百晓学者学者目录

周茹

博士生导师、教授、硕士生导师，宁夏医科大学

精选作品

期刊论文

2026

葛根素调控SIRT1-FOXO1信号通路介导的自噬对类固醇诱导的成骨细胞凋亡的影响

周凡，高扬，胡艳平，向超，万骐，周茹

《中国骨质疏松杂志》

2025

葛根素调控SIRT1-FOXO1通路抑制成骨细胞凋亡

周凡，高扬，胡艳平，向超，万骐，周茹

《中国骨质疏松杂志》

2025

Mechanism of action of aloperine in the treatment of pulmonary arterial hypertension based on network pharmacology and molecular docking methods

Yanrong Wang, Baolan Yan, Peng-Sheng Ma, Ru Zhou, Fang Zhao

Herz

DOI

2025

Preparation of 18β-Glycyrrhetinic Acid Liposome and Its Therapeutic Effect on Pulmonary Arterial Hypertension

Yanmin Pei, Meidong Si, Xuemei Ma, Siyun Liu, Fang Zhao, Ru Zhou

Drug Design Development and Therapy

DOI

2025

The Efficacy of Oxysophocarpine in Treating Cerebral Ischemia: Integration of Network Pharmacology and Experimental Validation

Zhi Wang, Haiqi Qiao, Yang Han Yu, Siyun Liu, Fang Zhao, Ru Zhou

Letters in Drug Design & Discovery

DOI

2025

Development and Evaluation of Aloperine-Loaded Nanostructured Lipid Carriers for the Treatment of Pulmonary Arterial Hypertension

Hui Liu, Siyun Liu, Peng-Sheng Ma, Long Ma, Yuxin Liu, Fang Zhao, Ru Zhou

International Journal of Nanomedicine

DOI

2024

吴茱萸碱通过调节核因子E2相关因子2/血红素加氧酶-1/核因子-κB信号通路对白细胞介素1β诱导的软骨细胞炎性损伤的影响

周凡，高扬，胡艳平，向超，熊和然，周茹

《河北中医》

2024

Exploring the therapeutic potential of 18β-Glycyrrhetinic acid in pulmonary arterial hypertension by integrating network pharmacology and experimental validation

Wenli Yang, Long Ma, Meidong Si, Fang Zhao, Ru Zhou

Journal of Functional Foods

DOI

2024

A metabolic profiling study of pulmonary arterial hypertension

Cong Li, Yang Yu, Long Ma, Meidong Si, Fang Zhao, Ru Zhou

Noordanesh.

DOI

2024

Isorhamnetin alleviates symptoms and inhibits oxidative stress levels in rats with pulmonary arterial hypertension.

Yefeng Chen, Ping Ma, Lei Bo, Yingjie Lv, Wei Zhou, Ru Zhou

PubMed

DOI

2024

Liquiritin Promotes Vasodilation Effects by Activating the K v and K ATP Channels in the Isolated Rat Thoracic Aorta

MengXue Ma, YouLan Che, Xin Yang, Zhi Wang, Ya Mei Bai, Yang Han Yu, Qingbin Xu, Ru Zhou

Pharmacognosy Magazine

DOI

2024

Exploring the Mechanism of Influence of Wolfberry (Lycium barbarum L.) on Pulmonary Arterial Hypertension Based on Network Pharmacology and Molecular Docking

Yang Wu, Jingjing Niu, Lei Bu, Cong Li, Yuxin Liu, Jinrui Jiang, Qingbin Xu, Ping Ma, Ru Zhou

Letters in Drug Design & Discovery

DOI

2024

The Vasodilator Effect and Mechanism of 18β-glycyrrhetinic Acid on Isolated Pulmonary Artery Rings in Rats

Huijuan Yang, Hailong Li, Yuxin Liu, Jinrui Jiang, Mei Hai, Cong Li, Zhiqiang Hu, Ru Zhou

Pharmacognosy Magazine

DOI

2023

连翘苷调节相关信号通路对地塞米松诱导的成骨细胞自噬和凋亡的影响

周凡，高扬，胡艳平，向超，熊和然，周茹

《中国骨质疏松杂志》

2023

Preparation of betaine injection and its therapeutic effect in pulmonary arterial hypertension

Youlan Che, Tian Dong Xia, Hui Liu, Cong Li, Siyun Liu, Ping Ma, Qingbin Xu, Ru Zhou

Basic & Clinical Pharmacology & Toxicology

DOI

2023

Application of Transcriptomics and Proteomics in Pulmonary Arterial Hypertension

Jinrui Jiang, Siyun Liu, Huijuan Yang, Yingjie Lv, Ping Ma, Qingbin Xu, Ru Zhou

Personalized Medicine

DOI

2022

18β-Glycyrrhetinic Acid Ameliorates Endoplasmic Reticulum Stress-Induced Inflammation in Pulmonary Arterial Hypertension Through PERK/eIF2α/NF-κB Signaling

Jialing Wang, Hui Liu, Zhi‐Cheng Jing, Fang Zhao, Ru Zhou

The Chinese Journal of Physiology

DOI

2021

Vasorelaxation Effect of Oxysophoridine on Isolated Thoracicc Aorta Rings of Rats

Nan Li, Yefeng Chen, Yanmin Pei, Liangjuan Han, Jun Tao Ren, Wei Ping Zhou, Ru Zhou

The Chinese Journal of Physiology

DOI

2021

Vasodilatory effects of betaine on isolated rat pulmonary artery rings

Lijun Tao, Lina Chen, Yanmin Pei, Ping Ma, Qingbin Xu, Jialing Wang, Yang Han Yu, Jiang Cheng, Ru Zhou

Die Pharmazie

DOI

2021

Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension

Yingjie Lv, Peng-Sheng Ma, Peng-Sheng Ma, Jialing Wang, Qingbin Xu, Jun Kai Fan, Lin Yan, Ping Ma, Ping Ma, Ru Zhou

European Journal of Pharmacology

DOI

2021

Pulmonary Arterial Hypertension and Flavonoids

Jialing Wang, Hailong Li, Tian Xia, Jun Feng, Ru Zhou

The Chinese Journal of Physiology

DOI

2020

Protective effects of isorhamnetin on pulmonary arterial hypertension: in vivo and in vitro studies

Zhi Chang, Jialing Wang, Zhi‐Cheng Jing, Ping Ma, Qingbing Xu, Jianrong Na, Jie Tian, Xuan Ma, Wei Ping Zhou, Ru Zhou

Phytotherapy Research

DOI

2019

Protective effects of 18β-glycyrrhetinic acid on pulmonary arterial hypertension via regulation of Rho A/Rho kinsase pathway

Min Zhang, Zhi Chang, Peng Zhang, Zhi‐Cheng Jing, Lin Yan, Jun Feng, Zhiqiang Hu, Qingbin Xu, Wei Ping Zhou, Ping Ma, Yinju Hao, Ru Zhou

Chemico-Biological Interactions

DOI

2019

Protective Effects of 18β-Glycyrrhetinic Acid on Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats

Min Zhang, Zhi Chang, Fang Zhao, Peng Zhang, Yinju Hao, Lin Yan, Ning Liu, Junli Wang, Lei Bo, Ping Ma, Wei Ping Zhou, Xuan Ma, Qingbin Xu, Ru Zhou

Frontiers in Pharmacology

DOI

2019

Aloperine Suppresses Human Pulmonary Vascular Smooth Muscle Cell Proliferation via Inhibiting Inflammatory Response

Zhi Chang, Peng Zhang, Min Zhang, Feng Jun, Zhiqiang Hu, Jiamei Yang, Yuhua Wu, Ru Zhou

The Chinese Journal of Physiology

DOI

2018

苦豆碱通过抑制炎症反应保护异丙肾上腺素诱导心脏肥厚作用的研究

郑婕，戴贵东，闫琳，王锐，郑萍，周茹

《宁夏医学杂志》

2018

Betaine Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibiting Inflammatory Response

Jiamei Yang, Ru Zhou, Min Zhang, Huanran Tan, Jianqiang Yu

Molecules

DOI

2017

回药核心方浸膏对大鼠胸主动脉血管环的舒张作用及机制研究

韩亮娟，任俊，李南，余建强，张万年，周茹

《宁夏医科大学学报》

2017

苦豆碱对野百合碱致大鼠肺动脉高压的保护作用

郝银菊，吴凡，周茹，李凤梅，李南，杨文莉，乔海琦，余建强

《中药药理与临床》

2017

人参皂苷Rg2对野百合碱诱导肺动脉高压模型大鼠的作用

周振兴，周茹

《标记免疫分析与临床》

2017

苦豆碱对异丙肾上腺素诱导的大鼠心肌肥厚作用的影响

郑婕，周茹，闫琳，王锐，郑萍，戴贵东

《宁夏医科大学学报》

2017

Protective effects of aloperin on monocroline-induced pulmonary hypertension via regulation of Rho A/Rho kinsase pathway in rats

Fan Wu, Wanxia Yao, Jiamei Yang, Min Zhang, Yanping Xu, Yinju Hao, Lin Yan, Yang Niu, Tao Sun, Jianqiang Yu, Ru Zhou

Biomedicine & Pharmacotherapy

DOI

2017

Neuroprotective Effects of Lycium barbarum Polysaccharide on Focal Cerebral Ischemic Injury in Mice

Peng Zhao, Ru Zhou, Xiaoyun Zhu, Gang Liu, Yuping Zhao, Peng-Sheng Ma, Wei Wu, Yang Niu, Tao Sun, Yuxiang Li, Jian‐Qiang Yu, Zhong‐Ming Qian

Neurochemical Research

DOI

2017

Neuroprotective Effect of Oxysophocarpine by Modulation of MAPK Pathway in Rat Hippocampal Neurons Subject to Oxygen–Glucose Deprivation and Reperfusion

Peng Zhao, Ren-Yuan Chang, Ning Liu, Jing Wang, Ru Zhou, Xue Qi, Yue Liu, Lin Ma, Yang Niu, Tao Sun, Yu‐Xiang Li, Yanping He, Jian‐Qiang Yu

Cellular and Molecular Neurobiology

DOI

2017

Protective effects of aloperine on monocrotaline-induced pulmonary hypertension in rats

Fan Wu, Yinju Hao, Jiamei Yang, Wanxia Yao, Yanping Xu, Lin Yan, Yang Niu, Tao Sun, Jian‐Qiang Yu, Ru Zhou

Biomedicine & Pharmacotherapy

DOI

2016

苦豆碱对氧糖剥夺再灌注损伤后海马神经元的保护作用

郝银菊，周茹，姚婉霞，李南，杨文莉，乔海琦，杜娟，余建强

《中药药理与临床》

2016

氧化苦参碱对缺氧缺血性脑损伤新生大鼠脑组织氧化应激指标的影响

李海宁，江玉敏，赵鹏，周茹，余建强

《宁夏医科大学学报》

2016

Protective effects of low‐dose rosuvastatin on isoproterenol‐induced chronic heart failure in rats by regulation of DDAH ‐ ADMA ‐ NO pathway

Ru Zhou, Ping Ma, Xiong Aiqin, Yehua Xu, Yang Wang, Qingbin Xu

Cardiovascular Therapeutics

DOI

2016

Oxymatrine attenuated isoproterenol-induced heart failure in rats via regulation of COX-2/PGI2 pathway

Ru Zhou, Qingbin Xu, Yehua Xu, Xiong Aiqin, Yang Wang, Ping Ma

Biomedicine & Pharmacotherapy

DOI

2016

Trans-cinnamaldehyde protected PC12 cells against oxygen and glucose deprivation/reperfusion (OGD/R)-induced injury via anti-apoptosis and anti-oxidative stress

Xue Qi, Ru Zhou, Yue Liu, Jing Wang, Wannian Zhang, Huanran Tan, Yang Niu, Tao Sun, Yu‐Xiang Li, Jian‐Qiang Yu

Molecular and Cellular Biochemistry

DOI

2016

Neuroprotective actions of taurine on hypoxic-ischemic brain damage in neonatal rats

Xiaoyun Zhu, Peng-Sheng Ma, Wei Wu, Ru Zhou, Yinju Hao, Yang Niu, Tao Sun, Yu‐Xiang Li, Jian‐Qiang Yu

Brain Research Bulletin

DOI

2016

Protective effects of aloin on oxygen and glucose deprivation-induced injury in PC12 cells

Ren-Yuan Chang, Ru Zhou, Xue Qi, Jing Wang, Fan Wu, Wenli Yang, Wannian Zhang, Tao Sun, Yu‐Xiang Li, Jian‐Qiang Yu

Brain Research Bulletin

DOI

2015

枸杞多糖对离体缺血性脑损伤后PARP-1和AIF的影响

周茹，郝银菊，姚婉霞，杨文莉，李南，乔海琦，杜娟，余建强

《中药药理与临床》

2015

苦参碱对神经病理性疼痛小鼠疼痛行为学的影响

周茹，郝银菊，姚婉霞，乔海琦，杨文莉，李南，杜娟，汪静，余建强

《中药药理与临床》

2015

丹参水提物对心肌缺血-再灌注损伤大鼠血流动力学的影响

周茹，何耀，和丽芬，王良芬，李永杰，晁若冰，杜俊蓉

《华西药学杂志》

2015

回药扎里奴思方对脑缺血再灌注损伤大鼠氧化应激的调节作用

赵启鹏，王小博，程秀丽，王少凡，张国鑫，张雅琳，孙红伟，余建强，周茹，郑婕，张万年

《宁夏医科大学学报》

2015

Anti-inflammation Effects of Oxysophoridine on Cerebral Ischemia–Reperfusion Injury in Mice

Yong-Sheng Wang, Yu‐Xiang Li, Peng Zhao, Hongbo Wang, Ru Zhou, Yinju Hao, Jie Wang, Shujing Wang, Juan Du, Lin Ma, Tao Sun, Jianqiang Yu

Inflammation

DOI

2015

Protective effects of aloperine on neonatal rat primary cultured hippocampal neurons injured by oxygen–glucose deprivation and reperfusion

Ning-Tian Ma, Ru Zhou, Ren-Yuan Chang, Yinju Hao, Lin Ma, Shaoju Jin, Juan Du, Jie Zheng, Chengjun Zhao, Yang Niu, Tao Sun, Wei Li, Kazuo Koike, Jian‐Qiang Yu, Yu‐Xiang Li

Journal of Natural Medicines

DOI

2015

Oxymatrine attenuated hypoxic-ischemic brain damage in neonatal rats via improving antioxidant enzyme activities and inhibiting cell death

Peng Zhao, Ru Zhou, Haining Li, Wan-Xia Yao, Hai-Qi Qiao, Shujing Wang, Yang Niu, Tao Sun, Yu‐Xiang Li, Jian‐Qiang Yu

Neurochemistry International

DOI

2015

Matrine attenuates focal cerebral ischemic injury by improving antioxidant activity and inhibiting apoptosis in mice

PENG ZHAO, Ru Zhou, Xiaoyun Zhu, Yinju Hao, Nan Li, Jie Wang, Yang Niu, Tao Sun, Yu‐Xiang Li, Jian‐Qiang Yu

International Journal of Molecular Medicine

DOI

2014

丹参水提物对大鼠心肌缺血——再灌注损伤氧化应激的影响

周茹，何耀，和丽芬，王良芬，李永杰，晁若冰，杜俊蓉

《中药药理与临床》

2014

氧化槐定碱对新生大鼠海马神经元氧糖剥夺再灌注损伤后细胞凋亡的影响

周茹，郝银菊，姚婉霞，杨文莉，杜娟，余建强

《中药药理与临床》

2014

Neuroprotective effects of oxysophocarpine on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion

Qing-Luan Zhu, Yu‐Xiang Li, Ru Zhou, Ning-Tian Ma, Ren-Yuan Chang, Tengfei Wang, Yi Zhang, Xiao-Ping Chen, Yinju Hao, Shaoju Jin, Lin Ma, Juan Du, Tao Sun, Jian‐Qiang Yu

Pharmaceutical Biology

DOI

2014

Lycium barbarum Polysaccharide Prevents Focal Cerebral Ischemic Injury by Inhibiting Neuronal Apoptosis in Mice

Tengfei Wang, Yu‐Xiang Li, Yongsheng Wang, Ru Zhou, Lin Ma, Yinju Hao, Shaoju Jin, Juan Du, Chengjun Zhao, Tao Sun, Jian‐Qiang Yu

PLoS ONE

DOI

2014

Effects of oxysophoridine on amino acids after cerebral ischemic injury in mice

Jianqiang Yu, Tengfei Wang, Yuxiang Li, Peng Zhao, Jie Wang, Xiaomin Zhang, Yinju Hao, Juan Du, Chengjun Zhao, Tao Sun, Ru Zhou, Shaoju Jin

Annals of Indian Academy of Neurology

DOI

2013

Oxysophoridine Protects Against Focal Cerebral Ischemic Injury by Inhibiting Oxidative Stress and Apoptosis in Mice

Tengfei Wang, Zhen Lei, Yu-Xiang Li, Yong‐Sheng Wang, Jie Wang, Shujing Wang, Yinju Hao, Ru Zhou, Shaoju Jin, Juan Du, Juan Li, Tao Sun, Jianqiang Yu

Neurochemical Research

DOI

2013

Anti-apoptotic and Neuroprotective Effects of Oxysophoridine on Cerebral Ischemia Both In Vivo and In Vitro

Rui Chen, Yuxiang Li, Jiang Ning, Ning-Tian Ma, Zhu Qingluan, Hao Yinju, Ru Zhou, Lin Ma, Tao Sun, Jianqiang Yu

Planta Medica

DOI

2012

苦参碱和氧化苦参碱抗血管过敏性损伤的作用

郑婕，闫琳，郑萍，周茹，王锐，戴贵东

《宁夏医科大学学报》

2010

氧化苦参碱对银屑病样小鼠模型氧化应激的拮抗作用

周茹，施惠娟，金少举

《宁夏医科大学学报》

2010

Cardioprotective effect of matrine on isoproterenol-induced cardiotoxicity in rats

Xiaobing Li, Ru Zhou, Ping Zheng, Lin Yan, Yang Wu, Xiao Xu, Guidong Dai

Journal of Pharmacy and Pharmacology

DOI

2009

氟伐他汀对脂多糖和血管紧张素Ⅱ致大鼠主动脉内皮细胞TF和TFPI表达的影响

周茹，纳春祥，徐清斌，王锐，郑萍

《宁夏医科大学学报》

2009

Relaxant Effects of Matrine on Aortic Smooth Muscles of Guinea Pigs

Jie Zheng, PING ZHENG, Xu Zhou, Lin Yan, Ru Zhou, Xueyan Fu, Guidong Dai

Biomedical and Environmental Sciences

DOI

2008

苦参碱对高胆固醇血症大鼠心肌缺血性损伤的保护作用

杨彩艳，郑萍，王小萍，闫琳，周茹，戴贵东

《中草药》

2008

Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat

Ru Zhou, Qingbin Xu, Ping Zheng, Lin Yan, Jie Zheng, Guidong Dai

European Journal of Pharmacology

DOI

2007

大鼠主动脉内皮细胞的贴壁法培养

周茹，郑婕，徐清斌，戴贵东

《宁夏医科大学学报》

2006

Ⅱ型胶原诱导的小鼠关节炎动物模型的建立及影响因素

周茹，杨以阜，左建平

《中国药理学通报》

2005

甘珀酸钠苦参素包合物的急性毒性及对CCl4肝损伤小鼠的保护作用

金少举，蒋袁絮，周茹，刘利军

《宁夏医科大学学报》

2003

月见草油对大鼠血脂的调节作用

闫琳，郑婕，周茹，金少举，杨卫东

《宁夏医科大学学报》

2003

麻黄碱水杨酸对小鼠中枢兴奋作用的研究

闫琳，周茹，郑婕，蒋袁絮，刘利军

《宁夏医科大学学报》

2003

银杏铬对正常动物及实验性糖尿病小鼠血糖的影响

蒋袁絮，闫琳，周茹，郑婕，刘玉春

《宁夏医科大学学报》

会议论文

2010

苦参碱及氧化苦参碱对抗原诱发的血管收缩反应的保护作用及其机制的研究

郑婕，郑萍，闫琳，周茹，王锐，戴贵东

《第十届全国心血管药理学术会议暨2010（重庆）国际心血管疾病与药物高峰论坛论文集》

研究方向

一：心脑肺血管药理学

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