian Chen, Junhui Zhang, Chuntao Tao, Zheng Du, Sen Wang, Jian Zhang, Jun Zeng, Ying Zhang, Chundong Zhang, Longhao Li, Youquan Bu, Yunlong Lei

Cancer Letters

DOI

2023

rRNA-Derived Small RNA rsRNA-28S Regulates the Chemoresistance of Prostate Cancer Cells by Targeting PTGIS

Deqian Qiao, Yiling Liu, Yunlong Lei, Chun‐Dong Zhang, Youquan Bu, Yishu Tang, Ying Zhang

Frontiers in Bioscience-Landmark

DOI

2023

Ciclopirox Olamine Induces Proliferation Inhibition and Protective Autophagy in Hepatocellular Carcinoma

Xinyan Wan, Junqi Xiang, Hui Fan, Ying Jiang, Yiting Lu, Chun‐Dong Zhang, Ying Zhang, Quanmei Chen, Yunlong Lei

Pharmaceuticals

DOI

2022

Transfer RNA-derived small RNAs (tsRNAs): Versatile regulators in cancer

Dandan Xu, Deqian Qiao, Yunlong Lei, Chun‐Dong Zhang, Youquan Bu, Ying Zhang

Cancer Letters

DOI

2022

ROS generation attenuates the anti-cancer effect of CPX on cervical cancer cells by inducing autophagy and inhibiting glycophagy

Hui Fan, Yujia He, Junqi Xiang, Jing Zhou, Xinyan Wan, Jiawei You, Kailong Du, Yue Li, Lin Cui, Yitao Wang, Chun‐Dong Zhang, Youquan Bu, Yunlong Lei

Redox Biology

DOI

2021

B-Myb accelerates colorectal cancer progression through reciprocal feed-forward transactivation of E2F2

Xiaoyan Fan, Yitao Wang, Tinghui Jiang, Tao Liu, Yuelei Jin, Kailong Du, Yulong Niu, Chunxue Zhang, Zhongyu Liu, Yunlong Lei, Youquan Bu

Oncogene

DOI

2021

PRR11 induces filopodia formation and promotes cell motility via recruiting ARP2/3 complex in non-small cell lung cancer cells

Zhili Wei, Ru Wang, Xun Yin, Lian Zhang, Yunlong Lei, Ying Zhang, Yi Li, Jiaqian Wu, Youquan Bu, Guoxiang Jin, Chun‐Dong Zhang

Genes & Diseases

DOI

2020

DJ-1 promotes epithelial-to-mesenchymal transition via enhancing FGF9 expression in colorectal cancer

Longhao Li, Chun‐Dong Zhang, Yi Li, Ying Zhang, Yunlong Lei

Biology Open

DOI

2020

Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma

Lian Zhang, Ying Zhang, Yunlong Lei, Zhili Wei, Yi Li, Yingxiong Wang, Youquan Bu, Chun‐Dong Zhang

Journal of Biological Chemistry

DOI

2019

Identification and characterization of the promoter of cancer-related gene LOXL2

Xin Liu, Tong Liu, Lanyue Hu, Tinghui Jiang, Hao Liu, Sen Wang, Yunlong Lei, Jiang Zhu, Youquan Bu

Experimental Cell Research

DOI

2019

Tubeimoside-I sensitizes colorectal cancer cells to chemotherapy by inducing ROS-mediated impaired autophagolysosomes accumulation

Jianghong Yan, Xiaoyun Dou, Jing Zhou, Yuanfeng Xiong, Ling Mo, Longhao Li, Yunlong Lei

Journal of Experimental & Clinical Cancer Research

DOI

2019

MCT1 relieves osimertinib-induced CRC suppression by promoting autophagy through the LKB1/AMPK signaling

Ping Jin, Jingwen Jiang, Na Xie, Li Zhou, Zhao Huang, Lu Zhang, Siyuan Qin, Shuyue Fu, Liyuan Peng, Wei Gao, Bowen Li, Yunlong Lei, Edouard Collins Nice, Chang Long Li, Jichun Shao, Ke Xie

Cell Death and Disease

DOI

2019

Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma

Jingwen Jiang, Lu Zhang, Hai‐Ning Chen, Yunlong Lei, Tao Zhang, Yuelong Wang, Ping Jin, Jiang Lan, Li Zhou, Zhao Huang, Bowen Li, Yuan Liu, Wei Qiang Gao, Ke Xie, Liangxue Zhou, Edouard Collins Nice, Yong Peng, Yihai Cao, Yuquan Wei, Kui Wang, Canhua Huang

Autophagy

DOI

2019

Targeting Metabolic–Redox Circuits for Cancer Therapy

Kui Wang, Jingwen Jiang, Yunlong Lei, Shengtao Zhou, Yuquan Wei, Canhua Huang

Trends in Biochemical Sciences

DOI

2019

CPX Targeting DJ-1 Triggers ROS-induced Cell Death and Protective Autophagy in Colorectal Cancer

Jing Zhou, Lu Zhang, Meng Wang, Li Zhou, Xuping Feng, Linli Yu, Jiang Lan, Wei Qiang Gao, Chun‐Dong Zhang, Youquan Bu, Canhua Huang, Haiyuan Zhang, Yunlong Lei

Theranostics

DOI

2019

Repurposing Brigatinib for the Treatment of Colorectal Cancer Based on Inhibition of ER-phagy

Zhe Zhang, Wei Qiang Gao, Li Zhou, Yan Chen, Siyuan Qin, Lu Zhang, Jiayang Liu, Yujia He, Yunlong Lei, Hai‐Ning Chen, Junhong Han, Zong‐Guang Zhou, Edouard Collins Nice, Chang Long Li, Canhua Huang, Xiawei Wei

Theranostics

DOI

2018

人ETV4蛋白截短体的构建与其在结直肠中的功能分析

刘浩，刘心，王义涛，张春冬，卜友泉，雷云龙，易发平

《重庆医科大学学报》

2018

肺癌细胞中沉默PRR11诱发自噬并抑制细胞增殖

张辉洁，Lian Zhang，Yunlong Lei，Ying Zhang，Yi Li，Youquan Bu，Fangzhou Song，Chundong Zhang

《重庆医科大学学报》

2018

Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress

Zhe Zhang, Lu Zhang, Li Zhou, Yunlong Lei, Yuanyuan Zhang, Canhua Huang

Redox Biology

DOI

2018

Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma

Yan Chen, Hai‐Ning Chen, Kui Wang, Lu Zhang, Zhao Huang, Jiayang Liu, Zhe Zhang, Maochao Luo, Yunlong Lei, Yong Peng, Zong‐Guang Zhou, Yuquan Wei, Canhua Huang

Journal of Hepatology

DOI

2018

DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis

Jing Zhou, Hao Liu, Lian Zhang, Xin Liu, Chun‐Dong Zhang, Yitao Wang, Qing He, Ying Zhang, Yi Li, Quanmei Chen, Lu Zhang, Kui Wang, Youquan Bu, Yunlong Lei

Cell Death and Disease

DOI

2017

Silencing of PRR11 suppresses cell proliferation and induces autophagy in NSCLC cells

Lian Zhang, Yunlong Lei, Ying Zhang, Yi Li, Youquan Bu, Fangzhou Song, Chun‐Dong Zhang

Genes & Diseases

DOI

2017

Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation

Yitao Wang, Chunxue Zhang, Yuelei Jin, Wang, Qing He, Zhu Liu, Qing Ai, Yunlong Lei, Yi Li, Fangzhou Song, Youquan Bu

Scientific Reports

DOI

2017

Redox Imbalance in the Development of Colorectal Cancer

Hao Liu, Xin Liu, Chun‐Dong Zhang, Huifang Zhu, Qian Xu, Youquan Bu, Yunlong Lei

Journal of Cancer

DOI

2016

Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

Qianhui Dou, Hai‐Ning Chen, Kui Wang, Kefei Yuan, Yunlong Lei, Kai Li, Jiang Lan, Yan Chen, Zhao Huang, Na Xie, Lu Zhang, Rong Xiang, Edouard Collins Nice, Yuquan Wei, Canhua Huang

Cancer Research

DOI

2016

Cancer drug resistance: redox resetting renders a way

Yuan Liu, Qifu Li, Li Zhou, Na Xie, Edouard Collins Nice, Haiyuan Zhang, Canhua Huang, Yunlong Lei

Oncotarget

DOI

2016

HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3

K Yuan, Yunlong Lei, H-N Chen, Yangchao Chen, T Zhang, K Li, Na Xie, Kui Wang, X Feng, Qiang Pu, W Yang, Min Wu, Rong Xiang, Edouard Collins Nice, Yi Wei, Canhua Huang

Cell Death and Differentiation

DOI

2015

Redox signaling: Potential arbitrator of autophagy and apoptosis in therapeutic response

Lu Zhang, Kui Wang, Yunlong Lei, Qifu Li, Edouard Collins Nice, Canhua Huang

Free Radical Biology and Medicine

DOI

2015

DEPDC1 is a novel cell cycle related gene that regulates mitotic progression

Yan Mi, Chun‐Dong Zhang, Youquan Bu, Ying Zhang, Longxia He, Hongxia Li, Huifang Zhu, Yi Li, Yunlong Lei, Jiang Zhu

BMB Reports

DOI

2014

FGF8 promotes colorectal cancer growth and metastasis by activating YAP1

Rui R Liu, Shan Huang, Yunlong Lei, Tao Zhang, Kui Wang, Bo Liu, Edouard Collins Nice, Rong Xiang, Ke Xie, Jingyi Li, Canhua Huang

Oncotarget

DOI

2014

Redox Regulation of Inflammation: Old Elements, a New Story

Yunlong Lei, Kui Wang, Longfei Deng, Yi Chen, Edouard Collins Nice, Canhua Huang

Medicinal Research Reviews

DOI

2014

Redox Regulation of Cancer Metastasis: Molecular Signaling and Therapeutic Opportunities

Wenyong Yang, Linzhi Zou, Canhua Huang, Yunlong Lei

Drug Development Research

DOI

2014

Itraconazole suppresses the growth of glioblastoma through induction of autophagy

Rui Liu, Jingyi Li, Tao Zhang, Linzhi Zou, Yi Chen, Kui Wang, Yunlong Lei, Kefei Yuan, Yi Li, Jiang Lan, Lin Cheng, Na Xie, Rong Xiang, Edouard Collins Nice, Canhua Huang, Yuquan Wei

Autophagy

DOI

2014

ROS-Mediated Autophagy Induced by Dysregulation of Lipid Metabolism Plays a Protective Role in Colorectal Cancer Cells Treated with Gambogic Acid

Haiyuan Zhang, Yunlong Lei, Ping Yuan, Lingjun Li, Chao Luo, Rui Gao, Jun Tian, Zuo‐Hua Feng, Edouard Collins Nice, Jun Sun

PLoS ONE

DOI

精选作品

期刊论文

Ru3: a novel ruthenium-based compound overcomes cisplatin resistance in non-small cell lung cancer via the E2F2-IGFBP3-GPX4 pathway

Construction of a Prognostic Model for Cervical Cancer Related to lncRNA Based on Differential Co-expression Network and Functional Study of Key Gene EGFR-AS1

PARP inhibitor BMN673 triggers PARylation-mediated ATF4-GDF15 pathway to drive autophagy and ferroptosis in ataxia telangiectasia mutated gene-deficient colorectal cancer cells

ETV4 interacts with LOXL2 to induce epigenetic activation of NID1 during colorectal cancer progression

ROS confer resistance to 3TC in p53 mutant colorectal cancer by promoting autophagy and ER stress

Epigenetic remodeling under oxidative stress: Mechanisms driving tumor metastasis

Erratum to “Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma” [J Hepatol 70 (1) 2019 66–77]

CRLF1 bridges AKT and mTORC2 through SIN1 to inhibit pyroptosis and enhance chemo-resistance in ovarian cancer

Reuterin promotes pyroptosis in hepatocellular cancer cells through mtDNA-mediated STING activation and caspase 8 expression

rRNA-Derived Small RNA rsRNA-28S Regulates the Chemoresistance of Prostate Cancer Cells by Targeting PTGIS

Ciclopirox Olamine Induces Proliferation Inhibition and Protective Autophagy in Hepatocellular Carcinoma

Transfer RNA-derived small RNAs (tsRNAs): Versatile regulators in cancer

ROS generation attenuates the anti-cancer effect of CPX on cervical cancer cells by inducing autophagy and inhibiting glycophagy

B-Myb accelerates colorectal cancer progression through reciprocal feed-forward transactivation of E2F2

PRR11 induces filopodia formation and promotes cell motility via recruiting ARP2/3 complex in non-small cell lung cancer cells

DJ-1 promotes epithelial-to-mesenchymal transition via enhancing FGF9 expression in colorectal cancer

Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma

Identification and characterization of the promoter of cancer-related gene LOXL2

Tubeimoside-I sensitizes colorectal cancer cells to chemotherapy by inducing ROS-mediated impaired autophagolysosomes accumulation

MCT1 relieves osimertinib-induced CRC suppression by promoting autophagy through the LKB1/AMPK signaling

Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma

Targeting Metabolic–Redox Circuits for Cancer Therapy

CPX Targeting DJ-1 Triggers ROS-induced Cell Death and Protective Autophagy in Colorectal Cancer

Repurposing Brigatinib for the Treatment of Colorectal Cancer Based on Inhibition of ER-phagy

人ETV4蛋白截短体的构建与其在结直肠中的功能分析

肺癌细胞中沉默PRR11诱发自噬并抑制细胞增殖

Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress

Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma

DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis

Silencing of PRR11 suppresses cell proliferation and induces autophagy in NSCLC cells

Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation

Redox Imbalance in the Development of Colorectal Cancer

Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

Cancer drug resistance: redox resetting renders a way

HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3

Redox signaling: Potential arbitrator of autophagy and apoptosis in therapeutic response

DEPDC1 is a novel cell cycle related gene that regulates mitotic progression

FGF8 promotes colorectal cancer growth and metastasis by activating YAP1

Redox Regulation of Inflammation: Old Elements, a New Story

Redox Regulation of Cancer Metastasis: Molecular Signaling and Therapeutic Opportunities

Itraconazole suppresses the growth of glioblastoma through induction of autophagy

ROS-Mediated Autophagy Induced by Dysregulation of Lipid Metabolism Plays a Protective Role in Colorectal Cancer Cells Treated with Gambogic Acid

会议论文

抗真菌药物环吡酮胺抑制结直肠癌的分子机制研究

Tubeimoside Ⅰ induces accumulation of impaired autophagolysosome against cervical cancer cells by both initiating autophagy and inhibiting lysosomal function

Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells

研究方向