高健｜盐城工学院｜学者主页

2026

OBE导向的化工热力学与固体物理跨学科课程融合设计与实践

高健，刘志平

《黑龙江高教研究》，Vol. 44, No. 3

2026

Synthetic biology for heparin biomanufacturing

Ying-Jia Pan, Zhangliang Liu, Peng Wang, Jian Gao, Jun-Zhong Li, Binying Lv, Jun-Yue Li, Xiang-Jiu Zhang, Liang Yin, Chang Dong, Jiaying Wang, Lei Huang, Jia-Zhang Lian, Ji-Ne Li, Jin-Shan Li, Zhi-Nan Xu

Bioresources and Bioprocessing

DOI

2026

Advances and challenges in building microbial cell factories for phytohormone biomanufacturing toward sustainable agriculture

Liangliang Fan, Kaifeng Wang, Lu Lin, Jian Gao, Tian‐Qiong Shi, Mei-Li Sun, Xiao‐Jun Ji

Biotechnology Advances

DOI

2026

Engineered microorganisms unlock a new era of diterpenoid biomanufacturing: recent advances and future perspectives

Yuting Han, Yuanhe Luo, Kaifeng Wang, Lu Lin, Jian Gao, Mei-Li Sun, Xiao‐Jun Ji

Bioresources and Bioprocessing

DOI

2026

Dynamic regulation of ROS stress in the accumulation of L-lysine in Escherichia coli

Li Zhang, Jianan Yang, Zhixuan Lv, Longjun Han, Zhiwei Zha, Zhijie Cheng, Xu Yang, Zhengyang Xu, Lei Yang, Jian Gao

Journal of Biotechnology

DOI

2025

多黏类芽孢杆菌Paenibacillus polymyxa ZJ-9芽孢萌发条件与过程的研究

黎槟瑞，张忆萱，高健，徐虹，李莎

《生物加工过程》

2023

来源于嗜热氢化杆菌的新型对苯二甲酸双(羟乙)酯水解酶的表达纯化与酶学性质

陈阳阳，高健，赵夷培，王浩，韩旭，张洁，顾群，侯颖，刘卫东

《生物工程学报》

2023

来源于海洋宏基因组塑料降解酶Ple629的耐热性提升改造

赵夷培，王浩，武攀，李志帅，刘夫锋，顾群，刘卫东，高健，韩旭

《生物工程学报》

2022

耐受性工程调控微生物细胞工厂胁迫抗性

张丽，高健，刘长青，邓丽娜

《生物工程学报》

2022

工业应用导向的蛋白质结构与功能研究进展

韩旭，李倩，韦泓丽，郑迎迎，商娜，陈纯琪，郭瑞庭，高健，刘卫东

《生物工程学报》

2022

聚对苯二甲酸乙二醇酯(PET)塑料水解酶结构、功能及改造

李志帅，高健，陈纯琪，郭瑞庭，刘卫东，韩旭

《生物加工过程》

2022

新型还原酶的挖掘与设计及手性醇的制备

王能强，吴思琪，王新凤，黎小军，徐樱翠，高健

《高校化学工程学报》

2021

来源于Exophiala aquamarina的新型玉米赤霉烯酮水解酶的性质及底物结合中心关键氨基酸的功能研究

梁爱玲，刘文婷，武攀，李倩，高健，张洁，刘卫东，贾士儒，郑迎迎

《中国生物工程杂志》

DOI

2021

Inactivation of Inulinase and Marination of High-Quality Jerusalem Artichoke (Helianthus tuberosus L.) Pickles With Screened Dominant Strains

Li Zhang, Wei Liu, Jiahong Ji, Lina Deng, Qian Feng, Wujian Shi, Jian Gao

Frontiers in Bioengineering and Biotechnology

DOI

2020

CRISPRi-Based Dynamic Regulation of Hydrolase for the Synthesis of Poly-γ-Glutamic Acid with Variable Molecular Weights

Yuanyuan Sha, Yibin Qiu, Yifan Zhu, Tao Sun, Zhengshan Luo, Jian Gao, Xiaohai Feng, Sha Li, Hong Liang Xu

ACS Synthetic Biology

DOI

2020

High‐yield strain of fusidic acid obtained by atmospheric and room temperature plasma mutagenesis and the transcriptional changes involved in improving its production in fungus Fusidium coccineum

Weiwei Huang, Xiangliang Ge, Y. Huang, X.T. Chai, L. Zhang, Y.X. Zhang, Linlong Deng, Chunming Liu, H. Xu, Jian Gao

Journal of Applied Microbiology

DOI

2020

Effects of exopolysaccharide derived from Pantoea alhagi NX-11 on drought resistance of rice and its efficient fermentation preparation

Liang Sun, Yanbo Yang, Rui Wang, Sha Li, Yibin Qiu, Peng Lei, Jian Gao, Hong Liang Xu, Fenglun Zhang, Yunfei Lv

International Journal of Biological Macromolecules

DOI

2019

Effects of amino acids on the fermentation of inulin or glucose to produceR,R‐2,3‐butanediol usingPaenibacillus polymyxaZJ‐9

Jian Gao, Ruifan Jiang, Chen Cao, H. Ni, L. Zhang, Linlong Deng, Hong Xu, R.Y. Jiang

Letters in Applied Microbiology

DOI

2019

CRISPR/Cas9-Based Genome Editing in the Filamentous Fungus Fusarium fujikuroi and Its Application in Strain Engineering for Gibberellic Acid Production

Tian‐Qiong Shi, Jian Gao, Weijian Wang, Kaifeng Wang, Guoqin Xu, He Huang, Xiao‐Jun Ji

ACS Synthetic Biology

DOI

2018

木质纤维基L-乳酸生物制造的技术经济分析

张丽，李寒，薛锋，高健，倪浩

《生物加工过程》

2018

基于项目引导的“学习共同体”生物分离工程课程教学模式改革与实践

薛锋，李凤伟，张丽，梁慧星，高健

《轻工科技》

2018

One-Step Bioprocess of Inulin to Product Inulo-Oligosaccharides Using Bacillus subtilis Secreting an Extracellular Endo-Inulinase

Ruifan Jiang, Yibin Qiu, Weiwei Huang, Li Zhang, Feng Xue, Hao Ni, Difen Mei, Jian Gao, Hong Xu

Applied Biochemistry and Biotechnology

DOI

2018

Production of ( R )-styrene oxide by recombinant whole-cell biocatalyst in aqueous and biphasic system

Feng Xue, Jian Gao

Green Sciences

DOI

2018

Production of R,R-2,3-butanediol of ultra-high optical purity from Paenibacillus polymyxa ZJ-9 using homologous recombination

Li Zhang, Can Cao, Ruifan Jiang, Hong Liang Xu, Feng Xue, Weiwei Huang, Hao Ni, Jian Gao

Bioresource Technology

DOI

2018

Identification and Characterization of a Novel Halohydrin Dehalogenase from Bradyrhizobium erythrophlei and Its Performance in Preparation of Both Enantiomers of Epichlorohydrin

Feng Xue, Jian Gao, Li Zhang, Li Han, He Huang

Catalysis Letters

DOI

2016

Research on the Solid State Fermentation of Jerusalem Artichoke Pomace for Producing R,R-2,3-Butanediol by Paenibacillus polymyxa ZJ-9

Can Cao, Li Zhang, Jian Gao, Hong Xu, Feng Xue, Weiwei Huang, Yan Li

Applied Biochemistry and Biotechnology

DOI

2016

A new l -arabinose isomerase with copper ion tolerance is suitable for creating protein–inorganic hybrid nanoflowers with enhanced enzyme activity and stability

Zheng Xu, Rui Wang, Chao Liu, Bo Chi, Jian Gao, Beining Chen, Hong Liang Xu

RSC Advances

DOI

2015

Paenibacillus polymyxaZJ-9混合发酵菊粉和葡萄糖合成R,R-2,3-丁二醇

徐尤勇，高健，徐虹，曹灿，黄巍巍

《食品与发酵工业》

2015

Construction and co-expression of polycistronic plasmids encoding thermophilic l-arabinose isomerase and hyperthermophilic β-galactosidase for single-step production of d-tagatose

Zheng Xu, Zheng Xu, Zhaoxian Xu, Zhaoxian Xu, Bao Tang, Sha Li, Jian Gao, Bo Chi, Hong Liang Xu

Biochemical Engineering Journal

DOI

2015

Introduction of the exogenous NADH coenzyme regeneration system and its influence on intracellular metabolic flux of Paenibacillus polymyxa

Li Zhang, Youyong Xu, Jian Gao, Hong Liang Xu, Can Cao, Feng Xue, Ge Ding, Yingyun Peng

Bioresource Technology

DOI

2014

Gene Cloning, Expression, and Characterization of an Exo-inulinase from Paenibacillus polymyxa ZJ-9

Jian Gao, Youyong Xu, Hong-Mei Yang, Hong Xu, Feng Xue, Sha Li, Xiaohai Feng

Applied Biochemistry and Biotechnology

DOI

2013

Production of S -acetoin from diacetyl by Escherichia coli transformant cells that express the diacetyl reductase gene of Paenibacillus polymyxa ZJ-9

Jian Gao, Y.Y. Xu, F.W. Li, Ge Ding

Letters in Applied Microbiology

DOI

2012

一株产纤维素酶的甲醇利用细菌的鉴定及其纤维素降解条件优化

高健，肖丹青，刘喜平，王能强，张大为

《工业微生物》

2012

利用絮凝及双水相萃取分离纯化发酵液中的R,R-2,3-丁二醇

高健，薛锋，李凤伟，徐虹

《食品与发酵工业》

2012

A 2,3‐butanediol dehydrogenase from Paenibacillus polymyxa ZJ ‐9 for mainly producing R,R‐2,3‐butanediol: Purification, characterization and cloning

Jian Gao, Huanhuan Yang, Xiaohai Feng, Sha Li, Hong Liang Xu

Journal of Basic Microbiology

DOI

2011

利用菊芋菊粉制备R,R-2,3-丁二醇发酵工艺条件的优化

杨欢欢，高健，徐虹，邵荣

《食品与发酵工业》

DOI

2011

酶工程课程教学改革探索

薛锋，高健

《河北职业教育》

2010

Optimization of medium for one-step fermentation of inulin extract from Jerusalem artichoke tubers using Paenibacillus polymyxa ZJ-9 to produce R,R-2,3-butanediol

Jian Gao, Hong Xu, Qiu-jie Li, Xiaohai Feng, Sha Li

Bioresource Technology

DOI

2009

“发酵工程”课程教学实践与思考

申玉香，高健，李朝霞，李风伟

《考试周刊》

2007

工科生物化学教学改革研究与实践

高健

《教育与职业》，No. 3

下载原文

1998

枯草芽孢杆菌α-乙酰乳酸脱羧酶基因的克隆及表达

高健，铁翠娟，王忠彦，何秀萍，胡永松，张博润

《微生物学通报》

精选作品

期刊论文

OBE导向的化工热力学与固体物理跨学科课程融合设计与实践

Synthetic biology for heparin biomanufacturing

Advances and challenges in building microbial cell factories for phytohormone biomanufacturing toward sustainable agriculture

Engineered microorganisms unlock a new era of diterpenoid biomanufacturing: recent advances and future perspectives

Dynamic regulation of ROS stress in the accumulation of L-lysine in Escherichia coli

多黏类芽孢杆菌Paenibacillus polymyxa ZJ-9芽孢萌发条件与过程的研究

来源于嗜热氢化杆菌的新型对苯二甲酸双(羟乙)酯水解酶的表达纯化与酶学性质

来源于海洋宏基因组塑料降解酶Ple629的耐热性提升改造

耐受性工程调控微生物细胞工厂胁迫抗性

工业应用导向的蛋白质结构与功能研究进展

聚对苯二甲酸乙二醇酯(PET)塑料水解酶结构、功能及改造

新型还原酶的挖掘与设计及手性醇的制备

来源于Exophiala aquamarina的新型玉米赤霉烯酮水解酶的性质及底物结合中心关键氨基酸的功能研究

Inactivation of Inulinase and Marination of High-Quality Jerusalem Artichoke (Helianthus tuberosus L.) Pickles With Screened Dominant Strains

CRISPRi-Based Dynamic Regulation of Hydrolase for the Synthesis of Poly-γ-Glutamic Acid with Variable Molecular Weights

High‐yield strain of fusidic acid obtained by atmospheric and room temperature plasma mutagenesis and the transcriptional changes involved in improving its production in fungus Fusidium coccineum

Effects of exopolysaccharide derived from Pantoea alhagi NX-11 on drought resistance of rice and its efficient fermentation preparation

Effects of amino acids on the fermentation of inulin or glucose to produceR,R‐2,3‐butanediol usingPaenibacillus polymyxaZJ‐9

CRISPR/Cas9-Based Genome Editing in the Filamentous Fungus Fusarium fujikuroi and Its Application in Strain Engineering for Gibberellic Acid Production

木质纤维基L-乳酸生物制造的技术经济分析

基于项目引导的“学习共同体”生物分离工程课程教学模式改革与实践

One-Step Bioprocess of Inulin to Product Inulo-Oligosaccharides Using Bacillus subtilis Secreting an Extracellular Endo-Inulinase

Production of ( R )-styrene oxide by recombinant whole-cell biocatalyst in aqueous and biphasic system

Production of R,R-2,3-butanediol of ultra-high optical purity from Paenibacillus polymyxa ZJ-9 using homologous recombination

Identification and Characterization of a Novel Halohydrin Dehalogenase from Bradyrhizobium erythrophlei and Its Performance in Preparation of Both Enantiomers of Epichlorohydrin

Research on the Solid State Fermentation of Jerusalem Artichoke Pomace for Producing R,R-2,3-Butanediol by Paenibacillus polymyxa ZJ-9

A new l -arabinose isomerase with copper ion tolerance is suitable for creating protein–inorganic hybrid nanoflowers with enhanced enzyme activity and stability

Paenibacillus polymyxaZJ-9混合发酵菊粉和葡萄糖合成R,R-2,3-丁二醇

Construction and co-expression of polycistronic plasmids encoding thermophilic l-arabinose isomerase and hyperthermophilic β-galactosidase for single-step production of d-tagatose

Introduction of the exogenous NADH coenzyme regeneration system and its influence on intracellular metabolic flux of Paenibacillus polymyxa

Gene Cloning, Expression, and Characterization of an Exo-inulinase from Paenibacillus polymyxa ZJ-9

Production of S -acetoin from diacetyl by Escherichia coli transformant cells that express the diacetyl reductase gene of Paenibacillus polymyxa ZJ-9

一株产纤维素酶的甲醇利用细菌的鉴定及其纤维素降解条件优化

利用絮凝及双水相萃取分离纯化发酵液中的R,R-2,3-丁二醇

A 2,3‐butanediol dehydrogenase from Paenibacillus polymyxa ZJ ‐9 for mainly producing R,R‐2,3‐butanediol: Purification, characterization and cloning

利用菊芋菊粉制备R,R-2,3-丁二醇发酵工艺条件的优化

酶工程课程教学改革探索

Optimization of medium for one-step fermentation of inulin extract from Jerusalem artichoke tubers using Paenibacillus polymyxa ZJ-9 to produce R,R-2,3-butanediol

“发酵工程”课程教学实践与思考

工科生物化学教学改革研究与实践

枯草芽孢杆菌α-乙酰乳酸脱羧酶基因的克隆及表达

研究方向